			Home About us Contact

Significant Force (significant + force)

Distribution by Scientific Domains

Medical Sciences	40%

Selected Abstracts

Pedophiles and Cyber-predators as Contaminating Forces: The Language of Disgust, Pollution, and Boundary Invasions in Federal Debates on Sex Offender Legislation

LAW & SOCIAL INQUIRY, Issue 3 2002
Mona Lynch
As a distinct class of criminals, sex offenders stand out as being particularly subject to the new "risk management" penal strategies that, according to a number of scholars, have come to dominate punishment rhetoric and practices in recent years. Nonetheless, the criminal justice policymaking that targets sex offenders appears to have a more emotionally based underside. In this paper, I examine the emotional drive that appears to undergird contemporary sex offender lawmaking, suggesting that a significant force propelling the current panoply of sex offender containment strategies is a constellation of emotional expressions of disgust, fear of contagion, and pollution avoidance, manifested in a legislative concern about boundary vulnerabilities between social spheres of the pure and the dangerous. To do so, I analyze the lawmaking discourse of U. S. legislators as they debated four proposed legislative bills directed at sex offenders during the late 1990s. [source]

Use of the U-clip for microvascular anastomosis

MICROSURGERY, Issue 8 2006
Jesse Taylor M.D.
Microvascular anastomosis is a demanding skill requiring technical excellence and a thorough knowledge of anatomy and physiology. Every suture placed in a microvascular anastomosis should be considered critical as each has the potential to compromise the delicate reconstruction. As such, any device that can facilitate microvascular suture placement deserves thorough evaluation. The U-clip (Coalescent Surgical, Sunnyvale, CA) is such a device in that it eliminates the often time consuming process of tying knots. We evaluated use of the U-clip in microvascular anastomosis of a 1.5 mm artery. We found the U-clip to offer some advantages including ease of use, traditional feel of directed suture placement (as compared to couplers), and elimination of time needed for knot tying. Its shortcomings include size (in diameter, the "pop-off" section of the device appears larger than standard 8-0 suture), the significant force required to "pop-off" the device and difficulty removing the device. © 2006 Wiley-Liss, Inc. Microsurgery, 2006. [source]

Phillips and Eternal Life: A Response to Haldane

PHILOSOPHICAL INVESTIGATIONS, Issue 3 2008
Mikel Burley
This paper responds to John Haldane's recent criticisms of D. Z. Phillips' treatment of the Christian belief in eternal life. I argue that Haldane's attempt to show that Phillips only partially elucidates, and hence misrepresents, this belief is unsuccessful, the biblical and theological passages cited by Haldane being amenable to elucidation in terms of which Phillips would have approved. Haldane makes three points to support his main claim, and I argue that none of these has significant force against Phillips' position unless we presuppose the truth of some realist account of meaning, which Phillips would, of course, reject. [source]

Sense of coherence and social support predict living liver donors' emotional stress prior to living-donor liver transplantation

CLINICAL TRANSPLANTATION, Issue 3 2008
Yesim Erim
Abstract:, The protection of the donors from physical or emotional harm has been a fundamental principle in living-donor liver donation from the beginning. Psychosomatic donor evaluation aims at the selection of eligible donors and the screening and exclusion of psychiatrically vulnerable donors. As clinical interviews may include subjective biases, efforts should be made to establish objective criteria for donor assessment. In recent research, protective factors have been reported to be a significant force behind healthy adjustment to life stresses and can be investigated as possible predictors of donors' eligibility. Being the central construct of Antonovsky's theory of salutogenesis, the sense of coherence is one of the most surveyed protective factors and a good predictor of individuals' stability when experiencing stress. Furthermore, family support has been shown to be a valuable protective resource in coping with stress. This study surveyed whether sense of coherence and social support predict donors' emotional strain prior to transplantation. Seventy-one donor candidates were included in the study during the donor evaluation prior to living-donor liver transplantation. Sense of coherence proved to be a significant predictor for all criterion variables, namely anxiety, depression and mental quality of life. In addition to this, donor candidates who were classified as eligible for donation in the psychosomatic interview had significantly higher values on sense of coherence total scores compared with rejected donors. In a multiple regression analysis, sense of coherence and social support together yielded a prediction of depression with an explained variance of 22% (R2 = 0.22). Sense of coherence and social support can be implemented as self-rating instruments in the psychosomatic selection of donors and would help to further objectify donors' eligibility. [source]

Characterization of the Biomechanical Properties of T4 Pili Expressed by Streptococcus pneumoniae,A Comparison between Helix-like and Open Coil-like Pili

CHEMPHYSCHEM, Issue 9-10 2009
Mickaël Castelain Dr.
Abstract Adhesion strategies: Open coil-like T4 pili use different adhesion strategies in the presence of external forces (see figure) compared to the helix-like P pili. When exposed to significant forces, bacteria expressing helix-like pili remain attached by distributing the external force among a multitude of pili, whereas bacteria expressing open coil-like pili sustain large forces primarily by their multitude of binding adhesins. Bacterial adhesion organelles, known as fimbria or pili, are expressed by Gram-positive as well as Gram-negative bacteria families. These appendages play a key role in the first steps of the invasion and infection processes, and they therefore provide bacteria with pathogenic abilities. To improve the knowledge of pili-mediated bacterial adhesion to host cells and how these pili behave under the presence of an external force, we first characterize, using force measuring optical tweezers, open coil-like T4 pili expressed by Gram-positive Streptococcus pneumoniae with respect to their biomechanical properties. It is shown that their elongation behavior can be well described by the worm-like chain model and that they possess a large degree of flexibility. Their properties are then compared with those of helix-like pili expressed by Gram-negative uropathogenic Escherichia coli (UPEC), which have different pili architecture. The differences suggest that these two types of pili have distinctly dissimilar mechanisms to adhere and sustain external forces. Helix-like pili expressed by UPEC bacteria adhere to host cells by single adhesins located at the distal end of the pili while their helix-like structures act as shock absorbers to dampen the irregularly shear forces induced by urine flow and to increase the cooperativity of the pili ensemble, whereas open coil-like pili expressed by S. pneumoniae adhere to cells by a multitude of adhesins distributed along the pili. It is hypothesized that these two types of pili represent different strategies of adhering to host cells in the presence of external forces. When exposed to significant forces, bacteria expressing helix-like pili remain attached by distributing the external force among a multitude of pili, whereas bacteria expressing open coil-like pili sustain large forces primarily by their multitude of binding adhesins which presumably detach sequentially. [source]