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Smaller Peak (smaller + peak)
Selected AbstractsMolecular dissection of the chromosome band 7q21 amplicon in gastroesophageal junction adenocarcinomas identifies cyclin-dependent kinase 6 at both genomic and protein expression levelsGENES, CHROMOSOMES AND CANCER, Issue 8 2008H. van Dekken Amplification of chromosome band 7q21 has been frequently detected in various types of cancer including gastroesophageal junction (GEJ) adenocarcinomas. At present, no gene has been disclosed that can explain this frequent amplification of 7q21 in GEJ carcinomas. Therefore, a detailed genomic analysis of the 7q21 region was performed on a selected series of GEJ adenocarcinomas, i.e., 14 primary adenocarcinomas and 10 cell lines, by array comparative genomic hybridization (aCGH) with a 7q11.22-q31.2 contig array. A distinct peak of amplification was identified at 92.1 Mb in 7q21.2, precisely comprising cyclin-dependent kinase 6 (CDK6), a gene involved in cell cycle regulation. A smaller peak was seen at 116.2 Mb in 7q31.2, the locus of the MET proto-oncogene. No distinct peak was detected for the hepatocyte growth factor (HGF) at 81.3 Mb in 7q21.11. An immunoprofile of HGF, CDK6 and MET revealed a strong correlation between aCGH and immunohistochemical protein expression for CDK6 (P = 0.002). Furthermore, immunohistochemistry did not show expression of CDK6 in Barrett's dysplasia and carcinoma in situ, correlating expression of CDK6 with a malignant phenotype. We conclude that high-resolution genomic analysis and immunoprofiling identify CDK6 as the main candidate target for the recurrent amplification of 7q21 in GEJ adenocarcinomas. © 2008 Wiley-Liss, Inc. [source] UV-B INDUCTION OF UV-B PROTECTION IN ULVA PERTUSA (CHLOROPHYTA),JOURNAL OF PHYCOLOGY, Issue 3 2005Young-Seok Han The green macroalga Ulva pertusa Kjellman produced UV-B absorbing compounds with a prominent absorption maximum at 294 nm in response only to UV-B, and the amounts induced were proportional to the UV-B doses. Under a 12:12-h light:dark regime, the production of UV-absorbing compounds occurred only during the exposure periods with little turnover in the dark. There was significant reduction in growth in parallel with the production of UV-B absorbing compounds. The polychromatic action spectrum for the induction of UV-B absorbing compounds in U. pertusa exhibits a major peak at 292 nm with a smaller peak at 311.5 nm. No significant induction was detected above 354.5 nm, and radiation below 285 nm caused significant reduction in the levels of UV-B absorbing compounds. After UV-B irradiation at 1.0 W·m,2 for 9 h, the optimal photosynthetic quantum yield of the samples with UV-B absorbing compounds slightly increased relative to the initial value, whereas that of thalli lacking the compounds declined to 30%,34% of the initial followed by subsequent recovery in dim light of up to 84%,85% of the initial value. There was a positive and significant relationship between the amount of UV-B absorbing compounds with antioxidant activity as determined by the ,,,-diphenyl-,-picrylhydrazyl scavenging assay. In addition to mat-forming characteristics and light-driven photorepair, the existence and antioxidant capacity of UV-B absorbing compounds may confer U. pertusa a greater selective advantage over other macroalgae, thereby enabling them to thrive in the presence of intense UV-B radiation. [source] Trading activity in stock index futures markets: The evidence of emerging marketsTHE JOURNAL OF FUTURES MARKETS, Issue 10 2002Yu Chuan Huang This study investigates the trading activity of the Taiwan Futures Exchange (TAIFEX) and Singapore Exchange Derivatives Trading Limited (SGX-DT) Taiwan Stock Index Futures markets by analyzing the intraday patterns of volume and volatility. In addition, the market closure theory, which may explain such patterns, is examined. Overall, the trading pattern appears to be U-shaped for the TAIFEX futures and U+W-shaped for the SGX-DT. For the SGX-DT futures, volatility follows the same pattern as that of the number of price changes. For the TAIFEX futures, however, after the peak at the close of the spot market, the volatility in the TAIFEX futures drops consistently until the end of the day while volatility in the SGX-DT still reaches a smaller peak at the close of the futures market. In addition, a visual inspection of the intraday patterns of these two markets shows that the market closure theory can effectively explain the intraday patterns of these two markets. The empirical results support the market closure theory in that liquidity demand from traders rebalancing their portfolios before and after market closures creates larger volume and volatility at both the open and close. © 2002 Wiley Periodicals, Inc. Jrl Fut Mark 22:983,1003, 2002 [source] Coupling between limb tremor and postural sway in Parkinson's diseaseMOVEMENT DISORDERS, Issue 3 2008Graham Kerr BSc, MPhED Abstract Increased tremor and postural instability are motor problems commonly associated with Parkinson's disease (PD). Despite the similarity between these oscillatory forms, little is known about the relation between them, especially for individuals with enhanced tremor. This study was designed to examine the nature of any relation between center of pressure (COP) excursions and postural/resting limb tremor of young, older individuals, and Parkinsonian participants in their different medication states. The resting and postural tremor for the PD participants was characterized by a single, prominent peak frequency between 4 and 7 Hz. The postural tremor for young/older participants contained smaller peaks between 1 to 4 and 7 to 12 Hz although no prominent peak was seen in their resting tremor. The AP and ML COP dynamics of all participants was characterized by a major peak between 0.1 and 0.5 Hz. An additional peak was observed in the COP output of the PD participants between 4 and 7 Hz. While no tremor-COP coupling was observed for the young/old groups, coherence analysis revealed a significant degree of coupling between COP motion and tremor between 4 and 7 Hz for PD participants. These results highlight that the amplified tremor in PD can manifest itself in COP dynamics. This finding may have implications for postural stability for this patient group. © 2007 Movement Disorder Society [source] Determination of Potassium Ferrocyanide in Foods by Resonance Rayleigh Scattering Method with Double-Charged Triaminotriphenylmethane DyesCHINESE JOURNAL OF CHEMISTRY, Issue 7 2007Yong-Li Li Abstract In pH 1.0 acidic medium, double-charged triaminotriphenylmethane dyes such as methyl green (MeG) and iodine green (IG) react with potassium ferrocyanide to form 2:1 ion-association complexes by virtue of electrostatic forces and hydrophobic interaction. It results in the change of absorption and the great enhancement of resonance Rayleigh scattering (RRS) and the appearance of new RRS spectra. Two systems have similar spectral characteristics and their maximum RRS wavelengths are all located at 276 nm and smaller peaks are located at 332 and 457 nm, respectively. The intensity of RRS is directly proportional to the concentration of [Fe(CN)6]4, in the range of 0.03,5.7 µg·mL,1 (MeG system) or 0.04,5.9 µg·mL,1 (IG system). The RRS method has high sensitivity and the detection limit (3,) for potassium ferrocyanide is 9.3 ng·mL,1 (MeG system) or 11.2 ng·mL,1 (IG system). The optimum conditions, influencing factors and effects of foreign substances are investigated. The method also has a good selectivity. A sensitive, rapid and simple RRS method for the determination of potassium ferrocyanide in salinized food and table salt has been developed. [source] | ||||||||||