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Structural Link (structural + link)

Distribution by Scientific Domains

Chemistry	40%

Selected Abstracts

ChemInform Abstract: Structural Link Between Giant Molybdenum Oxide Based Ions and Derived Keggin Structure: Modular Assemblies Based on the [BW11O39]9- Ion and Pentagonal {M,M5} Units (M,: W; M: Mo, W).

CHEMINFORM, Issue 36 2009
Nathalie Leclerc-Laronze
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Political Theology and Shakespeare Studies

LITERATURE COMPASS (ELECTRONIC), Issue 1 2009
Jennifer R. Rust
The current focus on political theology in Shakespeare studies is largely devoted to tracing how Shakespeare's dramas illuminate the structural link between religious and political forms in both early modernity and modern liberal democracy. Critics concerned with addressing Shakespeare's engagement with political theology are also interested in how Shakespeare's portrayal of sovereign bodies in crisis constitute an early representation of ,biopolitics'. These critics draw on theorists ranging from Carl Schmitt to Giorgio Agamben to inform their analyses of the way Shakespeare dramatizes sovereignty in a ,state of emergency' in his histories and tragedies. Plays such as Richard II, Coriolanus, and Hamlet have drawn particular attention insofar as they vividly interrogate the nature of the sovereign exception and decision highlighted by theorists of political theology. While this line of criticism adds a new theoretical dimension to Shakespeare studies, it also offers the potential for remapping our understanding of the religious and political history of early modern England in its attention to the deforming pressure of religious schism on traditional structures of sovereignty. [source]

The cytoskeleton and disease

THE JOURNAL OF PATHOLOGY, Issue 4 2004
Frans CS Ramaekers
Abstract Cytoskeletal research in recent years has revolutionized cell biology and biomedicine. The cytoskeleton spans the cytoplasm and interconnects the cell nucleus with the extracellular matrix, thereby forming a structural link between molecules involved in cell communication on the one hand, and gene expression on the other. Since the cytoskeleton is involved in virtually all cellular processes, abnormalities in this essential cellular component frequently result in disease. In this introduction, the basic structure of the cytoskeleton is briefly outlined. Furthermore, the disease processes in which the cytoskeleton plays a decisive role, and which are reviewed in detail in the papers in this issue, are briefly introduced. The advances in our understanding of the cytoskeleton and its function in disease will lead to new diagnostic and therapeutic applications in the foreseeable future. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [source]

Approximate knowledge modeling and classification in a frame-based language: The system CAIN

INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 6 2001
Colette Faucher
In this article, we present an extension of the frame-based language Objlog+, called CAIN, which allows the homogeneous representation of approximate knowledge (fuzzy, uncertain, and default knowledge) by means of new facets. We developed elements to manage approximate knowledge: fuzzy operators, extension of the inheritance mechanisms, and weighting of structural links. Contrary to other works in the domain, our system is strongly based on a theoretical approach inspired from Zadeh's and Dubois' works. We also defined an original instance classification mechanism, which has the ability to take into account the notions of typicality and similarity as they are presented in the psychological literature. Our model proposes consideration of a particular semantics of default values to estimate the typicality between a class and the instance to classify (ITC). In that way, the possibilities of the typicality representation proposed by frame-based languages are exploited. To find the most appropriate solution we do not systematically choose the most specific class that matches the ITC but we retain the most typical solution. Approximate knowledge is used to make the matching used during the classification process more flexible. Taking into account additional knowledge concerning heuristics and elements of cognitive psychology leads to the enrichment of the classification mechanism. © 2001 John Wiley & Sons, Inc. [source]

Atomic-resolution crystal structure of Borrelia burgdorferi outer surface protein A via surface engineering

PROTEIN SCIENCE, Issue 8 2006
Koki Makabe
Abstract Outer surface protein A (OspA) from Borrelia burgdorferi has an unusual dumbbell-shaped structure in which two globular domains are connected with a "single-layer" ,-sheet (SLB). The protein is highly soluble, and it has been recalcitrant to crystallization. Only OspA complexes with Fab fragments have been successfully crystallized. OspA contains a large number of Lys and Glu residues, and these "high entropy" residues may disfavor crystal packing because some of them would need to be immobilized in forming a crystal lattice. We rationally designed a total of 13 surface mutations in which Lys and Glu residues were replaced with Ala or Ser. We successfully crystallized the mutant OspA without a bound Fab fragment and extended structure analysis to a 1.15 Å resolution. The new high-resolution structure revealed a unique backbone hydration pattern of the SLB segment in which water molecules fill the "weak spots" on both faces of the antiparallel ,-sheet. These well-defined water molecules provide additional structural links between adjacent ,-strands, and thus they may be important for maintaining the rigidity of the SLB that inherently lacks tight packing afforded by a hydrophobic core. The structure also revealed new information on the side-chain dynamics and on a solvent-accessible cavity in the core of the C-terminal globular domain. This work demonstrates the utility of extensive surface mutation in crystallizing recalcitrant proteins and dramatically improving the resolution of crystal structures, and provides new insights into the stabilization mechanism of OspA. [source]