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Selected AbstractsChanges in body condition and body size affect breeding and recruitment in fluctuating house mouse populations in south-eastern AustraliaAUSTRAL ECOLOGY, Issue 3 2009GREGORY J. MUTZE Abstract Changes in body condition and body size in field populations of house mice, Mus domesticus, were examined to investigate why mouse populations do not increase rapidly in some years when favourable environmental and demographic conditions indicate they might. Mice had repeated seasonal patterns each year in breeding, growth rates and body condition that reflected the seasonal availability of food, but mean levels for each parameter varied among years. In most years mice lost body condition during summer, breeding declined and population growth slowed. Rapid population growth occurred when body condition was generally high and was maintained throughout summer. Female mice with large body length were more likely to breed than smaller mice, at all times, but changes in body condition accounted for most of the variability in female breeding activity between years and between habitats, and for the seasonal changes in the importance of body length. During rapid population growth, the recruitment rate of juveniles relative to the number of breeding females was 150,300% higher than in other years but adult survival rates were not higher. The data indicate that the ability of mice to maintain body condition, particularly when subject to moisture stress in summer, affects the proportion of females breeding, the number of juveniles weaned and their body condition at weaning, and is promoted by foraging conditions that favour maintenance of juvenile body condition after weaning. These factors, in turn, greatly affect juvenile recruitment rates and eventual population density of mice. Low juvenile survival is suggested as a reason that numbers of house mice in southern Australian cereal-growing areas do not increase rapidly in some years when other parameters are favourable. Similar processes are likely to play a role in regulating other rodent populations. [source] Rapidly progressive internal root resorption: a case reportDENTAL TRAUMATOLOGY, Issue 5 2008David Keinan Usually the process is asymptomatic and diagnosed upon routine radiographic examination. This case report presents a rapid progression of internal resorption related directly to traumatic injury. A 16-year-old female arrived at the emergency room after a mild extrusion of the mandibular incisors. The initial treatment included repositioning and splinting of the teeth. Radiographs performed at repositioning and splinting demonstrated normal configuration of the incisor's roots. Ten months later progressive internal resorption of the left mandibular first incisor was diagnosed. While treating this tooth similar process was detected in the right mandibular second incisor and in the mandibular left second incisor. The lower right first incisor reacted inconsistently to vitality test. As a result of the severe and rapidly progressive nature of the process, root canal treatments were performed in all lower incisors. The follow-up radiographs demonstrate arrest of the internal resorption process. [source] Animal models of early life stress: Implications for understanding resilienceDEVELOPMENTAL PSYCHOBIOLOGY, Issue 5 2010David M. Lyons Abstract In the mid-1950s, Levine and his colleagues reported that brief intermittent exposure to early life stress diminished indications of subsequent emotionality in rats. Here we review ongoing studies of a similar process in squirrel monkeys. Results from these animal models suggest that brief intermittent exposure to stress promotes the development of arousal regulation and resilience. Implications for programs designed to enhance resilience in human development are discussed. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 402,410, 2010. [source] Combining data from multiple years or areas to improve variogram estimationENVIRONMETRICS, Issue 6 2007John F. Walter III Abstract A requirement for geostatistical prediction is estimation of the variogram from the data. Often low sample size is a major impediment to elucidating a variogram even for a highly autocorrelated spatial process. This paper presents a methodology for improving variogram estimation when samples exist from multiple years or regions sharing a similar process for generating spatial autocorrelation. Such samples may come from annual monitoring programs for natural resources or from multiple geologic regions. As each set of samples contains some information on the spatial autocorrelation, combining information through the construction of a combined variogram cloud and binning to obtain a common variogram improves the estimation of the variogram. In both simulations and in real datasets of oyster abundance the method proposed here reduces the likelihood of failing to obtain a variogram from a set of samples and improves the efficiency of variogram estimation. In practice, the benefits obtained by estimating an otherwise elusive variogram generally outweigh the costs of using a slightly incorrect variogram model if different sampling stanzas are combined when they do not share the same spatial autocorrelation. Copyright © 2007 John Wiley & Sons, Ltd. [source] Learning from Abroad: The Role of Policy Transfer in Contemporary Policy-MakingGOVERNANCE, Issue 1 2000David P. Dolowitz In recent years there has been a growing body of literature within political science and international studies that directly and indirectly uses, discusses and analyzes the processes involved in lesson-drawing, policy convergence, policy diffusion and policy transfer. While the terminology and focus often vary, all of these studies are concerned with a similar process in which knowledge about policies, administrative arrangements, institutions and ideas in one political setting (past or present) is used in the development of policies, administrative arrangements, institutions and ideas in another political setting. Given that this is a growing phenomenon, it is something that anyone studying public policy needs to consider. As such, this article is divided into four major sections. The first section briefly considers the extent of, and reasons for, the growth of policy transfer. The second section then outlines a framework for the analysis of transfer. From here a third section presents a continuum for distinguishing between different types of policy transfer. Finally, the last section addresses the relationship between policy transfer and policy "failure." [source] The Re-Assessment and Reconstruction of Excavated BoatsINTERNATIONAL JOURNAL OF NAUTICAL ARCHAEOLOGY, Issue 2 2007Seán McGrail In response to papers by John Coates and by Owain Roberts, the author re-evaluates mid- to late-20th-century reconstruction drawings and models of prehistoric sewn-plank boats Ferriby 1 and Brigg 2. He concludes that an impartial and informed group should re-examine all surviving evidence for these boats and then build a small-scale ,as-found' model of each one. After being subjected to criticism, these models could become the basis for generally-agreed reconstruction models of the original form and structure of these two boats. A similar process would be the best way ahead for the Dover sewn-plank boat. © 2007 The Author [source] Measurement of Lens Protein Aggregation in Vivo Using Dynamic Light Scattering in a Guinea Pig/UVA Model for Nuclear CataractPHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 6 2008M. Francis Simpanya The role of UVA radiation in the formation of human nuclear cataract is not well understood. We have previously shown that exposing guinea pigs for 5 months to a chronic low level of UVA light produces increased lens nuclear light scattering and elevated levels of protein disulfide. Here we have used the technique of dynamic light scattering (DLS) to investigate lens protein aggregation in vivo in the guinea pig/UVA model. DLS size distribution analysis conducted at the same location in the lens nucleus of control and UVA-irradiated animals showed a 28% reduction in intensity of small diameter proteins in experimental lenses compared with controls (P < 0.05). In addition, large diameter proteins in UVA-exposed lens nuclei increased five-fold in intensity compared to controls (P < 0.05). The UVA-induced increase in apparent size of lens nuclear small diameter proteins was three-fold (P < 0.01), and the size of large diameter aggregates was more than four-fold in experimental lenses compared with controls. The diameter of crystallin aggregates in the UVA-irradiated lens nucleus was estimated to be 350 nm, a size able to scatter light. No significant changes in protein size were detected in the anterior cortex of UVA-irradiated lenses. It is presumed that the presence of a UVA chromophore in the guinea pig lens (NADPH bound to zeta crystallin), as well as traces of oxygen, contributed to UVA-induced crystallin aggregation. The results indicate a potentially harmful role for UVA light in the lens nucleus. A similar process of UVA-irradiated protein aggregation may take place in the older human lens nucleus, accelerating the formation of human nuclear cataract. [source] Parametric optimization of magnetic-field-assisted abrasive flow machining by the Taguchi methodQUALITY AND RELIABILITY ENGINEERING INTERNATIONAL, Issue 4 2002Sehijpal Singh Abstract Some hybrid-machining processes have been developed in the recent past with a view to devising composite machining processes, which are able to overcome the limitations of one process with the help of advantageous features of another similar process. The present paper identifies the parameters of abrasive flow machining (AFM) that significantly affect the material removal when a magnetic field is applied around the workpiece. The Taguchi method has been adopted for studying the effect of magnetic-field-assisted AFM parameters, individually, on the abrasion rate of work materials. Optimization of the process parameters has been carried out for the purpose of off-line monitoring of the process. Copyright © 2002 John Wiley & Sons, Ltd. [source] Signa De Caelo in the Lives of St Cuthbert: The Impact of Biblical Images and Exegesis on Early Medieval HagiographyTHE HEYTHROP JOURNAL, Issue 4 2000Sandra Duncan This article uses the two prose Lives of Cuthbert written by an anonymous monk of Lindisfarne and by Bede in the first half of the eighth century to illustrate how an understanding of the impact of biblical language and its accompanying exegetical tradition may help in the interpretation of hagiographical works. After an examination of recent scholarly work on the relationship scripture and hagiography and the impact of signa upon the early medieval thought-world, the paper examines the incidents that are recorded as happening during Cuthbert's time as a hermit on Farne. Looking first at the Lindisfarne account, the potential symbolism inherent in miracles concerning building materials such as rock, stone and wood, as well as living water and ravens are examined by outlining biblical parallels and then looking at the development of the symbols in the exegetical tradition. It thus becomes apparent that the writer was using a shared Christian symbolic language to make statements about Cuthbert as builder of the Northumbrian Church. A similar process is undertaken with Bede's account, noting differences and additions, and reaching the conclusion that it is more developed, showing Cuthbert as a teacher and pastor. In both cases the writers were using the events to foreshadow Cuthbert's imminent episcopal career, thus connecting the contemplative preparation with the subsequent active ministry. The article concludes that the hagiographers believed that God continued to speak to His Church through signa as He had spoken in the Bible and that it was natural His words should coincide with their own polemical and didactic concerns and intentions. [source] Establishment of Liebermannia dichroplusae n. comb. on the Basis of Molecular Characterization of Perezia dichroplusae Lange, 1987 (Microsporidia)THE JOURNAL OF EUKARYOTIC MICROBIOLOGY, Issue 3 2007YULIYA Y. SOKOLOVA ABSTRACT. Perezia dichroplusae Lange, 1987 is a parasite of the Malpighian tubules of an Argentine grasshopper, Dichroplus elongatus (Orthoptera, Acrididae, Melanoplinae). In order to determine relationships of this microsporidium with Perezia nelsoni and with other microsporidia, we sequenced its small subunit ribosomal RNA gene (SSU rDNA) (GenBank Accession No. EF016249) and performed phylogenetic analysis of the novel sequence against 17 microsporidian SSU rDNA sequences from GenBank, using neighbor-joining (NJ), maximum-parsimony (MP), and maximum-likelihood (ML) methods. This analysis revealed the highest similarity (96%) of the new sequence to Liebermannia patagonica, a parasite of gut epithelium cells of another grasshopper from Argentina, versus only 65% similarity to P. nelsoni, a parasite of muscles of paenaeid shrimps. In phylogenetic trees inferred from SSU rDNA sequences, the microsporidium from D. elongatus is sister taxon to L. patagonica and both cluster with Orthosomella operophterae. At the higher hierarchical level, the Liebermania,Orthosomella branch forms a clade with the Endoreticulatus,Cystosporogenus,Vittaforma group and with Enterocytozoon bieneusi. Perezia nelsoni falls into another large clade together with Nosema and Ameson species. We propose transferring P. dichroplusae to the genus Liebermannia and creating a new combination Liebermannia dichroplusae n. comb., based both on SSU rDNA sequence analysis and on common characters between P. dichroplusae and L. patagonica, which include the presence of elongated multinuclear sporonts, sporoblastogenesis by a similar process of sequentially splitting off sporoblasts, ovocylindrical spores of variable size, tissue tropism limited to epithelial cells, Orthoptera as hosts, and geographical distribution of hosts in the southern temperate region of Argentina. We argue that the condition of the nuclei in spores (i.e. diplokaryotic in L. patagonica or monokaryotic in L. dichroplusae) cannot be used to distinguish genera. Therefore, we remove the statement about the presence of diplokaryotic spores from the revised diagnosis of the genus Liebermannia. [source] A child with laryngo-onychocutaneous syndrome partially responsive to treatment with thalidomideBRITISH JOURNAL OF DERMATOLOGY, Issue 6 2006R.M. Strauss Summary Laryngo-onychocutaneous syndrome (LOCS) is a condition characterized by erosive or ulcerative skin lesions associated with excessive granulation tissue, at sites of trauma such as the digits, elbows and knees. Similar lesions can occur within the conjunctival mucosa, leading to corneal scarring and blindness. The main complications, however, occur in the respiratory tract, where a similar process of erosions and subsequent formation of granulation tissue causes airway obstruction which may lead to premature death. LOCS is now believed to be a nonblistering variant of junctional epidermolysis bullosa and to date there are no efficacious treatments available. We report a 16-year-old girl with LOCS who failed to respond to methylprednisolone and cyclophosphamide, but had a partial response to oral thalidomide with marked decrease in granulation tissue and tracheal secretions. Interruption of treatment resulted in prompt resurgence of the granulation tissue which was again controlled by reintroduction of thalidomide. We propose that in the absence of effective therapies for LOCS, a trial of thalidomide in these patients should be considered. [source] General and Facile Syntheses of Metal Silicate Porous Hollow NanostructuresCHEMISTRY - AN ASIAN JOURNAL, Issue 6 2010Jun Zheng Abstract Porous hollow nanostructures have attracted intensive interest owing to their unique structure and promising applications in various fields. A facile hydrothermal synthesis has been developed to prepare porous hollow nanostructures of silicate materials through a sacrificial-templating process. The key factors, such as the concentration of the free metal cation and the alkalinity of the solution, are discussed. Porous hollow nanostructures of magnesium silicate, nickel silicate, and iron silicate have been successfully prepared by using SiO2 spheres as the template, as well as a silicon source. Several yolk,shell structures have also been fabricated by a similar process that uses silica-coated composite particles as a template. As-prepared mesoporous magnesium silicate hollow spheres showed an excellent ability to remove Pb2+ ions in water treatment owing to their large specific surface and unique structures. [source] Reviewing child deaths,learning from the American experience,CHILD ABUSE REVIEW, Issue 2 2005Lisa Bunting Abstract Current systems for investigating child deaths in England, Wales and Northern Ireland have come under intense scrutiny in recent years and questions have been raised about the accuracy of child death investigations and resulting statistics. Research has highlighted the ways in which multidisciplinary input can contribute to investigative and review processes, a perspective which is further supported by recent UK policy developments. The experience of creating multidisciplinary child death review teams (CDRTs) in America highlights the potential benefits the introduction of a similar system might have. These benefits include improved multi-agency working and communication, more effective identification of suspicious cases, a decrease in inadequate death certification and a broader and more in-depth understanding of the causes of child deaths through the systematic collection and analysis of data. While a lack of funding, regional coordination and evaluation limit the impact of American CDRTs, the positive aspects of this process make it worthwhile, and timely, to consider how such a model might fit within our own context. Current policy developments such as the Home Office review of coroner services, the Children Bill and related Department for Education and Skills (DfES) work on developing screening groups demonstrate that strides have been made in respect of introducing a multidisciplinary process. Similarly, the development of local protocols for the investigation and[sol ]or review of child deaths in England, Wales and Northern Ireland highlights an increased focus on multidisciplinary processes. However, key issues from the American experience, such as the remit of CDRTs[sol ]screening panels, the need for national coordination and the importance of rigorous evaluation, can inform the development of a similar process in the UK. Copyright © 2005 John Wiley & Sons, Ltd. [source] Adalimumab for treatment of moderate to severe psoriasis and psoriatic arthritisDERMATOLOGIC THERAPY, Issue 2008M. R. Bongiorno ABSTRACT: Psoriasis and psoriatic arthritis are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises similar processes leading to inflammation of skin, entheses, and joints. Although traditional systemic agents can be effective, their use may be limited by lack of efficacy and concerns regarding adverse effects. The objective of this study was to assess the efficacy and safety of adalimumab, a fully human antitumor necrosis factor (anti-TNF) monoclonal antibody, over 16 weeks. The present authors report their personal experience in 15 patients with severe plaque psoriasis and psoriatic arthritis, refractory to other treatments, in which a decisive regression of joint/skin involvement was obtained. Psoriasis and psoriatic arthritis are chronic inflammatory disorders resulting from a combination of genetic and environmental factors. [source] Neurobehavioral assessment from fetus to infant: The NICU network neurobehavioral scale and the fetal neurobehavior coding scaleDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 1 2005Amy L. Salisbury Abstract This review provides an overview and definition of the concept of neurobehavior in human development. Two neurobehavioral assessments used by the authors in current fetal and infant research are discussed: the NICU Network Neurobehavioral Assessment Scale and the Fetal Neurobehavior Coding System. This review will present how the two assessments attempt to measure similar processes from pre to post-natal life by examining three main components of neurobehavior: neurological, behavioral and stress/reactivity measures. Assessment descriptions, strengths and weaknesses, as well as cautions and limitations are provided. © 2005 Wiley-Liss, Inc. MRDD Research Reviews 2005;11:14,20. [source] A new look at an old visual system: structure and development of the compound eyes and optic ganglia of the brine shrimp artemia salina linnaeus, 1758 (branchiopoda, anostraca)DEVELOPMENTAL NEUROBIOLOGY, Issue 2 2002Miriam Wildt Abstract Compared to research carried out on decapod crustaceans, the development of the visual system in representatives of the entomostracan crustaceans is poorly understood. However, the structural evolution of the arthropod visual system is an important topic in the new debate on arthropod relationships, and entomostracan crustaceans play a key role in this discussion. Hence, data on structure and ontogeny of the entomostracan visual system are likely to contribute new aspects to our understanding of arthropod phylogeny. Therefore, we explored the proliferation of neuronal stem cells (in vivo incorporation of bromodeoxyuridine) and the developmental expression of synaptic proteins (immunohistochemistry against synapsins) in the developing optic neuropils of the brine shrimp Artemia salina Linnaeus, 1758 (Crustacea, Entomostraca, Branchiopoda, Anostraca) from hatching to adulthood. The morphology of the adult visual system was examined in serial sections of plastic embedded specimens. Our results indicate that the cellular material that gives rise to the visual system (compound eyes and two optic ganglia) is contributed by the mitotic activity of neuronal stem cells that are arranged in three band-shaped proliferation zones. Synapsin-like immunoreactivity in the lamina ganglionaris and the medulla externa initiated only after the anlagen of the compound eyes had already formed, suggesting that the emergence of the two optic neuropils lags behind the proliferative action of these stem cells. Neurogenesis in A. salina is compared to similar processes in malacostracan crustaceans and possible phylogenetic implications are discussed. © 2002 Wiley Periodicals, Inc. J Neurobiol 52: 117,132, 2002 [source] Jobs, Houses, and Trees: Changing Regional Structure, Local Land-Use Patterns, and Forest Cover in Southern IndianaGROWTH AND CHANGE, Issue 3 2003Darla K. Munroe Land-use and -cover change is a topic of increasing concern as interest in forest and agricultural land preservation grows. Urban and residential land use is quickly replacing extractive land use in southern Indiana. The interaction between land quality and urban growth pressures is also causing secondary forest growth and forest clearing to occur jointly in a complex spatial pattern. It is argued that similar processes fuel the abandonment of agricultural land leading to private forest regrowth, changes in topography and land quality, and declining real farm product prices. However, the impact of urban growth and development on forests depends more strongly on changes in both the residential housing and labor markets. Using location quotient analysis of aggregate employment patterns, and the relationship between regional labor market changes, the extent of private forest cover was examined from 1967 to 1998. Then an econometric model of land-use shares in forty southern Indiana counties was developed based on the net benefits to agriculture, forestland, and urban uses. To test the need to control explicitly for changes in residential demand and regional economic structure, a series of nested models was estimated. Some evidence was found that changing agricultural profitability is leading to private forest regrowth. It was also uncovered that the ratio of urban to forest land uses is better explained by incorporating measures of residential land value and industrial concentration than simply considering population density alone. [source] Single host trees in a closed forest canopy matrix: a highly fragmented landscape?JOURNAL OF APPLIED ENTOMOLOGY, Issue 9-10 2007J. Müller Abstract:, Whether trees represent habitat islands and therefore are influenced by similar biogeographic processes as ,real' islands is controversial. For trees in highly fragmented landscapes the impacts of spatial isolation on arthropod communities have already been demonstrated. However, we have almost no evidence that in large forests the arthropod communities on single trees in a closed canopy matrix are influenced by similar processes. In the present study the influence of spatial isolation on the specialized oak crown fauna was analysed in a large broadleaved forest area in northern Bavaria, Germany. The dependence of specialists on the proportion of oaks in the surrounding forest was investigated by using flight interception traps (67 on oak, 19 on beech). As target species, saproxylic and herbivorous Coleoptera and Heteroptera were sampled. The following two hypotheses were tested: (1) The proportion of oak specialists differs for oaks in beech forests and oaks in oak forests. (2) The proportion of oak specialists increases with the proportion of oaks in the surrounding forest. For all species groups, the proportion of oak specialists was higher in oak crowns than in beech crowns. Herbivorous beetles and true bugs showed a higher proportion of specialists in oak forests than on single oaks in beech forests. The proportion of herbivorous oak specialists increased significantly with increasing numbers of adjacent oak trees, while saproxylic Coleoptera showed no relationship to oak density. For herbivorous Coleoptera a threshold of higher proportion occurred where >30% oak was present, and for Heteroptera a first threshold was identified at values >70% and a second at >30%. This indicates that larger habitat patches within a closed forest canopy matrix support larger populations of herbivorous oak specialists. Hence, similar effects of spatial isolation might occur in a closed forest as have already been shown for highly fragmented open landscapes. [source] ELECTRICAL CONDUCTIVITY AND KINETIC PARAMETERS OF RICE STARCHJOURNAL OF FOOD PROCESS ENGINEERING, Issue 5 2007E. MORALES SANCHEZ ABSTRACT In the present work, rice starch was studied by differential scanning calorimetry (DSC) and electrical conductivity as a function of temperature. The gelatinization temperature was calculated using both methods. Three stages of electrical conductivity were found. When the logarithm of conductivity was plotted versus temperature, the data have been well adjusted to the linear equation, indicating that a model for conductivity may be created using an Arrhenius-type expression to obtain kinetic parameters such as onset, peakset, endset temperatures and gelatinization energy (Eg). The conductivity Eg was calculated and compared to the enthalpy H calculated from the DSC data. It was found that Eg and enthalpy are similar processes. We conclude that electrical conductivity is an alternative method for the study of starch,water mixtures. PRACTICAL APPLICATIONS This research provides a new methodology to obtain kinetic parameters such as temperature of the beginning, medium and ending of gelatinizaiton, which are important for determining the cooking range needed to obtain desired characteristics in a processed starch-containing food. [source] Idealized design of perinatal careJOURNAL OF HEALTHCARE RISK MANAGEMENT, Issue S1 2006Faith McLellan PhD Idealized Design of Perinatal Care is an innovation project based on the principles of reliability science and the Institute for Healthcare Improvement's (IHI's) model for applying these principles to improve care.1 The project builds upon similar processes developed for other clinical arenas in three previous IHI Idealized Design projects. The Idealized Design model focuses on comprehensive redesign to enable a care system to perform substantially better in the future than the best it can do at present. The goal of Idealized Design of Perinatal Care is to achieve a new level of safer, more effective care and to minimize some of the risks identified in medical malpractice cases. The model described in this white paper, Idealized Design of Perinatal Care, represents the Institute for Healthcare Improvement's best current assessment of the components of the safest and most reliable system of perinatal care. The four key components of the model are: 1) the development of reliable clinical processes to manage labor and delivery; 2) the use of principles that improve safety (i.e., preventing, detecting, and mitigating errors); 3) the establishment of prepared and activated care teams that communicate effectively with each other and with mothers and families; and 4) a focus on mother and family as the locus of control during labor and delivery. Reviews of perinatal care have consistently pointed to failures of communication among the care team and documentation of care as common factors in adverse events that occur in labor and delivery. They are also prime factors leading to malpractice claims.2 Two perinatal care "bundles", a group of evidence-based interventions related to a disease or care process that, when executed together, result in better outcomes than when implemented individually , are being tested in this Idealized Design project: the Elective Induction Bundle and the Augmentation Bundle. Experience from the use of bundles in other clinical areas, such as care of the ventilated patient, has shown that reliably applying these evidence-based interventions can dramatically improve outcomes.3 The assumption of this innovation work is that the use of bundles in the delivery of perinatal care will have a similar effect. The authors acknowledge that other organizations have also been working on improving perinatal care through the use of simulation training and teamwork and communication training. IHI's model includes elements of these methods. The Idealized Design of Perinatal Care project has two phases. Sixteen perinatal units from hospitals around the US participated in Phase I, from February to August 2005. The goals of Phase I were identifying changes that would make the most impact on improving perinatal care, selecting elements for each of the bundles, learning how to apply IHI's reliability model to improve processes, and improving the culture within a perinatal unit. This white paper provides detail about the Idealized Design process and examines some of the initial work completed by teams. Phase II, which began in September 2005, expands on this work. This phase focuses particularly on managing second stage labor, including common interpretation of fetal heart monitoring, developing a reliable tool to identify harm, and ensuring that patient preferences are known and honored. [source] A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animalsJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 5 2003Chris K. Connolly Abstract Fifty-two CFLP mice had an open femoral diaphyseal osteotomy held in compression by a four-pin external fixator. The movement of 34 of the mice in their cages was quantified before and after operation, until sacrifice at 4, 8, 16 or 24 days. Thirty-three specimens underwent histomorphometric analysis and 19 specimens underwent torsional stiffness measurement. The expected combination of intramembranous and endochondral bone formation was observed, and the model was shown to be reliable in that variation in the histological parameters of healing was small between animals at the same time point, compared to the variation between time-points. There was surprisingly large individual variation in the amount of animal movement about the cage, which correlated with both histomorphometric and mechanical measures of healing. Animals that moved more had larger external calluses containing more cartilage and demonstrated lower torsional stiffness at the same time point. Assuming that movement of the whole animal predicts, at least to some extent, movement at the fracture site, this correlation is what would be expected in a model that involves similar processes to those in human fracture healing. Models such as this, employed to determine the effect of experimental interventions, will yield more information if the natural variation in animal motion is measured and included in the analysis. © 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved. [source] "The Other" and "The Enemy": Reflections on Fieldwork in UtahNORTH AMERICAN DIALOGUE (ELECTRONIC), Issue 1 2007Julie Brugger This paper is a reflection on doing anthropology in the United States, based on my research of the Grand Staircase-Escalante National Monument, a "protected area" in southern Utah. My research focuses on the meaning and practice of democracy in the United States by examining the impact of conservation policies on rural resource users. I question why social scientists who study conservation are able to see injustices in the protected area model when applied in "the Global South," but have not aimed critique at similar processes occurring in the U.S. Reflecting on the post fieldwork experiences of scholars Susan Harding, Faye Ginsburg, and James McCarthy, I suggest that, for American anthropologists, some "repugnant others" in the U.S. represent a threatening "enemy," while in other settings, they may not be perceived in this way. I conclude by suggesting we "write democratically" in order to overcome this limitation and realize the transformative potential of ethnography. [source] ,Bubble chamber model' of fast atom bombardment induced processesRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 15 2003Marina V. Kosevich A hypothesis concerning FAB mechanisms, referred to as a ,bubble chamber FAB model', is proposed. This model can provide an answer to the long-standing question as to how fragile biomolecules and weakly bound clusters can survive under high-energy particle impact on liquids. The basis of this model is a simple estimation of saturated vapour pressure over the surface of liquids, which shows that all liquids ever tested by fast atom bombardment (FAB) and liquid secondary ion mass spectrometry (SIMS) were in the superheated state under the experimental conditions applied. The result of the interaction of the energetic particles with superheated liquids is known to be qualitatively different from that with equilibrium liquids. It consists of initiation of local boiling, i.e., in formation of vapour bubbles along the track of the energetic particle. This phenomenon has been extensively studied in the framework of nuclear physics and provides the basis for construction of the well-known bubble chamber detectors. The possibility of occurrence of similar processes under FAB of superheated liquids substantiates a conceptual model of emission of secondary ions suggested by Vestal in 1983, which assumes formation of bubbles beneath the liquid surface, followed by their bursting accompanied by release of microdroplets and clusters as a necessary intermediate step for the creation of molecular ions. The main distinctive feature of the bubble chamber FAB model, proposed here, is that the bubbles are formed not in the space and time-restricted impact-excited zone, but in the nearby liquid as a ,normal' boiling event, which implies that the temperature both within the bubble and in the droplets emerging on its burst is practically the same as that of the bulk liquid sample. This concept can resolve the paradox of survival of intact biomolecules under FAB, since the part of the sample participating in the liquid,gas transition via the bubble mechanism has an ambient temperature which is not destructive for biomolecules. Another important feature of the model is that the timescale of bubble growth is no longer limited by the relaxation time of the excited zone (,10,12,s), but rather resembles the timescale characteristic of common boiling, sufficient for multiple interactions of gas molecules and formation of clusters. Further, when the bubbles burst, microdroplets are released, which implies that FAB processes are similar to those in spraying techniques. Thus, two processes contribute to the ion production, namely, release of volatile solvent clusters from bubbles and of non-volatile solute from sputtered droplets. This view reconciles contradictory views on the dominance of either gas-phase or liquid-phase effects in FAB. Some other effects, such as suppression of all other ions by surface-active compounds, are consistent with the suggested model. Copyright © 2003 John Wiley & Sons, Ltd. [source] Manually controlled human balancing using visual, vestibular and proprioceptive senses involves a common, low frequency neural processTHE JOURNAL OF PHYSIOLOGY, Issue 1 2006Martin Lakie Ten subjects balanced their own body or a mechanically equivalent unstable inverted pendulum by hand, through a compliant spring linkage. Their balancing process was always characterized by repeated small reciprocating hand movements. These bias adjustments were an observable sign of intermittent alterations in neural output. On average, the adjustments occurred at intervals of ,400 ms. To generate appropriate stabilizing bias adjustments, sensory information about body or load movement is needed. Subjects used visual, vestibular or proprioceptive sensation alone and in combination to perform the tasks. We first ask, is the time between adjustments (bias duration) sensory specific? Vision is associated with slow responses. Other senses involved with balance are known to be faster. Our second question is; does bias duration depend on sensory abundance? An appropriate bias adjustment cannot occur until unplanned motion is unambiguously perceived (a sensory threshold). The addition of more sensory data should therefore expedite action, decreasing the mean bias adjustment duration. Statistical analysis showed that (1) the mean bias adjustment duration was remarkably independent of the sensory modality and (2) the addition of one or two sensory modalities made a small, but significant, decrease in the mean bias adjustment duration. Thus, a threshold effect can alter only a very minor part of the bias duration. The bias adjustment duration in manual balancing must reflect something more than visual sensation and perceptual thresholds; our suggestion is that it is a common central motor planning process. We predict that similar processes may be identified in the control of standing. [source] Interrogating the production of urban space in China and Vietnam under market socialismASIA PACIFIC VIEWPOINT, Issue 2 2009Terry G. McGee Abstract This paper explores two issues. First, it focuses on the question of what is the most appropriate theoretical framework for the study of the urbanisation process in China and Vietnam over the last 30 years? It is argued that Le Fefebvre's theory of the ,production of urban space' offers the most useful approach because the political economy it adopts helps identify the major driving forces in the urbanisation process in these formerly socialist societies. The second issue involves the investigation of the differences and similarities in the urbanisation process in the two countries that are engaged in similar processes of structural economic transformation. The conclusion suggests that despite historical and cultural differences between Vietnam and China, the urbanisation process in both countries is exhibiting converging features as both countries are adopting a form of ,hybrid urbanisation' that involves a combination of socialist and market economies that does not involve an inevitable move to ,capitalism'. [source] A warm thermal enclave in the Late Pleistocene of the South-eastern United StatesBIOLOGICAL REVIEWS, Issue 2 2009Dale A. Russell ABSTRACT Physical and biological evidence supports the probable existence of an enclave of relatively warm climate located between the Southern Appalachian Mountains and the Atlantic Ocean in the United States during the Last Glacial Maximum. The region supported a mosaic of forest and prairie habitats inhabited by a "Floridian" ice-age biota. Plant and vertebrate remains suggest an ecological gradient towards Cape Hatteras (35°N) wherein forests tended to replace prairies, and browsing proboscideans tended to replace grazing proboscideans. Beyond 35°N, warm waters of the Gulf Stream were deflected towards the central Atlantic, and a cold-facies biota replaced "Floridian" biota on the Atlantic coastal plain. Because of niche diversity and relatively benign climate, biodiversity may have been greater in the south-eastern thermal enclave than in other unglaciated areas of North America. However, the impact of terminal Pleistocene megafaunal extinctions may also have been shorter and more severe in the enclave than further north. A comparison with biotic changes that occurred in North America approximately 55 million years (ma) ago at the Paleocene-Eocene Thermal Maximum suggests that similar processes of change took place under both ice-house and greenhouse climates. [source] DNA Microarrays: Experimental Issues, Data Analysis, and Application to Bacterial SystemsBIOTECHNOLOGY PROGRESS, Issue 5 2004Yandi Dharmadi DNA microarrays are currently used to study the transcriptional response of many organisms to genetic and environmental perturbations. Although there is much room for improvement of this technology, its potential has been clearly demonstrated in the past 5 years. The general consensus is that the bottleneck is now located in the processing and analysis of transcriptome data and its use for purposes other than the quantification of changes in gene expression levels. In this article we discuss technological aspects of DNA microarrays, statistical and biological issues pertinent to the design of microarray experiments, and statistical tools for microarray data analysis. A review on applications of DNA microarrays in the study of bacterial systems is presented. Special attention is given to studies in the following areas: (1) bacterial response to environmental changes; (2) gene identification, genome organization, and transcriptional regulation; and (3) genetic and metabolic engineering. Soon, the use of DNA microarray technologies in conjunction with other genome/system-wide analyses (e.g., proteomics, metabolomics, fluxomics, phenomics, etc.) will provide a better assessment of genotype-phenotype relationships in bacteria, which serve as a basis for understanding similar processes in more complex organisms. [source] Low-Temperature Plasticity of Naturally Deformed Calcite RocksACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 3 2002LIU Junlai Abstract Optical, cathodoluminescence and transmission electron microscope (TEM) analyses were conducted on four groups of calcite fault rocks, a cataclastic limestone, cataclastic coarse-grained marbles from two fault zones, and a fractured mylonite. These fault rocks show similar microstructural characteristics and give clues to similar processes of rock deformation. They are characterized by the structural contrast between macroscopic cataclastic (brittle) and microscopic mylonitic (ductile) microstructures. Intragranular deformation microstructures (i.e. deformation twins, kink bands and microfractures) are well preserved in the deformed grains in clasts or in primary rocks. The matrix materials are of extremely fine grains with diffusive features. Dislocation microstructures for co-existing brittle deformation and crystalline plasticity were revealed using TEM. Tangled dislocations are often preserved at the cores of highly deformed clasts, while dislocation walls form in the transitions to the fine-grained matrix materials and free dislocations, dislocation loops and dislocation dipoles are observed both in the deformed clasts and in the fine-grained matrix materials. Dynamic recrystallization grains from subgrain rotation recrystallization and subsequent grain boundary migration constitute the major parts of the matrix materials. Statistical measurements of densities of free dislocations, grain sizes of subgrains and dynamically recrystallized grains suggest an unsteady state of the rock deformation. Microstructural and cathodoluminescence analyses prove that fluid activity is one of the major parts of faulting processes. Low-temperature plasticity, and thereby induced co-existence of macroscopic brittle and microscopic ductile microstructures are attributed to hydrolytic weakening due to the involvement of fluid phases in deformation and subsequent variation of rock rheology. During hydrolytic weakening, fluid phases, e.g. water, enhance the rate of dislocation slip and climb, and increase the rate of recovery of strain-hardened rocks, which accommodates fracturing. [source] | ||||||||||||||||||||||