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Selected AbstractsEmotional vitality in infancy as a predictor of cognitive and language abilities in toddlerhoodINFANT AND CHILD DEVELOPMENT, Issue 4 2005Amanda J. Moreno Abstract Previous work by our group has shown that infant emotional vitality (EV), the lively expression of shared emotion both positive and negative, predicts cognitive and language abilities in toddlerhood. Specifically, infants who demonstrated a pattern of high emotional expression combined with high bids to their caregivers, fared significantly better on the Bayley II and Preschool Language Scales (PLS-3) at 2 years of age than infants who showed both low expression and low bids to mother. That study was conducted on a large, low-income, ethnically diverse sample. The current study was undertaken with a smaller but demographically similar sample as an effort to demonstrate the value of EV as a construct and to provide additional information about its links with later developmental outcomes. Replication that included a variation in the age at which EV was assessed provides support for the generalizability of the construct. In addition, this study examined EV's effects further into childhood than did the original study in order to insure they are not limited to a brief window in toddlerhood. The results indicate that over and above maternal psychological resources, EV expressed during positive/joyful and frustrating circumstances in 8-month-olds accounted for significant portions of variance in expressive language at 30 months and cognitive-developmental assessments at 24 and 36 months. This study supports EV as an important relational-emotional behaviour that increases experiences that optimize developmental outcomes. Successful replication suggests that EV holds promise as a construct with clinical utility for early interventions attempting to improve developmental outcomes in children from poor families. Copyright © 2005 John Wiley & Sons, Ltd. [source] Assessing the impact of pollution on the Japaratuba river in Brazil using the Drosophila wing spot testENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 2 2007Silmara de Moraes Pantalećo Abstract The Drosophila melanogaster somatic mutation and recombination test (SMART) was used to assess the genotoxicity of surface (S) and bottom (B) water and sediment samples collected from Sites 1 and 2 on the Japaratuba River (Sergipe, Brazil), an area impacted by a petrochemical industrial complex that indirectly discharges treated effluent (produced water) into the river. The genotoxicity tests were performed in standard (ST) cross and high bioactivation (HB) cross flies and were conducted on samples taken in March (dry season) and in July (rainy season) of 2003. Mutant spot frequencies found in treatments with unprocessed water and sediment samples from the test sites were compared with the frequencies observed for similar samples taken from a clean reference site (the Jacarecica River in Sergipe, Brazil) and those of negative (ultrapure water) controls. While samples from the Japaratuba River generally produced greater responses than those from the Jacarecica River, positive responses were detected for both the test and reference site samples. All the water samples collected in March 2003 were genotoxic. In July 2003, the positive responses were restricted to water samples collected from Sites 1 B and 2 S in the ST cross. The genotoxicity of the water samples was due to mitotic recombination, and the samples produced similar genotoxic responses in ST and HB flies. The spot frequencies found in the July water samples were considerably lower than those for the March water samples, suggesting a seasonal effect. The only sediment samples that were genotoxic were from Site 1 (March and July) and from the Jacarecica River (March). The genotoxins in these samples produced both somatic mutation (limited to the Site 1 sample in HB flies) and recombination. The results of this study indicate that samples from both the Japaratuba and Jacarecica Rivers were genotoxic, with the most consistently positive responses detected with Site 1 samples, the site closest to the putative pollution source. Environ. Mol. Mutagen. 48:, 2007. © 2007 Wiley-Liss, Inc. [source] Molecular diversity and characterization of nitrite reductase gene fragments (nirK and nirS) from nitrate- and uranium-contaminated groundwaterENVIRONMENTAL MICROBIOLOGY, Issue 1 2003Tingfen Yan Summary Nitrate-contaminated groundwater samples were analysed for nirK and nirS gene diversity. The samples differed with respect to nitrate, uranium, heavy metals, organic carbon content, pH and dissolved oxygen levels. A total of 958 nirK and 1162 nirS clones were screened by restriction fragment length polymorphism (RFLP) analysis: 48 and 143 distinct nirK and nirS clones, respectively, were obtained. A single dominant nirK restriction pattern was observed for all six samples and was 83% identical to the Hyphomicrobium zavarzinii nirK gene. A dominant nirS pattern was observed for four of the samples, including the background sample, and was 95% identical to the nirS of Alcaligenes faecalis. Diversity indices for nirK and nirS sequences were not related to any single geochemical characteristic, but results suggested that the diversity of nirK genes was inversely proportional to the diversity of nirS. Principal component analysis (PCA) of the sites based on geochemistry grouped the samples by low, moderate and high nitrate but PCA of the unique operational taxonomic units (OTUs) distributions grouped the samples differently. Many of the sequences were not closely related to previously observed genes and some phylogenetically related sequences were obtained from similar samples. The results indicated that the contaminated groundwater contained novel nirK and nirS sequences, functional diversity of both genes changed in relation to the contaminant gradient, but the nirK and nirS functional diversity was affected differently. [source] Cytomorphological alterations of the thymus, spleen, head-kidney, and liver in cardinal fish (Apogonidae, Teleostei) as bioindicators of stressJOURNAL OF MORPHOLOGY, Issue 1 2006Lev Fishelson Abstract Morphological and cytological alterations at the light microscope (LM) and transmission electron microscope (TEM) levels were observed in the thymus, spleen, head-kidney, and liver of cardinal fishes (Apogonidae, Teleostei) from the Gulf of Aqaba, Red Sea, sampled from a strongly polluted site at the northern end of the gulf, and compared to similar samples from a clean, reference site. At the polluted site, the most prominent change was the formation of numerous deposits of cells rich in phagosomes with lipofucin, melanin granules, and phagocytosed debris, including a high increase in number and dimensions of Hassall's corpuscles and melano-macrophage centers. The number of Hassall's corpuscles was 20 (±8.0)/mm2 and of melano-macrophage centers 18 (±4.0)/mm2 at the polluted site, and 7.0 (±4.0)/m2 vs. 5.0 (±2.0)/mm2 respectively at the reference site. In numerous instances the head kidney's melano-macrophage centers in fishes from the polluted site were encapsulated by reticulocytes, a phenomenon recognized as a marker of neoplasmosis and possible malignancy. In the spleens of fishes from the polluted site, numerous deposits of cell debris, peroxisomes, and enlarged lysosomes were also observed. The livers (hepatopancreas) of fishes from polluted waters demonstrated very strong hyperlipogeny. Many of their hepatocytes were laden with lipid vesicles, fragmented endoplasmic reticulula, and aberrant mitochondria. Although the observed alterations in the glands and liver do not indicate any immediate threat to the life of the fish, they can become crucial with respect to energy turnover and fecundity trajectories. This study strongly suggests the use of cytological alterations in vital organs, such as were observed, as pathological biomarkers to environmental stress. J. Morphol. © 2005 Wiley-Liss, Inc. [source] Proposals for 2001 samples of anonymized records: An assessment of disclosure riskJOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES A (STATISTICS IN SOCIETY), Issue 3 2001Angela Dale In 1991 Marsh and co-workers made the case for a sample of anonymized records (SAR) from the 1991 census of population. The case was accepted by the Office for National Statistics (then the Office of Population Censuses and Surveys) and a request was made by the Economic and Social Research Council to purchase the SARs. Two files were released for Great Britain,a 2% sample of individuals and a 1% sample of households. Subsequently similar samples were released for Northern Ireland. Since their release, the files have been heavily used for research and there has been no known breach of confidentiality. There is a considerable demand for similar files from the 2001 census, with specific requests for a larger sample size and lower population threshold for the individual SAR. This paper reassesses the analysis of Marsh and co-workers of the risk of identification of an individual or household in a sample of microdata from the 1991 census and also uses alternative ways of assessing risks with the 1991 SARs. The results of both the reassessment and the new analyses are reassuring and allow us to take the 1991 SARs as a base-line against which to assess proposals for changes to the size and structure of samples from the 2001 census. [source] MOCVD n-InAs thin layers compared with MBE samples , far infrared magnetophotoconductivityPHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 2 2003Z. Romanowski Abstract A comparison of the properties of n-InAs thin layers grown by the MOCVD method and, reported elsewhere, similar samples obtained by MBE processing is presented. The measured photoconductivity spectra exhibit a variety of peaks, among them , very narrow peaks (with the halfwidths of ,20 mT) due to cyclotron resonance (CR) and impurity cyclotron resonance (ICR) transitions. Measurements with tilted magnetic field allowed to correlate peaks with the CR or ICR transitions in the different sample regions: with 2D and 3D electron gas. The detailed analysis shows, that we observe peaks with positions more strongly dependent on the magnitude of the tilt angle than the standard 1/cos,, (, is a sample tilt angle) dependence. These lines were not observed in MBE samples. Results are discussed in terms of a correspondence between the distribution of carriers and the spatial structure of the sample. As a result one can state, that the MOCVD samples seem to have the same quality as samples obtained by the MBE method. [source] Common Adiponectin Gene Variants Show Different Effects on Risk of Cardiovascular Disease and Type 2 Diabetes in European SubjectsANNALS OF HUMAN GENETICS, Issue 4 2007D. R. Gable Summary Alterations in the secretion of adipokines may explain the link between obesity, type 2 diabetes (T2DM) and coronary artery disease (CAD). These conditions have been associated with variation in the adiponectin gene, although evidence for this relationship has been variable, with differences found even in similar samples. This study aims to clarify these inconsistencies by determining the impact of identified adiponectin gene (ADIPOQ) variants (,11391G>A,,1377C>G[promoter] and +45T>G[exon 2] and +276G>T[intron 2]) on the prospective risk of CAD and T2DM in healthy men, and on adverse metabolic markers, in myocardial infarct survivors and controls from different parts of Europe. The hazard ratio for cardiovascular disease varied across the ,11391GG/GA/AA(p = 0.03) and ,11371CC/CG/GG(p = 0.05) genotypes only. In contrast, only the +45T>G variant (3.80[1.76-8.24]) was associated with T2DM, while two haplotypes GCTT/GCGG (p < 0.05) and +276G>T(p = 0.01) increased risk in interaction with obesity. The variants were associated with a number of biomarkers in Southern but not Northern Europe (p = 0.01), despite no significant differences in allele or haplotype frequencies (p > 0.44). A risk haplotype could not be identified in either sample. Adiponectin gene variants are hence currently poor markers for the development of T2DM and CAD. Their influence on risk depends significantly on interactions that are not currently understood with either genetic variation elsewhere or the environment of the sample studied. [source] Application of RAPDs to the critical taxonomy of the English endemic elm Ulmus plotii DaceBOTANICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 3 2000MAX COLEMAN The taxonomy of the British elms is notoriously complicated and a satisfactory consensus classification remains elusive. This taxonomic complexity appears to be attributable to the reproductive biology of the species. Ulmus glabra Huds. reproduces sexually and its taxonomic status is widely (albeit not universally) accepted. In contrast, the suckering elms of the U. minor complex (U. minor Mill. emend. Richens sensu latissimo) rarely reproduce by seed in Britain. Instead they perpetuate predominantly by vegetative reproduction; arguments regarding their taxonomy are legion. We have used molecular markers (RAPDs) to investigate the amounts and partitioning of clonal diversity and taxon inter-relationships in the British elms, focusing on a particularly enigmatic suckering elm, U. plotii Druce. Our molecular data suggest that all samples of U. plotii that precisely match the type description are ramets of a single genet, the distribution of which is attributable to human planting. Morphologically similar samples, which have many but not all of the U. plotii diagnostic characters, do not cluster with U. plotii when the RAPD data are analysed using principal coordinates analysis (PCO). Instead, they are scattered on the PCO plots throughout the broader range of variability of the U. minor complex. The implications of these results for the taxonomy of the British elms are discussed, and the need to combine knowledge of population structure with taxonomic pragmatism is emphasized. [source] A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer's Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and TranslocationBRAIN PATHOLOGY, Issue 4 2003Ester Angulo Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer's disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls. Adenosine A1 receptor (A1R) immunoreactivity was found in degenerating neurons with neurofibrillary tangles and in dystrophic neurites of senile plaques. A high degree of colocalization for A1R and pA4 amyloid in senile plaques and for A1R and tau in neurons with tau deposition, but without tangles, was seen. Additionally, adenosine A2A receptors, located mainly in striatal neurons in controls, appeared in glial cells in the hippocampus and cerebral cortex of patients. On comparing similar samples from controls and patients, no significant change was evident for metabotropic glutamate receptors. In the human neuroblastoma SH-SY5Y cell line, agonists for A1R led to a dose-dependent increase in the production of soluble forms of amyloid precursor protein in a process mediated by PKC. A1R agonist induced p21 Ras activation and ERK1/2 phosphorylation. Furthermore, activation of A1R led to and ERK-dependent increase of tau phosphorylation and translocation towards the cytoskeleton. These results indicate that adenosine receptors are potential targets for AD. [source] | ||||||||||