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Selected AbstractsAn Innovative Strategy for Conducting Clinical Research: The Academic Associate ProgramACADEMIC EMERGENCY MEDICINE, Issue 2 2002Judd E. Hollander MD Performance of high-quality clinical research usually requires procurement of substantial funding to support and sustain the research infrastructure. The authors have developed a program to support a research infrastructure that minimizes financial start-up costs and maximizes productivity of clinical-educator faculty with limited protected time. The program integrates clinical research with undergraduate education. The authors report the experience with the academic associate program at two academic institutions. They describe the program, provide measures of program success, and discuss potential methods for other institutions to initiate similar programs. Similar programs can be developed in a variety of outpatient and inpatient settings allowing the performance of high-quality clinical research in a time-efficient and cost-effective manner. [source] Advances in vertebrate aging research 2007AGING CELL, Issue 2 2008Steven Austad Summary Among this year's highlights in vertebrate aging research, we find a study in which, contrary to the oxidative stress hypothesis of aging, reduced expression of a major cellular antioxidant, glutathione peroxidase 4, led to a small increase in mouse lifespan. By contrast, a large comparative proteomic analysis discovered a remarkably robust and previous unsuspected inverse association between species lifespan and relative frequency of cysteine residues in mitochondrially encoded respiratory chain proteins only, which the authors attribute to cysteine's ease of oxidation. Another study evaluated more cleanly than any previous work the hypothesis that blood glucose concentration is a key mediator of aging, and concluded that it wasn't. Several new mouse longevity mutants were also reported this year, some (PAPP-A, IRS-1, and IRS-2 knockouts) supporting previous work on the importance of insulin/insulin-like growth factor-1 signaling and aging. However, there were inconsistencies between laboratories in some of the results, which merit further investigation. Also, somewhat inconsistent with these findings, over-expression of insulin-like growth factor-1 in heart only lengthened life. From a completely new direction, type 5 adenylyl cyclase knockout mice were observed to live more than 30% longer than controls. Finally, a new program for evaluating potential pharmaceutical interventions in aging and longevity made its appearance, and is notable at this point chiefly for the excellence of its experimental design. A similar program for the disinterested evaluation of reported longevity mutations in mice would be a service to the community of vertebrate aging researchers. [source] District-level total factor productivity in agriculture: Western Cape Province, South Africa, 1952,2002AGRICULTURAL ECONOMICS, Issue 3 2009Beatrice Conradie Total factor productivity; Western Cape; South Africa Abstract This article measures total factor productivity (TFP) growth in Western Cape agriculture for 31 magisterial districts from 1952 to 2002 to illustrate the benefits of disaggregation compared with national TFPs. There is negative or low growth in the eastern districts and rapid growth in the western districts. The regions with substantial chicken, pigs, dairy, and, especially, export fruit production grew rapidly, whereas the sheep-dominated Karoo had negative growth. Productivity growth correlates mostly with output mix, which in turn depends on irrigation investment. A similar program will be needed at the national level if prosperity is to be extended to black smallholders who currently lack access to water and other modern infrastructure. [source] Mediation matters: States, insurers focus on ADR for Katrina reliefALTERNATIVES TO THE HIGH COST OF LITIGATION, Issue 3 2006Russ Bleemer Details on the role alternative dispute resolution will play in the recovery from Hurricanes Katrina and Rita in the deep south. Calls for deploying ADR have been answered: Two states have hired the American Arbitration Association to conduct mediation facilities for homeowners' claims, and a third will set up a similar program. At the same time, two large insurers have enlisted 9/11 victims fund special master Kenneth Feinberg to administer their mediation efforts. One of the company programs will focus on mediating commercial claims. [source] A break-even analysis of a community rehabilitation falls prevention serviceAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 3 2009Tracy Comans Abstract Objective: To identify and compare the minimum number of clients that a multidisciplinary falls prevention service delivered through domiciliary or centre-based care needs to treat to allow the service to reach a ,break-even' point. Method: A break-even analysis was undertaken for each of two models of care for a multidisciplinary community rehabilitation falls prevention service. The two models comprised either a centre-based group exercise and education program or a similar program delivered individually in the client's home. The service consisted of a physiotherapist, occupational therapist and therapy assistant. The participants were adults aged over 65 years who had experienced previous falls. Costs were based on the actual cost of running a community rehabilitation team located in Brisbane. Benefits were obtained by estimating the savings gained to society from the number of falls prevented by the program on the basis of the falls reduction rates obtained in similar multidisciplinary programs. Results: It is estimated that a multi-disciplinary community falls prevention team would need to see 57 clients per year to make the service break-even using a centre-based model of care and 78 clients for a domiciliary-based model. Conclusions and Implications: The service this study was based on has the capability to see around 300 clients per year in a centre-based service or 200-250 clients per year in a home-based service. Based on the best available estimates of costs of falls, multidisciplinary falls prevention teams in the community targeting people at high risk of falls are worthwhile funding from a societal viewpoint. [source] An Innovative Strategy for Conducting Clinical Research: The Academic Associate ProgramACADEMIC EMERGENCY MEDICINE, Issue 2 2002Judd E. Hollander MD Performance of high-quality clinical research usually requires procurement of substantial funding to support and sustain the research infrastructure. The authors have developed a program to support a research infrastructure that minimizes financial start-up costs and maximizes productivity of clinical-educator faculty with limited protected time. The program integrates clinical research with undergraduate education. The authors report the experience with the academic associate program at two academic institutions. They describe the program, provide measures of program success, and discuss potential methods for other institutions to initiate similar programs. Similar programs can be developed in a variety of outpatient and inpatient settings allowing the performance of high-quality clinical research in a time-efficient and cost-effective manner. [source] A review of social and behavioral efforts at oral cancer preventions in IndiaHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 11 2004Erich M. Sturgis MD Abstract Background. Oral cancer is a major public health problem in South-Central Asia, home to one fifth of the world's population. In most regions of India, it is the most common cancer in men and the third most common cancer in women. Prevention is an effective tool to reduce disease burden on society and may offer particular advantages in developing countries. Methods. The primary and secondary oral cancer prevention efforts in India were reviewed and presented. In addition, the scope of the oral cancer problem and the tobacco industry in India are discussed, and the chief etiologies in the region are summarized. Results and Conclusions. The effectiveness of these prevention efforts provides an excellent social/behavioral model for similar programs in other developing countries. Furthermore, similar programs may also be applicable to certain populations in schools or industries in the developed world. © 2004 Wiley Periodicals, Inc. Head Neck26: 937,944, 2004 [source] A support group for patients who have recovered from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS): The six-year experience of the Oklahoma TTP-HUS Study GroupJOURNAL OF CLINICAL APHERESIS, Issue 1 2003Mark A. Howard Abstract A support group for patients who have recovered from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), named The Oklahoma TTP-HUS Study Group, has been a successful program for 6 years. This group has met 3 times each year with an average attendance of 16 former patients; in addition, an average of 14 family members and friends have attended each meeting. Eighty-four percent of patients who attended a meeting were women as compared to 68% women among those who did not attend (P = 0.016). Twenty-three percent of patients who attended a meeting have relapsed as compared to 8% among those who did not attend (P = 0.006). There was also a difference in the rates of attendance among the different clinical categories of patients (P < 0.001). A survey of former patients, as well as their families and friends, documented that interest in learning more about TTP-HUS and talking with other people who have had TTP-HUS were principal motivations for attending the meetings. The meetings of The Oklahoma TTP-HUS Study Group have been successful not only for support of former patients but also for research. Long-term patient follow-up has been facilitated and the group discussions have revealed previously unreported persistent problems with cognitive ability and endurance. A survey of member centers of the American Association of Blood Banks and America's Blood Centers revealed no similar programs for patients who have recovered from TTP-HUS. The absence of a support group for TTP-HUS in the national survey contrasts to the 274 patient support groups and related wellness/education classes, including some for rare disorders, currently active in the Oklahoma City metropolitan area. The experience of The Oklahoma TTP-HUS Study Group suggests that it serves a previously unmet need. J. Clin. Apheresis 18:16,20, 2003. © 2003 Wiley-Liss, Inc. [source] MPP programs emerging around the world19JOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 1 2008Iris Geva-May This paper examines public policy and management programs in Canada, Europe, Australia, and New Zealand, and makes comparisons with similar programs in the United States. Our study of public policy programs shows that there are many challenges ahead in terms of making good decisions on the form and content of programs that will add value to governments and citizens. Appropriate choices in terms of program design and pedagogy will reflect different economic, social, environmental, and cultural influences and will be shaped by history, values, and the roles of public policy and management professionals within a particular governmental context. [source] | |||||||||||||