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Spray-dried Powders (spray-dried + powder)

Distribution by Scientific Domains

Chemistry	50%

Selected Abstracts

Effect of Externally Applied Plasticizer on Compaction Behavior of Spray-Dried Powders

JOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 4 2002
Sreeram Balasubramanian
The effects of an externally applied plasticizer on compaction behavior and green microstructure quality of spray-dried powders was investigated. The plasticizer was applied to the external surfaces of already spray-dried powders by spraying it on tumbling spray-dried granules. The apparent yield point of the spray-dried powder was reduced when the plasticizer was added. Microstructures of compacts made from these granules (with and without the externally applied plasticizer) were compared at different compaction pressures. Better knitting across granule interfaces and fewer defects were obtained for the granules with the externally applied plasticizer. [source]

Physico-chemical properties of protein-bound polysaccharide from Agaricus blazei Murill prepared by ultrafiltration and spray drying process

INTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 1 2007
Joo Heon Hong
Summary This study was conducted to develop the powder material and investigate the various physico-chemical properties of protein-bound polysaccharide with different molecular weight from Agaricus blazei Murill using ultrafiltration and spray-drying process. Powder properties of the three spray-dried powders were very different based on their molecular weights. The inlet temperature had less influence than pump rate on particle size of spray-dried powders. The moisture content of powders was increased with increasing pump rate and decreasing inlet temperature. Among these powders, SD-1, the molecular weight of which is below 10 kDa, was less flowable by internal cohesion. The decomposition temperature for the powders was in the range of 200,400 °C and showed relatively good enough for their thermal stabilities. [source]

Primary microparticles and agglomerates of morphine for nasal insufflation

JOURNAL OF PHARMACEUTICAL SCIENCES, Issue 12 2006
Paola Russo
Abstract The aim of this work was to study the characteristics of powders of morphine HCl suitable for nasal administration to be employed for pain treatment as alternative to injection. Primary microparticles of morphine were prepared by spray drying of aqueous drug solutions using sugars or sugar derivatives as drying protectors and particle shapers. The spray drying procedure modified morphine crystallinity making the substance amorphous and affecting its stability in dependence on the excipient employed. A tendency of the spray-dried powders to turn to varying degrees of yellow was observed. Tumbling the powder in a rotating pan allowed the agglomeration of the primary microparticles. Agglomerates were also obtained by tumbling a mixture of morphine crystals and spray-dried microparticles of excipients, with advantages for the stability of the preparation. A nasal device quantitatively insufflated all the morphine agglomerates. The in vitro transport of morphine through rabbit nasal mucosa was faster using nasal powders than with the saturated solution of morphine. Lactose was the most effective excipient for agglomerate manufacturing and delivery of spray-dried morphine. The agglomerates of morphine crystals mixed with mannitol/lecithin microparticles showed superior stability. However, the drug permeation through rabbit mucosa was slower than with spray-dried morphine microparticle agglomerates. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95:2553,2561, 2006 [source]