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Standard Design (standard + design)
Selected AbstractsEstablishing Efficacy of a New Experimental Treatment in the ,Gold Standard' DesignBIOMETRICAL JOURNAL, Issue 6 2005Dieter Hauschke Abstract Provided that there are no ethical concerns, the comparison of an active drug with placebo in a randomized two-arm clinical trial provides the most convincing way to demonstrate the efficacy of a new experimental treatment. However, in a placebo-controlled clinical trial it is not sufficient to demonstrate merely a statistically significant treatment difference. Regulatory authorities strongly recommend to assess additionally whether the observed treatment difference is also of clinical relevance. The inherent issue is the necessity of the a priori definition of what constitutes a clinically relevant difference in efficacy. This problem can be solved in a three-arm study by including an active control group. We address the necessary conditions in the gold standard design which allow the claim of efficacy for the new treatment with particular focus on assay sensitivity. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] When random sampling does not work: standard design falsely indicates maladaptive host preferences in a butterflyECOLOGY LETTERS, Issue 1 2002Michael C. Singer In experiments that investigate species' interactions, individuals are often chosen at random to represent their populations. However, this practice can generate misleading results when individuals of different species do not interact at random. We illustrate this effect by examining oviposition preferences of Euphydryas aurinia butterflies from three populations using three different plant genera. We first offered each insect a randomly chosen member of its own host population and a foreign host (Succisa pratensis) not present in the insect's habitat. The butterflies uniformly preferred the foreign Succisa over their own hosts. Preferences were apparently maladaptive because insects wasted time searching for a nonexistent plant. We repeated the experiment using individual hosts that had naturally received eggs in the field. The overall preference for Succisa and the appearance of maladaptation both disappeared. In the original experiments, our random choice of experimental host individuals had combined with strong within-species discrimination by the butterflies and with overlap of acceptability between host species to obscure the true nature of host preference. [source] Homogeneity of multilayers produced with a static mixerPOLYMER ENGINEERING & SCIENCE, Issue 1 2001J. C. Van Der Hoeven A multiflux static mixer can be used to produce multilayered structures. The flow is repeatedly cut, stretched and stacked by mixing elements in the channel of such a device. In the standard design, however, the obtained layer thicknesses are inhomogeneous. The causes for the multiflux static mixer's deviation from ideal behavior are identified by 3D numeical simulations as unequal pressure drops in the separating flows. Changes in the arrangements of the elements are proposed and their effects are verified by simulations and experiments. A significant improvement of the layer homogeneity is achieved by introducing additional elements with separatings walls at the inlets and at the outlets of the mixing elements. [source] Designing experiments for nonlinear models,an introduction,QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL, Issue 5 2010Rachel T. Johnson Abstract We illustrate the construction of Bayesian D -optimal designs for nonlinear models and compare the relative efficiency of standard designs with these designs for several models and prior distributions on the parameters. Through a relative efficiency analysis, we show that standard designs can perform well in situations where the nonlinear model is intrinsically linear. However, if the model is nonlinear and its expectation function cannot be linearized by simple transformations, the nonlinear optimal design is considerably more efficient than the standard design. Published in 2009 by John Wiley & Sons, Ltd. [source] Modification of a commercial electrospray nebulizer for operation in a liquid chromatography/mass spectrometry system at flow rates in the low,µL/min rangeRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 18 2001Alain Carrier A simple and inexpensive approach to convert the electrospray nebulizer of a commercial liquid chromatography/mass spectrometry (LC/MS) system (HP 1100) to accommodate lower flow rates has been proposed and evaluated. This modification consists of simply replacing the nebulizer needle by a commercially available stainless steel needle with a smaller internal diameter. Experiments were conducted in order to optimize operational parameters. Using two different internal diameter needle sizes, flow rates ranging from 1 to 250,µL/min could be accommodated. The modification presented allows an extension of the range of compatible flow rates without major modification of the standard design of the interface. Copyright © 2001 John Wiley & Sons, Ltd. [source] Establishing Efficacy of a New Experimental Treatment in the ,Gold Standard' DesignBIOMETRICAL JOURNAL, Issue 6 2005Dieter Hauschke Abstract Provided that there are no ethical concerns, the comparison of an active drug with placebo in a randomized two-arm clinical trial provides the most convincing way to demonstrate the efficacy of a new experimental treatment. However, in a placebo-controlled clinical trial it is not sufficient to demonstrate merely a statistically significant treatment difference. Regulatory authorities strongly recommend to assess additionally whether the observed treatment difference is also of clinical relevance. The inherent issue is the necessity of the a priori definition of what constitutes a clinically relevant difference in efficacy. This problem can be solved in a three-arm study by including an active control group. We address the necessary conditions in the gold standard design which allow the claim of efficacy for the new treatment with particular focus on assay sensitivity. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] CFD Simulation of Inlet Design Effect on Deoiling Hydrocyclone Separation EfficiencyCHEMICAL ENGINEERING & TECHNOLOGY (CET), Issue 12 2009S. Noroozi Abstract An Eulerian-Eulerian three-dimensional CFD model was developed to study the effect of different inlet designs on deoiling hydrocyclone separation efficiency. Reynolds averaged Navier Stokes and continuity equations were applied to solve steady turbulent flow through the cyclone with the Reynolds stress model. In addition, the modified drag correlation for liquid-liquid emulsion with respect to the Reynolds number range and viscosity ratio of two phases was used and the simulation results were compared with those predicted by the Schiller-Naumann correlation. Pressure profile, tangential and axial velocities and separation efficiency of the deoiling hydrocyclone were calculated for four different inlet designs and compared with the standard design. The simulation results for the standard design demonstrate an acceptable agreement with reported experimental data. The results show that all new four inlet designs offer higher efficiencies compared to the standard design. The difference between the efficiency of the LLHC, of the new inlets and the standard design can be improved by increasing the inlet velocity. Furthermore, the simulations show that the separation efficiency can be improved by about 10 % when using a helical form of inlet. [source] Designing experiments for nonlinear models,an introduction,QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL, Issue 5 2010Rachel T. Johnson Abstract We illustrate the construction of Bayesian D -optimal designs for nonlinear models and compare the relative efficiency of standard designs with these designs for several models and prior distributions on the parameters. Through a relative efficiency analysis, we show that standard designs can perform well in situations where the nonlinear model is intrinsically linear. However, if the model is nonlinear and its expectation function cannot be linearized by simple transformations, the nonlinear optimal design is considerably more efficient than the standard design. Published in 2009 by John Wiley & Sons, Ltd. [source] | ||||||||||