			Home About us Contact

Skin Temperature (skin + temperature)

Distribution by Scientific Domains

Medical Sciences	67%
Life Sciences	25%
Chemistry	4%

Distribution within Medical Sciences

Anesthesia & Pain Management	19%
Dermatology	5%
14 Other Subdomains	76%

Kinds of Skin Temperature

mean skin temperature

Selected Abstracts

Effects of linearly polarized 0.6,1.6 ,M irradiation on stellate ganglion function in normal subjects and people with complex regional pain (CRPS I)

LASERS IN SURGERY AND MEDICINE, Issue 5 2003
Jeffrey R. Basford MD
Abstract Background and Objectives Stellate ganglion blocks are an effective but invasive treatment of upper extremity pain. Linearly polarized red and near-infrared (IR) light is promoted as a safe alternative to this procedure, but its effects are poorly established. This study was designed to assess the physiological effects of this latter approach and to quantitate its benefits in people with upper extremity pain due to Complex Regional Pain Syndrome I (CRPS I, RSD). Study Design/Materials and Methods This was a two-part study. In the first phase, six adults (ages 18,60) with normal neurological examinations underwent transcutaneous irradiation of their right stellate ganglion with linearly polarized 0.6,1.6 ,m light (0.92 W, 88.3 J). Phase two consisted of a double-blinded evaluation of active and placebo radiation in 12 subjects (ages 18,72) of which 6 had upper extremity CRPS I and 6 served as "normal" controls. Skin temperature, heart rate (HR), sudomotor function, and vasomotor tone were monitored before, during, and for 30 minutes following irradiation. Analgesic and sensory effects were assessed over the same period as well as 1 and 2 weeks later. Results Three of six subjects with CRPS I and no control subjects experienced a sensation of warmth following active irradiation (P,=,0.025). Two of the CRPS I subjects reported a >50% pain reduction. However, four noted minimal or no change and improvement did not reach statistical significance for the group as a whole. No statistically significant changes in autonomic function were noted. There were no adverse consequences. Conclusions Irradiation is well tolerated. There is a suggestion in this small study that treatment is beneficial and that its benefits are not dependent on changes in sympathetic tone. Further evaluation is warranted. Lasers Surg. Med. 32:417,423, 2003. © 2003 Wiley-Liss, Inc. [source]

Pupillary reflex dilation and skin temperature to assess sensory level during combined general and caudal anesthesia in children,

PEDIATRIC ANESTHESIA, Issue 9 2004
John Emery MBBS, frca
Summary Background:, Regional anesthesia causes sympathetic blockade, vasodilation and higher skin temperature in anesthetized dermatomes. Measurement of skin temperature changes might provide a useful estimate of the level of caudal anesthesia in children. Pupillary reflex dilation (PRD) allows estimation of the sensory level during combined general/epidural anesthesia in adults, but has not been assessed in children. This study was designed to evaluate skin temperature and PRD as methods of estimating sensory level in children receiving combined general/caudal epidural anesthesia. Methods:, Twenty ASA I and II children aged 10 months,5 years were enrolled. Anesthesia was induced with sevoflurane and N2O in O2 and maintained with 1 MAC isoflurane and air in O2. Caudal epidural anesthesia was achieved by injection of 1 ml·kg,1 0.25% bupivacaine. Skin temperature was measured by rapid response infrared thermometry. PRD was measured using an ophthalmic ultrasound biomicroscope (UBM). The three criteria used to estimate sensory level were a drop in skin temperature of 0.5°C between dermatomes, PRD of 50% and PRD of 0.2 mm. Results:, A drop in skin temperature of 0.5°C between dermatomes allowed estimation of the sensory level in only 20% of patients. PRD of 50%, and PRD of 0.2 mm allowed estimation of the sensory level in 45 and 100% of patients, respectively. PRD was significantly greater above the T10 dermatome compared with L2 (P < 0.01). The maximum pupillary dilation was significantly greater in children over 2 years of age [1.3 ± 0.8 mm sd)] compared with children less than two years of age [0.6 ± 0.3 mm sd)]. Conclusions:, Skin temperature cannot be used to estimate sensory level during combined general/caudal epidural anesthesia. PRD of 0.2 mm is sensitive to the loss of analgesia but is not clinically useful. PRD may be useful above 2 years of age. [source]

Effect of pulse repetition rate on the perception of thermal sensation with pulsed shortwave diathermy

PHYSIOTHERAPY RESEARCH INTERNATIONAL, Issue 2 2000
Charles Conor Murray
Abstract Background and Purpose Pulsed shortwave diathermy (PSWD) is a form of therapy commonly used to enhance tissue repair and reduce pain. It is normally considered to be an athermal form of treatment; however, there is some evidence to suggest that thermal effects can arise with adequate dosage. The purpose of this study was to determine the pulse repetition rate (PRR) required to generate a ,possible' and ,definite' thermal sensation when PSWD was applied to the thigh. Method Thirty healthy subjects were randomly assigned to placebo or treatment groups. The treatment group was exposed to PSWD at a constant setting of pulse duration (400 µs) and pulse power (190 W) while the PRR was increased from 26 Hz to 400 Hz in 10 increments. Each dose was applied for a period of two minutes. At the end of each application, subjects were asked if they felt a (1) ,possible' or (2) ,definite' thermal sensation. Skin temperature was measured immediately after each application. Placebo subjects were exposed to PSWD at its lowest settings throughout the experiment (pulse power = 5W; pulse duration = 65 µs and PRR = 26 Hz). Results The results showed a significant correlation (p<0.048) between PRR at ,definite' thermal sensation and skin temperature post-treatment and PRR at ,possible' thermal sensation (p<0.001). Mean skin temperature increased significantly as PRR was increased, from 28.69 (±0.75) °C pre-treatment to 31.14 (±1.04) °C post-treatment, a mean difference of 2.34 °C. Conclusions These results suggest that PSWD at adequate dosages can generate thermal effects, and that there is a relationship between these thermal effects and the PRR used. These results may have significant implications for the safe use of PSWD in the clinical arena. Copyright © 2000 Whurr Publishers Ltd. [source]

Infants sleeping outdoors in a northern winter climate: skin temperature and duration of sleep

ACTA PAEDIATRICA, Issue 9 2010
Marjo Tourula
Abstract Aim:, The aim of the study is to describe the relationships among thermal environment, skin temperatures and infants' daytime outdoor sleep duration in northern winter conditions. Methods:, This study is a cross-over observational study. Skin temperatures of three-month-old infants were recorded from seven skin sites continuously throughout outdoor (n = 34) and indoor sleep (n = 33) in the families' homes. The duration of the sleep was observed, and temperature and the air velocity of the environment were recorded. Results:, Skin temperatures increased towards the end of indoor sleeping, whereas they decreased during outdoor sleeping. The cooling rate of mean skin temperature (Tsk) increased in lower outdoor temperatures (rs = 0.628, p < 0.001) in spite of increased clothing. On some occasions, cold extremities were observed, suggesting slight deviations from thermoneutrality. Sleep time was 92 min longer in outdoors than in indoors. However, outdoor sleep duration was shortened when the cooling rate of Tsk increased (rs = 0.611, p < 0.001). Conclusion:, The longest sleep was recorded outdoors when the cooling rate of Tsk was minimal. Restriction of movements by clothing probably increases the length of sleep, and a cold environment makes swaddling possible without overheating. A decrease in ambient temperature increased the cooling rate, suggesting that the cold protection of the clothing compensated only partly for the increased heat loss. [source]

Evaluation of sympathetic vasoconstrictor response following nociceptive stimulation of latent myofascial trigger points in humans

ACTA PHYSIOLOGICA, Issue 4 2009
Y. Kimura
Abstract Aim:, Myofascial trigger points (MTrPs) are a major cause of musculoskeletal pain. It has been reported that stimulation of a latent MTrP increases motor activity and facilitates muscle pain via activation of the sympathetic nervous system. However, the magnitude of the sympathetic vasoconstrictor response following stimulation of MTrP has not been studied in healthy volunteers. The aims of this study were to (1) evaluate the magnitude of the vasoconstrictor response following a nociceptive stimulation (intramuscular glutamate) of MTrPs and a breath-hold manoeuvre (activation of sympathetic outflow) and (2) assess whether the vasoconstrictor response can be further modulated by combining a nociceptive stimulation of MTrPs and breath-hold. Methods:, Fourteen healthy subjects were recruited in this study. This study consisted of four sessions (normal breath group as control, breath-hold group, glutamate MTrP injection group and glutamate MTrP injection + breath-hold group). Skin blood flow and skin temperature in both forearms were measured with laser Doppler flowmetry and infrared thermography, respectively, in each session (before the treatment, during the treatment and after the treatment). Results:, Glutamate injection into MTrPs decreased skin temperature and blood flow in the peripheral area. The magnitudes of the reduction were comparable to those induced by the breath-hold manoeuvre, which has been used to induce sympathetic vasoconstrictor response. Conclusion:, The combination of glutamate injection into latent MTrPs together with the breath-hold manoeuvre did not result in further decrease in skin temperature and blood flow, indicating that sympathetic vasoconstrictor activity is fully activated by nociceptive stimulation of MTrPs. [source]

Non-invasive monitoring of muscle blood perfusion by photoplethysmography: evaluation of a new application

ACTA PHYSIOLOGICA, Issue 4 2005
M. Sandberg
Abstract Aim:, To evaluate a specially developed photoplethysmographic (PPG) technique, using green and near-infrared light sources, for simultaneous non-invasive monitoring of skin and muscle perfusion. Methods:, Evaluation was based on assessments of changes in blood perfusion to various provocations, such as post-exercise hyperaemia and hyperaemia following the application of liniment. The deep penetrating feature of PPG was investigated by measurement of optical radiation inside the muscle. Simultaneous measurements using ultrasound Doppler and the new PPG application were performed to elucidate differences between the two methods. Specific problems related to the influence of skin temperature on blood flow were highlightened, as well. Results:, Following static and dynamic contractions an immediate increase in muscle perfusion was shown, without increase in skin perfusion. Liniment application to the skin induced a rapid increase in skin perfusion, but not in muscle. Both similarities and differences in blood flow measured by Ultrasound Doppler and PPG were demonstrated. The radiant power measured inside the muscle, by use of an optical fibre, showed that the near-infrared light penetrates down to the vascular depth inside the muscle. Conclusions:, The results of this study indicate the potentiality of the method for non-invasive measurement of local muscle perfusion, although some considerations still have to be accounted for, such as influence of temperature on blood perfusion. [source]

High prevalence of vasomotor reflex impairment in newly diagnosed leprosy patients

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 10 2005
X. Illarramendi
Abstract Background, Initial nerve damage in leprosy occurs in small myelinated and unmyelinated nerve fibers. Early detection of leprosy in the peripheral nervous system is challenging as extensive nerve damage may take place before clinical signs of leprosy become apparent. Patients and methods, In order to determine the prevalence of, and factors associated with, peripheral autonomic nerve dysfunction in newly diagnosed leprosy patients, 76 Brazilian patients were evaluated prior to treatment. Skin vasomotor reflex was tested by means of laser Doppler velocimetry. Blood perfusion and reflex vasoconstriction following an inspiratory gasp were registered on the second and fifth fingers. Results, Vasomotor reflex was impaired in at least one finger in 33/76 (43%) patients. The fifth fingers were more frequently impaired and suffered more frequent bilateral alterations than the second fingers. Multivariate regression analysis showed that leprosy reaction (adjusted odds ratio = 8·11, 95% confidence interval: 1·4,48·2) was associated with overall impaired vasomotor reflex (average of the four fingers). In addition, palmar erythrocyanosis and an abnormal upper limb sensory score were associated with vasomotor reflex impairment in the second fingers, whereas anti-phenolic glycolipid-I antibodies, ulnar somatic neuropathy and a low finger skin temperature were associated with impairment in the fifth fingers. Conclusions, A high prevalence of peripheral autonomic dysfunction as measured by laser Doppler velocimetry was observed in newly diagnosed leprosy patients, which is clinically evident late in the disease. Autonomic nerve lesion was more frequent than somatic lesions and was strongly related to the immune-inflammatory reaction against M. leprae. [source]

The relation between skin temperature increase and sensory block height in spinal anaesthesia using infrared thermography

ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 9 2010
F. G. A. M. Van HAREN
Background and objectives: To evaluate the feasibility of determining the extent of sympathetic blockade by skin temperature measurement with infrared thermography and relate the cranial extent of the temperature increase to that of the sensory block after spinal anaesthesia. Methods: Before and 5, 10 and 20 min after the administration of spinal anaesthesia, skin temperatures were measured with infrared thermography at the dermatomes T2,L3, in 12 male patients scheduled for lower limb surgery. The most cephalad dermatome at which sensory blockade occurred was related to the dermatome at which the largest temperature jump (corrected for baseline temperature) occurred. Results: The baseline temperatures showed considerable variation across the dermatomes, being lower below T12 than at the thoracic dermatomes. The mean difference between the level of the cephalad skin temperature elevation front (mean 1.03 °C, SD 0.8 °C) and cranial sensory block height was 0.10 dermatomes (SD 1.16), correlation coefficient (0.88, P<0.001). Conclusion: The varying baseline temperatures across the trunk, the limited sympathetic block-induced increase in skin temperature at the trunk and the difficult control of influences from the surroundings partly obscured the extent of the skin temperature increase and its correlation to sensory block height. These factors have to be controlled to improve the use of infrared cameras as an easy bedside tool for predicting the cranial extent of (sympathetic blockade during) spinal anaesthesia. [source]

Relationship between ambient temperature and heat flux in the scrotal skin

INTERNATIONAL JOURNAL OF ANDROLOGY, Issue 4 2009
G.-S. Song
Summary Excessive scrotal heating or cooling may lead to the cessation of spermatogenesis. Data regarding heat exchange rates in scrotal skin can be used to control testicular temperature within the appropriate range. Heat flux (HF) in the scrotal skin surface is generated based on the surrounding environment. This study aims to elucidate the HF of scrotal skin by varying ambient temperature. Twenty college students including seven varicoceles volunteered as the subjects (mean age: 22.95 ± SD 1.96 years; height: 175.00 ± 5.17 cm; weight: 68.40 ± 8.65 kg; body mass index: 22.28 ± 2.15), and participated in the experiments from September 11 to October 4, 2006. The environmental temperature was controlled at 20 °C and 25 °C in the first and second experiment respectively. The HF and skin temperature on both sides of the scrotal surface were measured for 60 min in the environmental chamber. The results revealed that the HF was 87.64 ± 12.69 W/m2 and 78.91 ± 12.09 W/m2 in the left and right side of the scrotum respectively. The scrotal skin temperature (SST) was 30.28 ± 0.75 °C and 30.24 ± 0.62 °C on the left and right side of the scrotum in the 20 °C environment respectively. In the 25 °C environment the HF was 53.54 ± 8.86 W/m2 and 45.25 ± 8.32 W/m2, and the SST was 32.29 ± 0.61 °C and 32.07 ± 0.36 °C on the left and right side of the scrotum respectively. The cooling source power to decrease testicular temperature is suggested at 290 W/m2. This suggested value could be adopted a cooling device as clinical therapy for a heat stress patient to decrease testicular temperature affecting spermatogenesis. [source]

Torpor in an African caprimulgid, the freckled nightjar Caprimulgus tristigma

JOURNAL OF AVIAN BIOLOGY, Issue 3 2007
Andrew E. McKechnie
Recent data suggest that facultative hypothermic responses such as torpor are more important in the energy balance of birds from tropical and sub-tropical regions than previously thought. We used telemetric measurements of skin temperature (Tskin) for five individuals on 151 bird-nights to investigate the occurrence of torpor during winter in an 81 g African caprimulgid, the freckled nightjar Caprimulgus tristigma. We found that freckled nightjars have the capacity to enter torpor, with a minimum observed Tskin of 12.8°C. During the torpor bouts we observed, complete rewarming typically occurred after sunrise, and coincided with the availability of solar radiation. There was considerable inter-individual variability in the frequency and depth of torpor bouts, with one female nightjar exhibiting particularly frequent and deep torpor. Our results confirm the ability to use torpor by a nocturnal aerial insectivore from the Afrotropics, and reiterate the variability in patterns of torpor that can exist within a population. [source]

Pulse oximeter perfusion index as an early indicator of sympathectomy after epidural anesthesia

ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 8 2009
Y. GINOSAR
Background: The pulse oximeter perfusion index (PI) has been used to indicate sympathectomy-induced vasodilatation. We hypothesized that pulse oximeter PI provides an earlier and clearer indication of sympathectomy following epidural anesthesia than skin temperature and arterial pressure. Methods: Forty patients received lumbar epidural catheters. Patients were randomized to receive either 10 ml 0.5% bupivacaine or 10 ml 0.25% bupivacaine. PI in the toe, mean arterial pressure (MAP) and toe temperature were all assessed at baseline and at 5, 10 and 20 min following epidural anesthesia. The effect of epidural anesthesia over time was assessed by repeated measures analysis of variance. Additionally, we defined clinically evident sympathectomy criteria (a 100% increase in the PI, a 15% decrease in MAP and a 1 °C increase in toe temperature). The numbers of patients demonstrating these changes for each test were compared using the McNemar test for each time point. Results: Twenty-nine subjects had photoplethysmography signals that met a priori signal quality criteria for analysis. By 20 min, PI increased by 326%, compared with a 10% decrease and a 3% increase in MAP and toe temperature, respectively. For PI 15/29, 26/29 and 29/29 of the subjects met the sympathectomy criteria at 5, 10 and 20 min, respectively, compared with 4/29, 6/29 and 18/29 for MAP changes and 3/29, 8/29 and 14/29 for toe temperature changes. Conclusions: PI was an earlier, clearer and more sensitive indicator of the development of epidural-induced sympathectomy than either skin temperature or MAP. [source]

Aminolevulinic acid-loaded Witepsol microparticles manufactured using a spray congealing procedure: implications for topical photodynamic therapy

JOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 9 2009
Rasil Al-Kassas
Abstract Objectives The aim was to enhance aminolevulinic acid (ALA) stability by incorporation into low-melting microparticles prepared using a spray congealing procedure and to evaluate temperature-triggered release, allowing topical bioavailability following melting at skin temperature. Methods ALA-loaded Witepsol microparticles were prepared using a novel spray congealing technique. Entrapment efficiency was compared with conventional emulsion-based methods and modelled drug release profiles determined using a membrane separation technique. Raised receiver medium temperature was used to determine triggered release. Bioavailability and lipid-mediated enhancement of ALA penetration were determined in excised murine skin. Key findings ALA-loaded Witepsol microparticles were spherical, with a mean diameter of 20 ,m. Loading and stability studies demonstrated effective encapsulation, ranging from 91% to 100%, with no evidence of degradation to pyrazine derivatives. ALA release correlated with dissolution medium temperature, triggered at temperatures close to that of skin. Results suggested that molten Witepsol enhanced cutaneous permeation, whereas incorporation of microparticles in a semi-solid vehicle attenuated ALA penetration. Optimal use was direct application under occlusion. Conclusions Spray congealing is superior to the emulsion-based procedures with respect to encapsulation efficiency of ALA in Witepsol matrices, providing temperature-triggered release, enhanced stability and improved penetration of ALA through keratinised skin. These features could improve ALA delivery to superficial lesions as part of photodynamic therapy. [source]

Effects of Variation at the ALDH2 Locus on Alcohol Metabolism, Sensitivity, Consumption, and Dependence in Europeans

ALCOHOLISM, Issue 7 2006
Peter A. Dickson
Background: The low-activity variant of the aldehyde dehydrogenase 2 (ALDH2) gene found in East Asian populations leads to the alcohol flush reaction and reduces alcohol consumption and risk of alcohol dependence (AD). We have tested whether other polymorphisms in the ALDH2 gene have similar effects in people of European ancestry. Methods: Serial measurements of blood and breath alcohol, subjective intoxication, body sway, skin temperature, blood pressure, and pulse were obtained in 412 twins who took part in an alcohol challenge study. Participants provided data on alcohol reactions, alcohol consumption, and symptoms related to AD at the time of the study and subsequently. Haplotypes based on 5 single-nucleotide polymorphisms (SNPs) were used in tests of the effects of variation in the ALDH2 gene on alcohol metabolism and alcohol's effects. Results: The typed SNPs were in strong linkage disequilibrium and 2 complementary haplotypes comprised 83% of those observed. Significant effects of ALDH2 haplotype were observed for breath alcohol concentration, with similar but smaller and nonsignificant effects on blood alcohol. Haplotype-related variation in responses to alcohol, and reported alcohol consumption, was small and not consistently in the direction predicted by the effects on alcohol concentrations. Conclusions: Genetic variation in ALDH2 affects alcohol metabolism in Europeans. However, the data do not support the hypothesis that this leads to effects on alcohol sensitivity, consumption, or risk of dependence. [source]

Use of a pharmacokinetic/pharmacodynamic approach in the cat to determine a dosage regimen for the COX-2 selective drug robenacoxib

JOURNAL OF VETERINARY PHARMACOLOGY & THERAPEUTICS, Issue 1 2009
J. M. GIRAUDEL
This study investigated the analgesic, anti-inflammatory and antipyretic efficacy of the new COX-2 selective inhibitor robenacoxib in the cat and established pharmacodynamic (PD) parameters for these effects. Robenacoxib, at a dosage of 2 mg/kg administered subcutaneously, was evaluated in a kaolin-induced paw inflammation model in 10 cats, using both clinically relevant endpoints (lameness scoring, locomotion tests) and other indicators of inflammation (body and skin temperature, thermal pain threshold) to establish its pharmacological profile. A pharmacokinetic/pharmacodynamic (PK/PD) modelling approach, based on indirect response models, was used to describe the time course and magnitude of the responses to robenacoxib. All endpoints demonstrated good responsiveness to robenacoxib administration and both the magnitude and time courses of responses were well described by the indirect pharmacodynamic response models. Pharmacokinetic and clinically relevant pharmacodynamic parameters were used to simulate dosage regimens that will assist the planning of clinical trials and the selection of an optimal dosage regimen for robenacoxib in the cat. [source]

Landing responses of Anopheles gambiae elicited by oxocarboxylic acids

MEDICAL AND VETERINARY ENTOMOLOGY, Issue 2 2002
T. P. Healy
Abstract A wind tunnel bioassay and video system were used to observe Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) landing on glass cylinders, heated to human skin temperature (34°C) and treated with aqueous solutions of oxocarboxylic acids. Six of nine compounds tested: 2-oxobutanoic, 2-oxo-3-methylbutanoic, 2-oxopentanoic, 2-oxo-3-methylpentanoic, 2-oxo-4-methylpentanoic and 2-oxohexanoic elicited significant landing responses in comparison to a water control. Landing responses appeared to be restricted to C4,C6, 2-oxocarboxylic acids. A solution of 1 µg/µL of 2-oxopentanoic acid elicited the highest level of response that was temperature dependent: significant numbers of landings occurred only within ±,2°C of human skin temperature. Chemical analysis by linked gas-liquid chromatography/mass spectrometry of methyl-oxime, trimethylsilyl derivatized samples of human sweat extracts revealed the presence of 2-oxopropanoic (pyruvic) acid and three behaviourally active, branched chain acids: 2-oxo-3-methylbutanoic, 2-oxo-3-methylpentanoic and 2-oxo-4-methylpentanoic. [source]

Pupillary reflex dilation and skin temperature to assess sensory level during combined general and caudal anesthesia in children,

Changes in Diapered and Nondiapered Infant Skin Over the First Month of Life

PEDIATRIC DERMATOLOGY, Issue 1 2000
Marty O. Visscher Ph.D.
Diapered and nondiapered skin sites were contrasted to the volar forearm of adults (mothers). Thirty-one term infants were evaluated in the hospital on postnatal day 1 and at home on days 4, 7, 14, 21, and 28 for a total of six visits. Measurements included baseline skin hydration, continuous capacitive reactance, peak water sorption, rate of water desorption, skin pH, skin temperature, and environmental conditions. Changes in epidermal barrier properties over the first 4 weeks of life included an increase in surface hydration, a decrease in transepidermal water movement under occlusion, a decrease in surface water desorption rate, and a decrease in surface pH. Diapered and nondiapered regions were indistinguishable at birth but exhibited differential behavior over the first 14 days, with the diapered region showing a higher pH and increased hydration. Maternal measurements remained constant throughout the period. We conclude that healthy newborn skin undergoes progressive changes in epidermal barrier properties over the first 28 days. Adult skin testing does not replicate newborn skin during the first month of life. [source]

Effect of pulse repetition rate on the perception of thermal sensation with pulsed shortwave diathermy

Potential impact of a new blood glucose monitoring device: the GlucoWatch® Biographer

PRACTICAL DIABETES INTERNATIONAL (INCORPORATING CARDIABETES), Issue 4 2002
NN Chan
Abstract Home blood glucose monitoring may be laborious, time-consuming, inconvenient and painful. Failure to test may preclude optimisation of glycaemic control. We aimed to evaluate the potential usefulness of a new noninvasive automatic glucose monitor, the GlucoWatch® Biographer. Eight patients with type 1 diabetes and two with type 2 diabetes (4M:6F) aged between 23 and 65 years participated in this study. All participants were given 1 hour of instruction prior to provision of the GlucoWatch®. They were given contact numbers and reviewed weekly. Several disadvantages were encountered by the participants, which included the daily 3 hour calibration period (n = 10), skin irritations (n = 6) and skipped measurements (n = 2) due to unsatisfactory probe contact due to skin temperature or sweats. Several patients, however, found it invaluable to have their daily profile monitored to allow insulin dosage adjustment and detection of hypoglycaemia. The GlucoWatch® Biographer is an invaluable tool that allows noninvasive detection of glucose trends, which contributes to glycaemic control. However, it is not suitable for every patient. Self-motivation and ability to learn how to use the device are the key factors. Copyright © 2002 John Wiley & Sons, Ltd. [source]

2-D DIGE and MS/MS analysis of protein serum expression in rats housed in concrete and clay cages in winter

PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 17 2008
Jong-Choon Kim
Abstract In a previous study, we examined the physiological responses of male Sprague,Dawley rats over a 4-week exposure to concrete and clay cages. No general toxicological changes were observed in rats exposed to either of the two cage types in summer. Under winter conditions, however, various general toxicological effects were detected in rats housed in concrete cages, although rats housed in clay cages showed no such effects. The infrared thermographic examination indicated that skin temperature in the concrete-housed rats was abnormally low, but not so in the clay-housed rats. We examined proteomic changes in the serum of rats housed in winter in concrete and clay cages using two-dimensional differential in-gel electrophoresis and mass spectrometry/mass spectrometry. Five proteins were identified and quantitatively validated; all were cold stress-induced, acute phase proteins that were either up-regulated (haptoglobin) or down-regulated (alpha-1-inhibitor III, alpha-2u globulin, complement component 3, and vitamin D-binding protein) in the concrete-housed rats. These results suggest that the 4-week exposure to a concrete cage in winter elicited a typical systemic inflammatory reaction (i.e. acute phase response) in the exposed rats. [source]

Biological rhythm development in preterm infants: Does health status influence body temperature circadian rhythm?

RESEARCH IN NURSING & HEALTH, Issue 3 2001
Karen A. ThomasArticle first published online: 18 JUL 200
Abstract Twenty-six preterm infants, postconceptional age from 28 to 35 weeks and postnatal age approximately 14 days, were included in a study of the development of temperature circadian rhythm. Insulated abdominal skin temperature and incubator air temperature were recorded continuously at 1-min intervals for 24 hr. Using cosinor analysis, cycle mesor, amplitude, and acrophase were determined. Initial results from regression analysis did not confirm a predicted linear relationship between postconceptional age and amplitude; however, dividing the sample according to health status into sick (N,=,15) and not sick (N,=,11) groups revealed differing regression models. For not sick infants, amplitude increased with postconceptional age (R2,=,.405), whereas no relationship was found between postconceptional age and cycle amplitude in sick infants (R2,=,.069). These results indicate that healthy preterm infants demonstrate emergence of circadian temperature rhythm. Implications include potential time-based periods of vulnerability, overheating and hyperthermia, and management of incubator operation. © 2001 John Wiley & Sons, Inc. Res Nurs Health 24: 170,180, 2001 [source]

Passive microwave radiometer channel selection basedoncloudandprecipitation information content

THE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 617 2006
Sabatino Di Michele
Abstract The information content of microwave frequencies between 5 and 200 GHz for rain, snow and cloud water retrievals over ocean and land surfaces was evaluated using optimal estimation theory. The study was based on large datasets representative of summer and winter meteorological conditions over North America, Europe, Central Africa, South America and the Atlantic obtained from short-range forecasts with the operational ECMWF model. The information content of rain, snow and cloud water was traded off against the uncertainties due to the natural variability of other variables that microwave observations are sensitive to. These are surface emissivity, land surface skin temperature, atmospheric temperature and moisture. The estimation of the underlying error statistics was based on ECMWF model forecast error statistics. The results suggest that a number of frequency bands are most suited for the retrieval of (i) rain over oceans: 15,18, 35,40, 80, 145, 118.75±10,14 GHz; rain over land: 85,100, 135,140 GHz, (ii) snow over land and oceans: 95,100, 140,150, 187 GHz, (iii) clouds over oceans: 40, 80,85 GHz; clouds over land: 90,100, 135,140 GHz. For radiometers designed for global and multi-season applications, several channels in all of the above frequency ranges would be desirable for optimizing channel usage in hydrometeor retrievals depending on the observed situation. Copyright © 2006 Royal Meteorological Society. [source]

Chlorpyrifos-Induced Hypothermia and Vasodilation in the Tail of the Rat: Blockade by Scopolamine,

BASIC AND CLINICAL PHARMACOLOGY & TOXICOLOGY, Issue 1 2000
Christopher J. Gordon
Organophosphate pesticides such as chlorpyrifos reduce core temperature (Tc) in laboratory rodents. The mechanism(s) responsible for the chlorpyrifos-induced hypothermia are not well known. This study assessed the role of a key effector for thermoregulation in the rat, vasomotor control of heat loss from the tail, and its possible cholinergic control during chlorpyrifos-induced hypothermia. Tc and motor activity were monitored by telemetry in female Long-Evans rats maintained at an ambient temperature (Ta) of 25°. Tail skin temperature (Tsk(t)) was measured hourly. Rats were dosed with chlorpyrifos (0 or 25 mg/kg orally). Two hr later the rats were dosed with saline or scopolamine (1.0 mg/kg intraperitoneally). Two hr after chlorpyrifos treatment there was a marked elevation in Tsk(t) concomitant with a 0.5° reduction in Tc. Scopolamine administered to control rats led to a marked elevation in Tc with little change in Tsk(t). Rats treated with chlorpyrifos and administered scopolamine underwent a marked vasoconstriction and elevation in Tc. Vasodilation of the tail is an important thermoeffector to reduce Tc during the acute stages of chlorpyrifos exposure. The blockade of the response by scopolamine suggests that the hypothermic and vasodilatory response to chlorpyrifos is mediated via a cholinergic muscarinic pathway in the CNS. [source]

Influence of blood flow and millimeter wave exposure on skin temperature in different thermal models

BIOELECTROMAGNETICS, Issue 1 2009
S.I. Alekseev
Abstract Recently we showed that the Pennes bioheat transfer equation was not adequate to quantify mm wave heating of the skin at high blood flow rates. To do so, it is necessary to incorporate an "effective" thermal conductivity to obtain a hybrid bioheat equation (HBHE). The main aim of this study was to determine the relationship between non-specific tissue blood flow in a homogeneous unilayer model and dermal blood flow in multilayer models providing that the skin surface temperatures before and following mm wave exposure were the same. This knowledge could be used to develop multilayer models based on the fitting parameters obtained with the homogeneous tissue models. We tested four tissue models consisting of 1,4 layers and applied the one-dimensional steady-state HBHE. To understand the role of the epidermis in skin models we added to the one- and three-layer models an external thin epidermal layer with no blood flow. Only the combination of models containing the epidermal layer was appropriate for determination of the relationship between non-specific tissue and dermal blood flows giving the same skin surface temperatures. In this case we obtained a linear relationship between non-specific tissue and dermal blood flows. The presence of the fat layer resulted in the appearance of a significant temperature gradient between the dermis and muscle layer which increased with the fat layer thickness. Bioelectromagnetics 30:52,58, 2009. © 2008 Wiley-Liss, Inc. [source]

Partial-body exposure of human volunteers to 2450,MHz pulsed or CW fields provokes similar thermoregulatory responses,

BIOELECTROMAGNETICS, Issue 4 2001
Eleanor R. Adair
Abstract Many reports describe data showing that continuous wave (CW) and pulsed (PW) radiofrequency (RF) fields, at the same frequency and average power density (PD), yield similar response changes in the exposed organism. During whole-body exposure of squirrel monkeys at 2450 MHz CW and PW fields, heat production and heat loss responses were nearly identical. To explore this question in humans, we exposed two different groups of volunteers to 2450,MHz CW (two females, five males) and PW (65,,s pulse width, 104,pps; three females, three males) RF fields. We measured thermophysiological responses of heat production and heat loss (esophageal and six skin temperatures, metabolic heat production, local skin blood flow, and local sweat rate) under a standardized protocol (30,min baseline, 45,min RF or sham exposure, 10,min baseline), conducted in three ambient temperatures (Ta,=,24, 28, and 31°C). At each Ta, average PDs studied were 0, 27, and 35,mW/cm2 (Specific absorption rate (SAR),=,0, 5.94, and 7.7,W/kg). Mean data for each group showed minimal changes in core temperature and metabolic heat production for all test conditions and no reliable differences between CW and PW exposure. Local skin temperatures showed similar trends for CW and PW exposure that were PD-dependent; only the skin temperature of the upper back (facing the antenna) showed a reliably greater increase (P,=,.005) during PW exposure than during CW exposure. Local sweat rate and skin blood flow were both Ta - and PD-dependent and showed greater variability than other measures between CW and PW exposures; this variability was attributable primarily to the characteristics of the two subject groups. With one noted exception, no clear evidence for a differential response to CW and PW fields was found. Bioelectromagnetics 22:246,259, 2001. © 2001 Wiley-Liss, Inc. [source]

Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles

BIOPHARMACEUTICS AND DRUG DISPOSITION, Issue 2 2009
Ryan F. Donnelly
Abstract A novel 5-aminolevulinic acid (ALA)-containing microparticulate system was produced recently, based on incorporation of ALA into particles prepared from a suppository base that maintains drug stability during storage and melts at skin temperature to release its drug payload. The novel particulate system was applied to the skin of living animals, followed by study of protoporphyrin IX (PpIX) production. The effect of formulating the microparticles in different vehicles was investigated and also the phototoxicity of the PpIX produced using a model tumour. Particles formulated in propylene glycol gels (10% w/w ALA loading) generated the highest peak PpIX fluorescence levels in normal mouse skin. Peak PpIX levels induced in skin overlying subcutaneously implanted WiDr tumours were significantly lower than in normal skin for both the 10% w/w ALA microparticles alone and the 10% w/w ALA microparticles in propylene glycol gels during continuous 12,h applications. Tumours not treated with photodynamic therapy continued to grow over the 17 days of the anti-tumour study. However, those treated with 12,h applications of either the 10% w/w ALA microparticles alone or the 10% w/w ALA microparticles in propylene glycol gel followed by a single laser irradiation showed no growth. The gel formulation performed slightly better once again, reducing the tumour growth rate by approximately 105%, compared with the 89% reduction achieved using particles alone. Following the promising results obtained in this study, work is now going on to prepare particle-loaded gels under GMP conditions with the aim of initiating an exploratory clinical trial. Copyright © 2009 John Wiley & Sons, Ltd. [source]

Maternal Analgesia During Labor Disturbs Newborn Behavior: Effects on Breastfeeding, Temperature, and Crying

BIRTH, Issue 1 2001
Anna-Berit Ransjö-Arvidson RNMTD
Background:Newborns not exposed to analgesia, when placed on the mother's chest, exhibit an inborn prefeeding behavior. This study was performed to assess the effects of different types of analgesia during labor on the development of spontaneous breastfeeding movements, crying behavior, and skin temperature during the first hours of life in healthy term newborns.Methods:Video recordings were made of 28 newborns who had been dried and placed in skin-to-skin contact between their mother's breasts immediately after delivery. The video recordings were analyzed blindly with respect to infant exposure to analgesia. Defined infant behaviors were assessed every 30 seconds. Group 1 mothers (n = 10) had received no analgesia during labor, group 2 mothers (n= 6) had received mepivacaine via pudendal block, and group 3 mothers (n= 12) had received pethidine or bupivacaine or more than one type of analgesia during labor.Results:All infants made finger and hand movements, but the infant's massagelike hand movements were less frequent in infants whose mothers had received labor analgesia. A significantly lower proportion of group 3 infants made hand-to-mouth movements (p < 0.001), and a significantly lower proportion of the infants in groups 2 and 3 touched the nipple with their hands before suckling (p < 0.01), made licking movements (p < 0.01), and sucked the breast (p < 0.01). Nearly one-half of the infants, all in groups 2 or 3, did not breastfeed within the first 2.5 hour of life. The infants whose mothers had received analgesia during labor had higher temperatures (p= 0.03) and they cried more (p= 0.05) than infants whose mothers had not received any analgesia.Conclusions:The present data indicate that several types of analgesia given to the mother during labor may interfere with the newborn's spontaneous breast-seeking and breastfeeding behaviors and increase the newborn's temperature and crying. [source]

Sequential application of cold and sodium lauryl sulphate decreases irritation and barrier disruption in vivo in humans

BRITISH JOURNAL OF DERMATOLOGY, Issue 4 2005
J.W. Fluhr
Summary Background, Irritant contact dermatitis (ICD) is one of the most frequent types of occupational dermatitis. Different factors are involved in the development of contact dermatitis. In the food-processing industry, the combined exposure to different irritants may be involved in the development of ICD. Few data have been published regarding the irritant potential of sodium lauryl sulphate (SLS) in combination with cold. Objectives, The present study was intended to analyse whether cold exposure and low skin temperature influence the development of ICD. Methods, Twenty (part I) and 12 (part II) healthy volunteers were exposed twice daily for 4 days to SLS alone, different low temperatures alone (4 °C six times for 90 s with an interval of 20 s or 15 °C for 10 min) or a combination of cold and SLS (19·6 µL SLS 1% cm,2, part I; or 52·6 µL SLS 0·5% cm,2, part II) using the tandem repetitive irritation test. Irritant cutaneous reactions were measured by noninvasive biophysical methods with transepidermal water loss as a parameter for permeability barrier function and skin colour reflectance together with visual scoring as parameters for inflammatory reactions. Results, Cold alone caused no significant skin reaction compared with untreated control. Exposure to SLS alone and SLS together with cold (independent of the applied temperature of 4 or 15 °C) twice daily induced a clear irritant reaction and barrier disturbance. Reactions did not differ whether SLS was applied before or after cold. Furthermore, ,tandem application' of cold and SLS diminished the barrier disruption and irritant reaction compared with SLS alone. Conclusions, We conclude that the application of cold may have a protective effect on the development of ICD, at least in our short-term model. [source]

High insulin levels are positively associated with peripheral nervous system function

ACTA NEUROLOGICA SCANDINAVICA, Issue 2 2009
H. Isojärvi
Objective,,, The aim of this study was to analyze peripheral nervous system (PNS) function in overweight and obese individuals. Materials and Methods,,, Forty-four adult non-diabetic overweight individuals were recruited. Peroneal motor nerve conduction and radial, sural, and medial plantar sensory nerve conduction were studied. Insulin and glucose levels were determined twice (over a 2- to 3-year period) with an oral glucose tolerance test (OGTT). Multiple stepwise linear regression models adjusted for age, height, weight, and skin temperature were used to analyze the data. Results,,, Analysis revealed that baseline insulin levels measured 120 min after an OGTT explained 18% of the variation in peroneal F -wave minimum latency, 8% of peroneal F -wave maximum latency variation, 15% of sural sensory latency variation, 13% of sural sensory nerve conduction velocity (NCV) variation, and 10% of the variation in medial plantar sensory NCV. Discussion and Conclusion,,, Our study shows that serum insulin levels measured 120 min after an OGGT are positively associated with PNS function. High insulin levels without notably high glucose levels appear to be beneficial for the function of the PNS. [source]