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Standard Technology (standard + technology)
Selected AbstractsVertical Foreclosure, Technological Choice, and Entry on the Intermediate MarketJOURNAL OF ECONOMICS & MANAGEMENT STRATEGY, Issue 3 2000Eric Avenel This paper analyzes the profitability of vertical integration for an upstream monopoly facing a potential competitor. We show that it depends on the technology used by the firm when it integrates. We distinguish two types of technologies: standard technologies, used by nonintegrated firms, and nonstandard technologies, reserved for integrated firms and implying the complete foreclosure of nonintegrated firms. Vertical integration with the adoption of a nonstandard technology dominates vertical integration with the adoption of a standard technology and is profitable, as long as the degree of competition in the downstream industry is sufficiently low. [source] Vertical Foreclosure, Technological Choice, and Entry on the Intermediate MarketJOURNAL OF ECONOMICS & MANAGEMENT STRATEGY, Issue 2 2000Eric Avenel This paper analyzes the profitability of vertical integration for an upstream monopoly facing a potential competitor. We show that it depends on the technology used by the firm when it integrates. We distinguish two types of technologies: standard technologies, used by nonintegrated firms, and nonstandard technologies, reserved for integrated firms and implying the complete foreclosure of nonintegrated firms. Vertical integration with the adoption of a nonstandard technology dominates vertical integration with the adoption of a standard technology and is profitable, as long as the degree of competition in the downstream industry is sufficiently low. [source] Life-Cycle Flexibility: How to Measure and Improve the Innovative Capability in Turbulent Environments,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 5 2006Tommaso Buganza Managing innovation in rapidly moving environments, such as Interned-based services, is a major challenge for the consolidated theories on product and service development. The innovation management literature identifies flexibility as the right way for coping with these challenges. By increasing the development process flexibility, it is possible to reduce the development time as well as the time and cost needed for last-minute concept changes. But this is not enough. The product or service must also be flexible after it has been released: A life-cycle flexibility (LCF) must be pursued. Focused on the Italian on-line discount brokers industry, this article is a result of a two-staged research process that started with a qualitative explorative phase (i.e., case-study methodology) and ended with a quantitative explorative one (i.e., questionnaire methodology). It identifies three different LCF dimensions,frequency of adaptation, rapidity of adaptation, and quality of adaptation,and it defines a metric for each of them. Subsequently, it identifies five managerial and organizational practices that increase at least one of the three LCF dimensions: (1) to manage the back-end technological competences; (2) to share the front-end technological competences with external suppliers; (3) to utilize open and standard technologies; (4) to have a low formalization of the new service development (NSD) procedures; and (5) to have high formalization of the NSD organization. [source] Capturing human motion using body-fixed sensors: outdoor measurement and clinical applicationsCOMPUTER ANIMATION AND VIRTUAL WORLDS (PREV: JNL OF VISUALISATION & COMPUTER ANIMATION), Issue 2 2004Kamiar Aminian Abstract Motion capture is mainly based on standard systems using optic, magnetic or sonic technologies. In this paper, the possibility to detect useful human motion based on new techniques using different types of body-fixed sensors is shown. In particular, a combination of accelerometers and angular rate sensors (gyroscopes) showed a promising design for a hybrid kinematic sensor measuring the 2D kinematics of a body segment. These sensors together with a portable datalogger, and using simple biomechanical models, allow capture of outdoor and long-term movements and overcome some limitations of the standard motion capture systems. Significant parameters of body motion, such as nature of motion (postural transitions, trunk rotation, sitting, standing, lying, walking, jumping) and its spatio-temporal features (velocity, displacement, angular rotation, cadence and duration) have been evaluated and compared to the camera-based system. Based on these parameters, the paper outlines the possibility to monitor physical activity and to perform gait analysis in the daily environment, and reviews several clinical investigations related to fall risk in the elderly, quality of life, orthopaedic outcome and sport performance. Taking advantage of all the potential of these body-fixed sensors should be promising for motion capture and particularly in environments not suitable for standard technology such as in any field activity. Copyright © 2004 John Wiley & Sons, Ltd. [source] Clinical applications of laser scanning cytometryCYTOMETRY, Issue 3 2002Attila Tárnok Abstract This study reviews existing and potential clinical applications of laser scanning cytometry (LSC) and outlines possible future developments. LSC provides a technology for solid phase cytometry. Fluorochrome-labeled specimens are immobilized on microscopic slides that are placed on a conventional epifluorescence microscope and analyzed by one or two lasers. Data comparable to flow cytometry are generated. In addition, the position of each event is recorded, a feature that allows relocalization and visualization of each measured event. The major advantage of LSC compared with other cytometric methods is the combination of two features: (a) the minimal clinical sample volume needed and (b) the connection of fluorescence data and morphological information for the measured event. Since the introduction of LSC, numerous methods have been established for the analysis of cells, cellular compartments, and tissues. Although most cytometric methods use only two or three colors, the characterization of specimens with up to five fluorochromes is possible. Most clinical applications have been designed to determine ploidy and immunophenotype; other applications include analyses of tissue biopsies and sections, fluorescence in situ hybridization, and the combination of vital and nonvital information on a single-cell basis. With the currently available assays, LSC has proven its wide spectrum of clinical applicability in slide-based cytometry and can be introduced as a standard technology in multiple clinical settings. Cytometry (Clin. Cytometry) 50:133,143, 2002. © 2002 Wiley-Liss, Inc. [source] Vertical Foreclosure, Technological Choice, and Entry on the Intermediate MarketJOURNAL OF ECONOMICS & MANAGEMENT STRATEGY, Issue 3 2000Eric Avenel This paper analyzes the profitability of vertical integration for an upstream monopoly facing a potential competitor. We show that it depends on the technology used by the firm when it integrates. We distinguish two types of technologies: standard technologies, used by nonintegrated firms, and nonstandard technologies, reserved for integrated firms and implying the complete foreclosure of nonintegrated firms. Vertical integration with the adoption of a nonstandard technology dominates vertical integration with the adoption of a standard technology and is profitable, as long as the degree of competition in the downstream industry is sufficiently low. [source] Vertical Foreclosure, Technological Choice, and Entry on the Intermediate MarketJOURNAL OF ECONOMICS & MANAGEMENT STRATEGY, Issue 2 2000Eric Avenel This paper analyzes the profitability of vertical integration for an upstream monopoly facing a potential competitor. We show that it depends on the technology used by the firm when it integrates. We distinguish two types of technologies: standard technologies, used by nonintegrated firms, and nonstandard technologies, reserved for integrated firms and implying the complete foreclosure of nonintegrated firms. Vertical integration with the adoption of a nonstandard technology dominates vertical integration with the adoption of a standard technology and is profitable, as long as the degree of competition in the downstream industry is sufficiently low. [source] RNA interference in pain researchJOURNAL OF NEUROCHEMISTRY, Issue 2 2006Thomas Röhl Abstract Within the course of only the last few years, RNA interference (RNAi) has been established as a standard technology for investigation of protein function and target validation. The present review summarizes recent progress made in the application of RNAi in neurosciences with special emphasis on pain research. RNAi is a straightforward method to generate loss-of-function phenotypes for any gene of interest. In mammals, silencing is induced by small interfering RNAs (siRNAs), which have been shown to surpass traditional antisense molecules. Due to its high specificity, RNAi has the potential for subtype selective silencing of even closely related genes. One of the major challenges for in vivo investigations of RNAi remains efficient delivery of siRNA molecules to the relevant tissues and cells, particularly to the central nervous system. Various examples will be given to demonstrate that intrathecal application of siRNAs is a suitable approach to analyse the function of receptors or other proteins that are hypothesized to play an important role in pain signalling. Intensive efforts are currently ongoing to solve remaining problems such as the risk of off-target effects, the stability of siRNA molecules and their efficient delivery to the CNS. RNAi has thus demonstrated that it is an extremely valuable tool for the development of new analgesic drugs. [source] | |||||||||||||