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Specific Goals (specific + goal)

Distribution by Scientific Domains

Medical Sciences	47%
Humanities and Social Sciences	21%
Engineering	15%
3 Other Domains	17%

Selected Abstracts

Testing and improving experimental parameters for the use of low molecular weight targets in array-CGH experiments,

HUMAN MUTATION, Issue 11 2006
Marianne Stef
Abstract Array,comparative genomic hybridization (CGH) has evolved as a useful technique for the detection and characterization of deletions, and, to a lesser extent, of duplications. The resolution of the technique is dictated by the genomic distance between targets spotted on the microarray, and by the targets' sizes. The use of region-specific, high-resolution microarrays is a specific goal when studying regions that are prone to rearrangements, such as those involved in deletion syndromes. The aim of the present study was to evaluate the best experimental conditions to be used for array-CGH analysis using low molecular weight (LMW) targets. The parameters tested were: the target concentration, the way LMW targets are prepared (either as linearized plasmids or as purified PCR products), and the way the targets are attached to the array-CGH slide (in a random fashion on amino-silane coated slides, or by one amino-modified end on epoxysilane-coated slides). As a test case, we constructed a microarray harboring LMW targets located in the CREBBP gene, mutations of which cause the Rubinstein-Taybi syndrome (RTS). From 10 to 15% of RTS patients have a CREBBP deletion. We showed that aminosilane- and epoxysilane-coated slides were equally efficient with targets above 1,000,bp in size. On the other hand, with the smallest targets, especially those below 500,bp, epoxysilane-coated slides were superior to aminosilane-coated slides, which did not allow deletion detection. Use of the high resolution array allowed us to map intragenic breakpoints with precision and to identify a very small deletion and a duplication that were not detected by the currently available techniques for finding CREBBP deletions. Hum Mutat 27(11), 1143,1150, 2006. © 2006 Wiley-Liss, Inc. [source]

Quality of offering on the world wide web

INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 9 2002
G. Mantzaridis
Abstract The definition of quality in a ,life' environment, such as that of the World Wide Web has proven to have many, often conflicting interpretations. Factors such as the point of view, the expertise and type of usage of the critic can influence dramatically such a definition and its results. Thus, the key point is to distance oneself from single perspectives and obtain a complete picture of the system as a single entity working towards a specific goal. This paper is an attempt at creating a general model of quality procedures. It will concentrate mainly in customer service, system viability and quality of offering evaluation. Some of the material mentioned is based on adapted classical models that can be used equally to apply and observe standards of offerings in the wider WEB community. Copyright © 2002 John Wiley & Sons, Ltd. [source]

Self-Efficacy: A Concept Analysis

NURSING FORUM, Issue 2 2009
Kristen Zulkosky MSN
TOPIC.,Concept analysis and self-efficacy. PURPOSE.,This paper provides an in-depth analysis of the concept self-efficacy through the use of Rodger's model. SOURCES.,Published research. CONCLUSION.,Self-efficacy beliefs influence how people think, feel, motivate themselves, and act. Self-efficacy is concerned about the perception or judgment of being able to accomplish a specific goal and cannot be sensed globally. In order to gain a sense of self-efficacy, a person can complete a skill successfully, observe someone else doing a task successfully, acquire positive feedback about completing a task, or rely on physiological cues. [source]

Beyond breaking bad news

CANCER, Issue 2 2008
The roles of hope, hopefulness
Abstract BACKGROUND. Hope is important to patients, yet physicians are sometimes unsure how to promote hope in the face of life-threatening illness. ANALYSIS. Hope in medicine is of two kinds: specific (hope for specific outcomes) and generalized (a nonspecific sense of hopefulness). At the time of diagnosis of a life-ending condition, the specific goal of a long life is dashed, and there may be no medically plausible specific outcome that the patient feels is worth wishing for. Yet the physician may nonetheless maintain an open-ended hopefulness that is compatible with the physician's obligation to be truthful; this hopefulness can help sustain patient and family through the turbulent period of adaptation to the unwelcome reality of major illness. As this adaptation evolves, the physician can help patients and families adapt to suffering and loss of control by selecting and achieving specific goals such as improvement of the patient's environment in hospital or hospice, pain control, and relief of sleeplessness. Thus hope for specific (but far more modest) future events can again become a positive part of the patient s emotional landscape. The authors do not propose that physicians remain upbeat no matter the circumstance, for they must respect the constraints of reality and the patients' mortality. However, physicians can provide both cognitive and affective support as patients learn how to adapt. Hope and hopefulness are both important in this process. SUMMARY. Hope is always important to patients. Physicians can and should promote hopefulness without endorsing unrealistic hope. Cancer 2008. © 2008 American Cancer Society. [source]

Patient-Reported Outcomes with Botulinum Toxin Type A Treatment of Glabellar Rhytids: A Double-Blind, Randomized, Placebo-Controlled Study

DERMATOLOGIC SURGERY, Issue 2007
FACS, STEVEN FAGIEN MD
BACKGROUND Global patient-reported outcomes do not evaluate specific aspects of treatment that are important to patients. OBJECTIVE The objective was to evaluate self-perception of age and specific outcomes that are important to patients receiving botulinum toxin type A or placebo for moderate to severe glabellar lines (using the Facial Line Outcomes Questionnaire to assess how much facial lines bother them, make them look older, detract from their facial appearance, prevent a smooth facial appearance, and make them look tired, stressed, or angry). METHODS AND MATERIALS In the double-blind phase of this 12-week study, 70 patients were randomly assigned to treatment with 20 U botulinum toxin type A (BOTOX Cosmetic) or placebo. At Week 4, those still with moderate or severe glabellar lines were offered open-label 20 U botulinum toxin type A. RESULTS Median glabellar line severity was significantly lower after botulinum toxin treatment than after placebo. Compared with placebo, botulinum toxin also resulted in significantly superior patient assessments and a greater proportion of patients considering they looked younger than their current age. CONCLUSIONS Botulinum toxin type A can achieve specific goals of treatment that are important to patients and help them feel that they look younger than their current age. [source]

State-of-the-art methodologies in alcohol-related health services research

ADDICTION, Issue 11s3 2000
Harold I. Perl
Many of the failures to replicate clinical findings of treatment efficacy in more realistic field and community settings can be attributed to inappropriate research designs and other methodological shortcomings. In order to increase research designers' awareness of existing methodologies that may be better suited to answer the critical questions inherent in health services research on alcohol-related issues, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) convened an expert conference with three specific goals: (1) to identify the critical issues involved in alcohol services research; (2) to develop a primer that explicated each key area; and (3) to compile the resulting primers into an accessible resource for researchers, policy makers and consumers. The 9 papers in this special supplement are the product of that conference and are organized broadly around three phases of the research process: study design and implementation, data collection and use, and the analysis and interpretation of data. A final summary paper discusses the issues and offers a synthesis of key themes as well as some direction for the future. [source]

An ESOL Methods Course in a Latino Neighborhood

FOREIGN LANGUAGE ANNALS, Issue 4 2002
Thomas C. Cooper
ABSTRACT: This article describes a model for situating an ESOL methods course in a Spanish-speaking community. The methods course had two specific goals: (1) to organize ESOL classes for children and adults in a Latino neighborhood that serve as a practicum for university students working for an ESOL teaching endorsement and (2) to include a service-learning project in the methods course so that the university students can become acquainted with the milieu of the children growing up in a Latino community. While it is not a difficult task to place an ESOL methods course in an ethnic neighborhood, the amount of planning and organization required exceeds to some degree the preparation necessary for a traditional university course held on campus. The rewards, however, far outweigh the extra effort, because the university students benefit from gaining actual ESOL teaching experience as they learn about an ethnic neighborhood, and the community residents benefit from the collaboration between the university and their neighborhood. [source]

Mid-term report on St Luke's College of Nursing's 21st century Center of Excellence Program: Core elements and specific goals of people-centered care

JAPAN JOURNAL OF NURSING SCIENCE, Issue 1 2006
Hiroko KOMATSU
Abstract Aim:, This paper, at the halfway point of the 5 year Center of Excellence (COE) Program, aims to extract common core elements of each COE project working on the development of people-centered care and to clarify future issues related to the COE Program through the evaluation of those elements. Methods:, All data obtained in such research activities, including records, interviews, meeting minutes, and results, are shared for each project in COE section meetings or general assemblies and the findings that are established there are accumulated. We also have set up a working group to develop the people-centered care concept by continuously reviewing the core elements of people-centered care based on the collected data. In order to track the projects in an orderly manner, we classified and organized the activities of the 11 COE projects based on the Process Evaluation Model and reviewed common important elements. Results:, The characteristic components, related to participation, relationships, capacity-building, empowerment, and product (specific achievements), were extracted as common core elements of each COE project. Conclusion:, In order to maintain the sustainability of people-centered care incorporated in communities, concrete strategies for improving economic efficiency, social significance and utility, and evaluation methods need to be developed. [source]

The rationale of value-laden medicine

JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 1 2002
Michael H. Kottow MA(Soc) MD
Abstract Medicine is becoming increasingly confident that scientific advances, especially in the area of genetics, will allow a major improvement in the control and eradication of disease. This development seems to go hand in hand with health-enhancement strategies, erasing the distinction between the states of health and disease, and blurring the specific goals of medical services. Medicine tends to become an increasingly technocentric practice that relies heavily on expert knowledge and on epidemiological evidence, neglecting the lived-body experience of being ill, and tending to transform costly medical services into commodities only affordable by the affluent. This paper argues that disease is not merely a functional description, but rather a definitely value-laden organismic state that is experienced by the patient, needs to be explored and treated by medical practitioners, and requires the assessment and participation of social institutions concerned with the delivery and support of medical services. Each of these perspectives introduces its own set of values, both in the clinical encounter and in public health programmes. Bioethics seems to be the appropriate discipline to discuss all these values involved, and help assign them properly in order to rescue the caring concern of medicine for the sick, as well as uphold a principle of fairness in publicly funded medical services. [source]

Laboratory Models Available to Study Alcohol-Induced Organ Damage and Immune Variations: Choosing the Appropriate Model

ALCOHOLISM, Issue 9 2010
Nympha B. D'Souza El-Guindy
The morbidity and mortality resulting from alcohol-related diseases globally impose a substantive cost to society. To minimize the financial burden on society and improve the quality of life for individuals suffering from the ill effects of alcohol abuse, substantial research in the alcohol field is focused on understanding the mechanisms by which alcohol-related diseases develop and progress. Since ethical concerns and inherent difficulties limit the amount of alcohol abuse research that can be performed in humans, most studies are performed in laboratory animals. This article summarizes the various laboratory models of alcohol abuse that are currently available and are used to study the mechanisms by which alcohol abuse induces organ damage and immune defects. The strengths and weaknesses of each of the models are discussed. Integrated into the review are the presentations that were made in the symposium "Methods of Ethanol Application in Alcohol Model,How Long is Long Enough" at the joint 2008 Research Society on Alcoholism (RSA) and International Society for Biomedical Research on Alcoholism (ISBRA) meeting, Washington, DC, emphasizing the importance not only of selecting the most appropriate laboratory alcohol model to address the specific goals of a project but also of ensuring that the findings can be extrapolated to alcohol-induced diseases in humans. [source]

Novel antennas for ultra-wideband communications

MICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 3 2004
N. Fortino
Abstract Two novel antennas for UWB communications, both inspired from bowtie and triangular patch structures, are presented and tested. This paper proposes their study and optimization in order to cover the new WPAN standard and facilitate their integration on communication devices. This work has then been centered around three specific goals: wide bandwidth, minimum size, and low cost. © 2004 Wiley Periodicals, Inc. Microwave Opt Technol Lett 41: 166,169, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.20082 [source]

Conceptions of Literature in University Language Courses

MODERN LANGUAGE JOURNAL, Issue 2 2009
CECILIA ALVSTAD
In this article we set out to explore and discuss reasons for reading literary texts in university curricula of foreign languages. Our analysis is based on 2 sources of information: 16 syllabi of Spanish as a foreign language and a questionnaire in which 11 university instructors teaching these syllabi express their intentions. We point to a number of risks when emphasis is predominantly placed on instrumental goals such as acquisition of vocabulary and grammar or cultural knowledge. We suggest, instead, that the literary modules within language curricula should formulate their own specific goals. Rather than privileging linguistic and cultural competences to be trained, the literary modules could, for example, raise students' awareness of the facts that there are many ways of reading a text but that interpretation nevertheless remains a historically situated and constrained activity. [source]

The UKIRT Infrared Deep Sky Survey (UKIDSS)

MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2007
A. Lawrence
ABSTRACT We describe the goals, design, implementation, and initial progress of the UKIRT Infrared Deep Sky Survey (UKIDSS), a seven-year sky survey which began in 2005 May. UKIDSS is being carried out using the UKIRT Wide Field Camera (WFCAM), which has the largest étendue of any infrared astronomical instrument to date. It is a portfolio of five survey components covering various combinations of the filter set ZYJHK and H2. The Large Area Survey, the Galactic Clusters Survey, and the Galactic Plane Survey cover approximately 7000 deg2 to a depth of K, 18; the Deep Extragalactic Survey covers 35 deg2 to K, 21, and the Ultra Deep Survey covers 0.77 deg2 to K, 23. Summed together UKIDSS is 12 times larger in effective volume than the 2MASS survey. The prime aim of UKIDSS is to provide a long-term astronomical legacy data base; the design is, however, driven by a series of specific goals , for example, to find the nearest and faintest substellar objects, to discover Population II brown dwarfs, if they exist, to determine the substellar mass function, to break the z= 7 quasar barrier; to determine the epoch of re-ionization, to measure the growth of structure from z= 3 to the present day, to determine the epoch of spheroid formation, and to map the Milky Way through the dust, to several kpc. The survey data are being uniformly processed. Images and catalogues are being made available through a fully queryable user interface , the WFCAM Science Archive (http://surveys.roe.ac.uk/wsa). The data are being released in stages. The data are immediately public to astronomers in all ESO member states, and available to the world after 18 months. Before the formal survey began, UKIRT and the UKIDSS consortia collaborated in obtaining and analysing a series of small science verification (SV) projects to complete the commissioning of the camera. We show some results from these SV projects in order to demonstrate the likely power of the eventual complete survey. Finally, using the data from the First Data Release, we assess how well UKIDSS is meeting its design targets so far. [source]

The Six-Party Talks and North Korea's Denuclearization: Evaluation and Prospects

PACIFIC FOCUS, Issue 2 2010
Tae-Hwan Kwak
The six-party process for North Korea's denuclearization has long been stalled since the Six-Party Talks (SPT) failed to agree on a verification protocol in early December 2008. The DPRK officially stated on 10 February 2005 that it already possessed nuclear weapons. It now wants to be recognized as a nuclear power. The North Korean nuclear issue, a key obstacle to the Korean peace process, needs to be resolved peacefully through the six-party process. The author has argued over the years that while the six-party process is the best means to resolve the North's nuclear issue, bilateral US,DPRK talks are equally important to a peaceful and diplomatic resolution of the DPRK's issue. The peaceful resolution of the North's nuclear issue is prerequisite to building a peace regime on the Korean peninsula and regional peace in Northeast Asia. The author has two specific goals: (i) to evaluate the stalled SPT for denuclearizing the Korean peninsula since December 2008; and (ii) to make policy recommendations for continued denuclearization of the Korean peninsula in the framework of the SPT. The first part of this article examines DPRK's denuclearization process up to the point when the SPT failed to adopt a written verification protocol in December 2008. Since then, the six-party process has been stalled. The second part discusses the impact of the DPRK's rocket launch in April 2009 and its second nuclear test in May on the SPT. The third part evaluates the DPRK's new proposal for peace treaty talks and its new conditions for returning to the SPT. Finally, this article proposes key issues on agenda to be negotiated at the next SPT and some policy recommendations for achieving denuclearization of the Korean peninsula. [source]

On the Prospects for Democratic Deliberation: Values Analysis Applied to AustralianPolitics

POLITICAL PSYCHOLOGY, Issue 2 2000
John S. Dryzek
Democratic theorists increasingly stress that democratic legitimacy rests primarily on authentic deliberation. Critics of deliberative democracy believe that this hope is unrealistic,that deliberation either will prove intractable across political differences or will exacerbate instability. This paper deploys some tools of political psychology, notably Q methodology and values analysis, to investigate the conditions under which effective deliberation is likely to occur. These tools are applied to contemporary political debates in Australia, concerned with how the Australian polity should be constituted in light of a reform agenda underpinned by a discourse we term "Inclusive Republicanism." An investigation of the character of the basic value commitments associated with discursive positions in these debates shows that some differences will yield to deliberation, but others will not. When two discourses subscribe to different value bases, deliberation will induce reflection and facilitate positive-sum outcomes. When a discourse has a value base but finds its specific goals opposed by a competitor that otherwise has no value base of its own, deliberation will be ineffective. When one discourse subscribes to a value base that another questions, but without providing an alternative, deliberation can help to bridge idealism and cynicism. [source]

DoE in engine development

QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL, Issue 6 2008
Karsten Röpke
Abstract Stricter legal emission limits and increasing customer expectations lead to a growing number of controllable engine components and thus to a higher engine control complexity. For engine development, however, this means much greater time and effort is required to find the optimal combination of all selectable parameters. This trend can be observed in the field of Gasoline as well as for Diesel engines. At the same time, the development time from the first idea up to the introduction of a new production engine has become even shorter, and the costs have to be reduced. Since the number of measuring points required for complete operational-test measurements rises exponentially with the number of input variables, it is quite obvious that full factorial measurements are no longer possible. Therefore the method ,Design of Experiments' (DoE) is widely accepted as a suitable tool in the automotive sector and among its suppliers. In the meantime the term ,DoE'/,DoE-Process' covers often also the measurement procedure and the modeling. Likewise, this method is broadly applied in the IAV (author's note: IAV is a German provider of engineering services to the automotive industry) during the advanced development stage up to the production engine applications. Whereas DoE is used mainly in the area of steady-state applications recent research work shows a great potential also to optimize transient engine behavior. This paper will give an overview about the usage of statistical methods (mainly Design of Experiments) in the production engine calibration. ,Engine calibration' is the term for finding the optimal settings of the engine controller unit; optimal in terms of minimal emissions, minimal fuel consumption, good drivability and other brand specific goals. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Theory and Practice in the Design of Physician Payment Incentives

THE MILBANK QUARTERLY, Issue 2 2001
James C. Robinson
Combining the economic literature on principal-agent relationships with examples of marketplace innovations allows analysis of the evolution of methods for paying physicians. Agency theory and the economic principles of performance-based compensation are applied in the context of imperfect information, risk aversion, multiple interrelated tasks, and team production efficiencies. Fee-for-service and capitation are flawed methods of motivating physicians to achieve specific goals. Payment innovations that blend elements of fee-for-service, capitation, and case rates can preserve the advantages and attenuate the disadvantages of each. These innovations include capitation with fee-for-service carve-outs, department budgets with individual fee-for-service or "contact" capitation, and case rates for defined episodes of illness. The context within which payment incentives are embedded, includes such nonprice mechanisms as screening and monitoring and such organizational relationships as employment and ownership. The analysis has implications for health services research and public policy with respect to physician payment incentives. [source]

Self-Regulation Research in Work and I/O Psychology

APPLIED PSYCHOLOGY, Issue 2 2005
Ruth Kanfer
Les recherches de psychologie industrielle/organisationnelle (I/O) sur les objectifs et l'autorégulation ont prospéré durant les trois dernières décennies. Initiés par le travail fécond de Locke, Latham et de leurs collègues qui ont souligné l'influence positive d'objectifs elairs et sollicitants sur les performances, de nombreux courants de recherche sont apparus pour étudier à la fois les déterminants et les conséquences des objectifs et des processus d'autorégulation sur les conduites et les variables dépendantes relatives au travail (voir par exemple Locke, Shaw, Saari, & Latham, 1981; Vancouver, 2000 pour une revue de questions). Vancouver et Day (2005) constatent que si les chercheurs en organisations ont tenté d'évaluer la validité externe et critérielle, ils se sont moins intéressés à la validité interne et de construction des variables-clés et de concepts tels que les objectifs, la rétroaction, la divergence et l'efficacité personnelle. Dans le même ordre d'idées, Vancouver et Day (2004) concluent que les validations des interventions I/O fondées sur la perspective objectif/autorégulation détectent généralement des effcts positifs, mais que ces travaux sont insuffisants pour déterminer les dimensions spécifiques du processus objectif/autorégulation qui sont en rapport avec l'amélioration de la performance. Dans ce court article, j'aborde ces problèmes concemant la recherche sur les objectifs et l'autorégulation d'un triple point de vue: le progrès scientifique, les applications et les buts des investigations I/O. Over the past three decades, industrial/organisational (I/O) research on goals and self-regulation has flourished. Beginning with the seminal work by Locke, Latham, and their colleagues showing the positive influence of difficult and specific goals on task performance, multiple streams of research have emerged to investigate both the determinants and consequences of goals and self-regulation processes on work-related behaviors and outcomes (see, e.g. Locke, Shaw, Saari, & Latham, 1981; Vancouver, 2000, for reviews). In a review of this work, Vancouver and Day (2005) suggest that although organisational researchers have sought evidence for external and criterion-related validity, less attention has been given to the construct and internal validity of key variables and concepts, such as goals, self-efficacy, feedback, discrepancy, and self-efficacy. In a related vein, Vancouver and Day (2005) conclude that although I/O intervention studies based on the goal/self-regulation perspective show generally positive effects, such studies are insufficient for understanding how specific aspects of the goal/self-regulation process relate to enhanced performance. In this short note, I consider these concerns about goal/self-regulation research in I/O psychology from three perspectives: (1) scientific progress, (2) applications, and (3) the goals of I/O research. [source]