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Simplicity
Kinds of Simplicity Selected AbstractsSimplicity and Analysis in Early WittgensteinEUROPEAN JOURNAL OF PHILOSOPHY, Issue 1 2003Peter M. Sullivan First page of article [source] Simplicity versus Fairness in Means Testing: The Case of Civil Legal AidFISCAL STUDIES, Issue 4 2003Alexy Buck Abstract For most state financial benefits, the making of any payment, or its level, depends upon a means test to assess the applicant's income or wealth. Attempts to make such tests fair often lead to procedures that are complicated to administer and confusing for the applicant. This paper describes the analysis underlying a review of means testing for civil legal aid in England and Wales, to achieve considerable simplification without sacrificing fairness. [source] Performance characterization of a non-linear system as both an adaptive notch filter and a phase-locked loopINTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, Issue 1 2004M. Karimi-Ghartemani Abstract The behaviour of a non-linear dynamical system is described. The system may be characterized as an adaptive notch filter, or alternatively, as a phase-locked loop. Either way, the system has the inherent capability of directly providing estimates of the parameters of the extracted sinusoidal component of its input signal, namely its amplitude, phase and frequency. The structure and mathematical properties of the system are presented for two cases of fixed-frequency and varying-frequency operation. The effects of parameter setting of the system on its performance are studied in detail using computer simulations. Transient and steady-state behaviour of the system are studied in the presence of noise. Simplicity of structure, high noise immunity and robustness and the capability of direct estimation of amplitude, phase and frequency are the salient features of the system when envisaged as an adaptive notch filter or a phase-locked loop. Copyright © 2004 John Wiley & Sons, Ltd. [source] Beyond Simplicity and Convention in IRINTERNATIONAL STUDIES REVIEW, Issue 3 2006JAMES N. ROSENAU No abstract is available for this article. [source] A Laboratory Procedure for Optimal Implant Abutment PreparationJOURNAL OF PROSTHODONTICS, Issue 6 2009Tuncer Burak Özcelik DDS Abstract Simplicity and predictability have made cement-retained implant crowns the recent restoration of choice. The taper of the abutment is of particular importance for cement-retained implant restorations. The ideal taper of the implant abutment allows the clinician to control the overall retention of restorations. The technique described in this report presents the laboratory preparation of an implant abutment for a cement-retained crown using a counter gauge to control the preparation taper. [source] Hume's Reflections on the Identity and Simplicity of Mind,PHILOSOPHY AND PHENOMENOLOGICAL RESEARCH, Issue 3 2001DONALD C. AINSLIE The article presents a new interpretation of Hume's treatment of personal identity, and his later rejection of it in the "Appendix" to the Treatise. Hume's project, on this interpretation, is to explain beliefs about persons that arise primarily within philosophical projects, not in everyday life. the belief in the identity and simplicity of the mind as a bundle of perceptions is an abstruse belief, not one held by the "vulgar" who rarely turn their minds on themselves so as to think of their perceptions. the author suggests that it is this philosophical observation of the mind that creates the problems that Hume finally acknowledges in the "Appendix." He is unable to explain why we believe that the perceptions by means of which we observe our minds while philosophizing are themselves part of our minds. This suggestion is then tested against seven criteria that any interpretation of the "Appendix" must meet. [source] Aquinas on Simplicity: an Investigation into the Foundations of his Philosophical Theology.THE HEYTHROP JOURNAL, Issue 4 2009By Peter Weigel No abstract is available for this article. [source] The Sophistication of Simplicity . . . Optimizing Emergency DosingACADEMIC EMERGENCY MEDICINE, Issue 5 2008Robert Luten MD First page of article [source] A new approach to aid the characterisation and identification of metabolites of a model drug; partial isotope enrichment combined with novel formula elucidation softwareRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 2 2009Kirsten Hobby This work describes the identification of ,isotopically enriched' metabolites of 4-cyanoaniline using the unique features of the software package ,Spectral Simplicity'. The software is capable of creating the theoretical mass spectra for partially isotope-enriched compounds, and subsequently performing an elemental composition analysis to give the elemental formula for the ,isotopically enriched' metabolite. A novel mass spectral correlation method, called ,FuzzyFit', was employed. ,FuzzyFit' utilises the expected experimental distribution of errors in both mass accuracy and isotope pattern and enables discrimination between statistically probable and improbable candidate formulae. The software correctly determined the molecular formulae of ten previously described metabolites of 4-cyanoaniline confirming the technique of partial isotope enrichment can produce results analogous to standard methodologies. Six previously unknown species were also identified, based on the presence of the unique ,designer' isotope ratio. Three of the unknowns were tentatively identified as N-acetylglutamine, O-methyl-N acetylglucuronide and a putative fatty acid conjugate. The discovery of a significant number of unknown species of a model drug with a comprehensive history of investigation highlights the potential for enhancement to the analytical process by the use of ,designer' isotope ratio compounds. The ,FuzzyFit' methodology significantly aided the elucidation of candidate formulae, by provision of a vastly simplified candidate formula data set. Copyright © 2008 John Wiley & Sons, Ltd. [source] Algebraic modifications to second quantization for non-Hermitian complex scaled hamiltonians with application to a quadratically convergent multiconfigurational self-consistent field methodINTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 6 2005Danny L. Yeager Abstract The algebraic structure for creation and annihilation operators defined on orthogonal orbitals is generalized to permit easy development of bound-state techniques involving the use of non-Hermitian Hamiltonians arising from the use of complex-scaling or complex-absorbing potentials in the treatment of electron scattering resonances. These extensions are made possible by an orthogonal transformation of complex biorthogonal orbitals and states as opposed to the customary unitary transformation of real orthogonal orbitals and states and preserve all other formal and numerical simplicities of existing bound-state methods. The ease of application is demonstrated by deriving the modified equations for implementation of a quadratically convergent multiconfigurational self-consistent field (MCSCF) method for complex-scaled Hamiltonians but the generalizations are equally applicable for the extension of other techniques such as single and multireference coupled cluster (CC) and many-body perturbation theory (MBPT) methods for their use in the treatment of resonances. This extends the domain of applicability of MCSCF, CC, MBPT, and methods based on MCSCF states to an accurate treatment of resonances while still using L2 real basis sets. Modification of all other bound-state methods and codes should be similarly straightforward. © 2005 Wiley Periodicals, Inc. Int J Quantum Chem, 2005 [source] Generate and Repair Machine TranslationCOMPUTATIONAL INTELLIGENCE, Issue 3 2002Kanlaya Naruedomkul We propose Generate and Repair Machine Translation (GRMT), a constraint,based approach to machine translation that focuses on accurate translation output. GRMT performs the translation by generating a Translation Candidate (TC), verifying the syntax and semantics of the TC and repairing the TC when required. GRMT comprises three modules: Analysis Lite Machine Translation (ALMT), Translation Candidate Evaluation (TCE) and Repair and Iterate (RI). The key features of GRMT are simplicity, modularity, extendibility, and multilinguality. An English,Thai translation system has been implemented to illustrate the performance of GRMT. The system has been developed and run under SWI,Prolog 3.2.8. The English and Thai grammars have been developed based on Head,Driven Phrase Structure Grammar (HPSG) and implemented on the Attribute Logic Engine (ALE). GRMT was tested to generate the translations for a number of sentences/phrases. Examples are provided throughout the article to illustrate how GRMT performs the translation process. [source] Range Scan Registration Using Reduced Deformable ModelsCOMPUTER GRAPHICS FORUM, Issue 2 2009W. Chang Abstract We present an unsupervised method for registering range scans of deforming, articulated shapes. The key idea is to model the motion of the underlying object using a reduced deformable model. We use a linear skinning model for its simplicity and represent the weight functions on a regular grid localized to the surface geometry. This decouples the deformation model from the surface representation and allows us to deal with the severe occlusion and missing data that is inherent in range scan data. We formulate the registration problem using an objective function that enforces close alignment of the 3D data and includes an intuitive notion of joints. This leads to an optimization problem that we solve using an efficient EM-type algorithm. With our algorithm we obtain smooth deformations that accurately register pairs of range scans with significant motion and occlusion. The main advantages of our approach are that it does not require user specified markers, a template, nor manual segmentation of the surface geometry into rigid parts. [source] LazyBrush: Flexible Painting Tool for Hand-drawn CartoonsCOMPUTER GRAPHICS FORUM, Issue 2 2009Daniel Sýkora Abstract In this paper we present LazyBrush, a novel interactive tool for painting hand-made cartoon drawings and animations. Its key advantage is simplicity and flexibility. As opposed to previous custom tailored approaches [SBv05, QWH06] LazyBrush does not rely on style specific features such as homogenous regions or pattern continuity yet still offers comparable or even less manual effort for a broad class of drawing styles. In addition to this, it is not sensitive to imprecise placement of color strokes which makes painting less tedious and brings significant time savings in the context cartoon animation. LazyBrush originally stems from requirements analysis carried out with professional ink-and-paint illustrators who established a list of useful features for an ideal painting tool. We incorporate this list into an optimization framework leading to a variant of Potts energy with several interesting theoretical properties. We show how to minimize it efficiently and demonstrate its usefulness in various practical scenarios including the ink-and-paint production pipeline. [source] Drawing for Illustration and Annotation in 3DCOMPUTER GRAPHICS FORUM, Issue 3 2001David Bourguignon We present a system for sketching in 3D, which strives to preserve the degree of expression, imagination, and simplicity of use achieved by 2D drawing. Our system directly uses user-drawn strokes to infer the sketches representing the same scene from different viewpoints, rather than attempting to reconstruct a 3D model. This is achieved by interpreting strokes as indications of a local surface silhouette or contour. Strokes thus deform and disappear progressively as we move away from the original viewpoint. They may be occluded by objects indicated by other strokes, or, in contrast, be drawn above such objects. The user draws on a plane which can be positioned explicitly or relative to other objects or strokes in the sketch. Our system is interactive, since we use fast algorithms and graphics hardware for rendering. We present applications to education, design, architecture and fashion, where 3D sketches can be used alone or as an annotation of an existing 3D model. [source] A Linear Model for the Continuous Network Design ProblemCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 5 2006S. Travis Waller A linear programming formulation is introduced based on a dynamic traffic assignment (DTA) model that propagates traffic according to the cell transmission model. The introduced approach is limited to continuous link improvements and does not provide for new link additions. The main contribution of the article is to provide an analytical formulation for network design that accounts for DTA conditions that can be used for further analysis and extensions. The model is tested on a single destination example network, resembling a freeway corridor, for various congestion levels, loading patterns and budget sizes, to demonstrate the simplicity and effectiveness of the approach. [source] In search of simplicity: a self-organizing group communication overlayCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 7 2010Matei Ripeanu Abstract Group communication primitives have broad utility as building blocks for distributed applications. The challenge is to create and maintain the distributed structures that support these primitives while accounting for volatile end-nodes and variable network characteristics. Most solutions proposed to date rely on complex algorithms or on global information, thus limiting the scale of deployments and acceptance outside the academic realm. This article introduces a low-complexity, self-organizing solution for building and maintaining data dissemination trees, which we refer to as Unstructured Multi-source Overlay (UMO). UMO uses traditional distributed systems techniques: layering, soft-state, and passive data collection to adapt to the dynamics of the physical network and maintain data dissemination trees. The result is a simple, adaptive system with lower overheads than more complex alternatives. We implemented UMO and evaluated it on a 100-node PlanetLab testbed and on up to 1024-node emulated ModelNet networks. Extensive experimental evaluations demonstrate UMOs low overhead, efficient network usage compared with alternative solutions, and the ability to quickly adapt to network changes and to recover from failures. Copyright © 2009 John Wiley & Sons, Ltd. [source] Visual event-related potentials in children with phenylketonuriaACTA PAEDIATRICA, Issue 1 2000RM Henderson Visual event-related potentials (ERPs) were examined in 16 children (aged 5,14 y) with phenylketonuria (PKU) and 16 age- and sex-matched controls. Lifetime median measures of phenylalanine (Phe) were 230-460 ,mol/l. The most recent Phe levels were 56,624 ,mol/l. ERPs were recorded whilst the children performed a discrimination task. All stimuli were square wave gratings degree, which appeared for 33 ms. A response to an infrequent grating that differed in orientation or spatial frequency was required. The older children with PKU had a delay in the first peak (P1) of the ERP, and age-related changes in the amplitude of P1. There was attenuation of the second peak across age groups in PKU. There was no evidence of reduced response accuracy or longer reaction times in children with PKU. Latencies of the cognitive P3 were not delayed in PKU. The delayed early peaks are consistent with previous studies that have shown delayed visual evoked potentials in PKU. The lack of differences in reaction time and P3 may be due to relatively good Phe control in children with PKU, or to the simplicity of the task. Suggestions are made for future ERP studies of PKU. [source] Generation of Thin Surface Plasma Layers for Atmospheric-Pressure Surface TreatmentsCONTRIBUTIONS TO PLASMA PHYSICS, Issue 5-6 2004ernák Abstract Thin layers of atmospheric-pressure non-equilibrium plasma can be generated by pulse surface corona discharges and surface barrier discharges developing on the treated surfaces or brought into a close contact with the treated surfaces. Plasma sources based on these discharge types have the potential of meeting the basic on-line production requirements in the industry and can be useful for a wide range of surface treatments and deposition processes including continuous treatment of textiles. Comparing with atmospheric pressure glow discharge sources, the potential advantages of these plasma sources include their simplicity, robustness, and capability to process in a wide range of working gases. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Cells meeting our immunophenotypic criteria of endothelial cells are large plateletsCYTOMETRY, Issue 2 2007Michiel H. Strijbos Abstract Background Circulating endothelial cells (CEC) are shed from damaged vasculature, making them a rational choice to serve as surrogate marker for vascular damage. Currently, various techniques and CEC definitions are in use, and their standardization and validation is needed. A flow cytometric single platform assay defining CEC as forward light scatter (FSC)low-to-intermedate, sideward light scatter (SSC)low, CD45,, CD31++ and CD146+ is a promising approach to enumerate CEC because of its simplicity (Mancuso et al., Blood 2001;97:3658,3661). Here, we set out to confirm the endothelial nature of these cells. Methods We isolated cells with a FSClow-to-intermediate, SSClow, CD31++, CD45dim immunophenotype (termed "cells meeting our immunophenotypic criteria for endothelial cells" [CMOIC]) from healthy donors to study the expression of endothelium-associated markers using several techniques. Special attention was paid to reagents identifying the endothelial cell-specific marker CD146. We compared antigen expression patterns of CMOIC with those of the HUVEC endothelial cell line and lymphocytes. Electron microscopy was used to detect the presence of endothelial cell-specific Weibel,Palade bodies in the sorted cells. Results CD146 expression was negative on CMOIC for all tested CD146 mAbs, but positive on HUVEC cells and a minor subset of T lymphocytes. Using flow cytometry, we found no expression of any endothelium-associated marker except for CD31 and CD34. HUVEC cells were positive for all endothelial markers except for CD34. Evaluation of CMOIC morphology showed a homogenous population of cells with a highly irregular nucleus-like structure and positive endothelial immunohistochemistry. CMOIC contained neither nuclei nor DNA. Electron microscopy revealed the absence of a nucleus, the absence of endothelial specific Weibel,Palade bodies, and revealed CMOIC to be large platelets. Conclusion The vast majority of cells with the immunophenotype FSClow-to-intermediate, SSClow, CD45,, CD31++ do not express CD146 and are large platelets rather than endothelial cells. © 2007 Clinical Cytometry Society. [source] Slit-flow ektacytometry: Laser diffraction in a slit rheometerCYTOMETRY, Issue 1 2005Sehyun Shin Abstract Background Deformability of red blood cells (RBCs) is a determinant of blood flow resistance as RBCs pass through small capillaries of the microcirculation. Available techniques for measuring RBC deformability often require a washing process after each measurement, which is not optimal for day-to-day clinical use. Methods A laser diffraction technique has been combined with slit-flow rheometry, which shows significant advances in ektacytometric design, operation, and data analysis. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element that is in contact with the blood sample. Results With slit ektacytometry, the deformation of RBCs subjected to continuously decreasing shear stress in a slit flow can be quickly measured with extremely small quantities of blood. The measurements with the slit ektacytometer were compared with those of LORCA and a strong correlation was apparent. The deformability of the hardened RBCs was markedly lower than that of the normal RBCs. In addition, the young cells showed higher values of the elongation index than did the old cells. Conclusions The newly developed slit ektacytometer can measure RBC deformability with ease and accuracy. In addition, the slit ektacytometer can be easily used in a clinical setting owing to the incorporation of a disposable element that holds the blood sample. © 2005 Wiley-Liss, Inc. [source] The treatment of CIN: what are the risks?CYTOPATHOLOGY, Issue 3 2009W. Prendiville The treatment of squamous cervical intraepithelial neoplasia is to remove or destroy the transformation zone (TZ). It is likely that no method of treatment is superior to another if it is performed properly and the limited available evidence supports this view. The significant advantages of excision (simplicity, cost, outpatient procedure, histological examination of the entire TZ) mean that treatment thresholds may have lowered over the last decade. Long-term pregnancy-related morbidity associated with excision has been reported recently. The evidence would suggest that this increase equates to a genuine increase in serious adverse outcome for cone biopsy but not large loop excision of the transformation zone (LLETZ). The available data also point to an increase in both incomplete excision and premature labour associated with the excision of large endocervical TZs. The clinical implications arising from this are firstly that women with large type 2 and 3 TZs need appropriate counselling before treatment and that the threshold for treating young women with mild abnormalities needs review. [source] Extracellular interactome of the FGF receptor,ligand system: Complexities and the relative simplicity of the wormDEVELOPMENTAL DYNAMICS, Issue 2 2009Urszula M. Polanska Abstract Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate a multitude of biological functions in embryonic development and in adult. A major question is how does one family of growth factors and their receptors control such a variety of functions? Classically, specificity was thought to be imparted by alternative splicing of the FGFRs, resulting in isoforms that bind specifically to a subset of the FGFs, and by different saccharide sequences in the heparan sulfate proteoglycan (HSPG) co-receptor. A growing number of noncanonical co-receptors such as integrins and neural cell adhesion molecule (NCAM) are now recognized as imparting additional complexity to classic FGFR signaling. This review will discuss the noncanonical FGFR ligands and speculate on the possibility that they provide additional and alternative means to determining the functional specificity of FGFR signaling. We will also discuss how invertebrate models such as C. elegans may advance our understanding of noncanonical FGFR signaling. Developmental Dynamics 238:277,293, 2009. © 2008 Wiley-Liss, Inc. [source] Lineage-independent mosaic expression and regulation of the Ciona multidom gene in the ancestral notochordDEVELOPMENTAL DYNAMICS, Issue 7 2007Izumi Oda-Ishii Abstract The transcription factor Ciona Brachyury (Ci-Bra) plays an essential role in notochord development in the ascidian Ciona intestinalis. We characterized a putative Ci-Bra target gene, which we named Ci - multidom, and analyzed in detail its expression pattern in normal embryos and in embryos where Ci - Bra was misexpressed. Ci - multidom encodes a novel protein, which contains eight CCP domains and a partial VWFA domain. We show that an EGFP-multidom fusion protein localizes preferentially to the endoplasmic reticulum (ER), and is excluded from the nucleus. In situ hybridization experiments demonstrate that Ci - multidom is expressed in the notochord and in the anterior neural boundary (ANB). We found that the expression in the ANB is fully recapitulated by an enhancer element located upstream of Ci - multidom. By means of misexpression experiments, we provide evidence that Ci-Bra controls transcription of Ci - multidom in the notochord; however, while Ci-Bra is homogeneously expressed throughout this structure, Ci - multidom is transcribed at detectable levels only in a random subset of notochord cells. The number of notochord cells expressing Ci - multidom varies among different embryos and is independent of developmental stage, lineage, and position along the anterior,posterior axis. These results suggest that despite its morphological simplicity and invariant cell-lineage, the ancestral notochord is a mosaic of cells in which the gene cascade downstream of Brachyury is differentially modulated. Developmental Dynamics 236:1806,1819, 2007. © 2007 Wiley-Liss, Inc. [source] Supraspinal input is dispensable to generate glycine-mediated locomotive behaviors in the zebrafish embryoDEVELOPMENTAL NEUROBIOLOGY, Issue 5 2006Gerald B. Downes Abstract The anatomy of the developing zebrafish spinal cord is relatively simple but, despite this simplicity, it generates a sequence of three patterns of locomotive behaviors. The first behavior exhibited is spontaneous movement, then touch-evoked coiling, and finally swimming. Previous studies in zebrafish have suggested that spontaneous movements occur independent of supraspinal input and do not require chemical neurotransmission, while touch-evoked coiling and swimming depend on glycinergic neurotransmission as well as supraspinal input. In contrast, studies in other vertebrate preparations have shown that spontaneous movement requires glycine and other neurotransmitters and that later behaviors do not require supraspinal input. Here, we use lesion analysis combined with high-speed kinematic analysis to re-examine the role of glycine and supraspinal input in each of the three behaviors. We find that, similar to other vertebrate preparations, supraspinal input is not essential for spontaneous movement, touch-evoked coiling, or swimming behavior. Moreover, we find that blockade of glycinergic neurotransmission decreases the rate of spontaneous movement and impairs touch-evoked coiling and swimming, suggesting that glycinergic neurotransmission plays critical yet distinct roles for individual patterns of locomotive behaviors. © 2006 Wiley Periodicals, Inc. J Neurobiol, 2006 [source] How should peripheral neuropathy be assessed in people with diabetes in primary care?DIABETIC MEDICINE, Issue 5 2003A population-based comparison of four measures Abstract Aims To test the accuracy of four measures of peripheral diabetic neuropathy in a primary care population. Methods Type 2 diabetic (n = 544) and 544 non-diabetic participants aged 45,76 years were randomly selected from general practice registers. Neuropathy was assessed using vibration threshold (VT) and scores for light touch, thermal sense and modified Michigan Neuropathy Screening Instrument questionnaire. These measures were assessed for variation with diabetes status, age, diabetes duration, HbA1c, and presence of retinopathy and nephropathy. Light touch, thermal sense and questionnaire scores were assessed against VT using ROC curve analysis. Results Only VT and light touch were different between diabetic and non-diabetic groups (P = 0.02 and < 0.0001, respectively). All measures were significantly associated with diabetes duration and retinopathy, and all except questionnaire score (P = 0.14) with age. None was associated with nephropathy and only questionnaire score was associated with HbA1c (P = 0.033). VT varied as expected across scores of light touch (,2 = 41.65, P = 0.0001), thermal sense (,2 = 15.86, P = 0.015) and questionnaire (,2 = 21.22, P = 0.047). Area under the curve values for light touch, thermal and questionnaire scores were 0.72 (95% confidence interval (CI) 0.63, 0.82), 0.63 (95% CI 0.52, 0.73) and 0.64 (95% CI 0.53, 0.74), respectively. Conclusions All measures had associations with risk factors for neuropathy, but light touch score (monofilament) had the strongest association with vibration threshold (the chosen gold standard) and thus appeared the most appropriate tool for use in primary care, because of its validity and simplicity of use. Diabet. Med. 20, 368,374 (2003) [source] Beta diversity of geometrid moths (Lepidoptera: Geometridae) in an Andean montane rainforestDIVERSITY AND DISTRIBUTIONS, Issue 5 2003Gunnar Brehm Abstract. Turnover in species composition of the extremely species-rich family Geometridae (Lepidoptera) was investigated along an elevational gradient ranging from 1040 m to 2677 m above sea level. Moths were sampled using weak light traps (30 W) in three field periods in 1999 and 2000 in an Andean montane rainforest in the province of Zamora-Chinchipe in southern Ecuador. A total of 13 938 specimens representing 1010 species were analysed. Similarities of ensembles of all geometrid moths and of the subfamilies Ennominae and Larentiinae were calculated using the NESS index (with mmax). Ordinations performed using nonmetric multidimensional scaling (NMDS) and correspondence analysis depicted a gradual change of the ensembles along the altitudinal gradient. Extracted ordination scores significantly correlate with altitude (,0.97 , r , ,0.95, P < 0.001) and with ambient air temperature (0.93 , r , 0.97, P < 0.001). Temperature is therefore assumed to be the most important abiotic determinant responsible for the species turnover among the moths. Matrix correlation tests were performed in order to compare faunal matrices with matrices derived from available environmental factors. Both tree diversity and vegetation structure significantly correlate with faunal data, but tree diversity explains considerably more of the data variability (range: Mantel r = 0.81,0.83, P < 0.001) than vegetation structure (range: Mantel r = 0.35, P < 0.005 to r = 0.43, P < 0.001). Tree diversity also changes gradually and scores of the first NMDS dimension are highly significantly correlated with altitude (r = 0.98, P < 0.001). A common underlying factor such as ambient temperature might also be responsible for such vegetation changes. Additionally, simulated model data was developed that assumed a constant turnover of moth species and equal elevational ranges of all species involved. Despite the simplicity of the models, they fit empirical data very well (Mantel r > 0.80 and P < 0.001 in all models). [source] Direct injection horse-urine analysis for the quantification and confirmation of threshold substances for doping control.DRUG TESTING AND ANALYSIS, Issue 8 2009Abstract Levodopa and dopamine have been abused as performance-altering substances in horse racing. Urinary 3-methoxytyramine is used as an indicator of dopaminergic manipulation resulting from dopamine or levodopa administration and is prohibited with a urinary threshold of 4 µg mL,1 (free and conjugated). A simple liquid chromatographic (LC)/mass spectrometric (MS) (LCMS) method was developed and validated for the quantification and identification of 3-methoxytyramine in equine urine. Sample preparation involved enzymatic hydrolysis and protein precipitation. Hydrophilic interaction liquid chromatography (HILIC) was selected as a separation technique that allows effective retention of polar substances like 3-methoxytyramine and efficient separation from matrix compounds. Electrospray ionization (ESI) in positive mode with product ion scan mode was chosen for the detection of the analytes. Quantification of 3-methoxytyramine was performed with fragmentation at low collision energy, resulting in one product ion, while a second run at high collision energy was performed for confirmation (at least three abundant ions). Studies on matrix effects showed ion suppression depending on the horse urine used. To overcome the variability of the results originating from the matrix effects, isotopic labelled internal standard was used and linear regression calibration methodology was applied for the quantitative determination of the analyte. The tested linear range was 1,20 µg mL,1. The relative standard deviations of intra- and inter- assay analysis of 3-methoxytyramine in horse urine were lower than 4.2% and 3.2%, respectively. Overall accuracy (relative percentage error) was less than 6.2%. The method was applied to case samples, demonstrating simplicity, accuracy and selectivity. Copyright © 2009 John Wiley & Sons, Ltd. [source] SCALES: a large-scale assessment model of soil erosion hazard in Basse-Normandie (northern-western France)EARTH SURFACE PROCESSES AND LANDFORMS, Issue 8 2010P. Le Gouée Abstract The cartography of erosion risk is mainly based on the development of models, which evaluate in a qualitative and quantitative manner the physical reproduction of the erosion processes (CORINE, EHU, INRA). These models are mainly semi-quantitative but can be physically based and spatially distributed (the Pan-European Soil Erosion Risk Assessment, PESERA). They are characterized by their simplicity and their applicability potential at large temporal and spatial scales. In developing our model SCALES (Spatialisation d'éChelle fine de l'ALéa Erosion des Sols/large-scale assessment and mapping model of soil erosion hazard), we had in mind several objectives: (1) to map soil erosion at a regional scale with the guarantee of a large accuracy on the local level, (2) to envisage an applicability of the model in European oceanic areas, (3) to focus the erosion hazard estimation on the level of source areas (on-site erosion), which are the agricultural parcels, (4) to take into account the weight of the temporality of agricultural practices (land-use concept). Because of these objectives, the nature of variables, which characterize the erosion factors and because of its structure, SCALES differs from other models. Tested in Basse-Normandie (Calvados 5500,km2) SCALES reveals a strong predisposition of the study area to the soil erosion which should require to be expressed in a wet year. Apart from an internal validation, we tried an intermediate one by comparing our results with those from INRA and PESERA. It appeared that these models under estimate medium erosion levels and differ in the spatial localization of areas with the highest erosion risks. SCALES underlines here the limitations in the use of pedo-transfer functions and the interpolation of input data with a low resolution. One must not forget however that these models are mainly focused on an interregional comparative approach. Therefore the comparison of SCALES data with those of the INRA and PESERA models cannot result on a convincing validation of our model. For the moment the validation is based on the opinion of local experts, who agree with the qualitative indications delivered by our cartography. An external validation of SCALES is foreseen, which will be based on a thorough inventory of erosion signals in areas with different hazard levels. Copyright © 2010 John Wiley & Sons, Ltd. [source] Particle swarm optimization of TMD by non-stationary base excitation during earthquakeEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 9 2008A. Y. T. Leung Abstract There are many traditional methods to find the optimum parameters of a tuned mass damper (TMD) subject to stationary base excitations. It is very difficult to obtain the optimum parameters of a TMD subject to non-stationary base excitations using these traditional optimization techniques. In this paper, by applying particle swarm optimization (PSO) algorithm as a novel evolutionary algorithm, the optimum parameters including the optimum mass ratio, damper damping and tuning frequency of the TMD system attached to a viscously damped single-degree-of-freedom main system subject to non-stationary excitation can be obtained when taking either the displacement or the acceleration mean square response, as well as their combination, as the cost function. For simplicity of presentation, the non-stationary excitation is modeled by an evolutionary stationary process in the paper. By means of three numerical examples for different types of non-stationary ground acceleration models, the results indicate that PSO can be used to find the optimum mass ratio, damper damping and tuning frequency of the non-stationary TMD system, and it is quite easy to be programmed for practical engineering applications. Copyright © 2008 John Wiley & Sons, Ltd. [source] A simple LMS-based approach to the structural health monitoring benchmark problemEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 6 2005J. Geoffrey Chase Abstract A structure's health or level of damage can be monitored by identifying changes in structural or modal parameters. However, the fundamental modal frequencies can sometimes be less sensitive to (localized) damage in large civil structures, although there are developing algorithms that seek to reduce this difficulty. This research directly identifies changes in structural stiffness due to modeling error or damage using a structural health monitoring method based on adaptive least mean square (LMS) filtering theory. The focus is on computational simplicity to enable real-time implementation. Several adaptive LMS filtering based approaches are used to analyze the data from the IASC,ASCE Structural Health Monitoring Task Group Benchmark problem. Results are compared with those from the task group and other published results. The proposed methods are shown to be very effective, accurately identifying damage to within 1%, with convergence times of 0.4,13.0 s for the twelve different 4 and 12 degree of freedom benchmark problems. The resulting modal parameters match to within 1% those from the benchmark problem definition. Finally, the methods developed require 1.4,14.0 Mcycles of computation and therefore could easily be implemented in real time. Copyright © 2004 John Wiley & Sons, Ltd. 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