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Stroke Study (stroke + study)

Distribution by Scientific Domains
Medical Sciences60%

Selected Abstracts

Perindopril protection against recurrent stroke study: An overview of published results

GERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 1 2005
Matthew Walters
The Perindopril Protection Against Recurrent Stroke Study was designed to clarify the role of intervention to lower blood pressure after stroke. Its aim was to determine the effect of long-term treatment with an angiotensin converting enzyme inhibitor-based blood pressure lowering regimen in patients with a history of non-disabling stroke. A series of publications have reported the design and both main and subsidiary analyses of the Perindopril Protection Against Recurrent Stroke Study trial. This article will provide an overview of the trial and draw together the results of previously-published primary, secondary and subgroup analyses. [source]

Cardiovascular Events in Hypertension Trials of Angiotensin-Converting Enzyme Inhibitors

JOURNAL OF CLINICAL HYPERTENSION, Issue 2005
William J. Elliott MD
Angiotensin-converting enzyme inhibitors are widely-prescribed drugs for hypertension and are supported by clinical trials in which they reduce cardiovascular events. In the high-risk patients in the Heart Outcomes Prevention Evaluation, the Perindopril Protection Against Recurrent Stroke Study, and European Trial of Reduction of Cardiac Events With Perindopril in Stable Coronary Artery Disease, ramipril and perindopril showed impressive benefits. One reason trandolapril did somewhat less well in the Prevention of Events With Angiotensin-Converting Enzyme Inhibition trial may be that its patients were very well treated with other effective modalities. In the Antihypertensive and Lipid Lowering to Prevent Heart Attack Trial, lisinopril-treated patients had a slightly lower incidence of myocardial infarction, despite much poorer control of blood pressure, perhaps because a second-line diuretic was prohibited by protocol. Although angiotensin-converting enzyme inhibitors can cause cough and angioedema (more common among blacks), angiotensin receptor blockers are currently more expensive and have fewer outcome trials to support their use. [source]

Matched Case,Control Data Analysis with Selection Bias

BIOMETRICS, Issue 4 2001
I-Feng Lin
Summary. Case-control studies offer a rapid and efficient way to evaluate hypotheses. On the other hand, proper selection of the controls is challenging, and the potential for selection bias is a major weakness. Valid inferences about parameters of interest cannot be drawn if selection bias exists. Furthermore, the selection bias is difficult to evaluate. Even in situations where selection bias can be estimated, few methods are available. In the matched case-control Northern Manhattan Stroke Study (NOMASS), stroke-free controls are sampled in two stages. First, a telephone survey ascertains demographic and exposure status from a large random sample. Then, in an in-person interview, detailed information is collected for the selected controls to be used in a matched case,control study. The telephone survey data provides information about the selection probability and the potential selection bias. In this article, we propose bias-corrected estimators in a case-control study using a joint estimating equation approach. The proposed bias-corrected estimate and its standard error can be easily obtained by standard statistical software. [source]

Perindopril protection against recurrent stroke study: An overview of published results

GERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 1 2005
Matthew Walters
The Perindopril Protection Against Recurrent Stroke Study was designed to clarify the role of intervention to lower blood pressure after stroke. Its aim was to determine the effect of long-term treatment with an angiotensin converting enzyme inhibitor-based blood pressure lowering regimen in patients with a history of non-disabling stroke. A series of publications have reported the design and both main and subsidiary analyses of the Perindopril Protection Against Recurrent Stroke Study trial. This article will provide an overview of the trial and draw together the results of previously-published primary, secondary and subgroup analyses. [source]

Quality-Adjusted Survival Estimation with Periodic Observations

BIOMETRICS, Issue 3 2001
Pai-Lien Chen
Summary. Quality-adjusted survival is a measure that integrates both longevity and quality-of-life information. The analysis of quality-adjusted survival in a clinical study with data collected at periodic intervals encounters difficulties due to incomplete information. Based on observed time points, the time axis is partitioned into a set of disjoint time intervals, and under a Markovian assumption on patient's health status, the expected quality-adjusted survival is estimated as the summed product of the quality of life and its mean sojourn time of each health state within partitioned intervals. It is shown that the estimator is asymptotically normal with a simple variance calculation. A simulation study is conducted to investigate the behavior of the estimator, and a stroke study illustrates the use of the estimator. [source]