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Striking Similarities (striking + similarity)
Selected AbstractsThe characteristics of heroin users entering treatment: findings from the Australian Treatment Outcome Study (ATOS)DRUG AND ALCOHOL REVIEW, Issue 5 2005JOANNE ROSS Abstract The current study aimed to describe the characteristics (demographics, drug use, mental and physical health) of entrants to treatment for heroin dependence in three treatment modalities; and to compare these characteristics with heroin users not in or seeking treatment. Participants were 825 current heroin users recruited from Sydney, Adelaide and Melbourne: 277 entering methadone/buprenorphine maintenance treatment (MT), 288 entering detoxification (DTX), 180 entering drug-free residential rehabilitation (RR) and 80 not in treatment (NT). Treatment entrants were generally long-term heroin users with previous treatment experience. The majority of the sample (55%) were criminally active in the month preceding interview. Injection-related health problems (74%) and a history of heroin overdose (58%) were commonly reported. There were high degrees of psychiatric co-morbidity, with 49% reporting severe psychological distress, 28% having current major depression, 37% having attempted suicide and 42% having a lifetime history of post-traumatic stress disorder. Personality disorders were also prevalent, with 72% meeting criteria for antisocial personality disorder and 47% screening positive for borderline personality disorder. Striking similarities were noted between the non-treatment and treatment groups in length of heroin use career, drug use and treatment histories. [source] Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28FEBS JOURNAL, Issue 20 2000Ralf Stohwasser The activation kinetics of constitutive and IFN,-stimulated 20S proteasomes obtained with homomeric (recPA28,, recPA28,) and heteromeric (recPA28,,) forms of recombinant 11S regulator PA28 was analysed by means of kinetic modelling. The activation curves obtained with increasing concentrations of the individual PA28 subunits (RecP28,/RecP28,/RecP28,+ RecP28,) exhibit biphasic characteristics which can be attributed to a low-level activation by PA28 monomers and full proteasome activation by assembled activator complexes. The dissociation constants do not reveal significant differences between the constitutive and the immunoproteasome. Intriguingly, the affinity of the proteasome towards the recPA28,, complex is about two orders of magnitude higher than towards the homomeric PA28, and PA28, complexes. Striking similarities can been revealed in the way how PA28 mediates the kinetics of latent proteasomes with respect to three different fluorogenic peptides probing the chymotrypsin-like, trypsin-like and peptidylglutamyl-peptide hydrolyzing like activity: (a) positive cooperativity disappears as indicated by a lack of sigmoid initial parts of the kinetic curves, (b) substrate affinity is increased, whereby (c), the maximal activity remains virtually constant. As these kinetic features are independent of the peptide substrates, we conclude that PA28 exerts its activating influence on the proteasome by enhancing the uptake (and release) of shorter peptides. [source] Interaction of Cytidine 5,-Monophosphate with Au(111): An In Situ Infrared Spectroscopic StudyCHEMPHYSCHEM, Issue 9-10 2009Thomas Doneux Dr. Abstract Attracted to gold: The interaction of cytidine 5,-monophosphate (CMP) with gold surfaces is studied at the Au(111) | aqueous solution interface. In situ infrared spectroscopy studies show that cytidine 5,-monophosphate is chemisorbed on Au(111) through the N3 atom of the pyrimidine ring (see picture). The interaction of cytidine 5,-monophosphate (CMP) with gold surfaces is studied by means of in situ infrared spectroscopy and cyclic voltammetry at the Au(111) | aqueous solution interface. Similar to other nucleic acid components, cytidine 5,-monophosphate is chemisorbed on the surface at positive potentials, and the amount of adsorbed CMP increases with the potential. Subtractively normalized interfacial Fourier-transform infrared spectroscopy (SNIFTIRS) is used to identify the adsorbed and desorbed species. Upon electrochemical desorption, the molecules released in solution are unprotonated on the N3 atom. Striking similarities are found between the spectrum of adsorbed CMP and the solution spectrum of protonated CMP. The origin of such similarities is discussed. The results strongly suggest that chemisorption occurs through the N3 atom of the pyrimidine ring. A comparison is drawn with cytidine, whose electrochemical and spectroscopic behaviors are also investigated. [source] Pregabalin Exerts Oppositional Effects on Different Inhibitory Circuits in Human Motor Cortex: A Double-blind, Placebo-controlled Transcranial Magnetic Stimulation StudyEPILEPSIA, Issue 5 2006Nicolas Lang Summary:,Purpose: To explore acute effects of pregabalin (PGB) on human motor cortex excitability with transcranial magnetic stimulation (TMS). Methods: PGB, 600 mg/day, was orally administered in 19 healthy subjects twice daily in a randomized, double-blind, placebo-controlled crossover design. Several measures of motor cortex excitability were tested with single- and paired-pulse TMS. Results: Mean short-interval intracortical inhibition (SICI) was reduced after PGB (74 ± 7% of unconditioned response) compared with placebo (60 ± 6% of unconditioned response). In contrast, mean long-interval intracortical inhibition (LICI) was increased by PGB (26 ± 4% of unconditioned response) compared with placebo (45 ± 8% of unconditioned response), and mean cortical silent period (CSP) showed an increase from 139 ± 8 ms or 145 ± 8 ms after placebo to 162 ± 7 ms or 161 ± 10 ms after PGB. Motor thresholds, intracortical facilitation, and corticospinal excitability were unaffected. Conclusions: The observed excitability changes with oppositional effects on SICI and LICI or CSP suggest ,-aminobutyric acid (GABA)B -receptor activation. They are markedly distinct from those induced by gabapentin, although both PGB and gabapentin are thought to mediate their function by binding to the ,(2)-, subunit of voltage-gated calcium channels. Conversely, the TMS profile of PGB shows striking similarities with the pattern evoked by the GABA-reuptake inhibitor tiagabine. [source] An evolutionary transition of vasa regulation in echinodermsEVOLUTION AND DEVELOPMENT, Issue 5 2009Celina E. Juliano SUMMARY Vasa, a DEAD box helicase, is a germline marker that may also function in multipotent cells. In the embryo of the sea urchin Strongylocentrotus purpuratus, Vasa protein is posttranscriptionally enriched in the small micromere lineage, which results from two asymmetric cleavage divisions early in development. The cells of this lineage are subsequently set aside during embryogenesis for use in constructing the adult rudiment. Although this mode of indirect development is prevalent among echinoderms, early asymmetric cleavage divisions are a derived feature in this phylum. The goal of this study is to explore how vasa is regulated in key members of the phylum with respect to the evolution of the micromere and small micromere lineages. We find that although striking similarities exist between the vasa mRNA expression patterns of several sea urchins and sea stars, the time frame of enriched protein expression differs significantly. These results suggest that a conserved mechanism of vasa regulation was shifted earlier in sea urchin embryogenesis with the derivation of micromeres. These data also shed light on the phenotype of a sea urchin embryo upon removal of the Vasa-positive micromeres, which appears to revert to a basal mechanism used by extant sea stars and pencil urchins to regulate Vasa protein accumulation. Furthermore, in all echinoderms tested here, Vasa protein and/or message is enriched in the larval coelomic pouches, the site of adult rudiment formation, thus suggesting a conserved role for vasa in undifferentiated multipotent cells set aside during embryogenesis for use in juvenile development. [source] Controls of mantle plumes and lithospheric folding on modes of intraplate continental tectonics: differences and similaritiesGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2009Evgueni Burov SUMMARY Mantle plume activity and lithospheric folding by far-field stresses exerted from plate boundaries are two important end-members as mechanisms for continental intraplate deformation. The topographic expression of mantle plume impingement on continental lithosphere and lithospheric folding has some striking similarities. Observations from a number of areas in Europe's intraplate lithosphere demonstrate that these mechanisms commonly interact in space and time. We present the results of thermomechanical modelling addressing the role of factors such as the presence of a hot upper mantle, the spatial dimensions of the plume and the time constants involved in the temporal succession of plume activity and lithospheric folding by stress accumulation in intraplate continental lithosphere. The results demonstrate that both the processes, plume,lithosphere interactions and folding may interact resulting either in strong amplification, attenuation or modification of their surface expression. These inferences are compatible with a number of key observations on the nature and the temporal succession of topography evolution in the Alpine foreland, the Pannonian Basin, the Scandinavian continental margin and the Iberian Peninsula. [source] A qualitative investigation into the donor lapsing experienceINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 4 2009Amber Nathan Donor attrition is costing charities a fortune. Previous research has examined the relative importance of the antecedents to donor loyalty versus lapsing. This study qualitatively builds on this. It reports the results of workshops and interviews that took lapsers and donors back through their donor and lapser journeys. It drills down into and unpacks their experiences,inclusive of the (previously undocumented) lapsing experience itself. It reveals striking similarities between the cancellation of a direct debit and other more conventional purchase decisions. Most worryingly, it seems that most people stop supporting a given charity because they had never really had any loyalty to it in the first place. Charities are not meeting people's needs as donors. There is a distinct lack of understanding between charities and their donors, and donors are lapsing because charities give them little reason to stay. The authors conclude with practical recommendations for the management of attrition. Copyright © 2009 John Wiley & Sons, Ltd. [source] Similarities and differences in the historical development of flood management in the alluvial stretches of the Lower Mississippi Basin and the Rhine Basin,§IRRIGATION AND DRAINAGE, Issue S1 2006Dick de Bruin ingénierie hydraulique fluviale; développement historique des bassins du Rhin et du Mississippi inférieur; plaines alluviales Abstract Although the rivers Rhine and Mississippi cannot be compared as features of nature,the Mississippi River as a feature of nature is much bigger and more impressive than the Rhine,one can still observe striking similarities on flood management in both river basins, in particular in the alluvial flat reaches. But there are also some fundamental differences, not only technically but also institutionally. Since industrialization (around 1800), inland navigation became a major user on both river systems and later flood control started developing more fundamentally. Large intervention works were needed, mainly developed and based on trial and error. In both cases it has led to irreversible effects, which demand continuous attention. For the alluvial stretches in both river basins, a review is given on the most important developments in river engineering over the last two centuries. For both rivers, nautical management and flood control were held in one institutional hand at national/federal level, because both uses/sectors need the creation and regular maintenance of one similar issue: a stable and deep main channel. But the way in which in particular flood management gradually developed institutionally, as an essential part of integrated water management in the alluvial flat lower reaches of both river systems, has diverged. Discussions on financing, priorities, public disclosure, multifunctional aspects, etc. have led in both basins to lengthy procedures and complicated policy making. This paper elaborates on the historic development of fundamentals in river engineering and river management in the alluvial plains of the Rhine Basin and the Lower Mississippi Basin, more in particular focusing on the development of flood protection dikes, and on the stabilization of major channels. Copyright © 2006 John Wiley & Sons, Ltd. Bien que le Rhin et le Mississippi ne puissent pas être comparés en termes physiques,le Mississippi est beaucoup plus grand et impressionnant que le Rhin,on peut pourtant observer des similitudes saisissantes dans la protection contre les inondations des deux bassins, en particulier dans les plaines alluviales. Mais il existe également quelques différences fondamentales, non seulement techniques mais institutionnelles. Depuis les débuts de l'industrialisation (vers 1800), la navigation est devenue un usage très important sur les deux fleuves et la protection contre les inondations à commencer à se mettre en place de façon plus systématique. De grands travaux d'intervention ont été nécessaires, principalement basés sur la règle empirique de l'essai/erreur. Dans les deux cas, ceci a entraîné des effets irréversibles, qui nécessitent une surveillance permanente. Pour les plaines alluviales des deux bassins, l'article passe en revue la plupart des développements de l'ingénierie hydraulique fluviale des deux cent dernières années. Pour les deux fleuves, la gestion de la navigation et la protection contre les inondations ont été regroupées dans une même institution au niveau national/fédéral, parce que les deux usages/secteurs demandaient la création et l'entretien régulier d'une même infrastructure: un canal principal stable et profond. Mais la manière dont la protection contre les inondations s'est progressivement développée sur le plan institutionnel, comme élément essentiel de la gestion intégrée de l'eau dans les plaines alluviales des deux fleuves, s'est différenciée. Des débats sur le financement, les priorités, l'information du public, les aspects multi fonctionnels, etc., ont conduit les deux bassins à mettre en place des procédures lourdes et des prises de décision complexes. Cet article présente le développement historique des principes fondamentaux de l'hydraulique fluviale et de la gestion de fleuve dans les plaines alluviales du bassin du Rhin et du bassin inférieur du Mississippi, en mettant l'accent sur le développement des digues de protection et la stabilisation des canaux principaux. Copyright © 2006 John Wiley & Sons, Ltd. [source] Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their nichesJOURNAL OF ANATOMY, Issue 1 2008Vanja Pekovic Abstract Adult stem cells have been identified in most mammalian tissues of the adult body and are known to support the continuous repair and regeneration of tissues. A generalized decline in tissue regenerative responses associated with age is believed to result from a depletion and/or a loss of function of adult stem cells, which itself may be a driving cause of many age-related disease pathologies. Here we review the striking similarities between tissue phenotypes seen in many degenerative conditions associated with old age and those reported in age-related nuclear envelope disorders caused by mutations in the LMNA gene. The concept is beginning to emerge that nuclear filament proteins, A-type lamins, may act as signalling receptors in the nucleus required for receiving and/or transducing upstream cytosolic signals in a number of pathways central to adult stem cell maintenance as well as adaptive responses to stress. We propose that during ageing and in diseases caused by lamin A mutations, dysfunction of the A-type lamin stress-resistant signalling network in adult stem cells, their progenitors and/or stem cell niches leads to a loss of protection against growth-related stress. This in turn triggers an inappropriate activation or a complete failure of self-renewal pathways with the consequent initiation of stress-induced senescence. As such, A-type lamins should be regarded as intrinsic modulators of ageing within adult stem cells and their niches that are essential for survival to old age. [source] Colston E. Warne Lecture: Is It Time for Another Round of Consumer Protection?JOURNAL OF CONSUMER AFFAIRS, Issue 1 2010The Lessons of Twentieth-Century U.S. History The first year of Barack Obama's presidency has returned consumer issues to center stage, with several contentious struggles over consumer protection. This moment can be viewed as a fourth wave of the twentieth-century consumer movement, and a comparison with the first three waves (during the Progressive Era, the New Deal, and the 1960s,1970s) offers instructive insights. In particular, the contemporary battle over the Consumer Financial Protection Agency bears striking similarities to the failed campaign for a Consumer Protection Agency in the 1970s. [source] Evolution of the middle ear apparatus in talpid molesJOURNAL OF MORPHOLOGY, Issue 6 2006Matthew J. Mason Abstract The middle ear structures of eight species of mole in the family Talpidae (Mammalia: Eulipotyphla) were studied under light and electron microscopy. Neurotrichus, Parascalops, and Condylura have a simple middle ear cavity with a loose ectotympanic bone, ossicles of a "microtype" morphology, and they retain a small tensor tympani muscle. These characteristics are ancestral for talpid moles. Talpa, Scalopus, Scapanus, and Parascaptor species, on the other hand, have a looser articulation between malleus and ectotympanic bone and a reduced or absent orbicular apophysis. These species lack a tensor tympani muscle, possess complete bullae, and extensions of the middle ear cavity pneumatize the surrounding basicranial bones. The two middle ear cavities communicate in Talpa, Scapanus, and Parascaptor species. Parascaptor has a hypertrophied malleus, a feature shared with Scaptochirus but not found in any other talpid genus. Differences in middle ear morphology within members of the Talpidae are correlated with lifestyle. The species with middle ears closer to the ancestral type spend more time above ground, where they will be exposed to high-frequency sound: their middle ears appear suited for transmission of high frequencies. The species with derived middle ear morphologies are more exclusively subterranean. Some of the derived features of their middle ears potentially improve low-frequency hearing, while others may reduce the transmission of bone-conducted noise. By contrast, the unusual middle ear apparatus of Parascaptor, which exhibits striking similarities to that of golden moles, probably augments seismic sensitivity by inertial bone conduction. J. Morphol. © 2006 Wiley-Liss, Inc. [source] Mineralogy and petrology of the angrite Northwest Africa 1296METEORITICS & PLANETARY SCIENCE, Issue 3 2005A. Jambon Dendritic olivine (,Fo50) crystallized first in association with anorthite microcrysts (An98,100) forming composite chains separated from one another by intergrown Al-Fe diopside-hedenbergite pyroxenes. In addition, some olivines with lower Mg# and increased CaO (up to 12%) are found between the chains as equant microphenocrysts. Pyroxenes and olivines are both normally zoned from Mg# = 0.52 to less than 0.01 in the rims. Ca-rich olivines are surrounded by, intergrown with, or replaced by subcalcic kirschsteinite. They appear after plagioclase crystallization stopped, at the end of the crystallization sequence. Minor phases are pyrrhotite, F-apatite, and titanomagnetite. Pyroxene is the last silicate phase to grow, interstitial to idiomorphic olivine-kirschsteinite. Numerous small vesicles and some channels are filled with microcristalline carbonate. The mode (vol%) is about 28% olivine, 3% kirschsteinite, 32% anorthite, 34% pyroxene, and 3% of the minor phases,close to that reported previously for D'Orbigny and Sahara (SAH) 99555. The bulk chemical composition of NWA 1296 is similar to D'Orbigny and SAH 99555; NWA 1296 differs by its texture and mineralogy, which are interpreted as resulting from rapid crystallization,an evidence of impact melting. Angrites cannot be produced by partial melting of a CV source because segregation of a "planetary" core is necessary to explain the low FeO/MgO ratio of magnesian olivines. Neither the odd Ca/Al ratio nor the very low SiO2 content can be explained by conventional partial melting scenarios. We suggest that carbonate is the key to angrite genesis. This is supported by the striking similarities with terrestrial melilitites (low SiO2, superchondritic Ca/Al ratio, presence of carbonate). The lack of alkalies could be the result of either loss after impact melting or absence of alkalies in the source. [source] New polymorphic microsatellite loci for different camel speciesMOLECULAR ECOLOGY RESOURCES, Issue 3 2003D. Evdotchenko Abstract New microsatellite loci were screened and sequenced from the genomic DNA of male Camelus bactrianus. Among 32 loci, 23 were amplified in bactrian and dromedary species, 19 in llama and 20 in alpaca. The different species had similar fragment lengths per locus, with more striking similarities between bactrian and dromedary and between llama and alpaca, respectively. Seven loci had more than 10 alleles each, nine were monomorphic in all species, and one was monomorphic in Old World and polymorphic in New World camels. The results show that the informative microsatellite loci can be widely applied to several species. [source] The Trinitarian Metaphysics of Jonathan Edwards and Nicolas MalebrancheTHE HEYTHROP JOURNAL, Issue 2 2002Jasper Reid This paper explores both the striking similarities and also the differences between Jonathan Edwards and Nicolas Malebranche's philosophical views on the Holy Trinity and, in particular, the ways in which they both gave important roles to specific Persons of the Trinity in the various different branches of their respective metaphysical systems,ontological, epistemological and ethical. It is shown that Edwards and Malebranche were in very close agreement on ontological questions pertaining to the Trinity, both with respect to the internal, triune nature of the divine substance (characterising the Three Persons as the divine power, as the consubstantial idea of God which was generated as He eternally reflected on Himself, and as the mutual love which proceeded between the Father and this idea), and also with respect to the various roles these Three Persons played in the creation of the world. In epistemology, Malebranche postulated an illuminating union between the mind of man and the divine Word, insisting on an absolutely direct involvement of the Second Person in all human cognition, both intellectual and sensible. On this point Edwards did differ, endorsing instead an empiricist epistemology which left no room for such a direct union with the Word. However, when it came to ethics, Edwards and Malebranche both gave the Third Person an utterly central role, postulating much the same kind of union as Malebranche alone had postulated in the epistemological case, only now between the will of man and the Holy Spirit. [source] Linguistic Markers of Psychological State through Media Interviews: John Kerry and John Edwards in 2004, Al Gore in 2000ANALYSES OF SOCIAL ISSUES & PUBLIC POLICY, Issue 1 2005James W. Pennebaker What can we learn about presidential candidates by examining their speech in natural conversation? In the present study, the television interviews from the 2004 Democratic presidential primary campaign of John Kerry (N= 29) and John Edwards (N= 34) were examined using linguistic analyses. Results indicate that Kerry and Edwards were similar in their use of positive emotion words, but that Kerry used significantly higher rates of negative emotion words than did Edwards. Comparisons with televised interviews of Al Gore from the 2000 presidential campaign (N= 17) revealed striking similarities in the linguistic styles of Gore and Kerry. Gore's linguistic style overlapped considerably with that of Kerry on pronoun usage and many cognitive domains. This study points to how linguistic analyses can give us a clearer picture of how political candidates think, act, and feel. [source] Potato yellow vein virus: its host range, distribution in South America and identification as a crinivirus transmitted by Trialeurodes vaporariorumANNALS OF APPLIED BIOLOGY, Issue 1 2000L F SALAZAR Summary Sporadic outbreaks of potato yellow vein disease (PYVD) were first observed in the early 1940's by potato growers in Antioquia, Colombia. Long known to be transmitted by the greenhouse whitefly (Trialeurodes vaporariorum), the precise identity of its causal agent (presumably viral in nature) has remained obscure. Here, we present evidence that a closterovirus with a bipartite genome, potato yellow vein virus (PYVV), is associated with PYVD. Electrophoretic analysis revealed that diseased tissue contains 4,5 disease-specific dsRNAs ranging in size from c. 9 000,1 800 bp. RT-PCR reactions containing pairs of degenerate primers directed against conserved motifs in the closterovirus heat-shock protein homologue produced products of the expected sizes. Comparison of the corresponding amino acid sequences revealed striking similarities between PYVV and two bipartite, whitefly-transmitted criniviruses, Cucurbit yellow stunting disorder and Tomato chlorosis viruses. Epidemiological surveys carried out in Rionegro, Colombia identified Polygonum mepalense, Polygonum spp., Rumex obtusifolium, Tagetes spp., and Catharanthus roseus as potential viral reservoirs. PYVV is transmitted through tubers, and visual symptoms alone cannot be used to determine infection status. A sensitive hybridisation-based assay for PYVV has been developed for use in seed certification programmes. [source] Mutualism versus pathogenesis: the give-and-take in plant,bacteria interactionsCELLULAR MICROBIOLOGY, Issue 3 2009María J. Soto Summary Pathogenic bacteria and mutualistic rhizobia are able to invade and establish chronic infections within their host plants. The success of these plant,bacteria interactions requires evasion of the plant innate immunity by either avoiding recognition or by suppressing host defences. The primary plant innate immunity is triggered upon recognition of common microbe-associated molecular patterns. Different studies reveal striking similarities between the molecular bases underlying the perception of rhizobial nodulation factors and microbe-associated molecular patterns from plant pathogens. However, in contrast to general elicitors, nodulation factors can control plant defences when recognized by their cognate legumes. Nevertheless, in response to rhizobial infection, legumes show transient or local defence-like responses suggesting that Rhizobium is perceived as an intruder although the plant immunity is controlled. Whether these responses are involved in limiting the number of infections or whether they are required for the progression of the interaction is not yet clear. Further similarities in both plant,pathogen and Rhizobium,legume associations are factors such as surface polysaccharides, quorum sensing signals and secreted proteins, which play important roles in modulating plant defence responses and determining the outcome of the interactions. [source] Dopamine, Morphine, and Nitric Oxide: An Evolutionary Signaling TriadCNS: NEUROSCIENCE AND THERAPEUTICS, Issue 3 2010George B. Stefano Morphine biosynthesis in relatively simple and complex integrated animal systems has been demonstrated. Key enzymes in the biosynthetic pathway have also been identified, that is, CYP2D6 and COMT. Endogenous morphine appears to exert highly selective actions via novel mu opiate receptor subtypes, that is, mu3,-4, which are coupled to constitutive nitric oxide release, exerting general yet specific down regulatory actions in various animal tissues. The pivotal role of dopamine as a chemical intermediate in the morphine biosynthetic pathway in plants establishes a functional basis for its expansion into an essential role as the progenitor catecholamine signaling molecule underlying neural and neuroendocrine transmission across diverse animal phyla. In invertebrate neural systems, dopamine serves as the preeminent catecholamine signaling molecule, with the emergence and limited utilization of norepinephrine in newly defined adaptational chemical circuits required by a rapidly expanding set of physiological demands, that is, motor and motivational networks. In vertebrates epinephrine, emerges as the major end of the catecholamine synthetic pathway consistent with a newly incorporated regulatory modification. Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, it is our overall contention that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, that is, COMT, drawn from cellular morphine expression. Our compelling hypothesis promises to initiate the reexamination of clinical studies, adding new information and treatment modalities in biomedicine. [source] Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse controlEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 11 2005Catharine A. Winstanley Abstract Although the subthalamic nucleus (STN) is involved in regulating motor function, and inactivation of this structure relieves the motor symptoms in Parkinsonian patients, recent data indicate that corticosubthalamic connections are involved in both the regulation of attention and the ability to withhold from responding. Considerable evidence suggests that the neural circuitry underlying such behavioural disinhibition or impulsive action can be at least partially dissociated from that implicated in impulsive decision-making and it has been suggested that the tendency to choose impulsively is related to the ability to form and use Pavlovian associations. To explore these hypotheses further, STN-lesioned rats were tested on the delay-discounting model of impulsive choice, where impulsivity is defined as the selection of a small immediate over a larger delayed reward, as well as in a rodent autoshaping paradigm. In contrast to previous reports of increased impulsive action, STN lesions decreased impulsive choice but dramatically impaired the acquisition of the autoshaping response. When the STN was lesioned after the establishment of autoshaping behaviour, lesioned subjects were more sensitive to the omission of reward, indicative of a reduction in the use of Pavlovian associations to control autoshaping performance. These results emphasize the importance of the STN in permitting conditioned stimulus,unconditioned stimulus associations to regulate goal-seeking, a function which may relate to the alterations in impulsive choice observed in the delay-discounting task. These data bear a striking similarity to those observed after lesions of the orbitofrontal cortex and are suggestive of an important role for corticosubthalamic connections in complex cognitive behaviour. [source] THE EFFECT OF ALTERNATIVE PREY ON THE DYNAMICS OF IMPERFECT BATESIAN AND MÜLLERIAN MIMICRIESEVOLUTION, Issue 6 2004Leena Lindström Abstract Both Batesian and Müllerian mimicries are considered classical evidence of natural selection where predation pressure has, at times, created a striking similarity between unrelated prey species. Batesian mimicry, in which palatable mimics resemble unpalatable aposematic species, is parasitic and only beneficial to the mimics. By contrast, in classical Müllerian mimicry the cost of predators' avoidance learning is shared between similar unpalatable co-mimics, and therefore mimicry benefits all parties. Recent studies using mathematical modeling have questioned the dynamics of Müllerian mimicry, suggesting that fitness benefits should be calculated in a way similar to Batesian mimicry; that is, according to the relative unpalatability difference between co-mimics. Batesian mimicry is very sensitive to the availability of alternative prey, but the effects of alternative prey for Müllerian dynamics are not known and experiments are rare. We designed two experiments to test the effect of alternative prey on imperfect Batesian and Müllerian mimicry complexes. When alternative prey were scarce, imperfect Batesian mimics were selected out from the population, but abundantly available alternative prey relaxed selection against imperfect mimics. Birds learned to avoid both Müllerian models and mimics irrespective of the availability of alternative prey. However, the rate of avoidance learning of models increased when alternative prey were abundant. This experiment suggests that the availability of alternative prey affects the dynamics of both Müllerian and Batesian mimicry, but in different ways. [source] Comparative assessment of the water balance and hydrology of selected Ethiopian and Kenyan Rift LakesLAKES & RESERVOIRS: RESEARCH AND MANAGEMENT, Issue 3 2008Tenalem Ayenew Abstract The study area is part of the East African Rift system, characterized by a cluster of lakes occupying an extremely faulted rift floor with geothermal manifestations. Some of the lakes illustrated contrasting water levels and size evolution over the last few decennia, believed to have been caused by various natural and anthropogenic factors. The relative importance of these factors, however, is unknown. This study attempts to present the hydrology of the lakes in a broader context, by giving more emphasis to lake water level fluctuations and to the water balance. These factors have far-reaching implications in regard to future management of the lake basin water. It also provides information on the relation of the groundwater with the lakes, and with the local and regional groundwater flow system from the adjacent highlands to the floor of the Rift. The methods utilized in this study include conventional hydrogeological field surveys, and hydrometeorological and data analyses, coupled with digital image processing and spatial analysis under a Geographic Information System environment. Ancillary supporting information has been obtained from environmental isotopes and hydrochemical data. The study results indicate the terminal Ethiopian lakes changed in size and water level significantly over the last half century. In contrast, the Kenyan lakes only exhibited slight changes. The lakes in both countries exhibit a striking similarity in their subsurface hydraulic connection, and are strongly governed by complex rift geological structures. Groundwater plays a vital role in the water balance of the study lakes. The study results indicate that future sustainable use of the study lakes demands that serious attention be given to the role of the groundwater component of the lake water balances. [source] Fairness, Justice, and Legitimacy: Experiences of People's Judges in South RussiaLAW & POLICY, Issue 2 2003Stefan Machura Which criteria do Russians use to evaluate the fairness of their judges, and how does perceived fairness of actual trials influence general beliefs about Russian courts? Lay assessors at courts in South Russia were asked about their experience serving on mixed courts. The justice of the verdicts rendered and the fairness of judges partly explain the respondents' view of national courts. According to the results, the respondents are also using similar criteria for fairness as Americans or Germans. The social and psychological group effects in a Russian court of lay assessors exhibit a striking similarity to other Western tribunals. [source] Structural and mutational analysis of the cell division protein FtsQMOLECULAR MICROBIOLOGY, Issue 1 2008Fusinita Van Den Ent Summary Bacterial cytokinesis requires the divisome, a complex of proteins that co-ordinates the invagination of the cytoplasmic membrane, inward growth of the peptidoglycan layer and the outer membrane. Assembly of the cell division proteins is tightly regulated and the order of appearance at the future division site is well organized. FtsQ is a highly conserved component of the divisome among bacteria that have a cell wall, where it plays a central role in the assembly of early and late cell division proteins. Here, we describe the crystal structure of the major, periplasmic domain of FtsQ from Escherichia coli and Yersinia enterocolitica. The crystal structure reveals two domains; the ,-domain has a striking similarity to polypeptide transport-associated (POTRA) domains and the C-terminal ,-domain forms an extended ,-sheet overlaid by two, slightly curved ,-helices. Mutagenesis experiments demonstrate that two functions of FtsQ, localization and recruitment, occur in two separate domains. Proteins that localize FtsQ need the second ,-strand of the POTRA domain and those that are recruited by FtsQ, like FtsL/FtsB, require the surface formed by the tip of the last ,-helix and the two C-terminal ,-strands. Both domains act together to accomplish the role of FtsQ in linking upstream and downstream cell division proteins within the divisome. [source] A new interpretation of the remarkable X-ray spectrum of the symbiotic star CH CygMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2006Peter J. Wheatley ABSTRACT We have re-analysed the ASCA X-ray spectrum of the bright symbiotic star CH Cyg, which exhibits apparently distinct hard and soft X-ray components. Our analysis demonstrates that the soft X-ray emission can be interpreted as scattering of the hard X-ray component in a photoionized medium surrounding the white dwarf. This is in contrast to previous analyses in which the soft X-ray emission was fitted separately and assumed to arise independently of the hard X-ray component. We note the striking similarity between the X-ray spectra of CH Cyg and Seyfert 2 galaxies, which are also believed to exhibit scattering in a photoionized medium. [source] Molecular and histochemical characterisation of two distinct poplar Melampsora leaf rust pathosystemsPLANT BIOLOGY, Issue 2 2010B. Boyle Abstract In this study, we compared interactions of two Melampsora foliar rust species with poplar, which resulted in either limited or abundant pathogen proliferation. In the pathosystem exhibiting limited pathogen growth, a defence response was observed after invasion of poplar leaf tissues by the biotroph, with late and clear production of reactive oxygen species (ROS) and other products. Characterisation of the histological, biochemical and transcriptional events occurring in both pathosystems showed striking similarity with components of plant defence reactions observed during qualitative resistance. Key components associated with development of an active defence response, such as up-regulation of pathogenesis-related (PR) genes, were observed during infection. Moreover, the time course and strength of gene induction appear to be critical determinants for the outcome of the tree,pathogen interaction. This work provides basic biochemical characterisation and expression data for the study of so-called partial resistance in the poplar,rust pathosystem, which is also applicable to other plant,pathogen interactions resulting in quantitative disease resistance. [source] | |||||||||||||||||||||||||||||||||||||