Home About us Contact
|
Home About us Contact | ||
|
|
||
Similar Evidence (similar + evidence)
Selected AbstractsThe adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?JOURNAL OF APPLIED TOXICOLOGY, Issue 2 2003Philip W. Harvey Abstract Current testing strategies to assess the endocrine disrupting properties of chemicals have omitted examination of the adrenal gland and do not adequately cover the process of steroidogenesis. Steroidogenesis is critical for adrenocortical function as well as that of the testes and ovaries, and presents multiple molecular targets for toxicity, ranging from general effects on all steroidogenic tissues (e.g. via StAR protein or CYP11A1 cholesterol side-chain cleavage) through to speci,c targets affecting only adrenocortical function (e.g. CYP11,/18 and glucocorticoid synthesis). Numerous chemicals of environmental relevance are now being shown to affect adrenocortical function both in vivo in aquatic species and in vitro in human cell lines, and given the vital role of the adrenal gland to human health and development, there is a strong case for including dedicated assessment techniques in screening batteries for endocrine-disrupting chemicals, not least to assist in general data interpretation (e.g. whether adrenal hypertrophy is due to stress or to a more sinister adrenocortical insuf,ciency). Cell lines such as H295R (derived from a human adrenocortical adenocarcinoma) currently exist that will allow assessment of cortisol production and most of the major enzymes and functional proteins in the steroidogenic pathway (e.g. StAR; CYP11A1/scc; CYP11,/18; CYP17; CYP19; CYP21; 3, -hydroxysteroid dehydrogenase). Adequate assessment of adrenocortical function, as with any component of the integrated endocrine system, probably also will require the development of speci,c in vivo methodology to include effects on hypothalamo-pituitary function. Finally, although there is currently no direct evidence that environmental exposure to endocrine-disrupting (oestrogenic) chemicals has actually caused adverse human health effects, lessons have been learned on their potential from the diethylstilboestrol case. Similar evidence exists from aminoglutethimide and etomidate on the lethal impact of unpredicted chemically induced adrenal insuf,ciency in sensitive human subgroups, and it would seem prudent to incorporate relevant tests for adrenal function and steroidogenesis into current regulatory validation programmes. Published in 2003 by John Wiley & Sons, Ltd. [source] Science and its application in assessing the welfare of laying hens in the egg industryAUSTRALIAN VETERINARY JOURNAL, Issue 10 2003JL BARNETT Objective To provide a rational framework for the scientific assessment of welfare and to use this framework to assess the welfare implications of issues relevant to the Australian egg industry. Procedure A well-accepted approach to the assessment of animal welfare, based on assessing how well the animal is adapting, is described. This approach is used to consider the welfare implications of issues such as space, perches, nest boxes, dust baths, abrasive strips and non-cage housing systems. Conclusions The role of science in the welfare debate is to provide biological facts and thus it is important to separate welfare and ethics. The welfare of an animal in response to a housing system or husbandry procedure can be assessed by evaluating how much has to be done by the animal in order to cope and the extent to which the coping attempts are succeeding. Using this approach there is evidence for improved welfare from increasing space in cages, based on reduced aggression, corticosterone concentrations and mortalities and increased production, and for incorporating perches, based on the reduction in injuries at depopulation. Similar evidence for the inclusion of dust baths and nest boxes is lacking. The data on abrasive strips are equivocal with recommendations from overseas for their inclusion, whereas some local data have shown an increase in mortality can occur. Similarly, the data on non-cage systems are equivocal. The data on bone strength suggest improved fitness in non-cage systems, the data on stress suggest fitness may be better, similar or worse in non-cage systems, and the limited data on immunology suggest fitness may be worse in non-cage systems than in conventional cages. [source] Are psychiatrists affecting the legal process by answering legal questions?CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2008Timothy Hardie Background,Psychiatrists are often asked to answer legal questions. The extent to which they answer strictly legal rather than medical matters is not known. Aim,To investigate how strongly psychiatrists in England and Wales express opinions on one legal question , that of diminished responsibility in respect of a murder charge, and how this is related to outcome in court. Method,Our data were extracted from psychiatric reports and case files supplied by the then Department of Constitutional Affairs (now the Ministry of Justice) on cases heard in the Crown Courts between 1 January 1997 and 31 December 2001 in which the defence of diminished responsibility had been raised. The cases had been selected by the Law Commission in their earlier review of partial defences to murder. We devised a reliable system of rating the presence/absence and strength of expression of a legal opinion in the medical reports. We tested the data for relationship between nature and strength of opinion and progression to trial and verdict. Results,Psychiatric reports were available on 143 of 156 cases in which diminished responsibility was considered. They yielded 338 opinions on at least one aspect of diminished responsibility. In 110 (93%) of the 118 cases in which there was a diminished verdict, this was made without trial and, therefore, without reference to a jury. In only eight (27%) out of the 30 cases that went to trial, was a diminished responsibility verdict made. Half of the reports (169) gave a clear opinion on diminished responsibility, a third (121) invited the court to draw a particular conclusion and only 11% (36) provided relevant evidence without answering the legal questions. When there was an opinion or an invitation to make a finding on the legal question, a trial was less likely. A trial was also less likely if reports agreed on what the verdict should be. Conclusions,Psychiatrists frequently answer the legal question of diminished responsibility. The judiciary and medical experts should join in research to examine the consequences of different styles or approaches in presentation of essentially similar evidence in court. Copyright © 2008 John Wiley & Sons, Ltd. [source] Do Crises Induce Reform?ECONOMICS & POLITICS, Issue 2 2001Simple Empirical Tests of Conventional Wisdom We find evidence for the crisis-induces-reform hypothesis at extreme values of the inflation rate and the black market premium. Episodes of extremely high inflation or black market premiums are followed by periods of better performance than episodes of moderately high inflation or black market premiums. We fail to find similar evidence of the crisis hypothesis when crisis is measured as a high current account deficit, a high budget deficit, or a negative per capita growth rate. The pattern of foreign aid disbursements may help explain the results. Foreign aid is reduced at extreme values of inflation or the black market premium, while it is actually increased for more extreme values of the current account deficit and the budget deficit. [source] Ownership Concentration in Privatized Firms: The Role of Disclosure Standards, Auditor Choice, and Auditing InfrastructureJOURNAL OF ACCOUNTING RESEARCH, Issue 5 2006OMRANE GUEDHAMI ABSTRACT We rely on a unique data set to estimate the impact of disclosure standards and auditor-related characteristics on ownership concentration in 190 privatized firms from 31 countries. Accounting transparency can help alleviate the agency conflict between minority investors and controlling shareholders, which is evident in the extent of ownership concentration, since the expropriation of corporate resources hinges on these private benefits remaining hidden. After controlling for other country-level and firm-level determinants, we find weak (no) evidence that extensive disclosure standards (auditor choice) reduce ownership concentration. In contrast, we report strong, robust evidence that ownership concentration is lower in countries with securities laws that specify a lower burden of proof in civil and criminal litigation against auditors, consistent with Ball's [2001] predictions. Collectively, our research implies that minority investors worldwide value legal institutions that discipline auditors in the event of financial reporting failure over both the presence of a Big 5 auditor and better disclosure standards. Re-estimating our regressions on a broad sample of western European public firms provides similar evidence on all of our predictions. [source] Timing of Plk1 and MPF activation during porcine oocyte maturation,MOLECULAR REPRODUCTION & DEVELOPMENT, Issue 1 2004Martin Anger Abstract A Polo-like kinase 1 (Plk1) appears involved in an autocatalytic loop between CDC25C phosphatase and M phase promoting factor (MPF) in Xenopus oocytes and leads to activation of MPF that is required for germinal vesicle breakdown (GVBD). Although similar evidence for such a role of Plk1 in MPF activation during maturation of mammalian oocytes is absent, changes in Plk1 enzyme activity correlate with MPF activation, Plk1 co-localizes with MPF, and microinjection of antibodies neutralizing Plk1 delays GVBD. In this study, we exploited the prolonged time required for maturation of porcine oocytes to define precisely the timing of Plk1 and MPF activation during maturation. GVBD typically occurs between 24 and 26 hr of culture in vitro and meiotic maturation is completed after 40,44-hr culture. We find that Plk1 is activated before MPF, which is consistent with its role in activating MPF in mammalian oocytes. Mol. Reprod. Dev. 69: 11,16, 2004. © 2004 Wiley-Liss, Inc. [source] Regional economic performance in China1THE ECONOMICS OF TRANSITION, Issue 1 2003Ajit Bhalla Abstract This paper investigates convergence patterns among China's provinces using GDP data for the period 1952,97. We analyze convergence behaviour on the basis of Markov chains proposed by Quah (1993) and the generalized entropy decomposition proposed by Shorrocks (1980, 1984). Both sets of results show similar evidence of convergence within the pre-defined geo-economic sub-regions, but no evidence is found of convergence between the sub-regions. This finding has important policy implications for regional economic development in China. JEL classification: C33, E20, O47. [source] Phonological memory as a predictor of language comprehension in Down syndrome: a five-year follow-up studyTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 2 2004Glynis Laws Background:, This study reports the language and memory progress over five years of 30 adolescents and young adults with Down syndrome, and investigates the relationship of earlier phonological memory abilities to later language development. Methods:, Tests of nonverbal ability, receptive vocabulary, grammar comprehension, digit span and nonword repetition were administered at two points in time. Results:, For the sample as a whole, there were significant gains in nonverbal ability, receptive vocabulary and grammar comprehension, but no increases in phonological memory measured by nonword repetition or digit span. However, there were considerable individual differences in progress which, in part, were related to chronological age. Phonological memory improved in many younger participants but there were signs of decline in some older ones. Partial correlations between earlier nonword repetition scores and later language scores, controlling for nonverbal ability and earlier language scores, indicated a significant role for phonological memory in the acquisition of vocabulary knowledge. There was similar evidence of a role for phonological memory in grammar comprehension, but only for younger participants. Earlier receptive vocabulary also predicted later nonword repetition scores, particularly for participants with higher levels of vocabulary knowledge. Conclusion:, Relationships among the processes involved in language and memory development in Down syndrome may be similar to those established for typical development. [source] Superficial lizards in cold climates: Nest site choice along an elevational gradientAUSTRAL ECOLOGY, Issue 7 2009J. SEAN DOODY Abstract Embryonic conditions may limit the distributions of egg-laying ectotherms, and recent research suggests that nesting mothers of wide-ranging species may use a number of factors to compensate for differing climates. However, while variation in temporal factors across environmental gradients are common or pervasive (i.e. seasonal timing of nesting), similar evidence for spatial factors is rare (e.g. aspect, openness and depth of nest sites). I tested the idea that a wide-ranging lizard, the Australia water dragon (Physignathus lesueurii), uses nest depth to counter climate differences along a temperature cline at their cold-end range margin. Two measures of nest depth were significantly, inversely related to elevation across six populations spanning 700 m. Elevation explained 83,86% of the variation in nest depth. These findings support a thermal compensatory mechanism for this pattern, although soil moisture compensation is plausible. My results directly support a recent, untested prediction that the evolution of viviparity in reptiles is preceded by a behavioural shift towards increasingly superficial nest sites in cold climates, followed by selection for increased egg retention to avoid temperature extremes. However, in the present study egg desiccation rates increased with increasing elevation in a dry year, suggesting that increased egg retention may evolve in response to lethal hydric conditions, rather than lethal temperatures. When considered alongside recent research, the present study indicates that water dragons possess several mechanisms for adjusting to climate change. [source] | ||||||||||||||||