Smaller Amplitude (smaller + amplitude)

Distribution by Scientific Domains


Selected Abstracts


Effects of Distraction Versus Spatial Discrimination on Laser-Evoked Potentials in Migraine

HEADACHE, Issue 3 2008
Marina De Tommaso MD
Objectives., To evaluate whether migraine patients exhibit less inhibition to painful stimuli when distracted from pain as compared to healthy subjects, testing the spatial discrimination of painful stimuli, the performance during the mental arithmetic task used to contrast the discrimination performance and the behavior of N1 and N2-P2 laser-evoked potentials (LEPs) amplitudes during spatial discrimination and during distraction. Methods., Eight migraine patients and 8 healthy controls were examined. During repetitive series of painful laser stimulation of the hand, they had to (1) perform a spatial discrimination task, contrasted by (2) a mental arithmetic task that served as distraction. Results., Patients made 50% to 100% more mistakes than controls in the spatial discrimination task (P < .001) as well as during mental arithmetic (P < .05). Whereas healthy subjects showed a marked decrease of the LEP vertex potential amplitudes during distraction compared to the discrimination task, no such attenuation of LEPs was seen in migraine patients (group × task interaction, P < .05). N1 amplitude exhibited a left-hemisphere dominance in both groups, significantly smaller amplitude in migraine patients, but no significant task modulation. Conclusion., Migraine patients exhibited reduced inhibition by attentional modulation of pain processing, accompanied by impaired spatial discrimination of painful stimuli. [source]


Comparison of the myoplasmic calcium transient elicited by an action potential in intact fibres of mdx and normal mice

THE JOURNAL OF PHYSIOLOGY, Issue 21 2008
Stephen Hollingworth
The myoplasmic free [Ca2+] transient elicited by an action potential (,[Ca2+]) was compared in fast-twitch fibres of mdx (dystrophin null) and normal mice. Methods were used that maximized the likelihood that any detected differences apply in vivo. Small bundles of fibres were manually dissected from extensor digitorum longus muscles of 7- to 14-week-old mice. One fibre within a bundle was microinjected with furaptra, a low-affinity rapidly responding fluorescent calcium indicator. A fibre was accepted for study if it gave a stable, all-or-nothing fluorescence response to an external shock. In 18 normal fibres, the peak amplitude and the full-duration at half-maximum (FDHM) of ,[Ca2+] were 18.4 ± 0.5 ,m and 4.9 ± 0.2 ms, respectively (mean ±s.e.m.; 16°C). In 13 mdx fibres, the corresponding values were 14.5 ± 0.6 ,m and 4.7 ± 0.2 ms. The difference in amplitude is statistically highly significant (P= 0.0001; two-tailed t test), whereas the difference in FDHM is not (P= 0.3). A multi-compartment computer model was used to estimate the amplitude and time course of the sarcoplasmic reticulum (SR) calcium release flux underlying ,[Ca2+]. Estimates were made based on several differing assumptions: (i) that the resting myoplasmic free Ca2+ concentration ([Ca2+]R) and the total concentration of parvalbumin ([ParvT]) are the same in mdx and normal fibres, (ii) that [Ca2+]R is larger in mdx fibres, (iii) that [ParvT] is smaller in mdx fibres, and (iv) that [Ca2+]R is larger and [ParvT] is smaller in mdx fibres. According to the simulations, the 21% smaller amplitude of ,[Ca2+] in mdx fibres in combination with the unchanged FDHM of ,[Ca2+] is consistent with mdx fibres having a ,25% smaller flux amplitude, a 6,23% larger FDHM of the flux, and a 9,20% smaller total amount of released Ca2+ than normal fibres. The changes in flux are probably due to a change in the gating of the SR Ca2+ -release channels and/or in their single channel flux. The link between these changes and the absence of dystrophin remains to be elucidated. [source]


Simulation of the Madden, Julian Oscillation and its teleconnections in the ECMWF forecast system

THE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 649 2010
Frédéric Vitart
Abstract A series of 46-day ensemble integrations starting on the 15th of each month from 1989 to 2008 has been completed with the European Centre for Medium-Range Weather Forecasts (ECMWF) forecast system. The Madden, Julian Oscillation (MJO) simulated by the hindcasts is diagnosed using an index based on combined empirical orthogonal functions (EOFs) of zonal winds at 200 and 850 hPa and outgoing long-wave radiation. Results indicate that the dynamical model is able to maintain the amplitude of the MJO during the 46 days of integrations and the model displays skill for up to about 20 days to predict the evolution of the MJO. However, the MJO simulated by the model has a too slow eastward propagation and has difficulties crossing the Maritime Continent. The MJO teleconnections simulated by the ECMWF forecast system have been compared to reanalyses. In the Tropics, the impact of the MJO on precipitation is generally consistent with reanalysis. In the Northern Extratropics, the MJO simulated by the model has an impact on North Atlantic weather regimes, but with a smaller amplitude than in reanalysis which can be partly explained by the too slow eastward propagation of the simulated MJO events. The impact of the MJO on the probabilistic skill scores has been assessed. Results indicate that the MJO simulated by the model has a statistically significant impact on weekly mean probabilistic skill scores in the Northern Extratropics, particularly at the time range 19, 25 days. At this time range, the reliability of the probabilistic forecasts over Europe depends strongly on the presence of an MJO event in the initial conditions. This result confirms that the MJO is a major source of predictability in the Extratropics in the sub-seasonal time-scale. Copyright © 2010 Royal Meteorological Society [source]


Bimanual coordination in Parkinson's disease: Deficits in movement frequency, amplitude, and pattern switching

MOVEMENT DISORDERS, Issue 1 2002
Winston D. Byblow BHK
Abstract Six patients with idiopathic Parkinson's disease (PD) and six age-matched controls participated in a variety of rhythmic bimanual coordination tasks. The main goal of the task was to perform inphase or antiphase patterns of pronation and supination of the forearms at a specified tempo, and to switch from one pattern to the other upon presentation of a visual cue. The availability of advance information was varied to examine whether deficits would emerge under choice versus pre-cue constraints. In pre-cue conditions, the subjects knew in advance which hand would be cued to initiate pattern change. In choice conditions, the cued hand was not known until the imperative stimulus was presented. Overall, the PD patients made movements with significantly lower frequencies and smaller amplitudes relative to controls. Patients exhibited spontaneous pattern switching from antiphase to inphase at significantly lower movement frequencies than controls. During intentional switching trials, the control group was significantly faster at initiating pattern change. PD and control groups differed in the time to initiate pattern switching to a greater extent under choice conditions, suggesting that patients used advance information to increase the speed of their response. The control group exhibited a preference for spontaneous switching and intentional switching through the subdominant hand. Patients exhibited a switching preference using the impaired limb (whether or not it was subdominant). The control group made more correct responses when the subdominant side was either pre-cued or presented in choice conditions. The patients maintained the subdominant/impaired side advantage under pre-cue conditions but not choice. In the maintenance of rhythmic movement, individuals with PD were able to use advance information in terms of both speed and accuracy. © 2001 Movement Disorder Society. [source]


How semiregular are irregular variables?

ASTRONOMISCHE NACHRICHTEN, Issue 4 2009
T. Lebzelter
Abstract We investigate the question whether there is a real difference in the light change between stars classified as semiregular (SRV) or irregular (Lb) variables by analysing photometric light curves of 12 representatives of each class. Using Fourier analysis we try to find a periodic signal in each light curve and determine the S/N of this signal. For all stars, independent of their variability class we detect a period above the significance threshold. No difference in the measured S/N between the two classes could be found. We propose that the Lb stars can be seen as an extension of the SRVs towards shorter periods and smaller amplitudes. This is in agreement with findings from other quantities which also showed no marked difference between the two classes (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]