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Spectrum Features (spectrum + feature)
Selected AbstractsIrritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorderACTA PSYCHIATRICA SCANDINAVICA, Issue 4 2009R. H. Perlis Objective:, Irritability is common during major depressive episodes, but its clinical significance and overlap with symptoms of anxiety or bipolar disorder remains unclear. We examined clinical correlates of irritability in a confirmatory cohort of Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study participants with major depressive disorder (MDD). Method:, Logistic regression was used to identify features associated with presence of irritability on the clinician-rated Inventory of Depressive Symptomatology. Results:, Of 2307 study participants, 1067(46%) reported irritability at least half the time during the preceding week; they were more likely to be female, to be younger, to experience greater depression severity and anxiety, and to report poorer quality of life, prior suicide attempts and suicidal ideation. Bipolar spectrum features were not more common among those with irritability. Conclusion:, Irritable depression is not a distinct subtype of MDD, but irritability is associated with greater overall severity, anxiety comorbidity and suicidality. [source] Psychotic features in borderline patients: is there a connection to mood dysregulation?BIPOLAR DISORDERS, Issue 4 2005Benvenuti A Objective:, To investigate the relationship between lifetime mood and psychotic spectrum features in patients with borderline personality disorder (BPD). Method:, The study sample consisted of BPD patients with (n = 39, BPD-M) or without (n = 21, BPD-noM) lifetime mood disorders. The diagnostic assessment was conducted with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). The diagnosis of BPD was made clinically and then confirmed by Gunderson's diagnostic interview for borderlines. Subjects were also administered the Structured Clinical Interview for Psychotic Spectrum (SCI-PSY) and the Mood Spectrum self-report questionnaire (MOODS-SR). Results:, BPD-M had significantly higher scores than BPD-noM on the ,lifetime' mood spectrum subdomains ,depressive mood' and ,depressive cognition'. The two groups did not differ on the scores of psychotic spectrum except for higher ,hypertrophic self-esteem' scores in BPD-noM. In BPD-noM both the depressive and the manic-hypomanic component of mood spectrum were significantly correlated with the ,delusion' subdomain of the psychotic spectrum. The depressive component was correlated with ,depersonalization/derealization' and the manic-hypomanic component was correlated with ,hypertrophic self-esteem'. In BPD-M, the manic-hypomanic component of mood spectrum was correlated with different subdomains of the psychotic spectrum: ,hypertrophic self-esteem', ,self-reference', ,interpretive attitude', ,anger/overreactivity, ,unusual and odd thoughts', ,illusions', ,delusions', ,hallucinations' and ,catatonia'. The depressive component of mood spectrum was ,uncorrelated' with the subdomains of the psychotic spectrum. Conclusions:, Our data support the hypothesis that ,lifetime' manic-hypomanic mood dysregulations are correlated with psychotic spectrum features in borderline patients. The assessment of these spectrum features in borderline patients may be useful to inform treatment choices. [source] | ||||||||||