Home  About us  Contact
 

Structure Different (structure + different)

Distribution by Scientific Domains
Medical Sciences40%
Chemistry40%

Selected Abstracts

Decomposing the construct of ambivalence over emotional expression in a Chinese cultural context

EUROPEAN JOURNAL OF PERSONALITY, Issue 3 2005
Sylvia Xiaohua Chen
The present study examined the construct of ambivalence over emotional expression proposed by King and Emmons (1990) in the Chinese context, and identified a factor structure different from those proposed in previous Western studies. The results of this study provided discriminant validity for this newly extracted two-factor structure of ambivalence, viz., Emotional Rumination and Emotional Suppression. Emotional Rumination was significantly predicted by the personality scales of introversion and inferiority, and the belief dimension of fate control, whereas Emotional Suppression was predicted by the personality scales of diversity, face, and harmony, and the belief dimension of social complexity. The different effects of Emotional Rumination and Emotional Suppression in predicting life satisfaction showed that emotional experience has its own specific characteristics in Chinese culture, and that responding to its emic characteristics will yield a more culturally responsive understanding of emotional experience and expression. Copyright © 2004 John Wiley & Sons, Ltd. [source]

Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein ,2-helical 180,195 segment, and comparison with full-length ,2-helix-derived peptides,

JOURNAL OF PEPTIDE SCIENCE, Issue 10 2008
Luisa Ronga
Abstract The 173,195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several ,spots' of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation-prone conformations. Here, we report CD and NMR studies on the ,2-helix-derived peptide of maximal length (hPrP[180,195]) that is able to exhibit a regular structure different from the prevalently random arrangement of other ,2-helix-derived peptides. This peptide, which has previously been shown to be affected by buffer composition via the ion charge density dependence typical of Hofmeister effects, corresponds to the C -terminal sequence of the PrPC full-length ,2-helix and includes the highly conserved threonine-rich 188,195 segment. At neutral pH, its conformation is dominated by ,-type contributions, which only very strong environmental modifications are able to modify. On TFE addition, an increase of ,-helical content can be observed, but a fully helical conformation is only obtained in neat TFE. However, linking of the 173,179 segment, as occurring in wild-type and mutant peptides corresponding to the full-length ,2-helix, perturbs these intrinsic structural propensities in a manner that depends on whether the environment is water or TFE. Overall, these results confirm that the 180,195 parental region in hPrPC makes a strong contribution to the chameleon conformational behavior of the segment corresponding to the full-length ,2-helix, and could play a role in determining structural rearrangements of the entire globular domain. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd. [source]

A new, broad-spectrum azole antifungal: posaconazole , mechanisms of action and resistance, spectrum of activity

MYCOSES, Issue 2006
H. Hof
Summary Posaconazole, a new triazole antifungal, exerts principally the same mechanism of action as the other azole derivatives, i.e. it inhibits the ergosterol production by binding and inhibiting the lanosterol-14,-demethylase which is present in almost all fungi except Pneumocystis and Pythium. Posaconazole has an exquisitely high affinity to this target. Since posaconazole has a chemical structure different from fluconazole and voriconazole, it can interact with an additional domain of the target so that it may inhibit even mutated strains resistant to fluconazole and voriconazole. In addition posaconazole is a bad substrate for efflux pumps in fungi, so it can stay active when other azoles are already inactive. Furthermore, the spectrum of posaconazole is rather large including also some zygomycetes resistant to other azoles. In conclusion, posaconazole is actually the most potent azole derivative used in medicine. A combination of posaconazole with other groups of antifungals may have a favourable effect. There are several methods to test the in vitro activities of posaconazole including the E-test, though interpretive breakpoints are still lacking. [source]

A three-dimensional hybrid framework based on novel [Co4Mo4] bimetallic oxide clusters with 3,5-bis(3-pyridyl)-1,2,4-triazole ligands

ACTA CRYSTALLOGRAPHICA SECTION C, Issue 3 2009
Quan-Guo Zhai
In the title organic,inorganic hybrid complex, poly[[[,-3,5-bis(3-pyridyl)-1,2,4-triazole]tri-,3 -oxido-tetra-,2 -oxido-oxidodicobalt(II)dimolybdenum(VI)] monohydrate], {[Co2Mo2O8(C12H9N5)]·H2O}n, the asymmetric unit is composed of two CoII centers, two [MoVIO4] tetrahedral units, one neutral 3,5-bis(3-pyridyl)-1,2,4-triazole (BPT) ligand and one solvent water molecule. The cobalt centers both exhibit octahedral [CoO5N] coordination environments. Four CoII and four MoVI centers are linked by ,2 -oxide and/or ,3 -oxide bridges to give an unprecedented bimetallic octanuclear [Co4Mo4O22N4] cluster, which can be regarded as the first example of a metal-substituted octamolybdate and exhibits a structure different from those of the eight octamolybdate isomers reported to date. The bimetallic oxide clusters are linked to each other through corner-sharing to give two-dimensional inorganic layers, which are further bridged by trans -BPT ligands to generate a three-dimensional organic,inorganic hybrid architecture with six-connected distorted ,-Po topology. [source]

Sedum telephium L. Polysaccharide Content Affects MRC5 Cell Adhesion to Laminin and Fibronectin

JOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 5 2000
L. RAIMONDI
In traditional medicine the fresh leaves and juice of Sedum telephium L. are used as wound-healing promoters. Cell adhesion represents a primary event in wound repair and in tissue homeostasis, and therefore we have investigated the effect of Sedum juice and its main fractions, polysaccharides and flavonols, on human fibroblast (MRC5) adhesion to fibronectin and laminin. Our findings revealed that total Sedum juice strongly inhibited cell adhesion to laminin and fibronectin (EC50 1.03 ± 0.12 mg mL,1). This anti-adhesive feature was concentrated mainly in the two polysaccharide fractions (EC50 values comprised between 0.09 and 0.44 mg mL,1). The flavonol fractions did not seem to contribute to this effect. A first attempt to elucidate the polysaccharide-related anti-adhesive feature of Sedum juice was also performed. The results confirmed that natural polysaccharides, with chemical structures different from heparin, were able to interfere with integrin-mediated cell behaviour and they contributed to the outstanding effects of Sedum juice and to the role of polysaccharides in cell-matrix interaction. [source]