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Slide Test (slide + test)
Selected AbstractsAssociation of components of the metabolic syndrome with the appearance of aggregated red blood cells in the peripheral blood.DIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 2 2005An unfavorable hemorheological finding Abstract Background Components of the metabolic syndrome are associated with low-grade inflammation. This can be accompanied by the synthesis of sticky proteins and erythrocyte aggregation. Methods The degree of erythrocyte aggregation was evaluated by a simple slide test and image analysis along with other markers of the acute-phase response, including the white blood cell count (WBCC), erythrocyte sedimentation rate (ESR), fibrinogen and high sensitivity C-reactive protein (hs-CRP) concentrations. Patients were categorized in four groups according to the absence or presence of 1, 2 and 3 or more components of the metabolic syndrome. Results We examined a total of 1447 individuals (576 women and 871 men) who gave their informed consent for participation. A significant cardiovascular risk factors, age and hemoglobin adjusted correlation was noted between the degree of erythrocyte aggregation and the number of components of the metabolic syndrome (r = 0.17, p < 0.0005). This correlation was better than that observed for clottable fibrinogen (r = 0.13 p < 0.0005), for ESR (r = 0.11 p < 0.0005) or WBCC (r = 0.13 p < 0.0005). A somewhat better correlation was noted for hs-CRP (r = 0.26 p < 0.0005). Conclusions The multiplicity of components of the metabolic syndrome is associated with enhanced erythrocyte aggregation, probably related to the presence of multiple adhesive macromolecules in the peripheral blood. The enhanced aggregation might contribute to capillary slow flow, tissue deoxygenation as well as vasomotor tone changes in the presence of multiple components of this syndrome. Copyright © 2004 John Wiley & Sons, Ltd. [source] Rheological determinants of red blood cell aggregation in diabetic patients in relation to their metabolic controlDIABETIC MEDICINE, Issue 2 2002K. Elishkevitz Abstract Aims To determine whether increased red blood cell adhesiveness/aggregation in diabetic patients is related to the extent of their metabolic control. Methods We measured erythrocyte adhesiveness/aggregation in a group of 85 adult patients with diabetes mellitus by using citrated venous whole blood and a simple slide test. The erythrocyte adhesiveness/aggregation was determined by measuring the size of the spaces that are formed between the aggregated erythrocytes. We divided the patients into those with either low or high erythrocyte adhesiveness/aggregation values. Results The erythrocyte adhesiveness/aggregation values of the two groups differed significantly in terms of their fibrinogen concentration, erythrocyte sedimentation rate, high sensitive C-reactive protein (CRP), total cholesterol and triglyceride concentrations. There was no difference between the two groups regarding the concentrations of HbA1c. Logistic regression was applied to construct a model to predict the belonging of a patient in the low or high erythrocyte adhesiveness/aggregation group. A linear regression was applied to construct a model to predict the erythrocyte adhesiveness/aggregation values. Both models turned out to include gender, age, fibrinogen, triglyceride, retinopathy, coronary artery disease and age and gender interaction. Neither HbA1c nor CRP entered the models. Conclusions The degree of erythrocyte adhesiveness/aggregation and several variables of the acute-phase response in patients with diabetes mellitus are not directly related to the degree of metabolic control as evaluated by means of HbA1c concentration. Diabetic patients might benefit from rheological or anti-inflammatory interventions regardless of their metabolic control. [source] The erythrocyte adhesiveness/aggregation test for the detection of an acute phase response and for the assessment of its intensityINTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 4 2002N. Maharshak Summary We have developed a simple slide test and image analysis to reveal the state of erythrocyte adhesiveness/aggregation in the peripheral blood of patients with various degrees of the humoral acute phase response. The significant correlation between the results of the erythrocyte adhesiveness/aggregation test (EAAT), the erythrocyte sedimentation rate and fibrinogen concentration support the notion that it is possible to use the EAAT as a marker for the intensity of the acute phase response. Within a group of 860 individuals, we were able to differentiate effectively between groups of patients with a different intensity of humoral acute phase response. The present study confirms previous observations that support the applicability of the EAAT to routine clinical practice. [source] Geometric effects in high-temperature vapour-phase lubrication using hydrocarbon feed gasesLUBRICATION SCIENCE, Issue 2 2002J. E. Gardner Abstract The effectiveness of ,far-field' vapour-phase lubrication, in which areas of a bearing surface that are cycled through the contact are exposed to vapour while outside the contact, has been demonstrated in both sliding and combined roll slide tests using acetylene vapours to deposit pyrolytic graphite. Friction coefficients as low as , = 0.008 have been measured for steel at 540°C with far-field acetylene concentrations as low as 5%. Effective vapour-phase lubrication depends on solid lubricant deposition that exceeds the contact's capacity to remove solid lubricant through wear. While the rate of removal is increased by increasing the sliding velocity, in far-field vapour-phase lubrication the rate of lubricant deposition, and therefore the lubrication effectiveness, is augmented by increased areas available for far-field deposition, such as those provided by performing wear tests with increased wear-track diameters. These geometric concepts may be considered in rolling-element bearing and gear set applications where vapour-phase lubrication is to be employed. [source] | ||||||||||