Software Solution (software + solution)

Distribution by Scientific Domains


Selected Abstracts


DFold: PCR design that minimizes secondary structure and optimizes downstream genotyping applications,

HUMAN MUTATION, Issue 1 2004
David Fredman
Abstract Secondary structures in polymerase chain reaction (PCR) target sequences have a negative impact on amplification success rates and on downstream uses of PCR products. For example, signal strength and allele discrimination in single nucleotide polymorphism (SNP) genotyping methods can be compromised by allele-biased amplification and/or by PCR product folding that limits access of interrogating probes. To increase the fidelity and robustness of PCR, and to aid follow-on applications, we have developed DFold (http://dfold.cgb.ki.se),a generalized software solution that creates PCR oligonucleotide primer designs devoid of stable secondary structures. We demonstrate the effectiveness of the tool by applying it to a range of dynamic allele-specific hybridization (DASH) assay designs, many of which we evaluate in the laboratory. We further consider how the system throughput may be made sufficiently high for use upon millions of target sequences in order to support whole-genome analyses. Hum Mutat 24:1,8, 2004. © 2004 Wiley-Liss, Inc. [source]


Three innovations in cost accounting

JOURNAL OF CORPORATE ACCOUNTING & FINANCE, Issue 3 2005
Alan Vercio
Leading-edge cost measurement does not necessarily mean the latest "alphabet soup" solution or yet another vendor's software solution. The foundation for useful and relevant cost measurement has a long and time-tested history. © 2005 Wiley Periodicals, Inc. [source]


Architecture-based semantic evolution of embedded remotely controlled systems

JOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 3 2003
Lawrence Chung
Abstract Evolution of a software system is a natural process. In most systems, evolution takes place during the maintenance phase of their life cycles. Those systems that have reached their limit in evolution have usually reached their end of useful life and may have to be replaced. However, there are systems in which evolution occurs during the operational phase of their life cycles. Such systems are designed to evolve while in use or, in other words, be adaptable. Semantically adaptable systems are of particular interest to industry as such systems often times adapt themselves to environment change with little or no intervention from their developing or maintaining organization. Since embedded systems usually have a restricted hardware configuration, it is difficult to apply the techniques developed for non-embedded systems directly to embedded systems. This paper focuses on evolution through adaptation and develops the concepts and techniques for semantic evolution in embedded systems. As the first step in the development of a software solution, architectures of software systems themselves have to be made semantically evolvable. In this paper we explore various architectural alternatives for the semantic evolution of embedded systems,these architectures are based on four different techniques that we have identified for semantic evolution in embedded systems. The development of these architectures follows the systematic process provided by the non-functional requirement (NFR) framework, which also permits the architectures to be rated in terms of their evolvability. As the field of embedded systems is vast, this paper concentrates on those embedded systems that can be remotely controlled. In this application domain the embedded system is connected to an external controller by a communication link such as ethernet, serial, radio frequency, etc., and receives commands from and sends responses to the external controller via the communication link. The architectures developed in this paper have been partly validated by applying them in a real embedded system,a test instrument used for testing cell phones. These architectures and techniques for semantic evolution in this application domain give a glimpse of what can be done in achieving semantic evolution in software-implemented systems. Copyright © 2003 John Wiley & Sons, Ltd. [source]


Modeling software evolution defects: a time series approach

JOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 1 2009
Uzma Raja
Abstract The Department of Information Systems, Statistics and Management Science, prediction of software defects and defect patterns is and will continue to be a critically important software evolution research topic. This study presents a time series analysis of multi-organizational multi-project defects reported during ongoing software evolution efforts. Using data from monthly defect reports for eight open source software projects over five years, this study builds and tests time series models for each sampled project. The resulting model accounts for the ripple effects of defect detection and correction by modeling the autocorrelation of code defect data. The autoregressive integrated moving average model (0,1,1) was found to hold for all sampled projects and thus provide a basis for both descriptive and predictive software defect analysis that is computationally efficient, comprehensible, and easy to apply. The model may be used to evaluate and compare the reliability of candidate software solutions, and to facilitate planning for software evolution budget and time allocation. Copyright © 2008 John Wiley & Sons, Ltd. [source]


A PROCESS ANALYSIS OF GLOBAL TRADE MANAGEMENT: AN INDUCTIVE APPROACH,

JOURNAL OF SUPPLY CHAIN MANAGEMENT, Issue 2 2010
WARREN H. HAUSMAN
This paper describes a new, detailed process model for Global Trade Management (GTM) that contains sufficient detail on cross-border trade processes to estimate the benefits of Information Technology-Enabled Global Trade Management (IT-GTM). Our methodology combines a grounded theory approach with data analysis and analytical modeling. GTM describes the processes required to support cross-border transactions between importers, exporters, their trading partners and governments. IT-GTM is the set of information technologies and software solutions that can be used by companies to carry out their global trading processes in a streamlined manner. We collect data on time reductions for individual trade process steps using IT-GTM and use Critical Path Analysis to calculate the resulting improvements in key metrics such as the Manufacture to Invoice Cycle and Days Sales Outstanding for exporters, and the Order to Receipt Cycle for importers. Under reasonably conservative scenarios the gross savings from IT-GTM amount to 1.7 percent and 0.6 percent of annual sales for exporters and importers, respectively. [source]


Untersuchung verschiedener Bodenmodelle zur Berechnung von Fundamentplatten im Rahmen von FEM-Lösungen

BAUTECHNIK, Issue 5 2004
Christian Barth Prof. Dr.-Ing.
#Die wirklichkeitsnahe Abbildung von Bauwerk-Boden-Wechselwirkungen in Finite-Elemente-Programmen ist ungeachtet des gegenwärtig hohen Entwicklungsstands der verfügbaren Software eine nicht zu unterschätzende Aufgabe. Einerseits erfordert die richtige Einbindung des Bodenmodells in die FE-Berechnung viele Überlegungen und Kenntnisse, andererseits sind die in der Software implementierten Bodenmodelle aber für den Anwender nicht immer in ihrer gesamten Komplexität durchschaubar. Anhand alltäglicher Aufgabenstellungen werden vier verschiedene häufig verwendete und in FEM-Lösungen implementierte Bodenmodelle unterschiedlicher Softwarehersteller untersucht. Die erzielten Ergebnisse werden gegenübergestellt, und der Versuch einer Bewertung wird vorgenommen. Investigation of different models for the analysis of foundation slabs with reference to FEM solutions. The realistic interaction between a foundation slab and the soil in FE-programs is a formidable and complex task, despite the availability of sophisticated software solutions. On the one hand the incorporation of the slab-soil behaviour into conventional software programs requires considerable experience and thought and, on the other hand, existing software programs are often difficult to understand because of their complexity. Using common design examples four different models, which arc frequently used in FE solutions, are applied in this study. The results are compared and critically examined. [source]