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Statistical Support (statistical + support)
Selected AbstractsStatistical support to non-clinicalPHARMACEUTICAL STATISTICS: THE JOURNAL OF APPLIED STATISTICS IN THE PHARMACEUTICAL INDUSTRY, Issue 2 2002Dennis Lendrem No abstract is available for this article. [source] A statistical method for scanning the genome for regions with rare disease allelesGENETIC EPIDEMIOLOGY, Issue 5 2010Chad GarnerArticle first published online: 21 JUN 2010 Abstract Studying the role of rare alleles in common disease has been prevented by the impractical task of determining the DNA sequence of large numbers of individuals. Next-generation DNA sequencing technologies are being developed that will make it possible for genetic studies of common disease to study the full frequency spectrum of genetic variation, including rare alleles. This report describes a method for scanning the genome for disease susceptibility regions that show an increased number of rare alleles among a sample of disease cases versus an ethnically matched sample of controls. The method was based on a hidden Markov model and the statistical support for a disease susceptibility region characterized by rare alleles was measured by a likelihood ratio statistic. Due to the lack of empirical data, the method was evaluated through simulation. The performance of the method was tested under the null and alternative hypotheses under a range of sequence generating and hidden Markov models parameters. The results showed that the statistical method performs well at identifying true disease susceptibility regions and that performance was primarily affected by the amount of variation in the neutral sequence and the number of rare disease alleles found in the disease susceptibility region. Genet. Epidemiol. 34: 386,395, 2010. © 2010 Wiley-Liss, Inc. [source] Understanding participation in e-learning in organizations: a large-scale empirical study of employeesINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 3 2010Thomas N. Garavan Much remains unknown in the increasingly important field of e-learning in organizations. Drawing on a large-scale survey of employees (N = 557) who had opportunities to participate in voluntary e-learning activities, the factors influencing participation in e-learning are explored in this empirical paper. It is hypothesized that key variables derived from the theories of planned behaviour and instructional design , general-person characteristics, motivation to learn, general and task-specific self-efficacy, situational barriers and enablers, and instructional design characteristics , will predict participation in e-learning. Using structural equation modelling, we find statistical support for the overall theoretical model proposed. We discuss the implications for practice. [source] Bayesian counterfactual analysis of the sources of the great moderationJOURNAL OF APPLIED ECONOMETRICS, Issue 2 2008Chang-Jin Kim We use counterfactual experiments to investigate the sources of the large volatility reduction in US real GDP growth in the 1980s. Contrary to an existing literature that conducts counterfactual experiments based on classical estimation and point estimates, we consider Bayesian analysis that provides a straightforward measure of estimation uncertainty for the counterfactual quantity of interest. Using Blanchard and Quah's (1989) structural VAR model of output growth and the unemployment rate, we find strong statistical support for the idea that a counterfactual change in the size of structural shocks alone, with no corresponding change in the propagation of these shocks, would have produced the same overall volatility reduction as what actually occurred. Looking deeper, we find evidence that a counterfactual change in the size of aggregate supply shocks alone would have generated a larger volatility reduction than a counterfactual change in the size of aggregate demand shocks alone. We show that these results are consistent with a standard monetary VAR, for which counterfactual analysis also suggests the importance of shocks in generating the volatility reduction, but with the counterfactual change in monetary shocks alone generating a small reduction in volatility. Copyright © 2007 John Wiley & Sons, Ltd. [source] Body size evolution in Mesozoic birds: little evidence for Cope's ruleJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 6 2008R. J. BUTLER Abstract Cope's rule, the tendency towards evolutionary increases in body size, is a long-standing macroevolutionary generalization that has the potential to provide insights into directionality in evolution; however, both the definition and identification of Cope's rule are controversial and problematic. A recent study [J. Evol. Biol. 21 (2008) 618] examined body size evolution in Mesozoic birds, and claimed to have identified evidence of Cope's rule occurring as a result of among-lineage species sorting. We here reassess the results of this study, and additionally carry out novel analyses testing for within-lineage patterns in body size evolution in Mesozoic birds. We demonstrate that the nonphylogenetic methods used by this previous study cannot distinguish between among- and within-lineage processes, and that statistical support for their results and conclusions is extremely weak. Our ancestor,descendant within-lineage analyses explicitly incorporate recent phylogenetic hypotheses and find little compelling evidence for Cope's rule. Cope's rule is not supported in Mesozoic birds by the available data, and body size evolution currently provides no insights into avian survivorship through the Cretaceous,Paleogene mass extinction. [source] On the systematics of the fungus gnat subfamily Mycetophilinae (Diptera): a combined morphological and molecular approachJOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH, Issue 3 2009E. Rindal Abstract The phylogenetic relationships within the fungus gnat subfamily Mycetophilinae (Diptera) are addressed using a combined morphological and molecular approach. Twenty-four species, representing nine genera of the tribe Mycetophilini and 15 genera of the tribe Exechiini, were included in the study. Analyses include nucleotide sequences of mitochondrial (cytochrome oxidase I and 16S), and nuclear (18S and 28S rDNA) genes, in addition to 65 morphological characters. A combined parsimony analysis, including all characters, supports the monophyly of the subfamily Mycetophilinae and two of its tribes, Exechiini and Mycetophilini. There is also statistical support for a Mycetophila- group and a Phronia- group within the tribe Mycetophilini. The Phronia- group includes the genera Phronia, Macrobrachius and Trichonta. The Mycetophila- group includes the genera Mycetophila, Epicypta, Platurocypta, Sceptonia and Zygomyia. A Bayesian analysis based on the nucleotide sequences alone also support these clades within Mycetophilini except for the position of Dynatosoma which is recovered as the sister taxon to the Phronia- group. A somewhat different pattern, however, is observed for the tribe Exechiini , neither molecular data nor the combined data set support unambiguously any intergeneric relationships within Exechiini. Zusammenfassung Die phylogenetischen Verwandtschaftsbeziehungen innerhalb der Pilzmücken der Unterfamilie Mycetophilinae (Diptera) wurden mit einem kombinierten morphologischen und molekularen Ansatz untersucht. Vierundzwanzig Arten aus 9 Gattungen des Tribus Mycetophilini und 15 Gattungen des Tribus Exechiini wurden in die Untersuchungen einbezogen. Die Ergebnisse einer kombinierten kladistischen Analyse von 65 morphologischen Merkmalen und den Nukleotidsequenzen der mitochondrialen Cytochrom Oxidase I und 16S Gene sowie der 18S und 28S Gene des Kerngenoms stützen die Monophylie der Unterfamilie Mycetophilinae sowie der beiden Tribus Exechiini und Mycetophilini. Weiterhin hatten die Mycetophila- und die Phronia- Gruppe innerhalb des Tribus Mycetophilini hohe statistische Unterstützung. Die Phronia- Gruppe schlie,t die Gattungen Phronia, Macrobrachius und Trichonta und die Mycetophila- Gruppe die Gattungen Mycetophila, Epicypta, Platurocypta, Sceptonia und Zygomyia ein. Die Gattung Dynatosoma gruppierte ebenso in der Mycetophila- Gruppe. Die Bayesische Analyse der Nukleotidsequenzen stützt ebenfalls die Monophylie der oben genannten Gruppen innerhalb des Tribus Mycetophilini. Ein anderes Bild ergab sich für den Tribus Exechiini. Weder die Analysen der molekularen Daten alleine noch in Kombination mit den morphologischen Daten ergaben für die einebezogenen Gattungen zweifelsfreie phylogenetische Verwandschaftsbeziehungen mit hoher statistischer Unterstützung. [source] Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohortALLERGY, Issue 8 2009S. Black Background:, Genetic variants of the two adjacent genes, IL13 and IL4 have frequently been reported as being associated with susceptibility to atopy and asthma, both in adults and children, and some studies also suggest association with lung function and chronic obstructive pulmonary disease. Methods:, In this study, we examined for the first time the effect of these variants in 2918 adults in a longitudinal birth cohort, the British National Survey of Health and Development, where there are extensive life style, developmental and environmental data. We examine two IL13 single nucleotide polymorphisms (SNPs) IL13 rs20541 (R110Q) and rs1800925 (,1024C>T) and one IL4 SNP, rs2070874 (,33C>T) with likely function. Results:, We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth. IL13 rs20541 does however act as a confounder for the IL13 rs1800925 associations, meaning that there is no statistical support for rs1800925 having an independent effect. There is nevertheless evidence for interaction between smoking and rs1800925, with allergy as outcome. None of the SNPs showed association with measures of lung function, nor any interaction with the effect of smoking on lung function. Conclusion:, In a longitudinal population cohort we have established a role for polymorphism of IL13 in determining susceptibility to both atopy and asthma. [source] Phylogeography of the longhorn cactus beetle Moneilema appressum LeConte (Coleoptera: Cerambycidae): was the differentiation of the Madrean sky islands driven by Pleistocene climate changes?MOLECULAR ECOLOGY, Issue 10 2005CHRISTOPHER IRWIN SMITH Abstract Although it has been suggested that Pleistocene climate changes drove population differentiation and speciation in many groups of organisms, population genetic evidence in support of this scenario has been ambiguous, and it has often been difficult to distinguish putative vicariance from simple isolation by distance. The sky island communities of the American Southwest present an ideal system in which to compare late Pleistocene range fragmentations documented by palaeoenvironmental studies with population genetic data from organisms within these communities. In order to elucidate the impact of Pleistocene climate fluctuations on these environments, biogeographic patterns in the flightless longhorn cactus beetle, Moneilema appressum were examined using mitochondrial DNA sequence data. Gene tree relationships between haplotypes were inferred using parsimony, maximum-likelihood, and Bayesian analysis. Nested clade analysis, Mantel tests, and coalescent modelling were employed to examine alternative biogeographic scenarios, and to test the hypothesis that Pleistocene climate changes drove population differentiation in this species. The program mdiv was used to estimate migration and divergence times between populations, and to measure the statistical support for isolation over ongoing migration. These analyses showed significant geographic structure in genetic relationships, and implicated topography as a key determinant of isolation. However, although the coalescent analyses suggested that a history of past habitat fragmentation underlies the observed geographic patterns, the nested clade analysis indicated that the pattern was consistent with isolation by distance. Estimated divergence times indicated that range fragmentation in M. appressum is considerably older than the end of the most recent glacial, but coincided with earlier interglacial warming events and with documented range expansions in other, desert-dwelling species of Moneilema. [source] The efficiency of natural gas futures marketsOPEC ENERGY REVIEW, Issue 2 2003Ahmed El Hachemi Mazighi Recent experience with the emergence of futures markets for natural gas has led to many questions about the drivers and functioning of these markets. Most often, however, studies lack strong statistical support. The objective of this article is to use some classical statistical tests to check whether futures markets for natural gas (NG) are efficient or not. The problem of NG market efficiency is closely linked to the debate on the value of NG. More precisely, if futures markets were really efficient, then: 1) spot prices would reflect the existence of a market assessment, which is proof that speculation and the manipulation of prices are absent; 2) as a consequence, spot prices could give clear signals about the value of NG; and 3) historical series on spot prices could serve as "clean" benchmarks in the pricing of NG in long-term contracts. On the whole, since the major share of NG is sold to power producers, the efficiency of futures markets implies that spot prices for NG are driven increasingly by power prices. On the other hand, if futures markets for natural gas fail the efficiency tests, this will reflect: 1) a lack of liquidity in futures markets and/or possibilities of an excess return in the short term; 2) a pass-through of the seasonality of power demand in the gas market; 3) the existence of a transitory process, before spot markets become efficient and give clear signals about the value of NG. Using monthly data on three segments of the futures markets, our findings show that efficiency is almost completely rejected on both the International Petroleum Exchange in London (UK market) and the New York Mercantile Exchange (US market). On the NYMEX, the principle of "co-movement" between spot and forward prices seems to be respected. However, the autocorrelation functions of the first differences in the price changes show no randomness of price fluctuations for three segments out of four. Further, both the NYMEX and the IPE fail, with regard to the hypothesis that the forward price is an optimal predictor of the spot price. Consequently, unless we have an increase in the liquidity of spot markets and an increase in the relative share of NG spot trading, futures markets cannot be considered as efficient. [source] Morphological and genetic differentiation in Isodon umbrosus by altitudinal variation in bumblebee pollinator assemblagesPLANT SPECIES BIOLOGY, Issue 1 2010IKUMI DOHZONO Abstract The corolla tube length of the bumblebee-pollinated plant Isodon umbrosus shows conspicuous geographical variation, corresponding with the proboscis length of its bumblebee pollinators across its distributional range. We hypothesized that altitudinal variation in the pollinator assemblage is a principal factor mediating morphological and genetic differentiation among I. umbrosus populations. We examined determinants of the morphological and genetic differentiation of Isodon umbrosus by analyzing floral morphology and allozyme variation across the distributional range. A reanalysis of previous data confirmed that altitude was a good indicator of pollinator assemblages. Corolla tube length was highly variable among the 15 study populations, and genetic differentiation among the populations (GST = 0.360) was also highly significant. The differentiation in corolla tube length was explained by altitudinal difference, a proxy of the difference in pollinator assemblages. Genetic differentiation among populations also tended to be affected by the same factor, but statistical support was weak. To better understand the mechanisms responsible for morphological and genetic differentiation in I. umbrosus, we need to investigate altitudinally different populations over a narrower geographical scale. [source] Micromechanics for fiber volume percent with a photocure vinyl ester compositePOLYMER COMPOSITES, Issue 3 2007Richard C. Petersen Micromechanics for fiber volume percent (Vf) from 0.0Vf to 54.0 Vf were conducted using (3 mm long × 9 ,m diameter) high-purity quartz fibers in a visible-light vinyl ester particulate-filled photocure resin. MTS fully articulated four-point bend fixtures were used with a 40 mm test span and 50 × 2 × 2 mm3 sample dimensions. Specimens were tested following the combined modified ASTM standards for advanced ceramics ASTM-C-1161,94 and polymers ASTM-D-6272,00 for modulus, flexural strength, and yield strength. Experimental data provided reliable statistical support for the dominant fiber contribution expressed through the rule-of-mixtures theory as a valid representation of micromechanical physics. The rule-of-mixtures micromechanics described by Vf could explain 92, 85, and 78% of the variability related to modulus, flexural strength, and yield strength respectively. Statistically significant improvements with fiber addition began at 10.3Vf for modulus, 5.4Vf for flexural strength, and 10.3Vf for yield strength, p < 0.05. In addition, correlation matrix analysis was performed for all mechanical test data. An increase in Vf correlated significantly with increases in modulus, flexural strength, and yield strength as measured by the four-point bending test, p < 10,10. All mechanical properties in turn correlated highly significantly with one another, p < 10,9. POLYM. COMPOS., 28:294,310, 2007. © 2007 Society of Plastics Engineers [source] Socioecological correlates of facial mobility in nonhuman anthropoidsAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 3 2009Seth D. Dobson Abstract Facial mobility, or the variety of facial movements a species can produce, is likely influenced by selection for facial expression in diurnal anthropoids. The purpose of this study is to examine socioecological correlates of facial mobility independent of body size, focusing on social group size and arboreality as possible evolutionary agents. Group size was chosen because facial expressions are important for group cohesion, while arboreality may limit the utility of facial expressions. Data for 12 nonhuman anthropoid species were taken from previous studies and analyzed using a phylogenetic generalized least-squares approach. Regression results indicate that group size is a good predictor of facial mobility independent of body size. No statistical support was found for the hypothesis that arboreality constrains the evolution of facial mobility. The correlation between facial mobility and group size may be a consequence of selection for more effective facial expression to help manage conflicts and facilitate bonding in larger groups. These findings support the hypothesis that the ultimate function of facial expression is related to group cohesion. Am J Phys Anthropol 2009. © 2009 Wiley-Liss, Inc. [source] Revisiting the Phylogenetic Position of Synchroma grandeTHE JOURNAL OF EUKARYOTIC MICROBIOLOGY, Issue 4 2009VISHWANATH PATIL ABSTRACT. Two new classes Synchromophyceae and Picophagea, belonging to the heterokonts, have been proposed recently in separate studies of 18S rRNA phylogenies. Here we revise the 18S phylogeny of these classes by including all available sequenced species and applying Bayesian and maximum likelihood methods; Synchroma grande groups with the photophagotrophic Chlamydomyxa labyrinthuloides with high statistical support. This clade is sister to Chrysophyceae, together they share a common ancestry. Our results show that the creation of class Synchromophyceae by Horn et al. was premature, because they did not include data from the closely related C. labyrinthuloides and Picophagus flagellatus species. A revision of these classes should include additional species and most likely multigene phylogenies. [source] Systematics and phylogeography of a threatened tortoise, the speckled padloperANIMAL CONSERVATION, Issue 3 2010S. R. Daniels Abstract This study investigated the systematics and phylogeography of a threatened tortoise of South Africa, the speckled padloper Homopus signatus. Sixty three specimens were collected from 17 localities that covered the distributional range of the two subspecies in western South Africa and a north-eastern population that was recently discovered near Pofadder. The Pofadder sample could not be assigned to either subspecies based on morphology. The samples were sequenced for two partial mtDNA fragments, nicotinamide adenine dinucleotide dehydrogenase component four and cytochrome b, which yielded ,1.1 kb, while a subset of the samples were sequenced for a 390 bp nuclear DNA (nDNA) fragment of prolactin. Phylogenetic analyses of mtDNA using minimum evolution, maximum parsimony and Bayesian inferences supported the monophyly of H. signatus and revealed that the Pofadder specimen was basal in the topology and sister to the remainder. The phylogenetic analyses did not support the recognition of two subspecies; there was statistical support for a Homopus signatus signatus clade but Homopus signatus cafer was not monophyletic. The nDNA analysis showed no difference between the subspecies and placed the Pofadder sample distant but not distinct from H. s. signatus. The mtDNA and the nDNA data suggest that the subspecies are invalid taxonomic units. The structure of the mtDNA network corresponded to the geographical distribution of populations. The north-western populations formed one haplocluster, corresponding to H. s. signatus, whereas the south-western populations formed three haploclusters, corresponding to H. s. cafer. The Pofadder sample was unconnected to the network. The morphology of the northern and southern morphotypes probably reflects selection for crypsis on the different substrate types of the regions, granites and sedimentary rocks, respectively. These results highlight that subspecies designations should be authenticated by molecular techniques because morphological plasticity can obfuscate phylogenetic relationships. We consider the western H. signatus populations as one taxonomic unit and recommend wider sampling of the Pofadder locality to clarify the taxonomic status of this lineage. [source] A molecular diagnostic for identifying central African forest artiodactyls from faecal pelletsANIMAL CONSERVATION, Issue 1 2010S. Ntie Abstract Small to medium-sized central African forest artiodactyls constitute a diverse yet heavily hunted group composed primarily of species within the genera Cephalophus, Neotragus, Tragelaphus and Hyemoschus. Of these genera, Cephalophus is the richest with as many as seven sympatric species known to occur in central African forests. However, differentiating species from their faeces or from tissue where the whole carcass is unavailable is very difficult. In order to develop a robust molecular diagnostic for species identification, a database of mitochondrial cytochrome b (553 bp) and control region (,675 bp) sequences was compiled from all forest Cephalophus species and other similarly sized, sympatric Tragelaphus, Neotragus and Hyemoschus species. Reference phylogenies from each marker were then used to recover the identity of sequences obtained from unknown faecal samples collected in the field. Results were then compared to determine which region best recovered species identity with the highest statistical support. Restriction fragment length polymorphisms (RFLPs) were also assessed as an alternative method for rapid species identification. Of the methods examined, tree-based analyses built on a geographically comprehensive database of control region sequences was the best means of reliably recovering species identity from central African duikers. However, three sister taxa appear indistinguishable (Cephalophus callipygus, Cephalophus ogilbyi and Cephalophus weynsi) and not all species were monophyletic. This lack of monophyly may be due to incomplete lineage sorting commonly observed in recently derived taxa, hybridization or the presence of nuclear translocated copies of mitochondrial DNA. The high level of intra-specific variation and lack of robust species-specific diagnostic sites made an RFLP-based approach to duiker species identification difficult to implement. The tree-based control region diagnostic presented here has many important applications including fine-scale mapping of species distributions, identification of confiscated tissue and environmental impact assessments. [source] Genetic variation within the Lidia bovine breedANIMAL GENETICS, Issue 4 2008J. Cañón Summary The results of an exhaustive data collection from a bovine population with a low level of exchangeability, the Lidia breed, are presented. A total of 1683 individuals from 79 herds were sampled and genetic diversity within and among lineages was assessed using 24 microsatellite loci on 22 different chromosomes. Expected heterozygosity ranged between 0.46 and 0.68 per lineage and there was significant inbreeding in the lineages, which included several farms [mean FIS = 0.11, bootstrap 95% confidence interval (0.09, 0.14)], mainly because of the high genetic divergence between herds within those lineages. High genetic differentiation between lineages was also found with a mean FST of 0.18 [bootstrap 95% confidence interval (0.17, 0.19)], and all pairwise values, which ranged from 0.07 to 0.35, were highly significant. The relationships among lineages showed weak statistical support. Nonetheless, lineages were highly discrete when analysed using correspondence analysis and a great proportion of the individuals were correctly assigned to their own lineage when performing standard assignment procedures. [source] Island-like radiation of Saussurea (Asteraceae: Cardueae) triggered by uplifts of the Qinghai,Tibetan PlateauBIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 4 2009YU-JIN WANG Increasing evidence suggests that geological or climatic events in the past triggered the radiative diversification of both animals and plants on islands as well as continents. The Qinghai,Tibetan Plateau (QTP) has been extensively uplifted since the Miocene, but there is little information on possible links between these events and biological diversification in this and adjacent regions. Partly to explore such links, we have examined the diversification of Saussurea (Asteraceae: Cardueae), a species-rich genus that is mostly endemic to QTP, but also occurs in arid highlands elsewhere in the Northern Hemisphere. The phylogenetic analyses were conducted on the basis of the nuclear (internal transcribed spacer, ITS) and plastid (trnL-F and psbA-trnH) sequences from 55 species, representing 19 sections from all six subgenera of Saussurea, and species from 15 genera of the Cardueae. The results suggest that the currently circumscribed genus Saussurea (s.l.) is a polyphyletic group and that five sections should be excluded from the genus. Samples from the other 14 sections (representing five subgenera) clustered as a monophyletic group (here designated the Saussurea s.s. lineage, SSSL) with high statistical support. However, none of the analyses (nuclear, plastid or combined) resolved SSSL's infrageneric phylogeny, and the parallel clades of the lineage indicate that island-like adaptive radiation occurred. Furthermore, this radiation appears to have occurred 14,7 Mya, during the period of the major uplift events of QTP. Thus, our results support the hypothesis that geological events may play important roles in driving biological diversification through continental radiation. © 2009 The Linnean Society of London, Biological Journal of the Linnean Society, 2009, 97, 893,903. [source] From Quantal Counts to Mechanisms and Systems: The Past, Present, and Future of Biometrics in Environmental ToxicologyBIOMETRICS, Issue 2 2000A. John Bailer Summary. As appreciation for human impact on the environment has developed, so have the experimental systems and associated statistical tools that quantify this impact. Toxicological study in particular has grown in its complexity and its need for advanced statistical support. Within this perspective, we describe statistical practice in environmental toxicology and risk assessment. We present two case studies, one from mammalian toxicology and one from aquatic toxicology, that highlight the evolution of statistical practice in environmental toxicology. 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