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South Indian Population (south + indian_population)

Distribution by Scientific Domains

Medical Sciences	77%

Selected Abstracts

North and South Indian Populations Share a Common Ancestral Origin of Friedreich's Ataxia but Vary in Age of GAA Repeat Expansion

ANNALS OF HUMAN GENETICS, Issue 3 2010
Inder Singh
Summary Friedreich's ataxia (FRDA) is caused by expansion of GAA repeats in the frataxin (FXN) gene on chromosome 9q13-q21.1. We analysed the origin of FRDA in 21 North Indian (NI) and eight South Indian (SI) families using five single nucleotide polymorphisms (SNPs) and a microsatellite marker spanning the GAA repeats. The NI and SI families were derived from Indo-European and Dravidian linguistic backgrounds respectively. The frequency of large normal (LNs) alleles of the GAA repeat correlate with the overall lower prevalence of FRDA in India compared to the European population. All of the expanded alleles in the Indian population share a common core haplotype suggesting a founder effect. The expanded alleles in the NI population demonstrate more similarity to those of Europeans in terms of age of GAA repeat expansion (15975 ± 2850 years) and association of LNs with expanded alleles. FRDA seems to have been introduced recently in the South Indian population since the average estimated age of the mutation in SI is 5425 ± 1750 years and unlike NI some of the haplotypes of LNs are not associated with the expanded alleles. [source]

Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, Issue 5 2007
M. Harishankar
Summary Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at ,607(C/A) and ,137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotype and haplotype frequencies did not differ significantly between normal healthy subjects and patients. The results suggest that the IL-18 gene promoter polymorphisms are not associated with susceptibility or resistance to pulmonary tuberculosis in south Indian population of Dravidian descent. [source]

North and South Indian Populations Share a Common Ancestral Origin of Friedreich's Ataxia but Vary in Age of GAA Repeat Expansion

Comparison of ADA 1997 and WHO 1985 criteria for diabetes in south Indians , the Chennai Urban Population Study

DIABETIC MEDICINE, Issue 12 2000
R. Deepa
SUMMARY Aims To compare the American Diabetes Association (ADA) fasting criteria and World Health Organization (WHO) 2-h criteria for diabetes in an urban south Indian population. Methods Subjects were drawn from the Chennai Urban Population Study. Of the 1001 subjects studied, 52 (5.2%) were diagnosed as having diabetes according to WHO 2-h criteria and 32 (3.2%) according to the ADA fasting criteria. Results Twenty-five (48%) of the subjects diagnosed with diabetes by the WHO 2-h criteria were not classified as having diabetes by the ADA fasting criteria. Similarly, of the 78 subjects (7.8%) classified as having impaired glucose tolerance (IGT), only eight (10.3%) had impaired fasting glucose (IFG) according to the ADA fasting criteria. The overall agreement between the WHO 2-h criteria and ADA fasting criteria was poor (, = 0.40). Conclusions Use of the ADA fasting criteria results in a lower prevalence rates of diabetes in this lean urban south Indian population. [source]

CYP2C9 and CYP2C19 genetic polymorphisms: frequencies in the south Indian population

FUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 1 2005
Rosemary Jose
Abstract The aim of the study was to establish the frequencies of CYP2C9*1, *2, *3 and CYP2C19*1, *2 and *3 in the south Indian population and to compare them with the inter-racial distribution of the CYP2C9 and CYP2C19 genetic polymorphisms. Genotyping analyses of CYP2C9 and CYP2C19 were conducted in unrelated, healthy volunteers from the three south Indian states of Andhra Pradesh, Karnataka and Kerala, by the polymerase chain reaction,restriction fragment-length polymorphism (PCR,RFLP). The allele frequencies of the populations of these three states were then pooled with our previous genotyping data of Tamilians (also in south India), to arrive at the distribution of CYP2C9 and CYP2C19 alleles in the south Indian population. Frequencies of CYP2C9 and CYP2C19 alleles and genotypes among various populations were compared using the two-tailed Fisher's exact test. The frequencies of CYP2C9*1, *2 and *3 in the south Indian population were 0.88 (95% CI 0.85,0.91), 0.04 (95% CI 0.02,0.06) and 0.08 (95% CI 0.06,0.11), respectively. The frequencies of CYP2C9 genotypes *1/*1, *1/*2, *1/*3, *2/*2, *2/*3 and *3/*3 were 0.78 (95% CI 0.74,0.82), 0.05 (95% CI 0.03,0.07), 0.15 (95% CI 0.12,0.18), 0.01 (95% CI 0.0,0.02), 0.01 (95% CI 0.0,0.02) and 0.0, respectively. CYP2C19*1, *2 and *3 frequencies were 0.64 (95% CI 0.60,0.68), 0.35 (95% CI 0.31,0.39) and 0.01 (95% CI 0.0,0.03), respectively. As a result of a significant heterogeneity, the data on CYP2C19 genotype frequencies were not pooled. The frequency of CYP2C9*2 mutant alleles in south Indians was higher than in Chinese and Caucasians, while CYP2C9*3 was similar to Caucasians. CYP2C19*2 was higher than in other major populations reported so far. The relatively high CYP2C19 poor-metabolizer genotype frequency of 12.6% indicates that over 28 million south Indians are poor metabolizers of CYP2C19 substrates. [source]

Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population

Molecular diversity of HLA-A*19 group of alleles in south Indian population

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, Issue 2 2006
V. Vettriselvi
Summary To determine the genetic diversity of the human leucocyte antigen (HLA)-A*19 group of alleles in the south Indian Tamil population, we studied 100 random healthy unrelated individuals. The frequency of HLA-A*19 was 37% with A*33 (45.9%), A*32 (29.7%), A*31 (16.2%), A*30 (5.4%), A*29 (2.7%) and A*74 (0%). The frequency distribution of the HLA-A*19 alleles was distinct and revealed marked similarities and variations with other populations [source]

Prevalence of idiopathic macular hole in adult rural and urban south Indian population

CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 3 2008
Parveen Sen MS
Abstract Background:, This study was undertaken to evaluate the prevalence of idiopathic macular hole in a defined community in Southern India. Methods:, In all, 7774 of the 9546 enumerated (81.43%) subjects availed themselves for an ophthalmic assessment which included a detailed ophthalmic examination and fundus photography. All data were entered and stored in a secure computerized database and statistical analysis was performed using spss for Windows. Results:, Thirteen subjects comprising six males and seven females were diagnosed with macular holes equating to a risk of 0.17%. Bilateral macular holes were found in two subjects. The mean age of subjects with a macular hole was 67 years. Increasing age and history of cataract surgery was strongly associated with an increased prevalence of macular holes (P < 0.0001). There was no difference in the prevalence of macular hole between the rural and urban communities. The mean logMAR visual acuity of subjects in the eye with a macular hole was 1.31 ± 0.45 whereas the acuity in the unaffected fellow eye was 0.70 ± 0.51. The mean spherical equivalent in the subjects with macular hole was ,0.56 ± 1.92 (,4.25 to +1.00). Conclusion:, Prevalence rate of idiopathic macular hole in South India appears to be comparable to that seen worldwide. [source]