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Sizeable Number (sizeable + number)
Selected AbstractsBody Dysmorphic Disorder and the Liposuction PatientDERMATOLOGIC SURGERY, Issue 5 2005Dee Anna Glaser MD background. Body dysmorphic disorder (BDD) is an under-recognized disorder that affects a sizeable number of patients who seek cosmetic enhancement, in particular liposuction. Understanding and recognizing BDD can positively impact the care delivered to patients. objective. To familiarize physicians with the presenting signs of BDD and present strategies for caring for BDD patients in a liposuction and/or cosmetic surgery practice. methods. Review of currently available literature and diagnostic criteria. results. BDD affects approximately 1% of patients in the United States, but as many as 7 to 15% of patients seeking cosmetic surgery. Patients with BDD will usually demonstrate an obsession with the area they seek treatment of. In addition, patients with BDD present a unique challenge to the liposuction surgeon. conclusions. Physicians who care for patients seeking liposuction or other cosmetic procedures should learn to recognize those who have BDD. Proper recognition and counseling of BDD patients can have a significant positive impact on not only their care but also on the patient-physician relationship. Failure to recognize BDD can, and often does, lead to patient dissatisfaction, as well as difficult future interactions with the BDD patient. [source] The heterogeneity of causes and courses of attention-deficit/hyperactivity disorderACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2009H-C. Steinhausen Objective:, Attention-deficit / Hyperactivity Disorder (ADHD) is a frequent mental disorder with onset in childhood and persistence into adulthood in a sizeable number of people. Despite a rather simple clinical definition, ADHD has many facets because of frequent co-morbid disorders and varying impact on psychosocial functioning. Thus, there is considerable heterogeneity in various domains. Method:, A review of recent research findings in: i) selected domains of aetiology reflecting the role of genes, brain structures and functioning and the interplay of causal factors and ii) clinical heterogeneity in terms of co-morbidities, gender effects, courses and outcomes. Results:, Molecular genetic studies have identified a number of candidate genes which have a small effect on behavioural variation in ADHD. In the most recent Genome Scan Meta Analysis of seven ADHD linkage studies, genome-wide significant linkage was identified on chromosome 16. The volume of both the total brain and various regions including the prefrontal cortex, the caudate nucleus and the vermis of the cerebellum is smaller in ADHD. Functional MRI has documented a specific deficit of frontostriatal networks in ADHD. Integrative aetiological models have to take the interaction of gene and environment on various dysfunctions into account. Clinical heterogeneity results from frequent associations with various co-morbidities, the impact of the disorder on psychosocial functioning, and gender effects. Partly, these effects are evident also in the course and outcome of ADHD. Conclusion:, ADHD is a chronic mental disorder with a complex aetiology. So far, various neurobiological factors have been identified that need to be studied further to better understand their interaction with environmental factors. The clinical presentation and the long-term course of ADHD are manifold. [source] Effect of the challenger experience on elementary children's attitudes to scienceJOURNAL OF RESEARCH IN SCIENCE TEACHING, Issue 10 2002Tina Jarvis This research explored how the Challenger experience influenced over 655 elementary boys' and girls' general attitudes to science and space during the 5 months after their visit by examining their responses to four different attitude scales. These were administered to the 10- to 11-year-olds immediately before and after the Challenger experience as well as 2 and 5 months later. Knowledge tests were also administered before and after the visit. A sample of children completed an existing measure of anxiety. Although there were mainly positive outcomes immediately after the Challenger experience, there were some negative effects. There were also noticeable differences between boys and girls. Some 24% of pupils were inspired to become scientists. There was also less fear of space travel with a greater appreciation of the use of science to protect the planet after the visit. Most girls improved and maintained their attitudes toward science in society. A sizeable number of pupils were relatively unaffected by the experience and there was a significant negative effect on a small group of anxious girls. There are indications that previsit preparation and careful choice of roles during the simulation are important. © 2002 Wiley Periodicals, Inc. J Res Sci Teach 39: 979,1000, 2002 [source] Peer assessment of competenceMEDICAL EDUCATION, Issue 6 2003John J Norcini Objective, This instalment in the series on professional assessment summarises how peers are used in the evaluation process and whether their judgements are reliable and valid. Method, The nature of the judgements peers can make, the aspects of competence they can assess and the factors limiting the quality of the results are described with reference to the literature. The steps in implementation are also provided. Results, Peers are asked to make judgements about structured tasks or to provide their global impressions of colleagues. Judgements are gathered on whether certain actions were performed, the quality of those actions and/or their suitability for a particular purpose. Peers are used to assess virtually all aspects of professional competence, including technical and non-technical aspects of proficiency. Factors influencing the quality of those assessments are reliability, relationships, stakes and equivalence. Conclusion, Given the broad range of ways peer evaluators can be used and the sizeable number of competencies they can be asked to judge, generalisations are difficult to derive and this form of assessment can be good or bad depending on how it is carried out. [source] The International Legal Framework for the Safeguarding and Promotion of LanguagesMUSEUM INTERNATIONAL, Issue 3 2008Janet Blake There are a sizeable number of international law provisions that answer the needs of speaker communities for the safeguarding and promotion of their languages, most of them rights-based. Some of UNESCO's cultural heritage instruments are also of relevance. This article analyses the existing law, its effectiveness and underlying principles and considers whether there is a need for further legal development in this area, as well as the usefulness of non-normative approaches. [source] G protein ,3 subunit 825T genotype is not associated with differing outcome in pediatric renal transplant recipientsPEDIATRIC TRANSPLANTATION, Issue 2 2002Berthold Hocher Recent studies have identified a novel polymorphism (C825T) of the gene encoding the ,3 subunit of heterotrimeric G proteins (GNB3), associated with enhanced activation of G proteins, which appears to be more common in hypertensive patients. The donor GNB3 825TT genotype was associated with reduced kidney allograft survival in adults. We examined (in 100 Caucasian pediatric renal transplant recipients) whether the GNB3 (C825T) polymorphism was associated with disease progression and outcome after renal transplantation. The slope of 1/creatinine was determined by linear regression analysis of a median of 12 points before and after renal transplantation, and the population was divided into two groups of equal size, before and after transplantation, according to the slope. The observed frequencies were 57 for the CC, 33 for the CT, and 10 for the TT haplotype. For comparison, 738 consecutive newborn babies with the same ethnic background were typed in the same hospital. Allele frequencies were statistically not significantly different (chi-square test, p =,0.1327). When dividing the pediatric renal transplant recipients into two groups with regard to the slope of 1/creatinine, both before and after renal transplantation, the observed proportions were CC 26, CT 17, and TT 7 in the group with the poorer slope and CC 31, CT 16, and TT 3 in the group with the better slope before renal transplantation (not significant [NS], chi-square test, p =,0.1777). The observed proportions after renal transplantation were CC 26, CT 16, and TT 8 in the group with the poorer slope and CC 31, CT 15, and TT 4 in the group with the better slope, respectively (NS, chi-square test, p =,0.167). Allograft survival was not associated with the T allele. In conclusion, in a sizeable number of pediatric renal transplant recipients the GNB3 C825T polymorphism was found not to be a genetic risk factor for end-stage kidney disease. In addition, kidney graft function and survival was also found not to be associated with a recipient GNB3 C825T polymorphism. [source] | ||||||||||