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Significant Contribution (significant + contribution)
Selected AbstractsHenry George and Classical Growth Theory: A Significant Contribution to Modeling Scale EconomiesAMERICAN JOURNAL OF ECONOMICS AND SOCIOLOGY, Issue 1 2001John Whitaker It is widely recognized that the analysis of economic growth in Henry George's Progress and Poverty was considerably influenced by the British classical tradition, especially the writings of Adam Smith, David Ricardo, and John Stuart Mill. What has been less clearly perceived is that George made significant extensions to the classical theory. This paper's aim is to provide an interpretation, and to some extent a "rational reconstruction," of George's positive analysis, largely leaving aside the striking normative lessons he drew from it. George's unsatisfactory treatment of capital is disposed of in Section I, while Section II,the core of the paper,follows George's lead in aggregating capital and labor into a single productive factor which is employed in a given natural environment. Section III adds the complication of improvement in the arts of production, and Section IV deals briefly with George's views on land speculation. Section V assesses, comparing George with his contemporary Alfred Marshall. [source] Mini-series: Significant contributions to biological chemistry over the past 125 years: Biochemistry in the United States in the first half of the twentieth centuryBIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, Issue 2 2002Mildred Cohn First page of article [source] The origins and present status of the radio wave controversy in NMRCONCEPTS IN MAGNETIC RESONANCE, Issue 4 2009D.I. Hoult Abstract The origins, history, and present status of the controversy surrounding a quantum description of the NMR signal as being due to radio waves are traced. With the Principle of Relativity and Coulomb's Law as formal starting points and the minimum of mathematics needed for understanding, the derivation of a classical electromagnetic theory of signal reception is first given. The agreement between that classical theory and a recent NMR experiment is then presented, leading to proof that, except for the highest field imaging experiments, there is no significant contribution of radio waves to the signal. Attention is drawn to the very different properties of the near and far energy, momenta, and fields inherent in the derivation. The role of the Correspondence Principle in formulating a quantum description is then emphasized and it is shown that the standard NMR interpretation of Dicke's theory of coherent spontaneous emission,that the latter is responsible for the NMR signal,cannot be correct. Finally, the author speculates on some of the intriguing relationships found in the classical electrodynamics of NMR signal reception and attempts to relate them to a common quantum electrodynamic precept of near field interaction: that the free induction decay voltage present at the terminals of an open-circuit receiving coil is based on an exchange of virtual photons between the nuclei in a sample and the free electrons in a receiving coil. © 2009 Crown in the right of Canada. Concepts Magn Reson Part A 34A: 193,216, 2009. [source] Potassium-transporting proteins in skeletal muscle: cellular location and fibre-type differencesACTA PHYSIOLOGICA, Issue 2 2010M. Kristensen Abstract Potassium (K+) displacement in skeletal muscle may be an important factor in the development of muscle fatigue during intense exercise. It has been shown in vitro that an increase in the extracellular K+ concentration ([K+]e) to values higher than approx. 10 mm significantly reduce force development in unfatigued skeletal muscle. Several in vivo studies have shown that [K+]e increases progressively with increasing work intensity, reaching values higher than 10 mm. This increase in [K+]e is expected to be even higher in the transverse (T)-tubules than the concentration reached in the interstitium. Besides the voltage-sensitive K+ (Kv) channels that generate the action potential (AP) it is suggested that the big-conductance Ca2+ -dependent K+ (KCa1.1) channel contributes significantly to the K+ release into the T-tubules. Also the ATP-dependent K+ (KATP) channel participates, but is suggested primarily to participate in K+ release to the interstitium. Because there is restricted diffusion of K+ to the interstitium, K+ released to the T-tubules during AP propagation will be removed primarily by reuptake mediated by transport proteins located in the T-tubule membrane. The most important protein that mediates K+ reuptake in the T-tubules is the Na+,K+ -ATPase ,2 dimers, but a significant contribution of the strong inward rectifier K+ (Kir2.1) channel is also suggested. The Na+, K+, 2Cl, 1 (NKCC1) cotransporter also participates in K+ reuptake but probably mainly from the interstitium. The relative content of the different K+ -transporting proteins differs in oxidative and glycolytic muscles, and might explain the different [K+]e tolerance observed. [source] Learning from New Product Development Projects: An Exploratory StudyCREATIVITY AND INNOVATION MANAGEMENT, Issue 4 2005Ursula Koners Knowledge generation is a cornerstone of new product development, and post-project reviews (PPRs) are widely recognized as a facilitator of project-to-project learning. Empirical research on PPRs is sparse, so this paper describes four in-depth exploratory case studies that look at how PPRs are conducted and the learning that can result. The results indicate that appropriately managed PPRs can make a significant contribution to knowledge generation and exchange. In addition, the study indicates the urgent need for more research into this important area. [source] The contribution of active medication to combined treatments of psychotherapy and pharmacotherapy for adult depression: a meta-analysisACTA PSYCHIATRICA SCANDINAVICA, Issue 6 2010P. Cuijpers Cuijpers P, van Straten A, Hollon SD, Andersson G. The contribution of active medication to combined treatments of psychotherapy and pharmacotherapy for adult depression: a meta-analysis. Objective:, Although there is sufficient evidence that combined treatments of psychotherapy and pharmacotherapy are more effective for depression in adults than each of the treatments alone, it remains unclear what the exact contribution of active medication is to the overall effects of combined treatments. This paper examines the contribution of active medication to combined psychotherapy and pharmacotherapy treatments. Method:, Meta-analysis of randomised controlled trials comparing the combination of psychotherapy and pharmacotherapy with the combination of psychotherapy and placebo. Results:, Sixteen identified studies involving 852 patients met our inclusion criteria. The standardised mean difference indicating the differences between the combination of psychotherapy and pharmacotherapy and the combination of psychotherapy and placebo was 0.25 (95% CI: 0.03,0.46), which corresponds to a numbers-needed-to-be-treated of 7.14. No significant differences between subgroups of studies were found. Conclusion:, Active medication has a small but significant contribution to the overall efficacy of combined treatments. [source] Tackling the Down Side: Social Capital, Women's Empowerment and Micro-Finance in CameroonDEVELOPMENT AND CHANGE, Issue 3 2001Linda Mayoux Micro-finance programmes are currently dominated by the ,financial self-sustainability paradigm' where women's participation in groups is promoted as a key means of increasing financial sustainability while at the same time assumed to automatically empower them. This article examines the experience of seven micro-finance programmes in Cameroon. The evidence indicates that micro-finance programmes which build social capital can indeed make a significant contribution to women's empowerment. However, serious questions need to be asked about what sorts of norms, networks and associations are to be promoted, in whose interests, and how they can best contribute to empowerment, particularly for the poorest women. Where the complexities of power relations and inequality are ignored, reliance on social capital as a mechanism for reducing programme costs may undermine programme aims not only of empowerment but also of financial sustainability and poverty targeting. [source] Conservation biogeography , foundations, concepts and challengesDIVERSITY AND DISTRIBUTIONS, Issue 3 2010David M. Richardson Abstract Conservation biogeography involves the application of biogeographical principles, theories, and analyses to problems regarding biodiversity conservation. The field was formally defined in 2005, and considerable research has been conducted in the ensuing 5 years. This editorial sets the context for 16 contributions in a special issue of Diversity and Distributions on developments and challenges in conservation biogeography. Papers are grouped into the following main themes: species distribution modelling; data requirements; approaches for assigning conservation priorities; approaches for integrating information from numerous disparate sources; special challenges involving invasive species; and the crucial issue of determining how elements of biodiversity are likely to respond to rapid climate change. One paper provides a synthesis of requirements for a robust conservation biogeography for freshwater ecosystems. Conservation biogeography is well poised to make a significant contribution to the process of providing policy makers with objectively formulated scenarios and options for the effective management of biodiversity. The editorial, and the papers in the special issue, deliberate on many of the exciting developments in play in the field, and the many complex challenges that lie ahead. [source] Sediment production in large gullies of the Mediterranean area (NE Spain) from high-resolution digital elevation models and geographical information systems analysisEARTH SURFACE PROCESSES AND LANDFORMS, Issue 5 2003J. A. Martínez-Casasnovas Abstract Recent studies in the Mediterranean area have shown gully erosion to have a very significant contribution to total soil loss. In the Penedès vineyard region (NE Spain), between 15 and 27% of the land is affected by large gullies and gully-wall retreat seems to be an ongoing process. Multi-date digital elevation model (DEM) analysis has allowed computation of sediment production by gully erosion, showing that the sediment production rates are very high by the, up-to-date, usual global standards. Here, we present a study carried out using large-scale multi-date (1975 and 1995) aerial photographs (1 : 5000 and 1 : 7000) to monitor sediment yield caused by large gullies in the Penedès region (NE Spain). High-resolution DEMs (1 m grid) were derived and analysed by means of geographical information systems techniques to determine the gully erosion rates. Rainfall characteristics within the same study period were also analysed in order to correlate with the soil loss produced. Mass movement was the main process contributing to total sediment production. This process could have been favoured by rainfalls recorded during the period: 58% of the events were of an erosive character and showed high kinetic energy and erosivity. A sediment production rate of 846 ± 40 Mg ha,1 year,1, a sediment deposition rate of 270 ± 18 Mg ha,1 year,1 and a sediment delivery ratio of 68·1% were computed for a gully area of 0·10 km2. The average net erosion within the study period (1975,95) was 576 ± 58 Mg ha,1 year,1. In comparison with other methods, the proposed method also includes sediment produced by processes other than only overland flow, i.e. downcutting, headcutting, and mass movements and bank erosion. Copyright © 2003 John Wiley & Sons, Ltd. [source] Seismic behaviour of hybrid systems made of PR composite frames coupled with dissipative bracingsEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 6 2008C. Amadio Abstract The paper investigates the dynamic behaviour of hybrid systems made of partially restrained (PR) steel,concrete composite frames coupled with viscoelastic dissipative bracings. A numerical model that accounts for both the resisting mechanisms of the joint and the viscoelastic contribution of the dissipative bracing is introduced and briefly discussed. The model is first validated against experimental outcomes obtained on a one-storey two-bay composite frame with partial strength semi-rigid joints subjected to free vibrations. A number of time-history analyses under different earthquake ground motions and peak ground accelerations are then carried out on the same type of frame. The purpose is to investigate the influence of the type of beam-to-column connection and property of the viscoelastic bracing on the performance of the hybrid system. The inherent stiffness of the bare PR frame and the plastic hysteresis of the beam-to-column joints, which always lead to only limited damage in the joint, are found to provide a significant contribution to the overall structural performance even under destructive earthquakes. This remark leads to the conclusion that the viscoelastic bracing can be effectively used within the hybrid system. Copyright © 2008 John Wiley & Sons, Ltd. [source] Cover Picture: Electrophoresis 7'09ELECTROPHORESIS, Issue 7 2009Article first published online: 16 APR 200 Issue no. 7 is a special issue on "Biomarker Discovery and Related Topics". It has 18 articles distributed among four parts including genomic, proteomic, glycoproteomic and metabolomic markers. "New separation technologies, improvements of existing methods and intuitive, elegant applications are providing a representative snapshot on the "state-of-the-art" of the bioanalytical aspects of biomarker discovery today". In addition, as recognition of his significant contribution to the field, this special issue is dedicated to the 70th birthday of Professor Barry L. Karger. [source] New ways to break an old bond: the bacterial carbon,phosphorus hydrolases and their role in biogeochemical phosphorus cyclingENVIRONMENTAL MICROBIOLOGY, Issue 10 2007John P. Quinn Summary Phosphonates are organophosphorus molecules that contain the highly stable C,P bond, rather than the more common, and more labile, C,O,P phosphate ester bond. They have ancient origins but their biosynthesis is widespread among more primitive organisms and their importance in the contemporary biosphere is increasingly recognized; for example phosphonate-P is believed to play a particularly significant role in the productivity of the oceans. The microbial degradation of phosphonates was originally thought to occur only under conditions of phosphate limitation, mediated exclusively by the poorly characterized C,P lyase multienzyme system, under Pho regulon control. However, more recent studies have demonstrated the Pho-independent mineralization by environmental bacteria of three of the most widely distributed biogenic phosphonates: 2-aminoethylphosphonic acid (ciliatine), phosphonoacetic acid, and 2-amino-3-phosphonopropionic acid (phosphonoalanine). The three phosphonohydrolases responsible have unique specificities and are members of separate enzyme superfamilies; their expression is regulated by distinct members of the LysR family of bacterial transcriptional regulators, for each of which the phosphonate substrate of the respective degradative operon serves as coinducer. Previously no organophosphorus compound was known to induce the enzymes required for its own degradation. Whole-genome and metagenome sequence analysis indicates that the genes encoding these newly described C,P hydrolases are distributed widely among prokaryotes. As they are able to function under conditions in which C,P lyases are inactive, the three enzymes may play a hitherto-unrecognized role in phosphonate breakdown in the environment and hence make a significant contribution to global biogeochemical P-cycling. [source] Psychometric properties of the Attitudes Towards Body Figure Questionnaire in Mexican female students and patients with eating disordersEUROPEAN EATING DISORDERS REVIEW, Issue 6 2006Claudia Unikel Santoncini Abstract The aim of this article was to determine the psychometric characteristics of the Attitudes Towards Body Figure Questionnaire in a sample of Mexican female students and to compare them with a sample of patients with eating disorders. A self-applicable questionnaire with 15 questions on the importance of one's weight, and figure was given to a sample of students with an average age of 18 years in Mexico City (N,=,408) and a sample of patients under treatment (N,=,87). The results showed adequate values of internal consistency and a factorial structure in two highly correlated factors that was corroborated in a confirmatory factorial analysis. The questionnaire yielded data with adequate concurrent and predictive validity as well as appropriate values of sensitivity and specificity. This questionnaire constitutes a significant contribution to the field of research on eating disorders and body image in adolescents in Mexico that is why its use is recommended for research and prevention work in the area. Copyright © 2006 John Wiley & Sons, Ltd and Eating Disorders Association. [source] The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patientsEUROPEAN JOURNAL OF NEUROLOGY, Issue 8 2007C. Smestad The human leucocyte antigen (HLA) class II haplotype DRB1*15,DQB1*06 (DR15,DQ6) is associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS have also been reported. However, the influence of HLA class I and II alleles on clinical phenotypes in MS has not yet been completely studied. This study aimed at evaluating the impact of HLA-A and -DRB1 alleles on clinical variables in Scandinavian MS patients. The correlation between HLA-A or -DRB1 alleles and age at onset, disease course and Multiple Sclerosis Severity Score (MSSS) were studied in 1457 Norwegian and Swedish MS patients by regression analyses and Kruskal,Wallis rank sum test. Presence of HLA-DRB1*15 was correlated with younger age at onset of disease (corrected P = 0.009). No correlation was found between HLA-A and the variables studied. This study analysed the effect of HLA-A on clinical variables in a large Scandinavian sample set, but could not identify any significant contribution from HLA-A on the clinical phenotype in MS. However, associations between HLA-DRB1*15 and age at onset of MS were reproduced in this extended Scandinavian MS cohort. [source] Ultrastructural localization of salivary mucins MUC5B and MUC7 in human labial glandsEUROPEAN JOURNAL OF ORAL SCIENCES, Issue 1 2010Monica Piras Piras M, Hand AR, Tore G, Ledda GP, Piludu M. Ultrastructural localization of salivary mucins MUC5B and MUC7 in human labial glands. Eur J Oral Sci 2010; 118: 14,18. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci As a result of their presence throughout the mouth in the submucosa or between muscle fibers, minor salivary glands secrete directly and continuously into the oral cavity, providing mucosal surfaces with highly glycosylated proteins that are active in bacterial aggregation and in oral tissue lubrication. In this study, we investigated the ultrastructural localization of the MUC5B and MUC7 mucins in human labial glands by means of a postembedding immunogold technique. Thin sections of normal human labial glands, obtained during surgery, were incubated with polyclonal antibodies to human salivary mucins MUC5B and MUC7, and then with gold-labeled secondary antibodies. Specific MUC5B reactivity was found in the secretory granules of mucous cells of all glands examined, and was associated with the luminal membrane of duct cells. MUC7 labeling was observed in the granules of both mucous and seromucous secretory cells of the glandular parenchyma. Quantitative analyses demonstrated that seromucous granules have higher immunogold labeling densities for MUC7 than mucous granules. Our immunohistochemical data extend the results of previous light microscopic studies of MUC5B and MUC7 localizations, pointing out the significant contribution of human labial glands in the secretion process of these two mucins. [source] SPECIFICITY AND SPECIALIZATION OF CONGENERIC MONOGENEANS PARASITIZING CYPRINID FISHEVOLUTION, Issue 5 2006Andrea, Imková Abstract Patterns and likely processes connected with evolution of host specificity in congeneric monogeneans parasitizing fish species of the Cyprinidae were investigated. A total of 51 Dactylogyrus species was included. We investigated (1) the link between host specificity and parasite phylogeny; (2) the morphometric correlates of host specificity, parasite body size, and variables of attachment organs important for host specificity; (3) the evolution of morphological adaptation, that is, attachment organ; (4) the determinants of host specificity following the hypothesis of specialization on more predictable resources considering maximal body size, maximal longevity, and abundance as measures of host predictability; and (5) the potential link between host specificity and parasite diversification. Host specificity, expressed as an index of host specificity including phylogenetic and taxonomic relatedness of hosts, was partially associated with parasite phylogeny, but no significant contribution of host phylogeny was found. The mapping of host specificity into the phylogenetic tree suggests that being specialist is not a derived condition for Dactylogyrus species. The different morphometric traits of the attachment apparatus seem to be selected in connection with specialization of specialist parasites and other traits favored as adaptations in generalist parasites. Parasites widespread on several host species reach higher abundance within hosts, which supports the hypothesis of ecological specialization. When separating specialists and generalists, we confirmed the hypothesis of specialization on a predictable resource; that is, specialists with larger anchors tend to live on fish species with larger body size and greater longevity, which could be also interpreted as a mechanism for optimizing morphological adaptation. We demonstrated that ecology of host species could also be recognized as an important determinant of host specificity. The mapping of morphological characters of the attachment organ onto the parasite phylogenetic tree reveals that morphological evolution of the attachment organ is connected with host specificity in the context of fish relatedness, especially at the level of host subfamilies. Finally, we did not find that host specificity leads to parasite diversification in congeneric monogeneans. [source] The Alzheimer ,-peptide shows temperature-dependent transitions between left-handed 31 -helix, ,-strand and random coil secondary structuresFEBS JOURNAL, Issue 15 2005Jens Danielsson The temperature-induced structural transitions of the full length Alzheimer amyloid ,-peptide [A,(1,40) peptide] and fragments of it were studied using CD and 1H NMR spectroscopy. The full length peptide undergoes an overall transition from a state with a prominent population of left-handed 31 (polyproline II; PII)-helix at 0 °C to a random coil state at 60 °C, with an average ,H of 6.8 ± 1.4 kJ·mol,1 per residue, obtained by fitting a Zimm,Bragg model to the CD data. The transition is noncooperative for the shortest N-terminal fragment A,(1,9) and weakly cooperative for A,(1,40) and the longer fragments. By analysing the temperature-dependent 3JHNH, couplings and hydrodynamic radii obtained by NMR for A,(1,9) and A,(12,28), we found that the structure transition includes more than two states. The N-terminal hydrophilic A,(1,9) populates PII-like conformations at 0 °C, then when the temperature increases, conformations with dihedral angles moving towards ,-strand at 20 °C, and approaches random coil at 60 °C. The residues in the central hydrophobic (18,28) segment show varying behaviour, but there is a significant contribution of ,-strand-like conformations at all temperatures below 20 °C. The C-terminal (29,40) segment was not studied by NMR, but from CD difference spectra we concluded that it is mainly in a random coil conformation at all studied temperatures. These results on structural preferences and transitions of the segments in the monomeric form of A, may be related to the processes leading to the aggregation and formation of fibrils in the Alzheimer plaques. [source] Accounting and NPM in UK Local Government , Contributions Towards Governance and AccountabilityFINANCIAL ACCOUNTABILITY & MANAGEMENT, Issue 2 2005Andrew Goddard Despite its size and economic importance, accounting in UK local government is still relatively under-researched. Two important developments which have emerged in recent years across the whole public sector are governance and New Public Management. It is timely to study the contribution which local government accounting makes in this changing context. Governance has proved a particularly contentious concept to define. This study has attempted to understand governance from the participants' perspective and consequently a grounded theory methodology has been used. The empirical research comprised four UK local authority case studies over a twelve month period. The grounded theory developed makes two important contributions to our knowledge of accounting and NPM in relation to governance and accountability in local government. These are the relative importance of accountability rather than governance per se to participants, and the more significant contribution to accountability made by budgeting practices rather than NPM practices such as performance indicators, contracting out of services and Best Value studies. The reasons for these findings are explored and theorised in the paper, using Bourdieu's concept of habitus. [source] Breakdown of wood in the Agüera streamFRESHWATER BIOLOGY, Issue 11 2002Joserra Díez SUMMARY 1. Breakdown of wood was compared at three sites of the Agüera catchment (Iberian Peninsula): two oligotrophic first-order reaches (one under deciduous forest, the other under Eucalyptus globulus plantations) and one third-order reach under mixed forest, where concentration of dissolved nutrients was higher. 2. Branches (diameter = 3 cm, length = 10 cm) of oak (Quercus robur), alder (Alnus glutinosa), pine (Pinus radiata) and eucalyptus, plus prisms (2.5 × 2.5 × 10 cm) of alder heartwood were enclosed in mesh bags (1 cm mesh size) and placed in the streams. Mass loss was determined over 4.5 years, whereas nutrient, lignin and ergosterol were determined over 3 years. In order to describe fungal dynamics, ergosterol was also determined separately on the outer and inner parts of some branches. 3. Breakdown rates ranged from 0.0159 to 0.2706 year,1 with the third-order reach having the highest values whatever the species considered. The most rapid breakdown occurred in alder heartwood and the slowest in pine branches; breakdown rates of oak, eucalyptus and alder branches did not differ significantly. 4. The highest nitrogen and phosphorus contents were found in alder, followed by oak, while pine and eucalyptus had low values. During breakdown, all materials rapidly lost phosphorus, but nitrogen content remained constant or slightly increased. Lignin content remained similar. 5. Peaks of ergosterol ranged from 0.023 to 0.139 mg g,1 and were higher in alder than in other species in two of the three sites. The third-order reach generally had the greatest increase in ergosterol, especially in alder branches, eucalyptus and alder heartwood. The overall species/site pattern of fungal biomass was thus consistent with the observed differences in breakdown. 6. When compared with leaves of the same species decomposing at these sites, wood breakdown appeared to be less sensitive to the tree species but more sensitive to stream water chemistry. Although wood breakdown is slower and its inputs are lower than those of leaf litter, its higher resistance to downstream transport results in a relatively high standing stock and a significant contribution to the energy flux. [source] Electrochemical Reduction of Oxygen on Carbon Supported Pt and Pt/Ru Fuel Cell Electrodes in Alkaline SolutionsFUEL CELLS, Issue 4 2003E.H. Yu Abstract A study of O2 reduction in 1 M NaOH solution at gas diffusion electrodes made from carbon supported Pt and Pt/Ru catalysts is reported. Two Tafel regions were observed for both the Pt and Pt/Ru electrodes. Although the same mechanism was suggested for oxygen reduction on both Pt and Pt/Ru catalysts, the O2 reduction activity was lower on Ru. Electrochemical Impedance Spectroscopy (EIS) analysis was carried out at different potentials and showed the significant contribution of diffusion on the reaction process and kinetics. The effect of methanol on O2 reduction was investigated in solutions containing various concentrations of methanol. The electrode performance deteriorated with increasing methanol concentration because of a mixed cathode potential. The methanol tolerance, i. e., the methanol concentration which polarises the O2 reduction reaction for O2 reduction, at the Pt/C electrode with a Pt loading of 1.2 mg cm,2 is 0.2 M methanol in 1 M NaOH. [source] The Place of Islam in the Geography of Religion: Trends and IntersectionsGEOGRAPHY COMPASS (ELECTRONIC), Issue 5 2007Richard Gale This article reviews recent geographical research on Islam and Muslim identities. In the wake of the events of 11 September 2001, the forms taken by public debate surrounding Muslim communities and societies have been manifold and not always edifying. In the present political climate, where public attitudes to a particular suite of issues are often as misinformed as they are deeply held, the need for academics to furnish insights born out of robust research is acute. While the responses of academics to debates coalescing around Muslim communities and identities have emanated predominantly from religious studies, sociology and anthropology, geographers, with their attention to the spatial components inherent to the articulation of social identities, are making an increasingly significant contribution to our knowledge in this field. This article reviews this contribution, focusing on four areas in which geographical research on Islam has been most pronounced: Muslim residential segregation and ,community cohesion'; the relationship between Islamic dress codes and spatial context in the articulation of Muslim gender identities; the contestation of space that has attended the architectural expression of Muslim identity in urban landscapes and the spatial politics embedded in the construction of Muslim identities at simultaneously national and transnational scales. While the predominant focus is therefore geographical, the article also establishes linkages to other writings on the spatiality of Islam where relevant to the specific themes under discussion. [source] Improving the quality of health information: the contribution of C-H-i-QHEALTH EXPECTATIONS, Issue 3 2002Tom Hain MSc RGN RSCN FAETC The quality of information should be the key driver in communicating health messages to the public. Staff at The Centre for Health Information Quality (C-H-i-Q) have worked with an extensive list of partner organizations from a range of disciplines. These stakeholders express a desire to see improvement in the standards of patient information, and display a willingness to embrace new approaches in order to achieve change. The result is an increasingly significant contribution in the development of the information-exchange model of health-care, where the aim is to maximize public confidence in health information. Key activities include defining principles of quality assurance, engaging with stakeholders, and developing tools and training for producers and providers of health information. [source] Post pancreaticoduodenectomy haemorrhage: outcome prediction based on new ISGPS Clinical severity gradingHPB, Issue 5 2008G. Rajarathinam Abstract Objective & background data. Mortality following pancreatoduodenectomy (PD) has fallen below 5%, yet morbidity remains between 30 and 50%. Major haemorrhage following PD makes a significant contribution to this ongoing morbidity and mortality. The aim of the present study was to validate the new International Study Group of Pancreatic Surgery (ISGPS) Clinical grading system in predicting the outcome of post pancreaticoduodenectomy haemorrhage (PPH). Material and methods. Between January 1998 and December 2007 a total of 458 patients who underwent Whipple's pancreaticoduodenectomy in our department were analysed with regard to haemorrhagic complications. The onset, location and severity of haemorrhage were classified according to the new criteria developed by an ISGPS. Risk factors for haemorrhage, management and outcome were analysed. Results. Severe PPH occurred in 14 patients (3.1%). Early haemorrhage (<24 hours) was recorded in five (36%) patients, and late haemorrhage (>24 hours) in nine (64%) patients. As per Clinical grading of ISGPS 7 (50%) belongs to Grade C and 7 (50%) belongs to Grade B. Haemostasis was attempted by surgery in 10 (71%) patients; angioembolisation was successful in two (14%) and endotherapy in one (7%) patient. The overall mortality is 29%(n=4). Age >60 years (p=0.02), sentinel bleeding (p=0.04), pancreatic leak (p=0.04) and ISGPS Clinical grade C (p=0.02) were associated with increased mortality. Conclusion. Early haemorrhage was mostly managed surgically with better outcome when endoscopy is not feasible. Late haemorrhage is associated with high mortality due to pancreatic leak and sepsis. ISGPS Clinical grading of PPH is useful in predicting the outcome. [source] Understanding the recent evolution of the human genome: insights from human,chimpanzee genome comparisons,HUMAN MUTATION, Issue 2 2007Hildegard Kehrer-Sawatzki Abstract The sequencing of the chimpanzee genome and the comparison with its human counterpart have begun to reveal the spectrum of genetic changes that has accompanied human evolution. In addition to gross karyotypic rearrangements such as the fusion that formed human chromosome 2 and the human-specific pericentric inversions of chromosomes 1 and 18, there is considerable submicroscopic structural variation involving deletions, duplications, and inversions. Lineage-specific segmental duplications, detected by array comparative genomic hybridization and direct sequence comparison, have made a very significant contribution to this structural divergence, which is at least three-fold greater than that due to nucleotide substitutions. Since structural genomic changes may have given rise to irreversible functional differences between the diverging species, their detailed analysis could help to identify the biological processes that have accompanied speciation. To this end, interspecies comparisons have revealed numerous human-specific gains and losses of genes as well as changes in gene expression. The very considerable structural diversity (polymorphism) evident within both lineages has, however, hampered the analysis of the structural divergence between the human and chimpanzee genomes. The concomitant evaluation of genetic divergence and diversity at the nucleotide level has nevertheless served to identify many genes that have evolved under positive selection and may thus have been involved in the development of human lineage-specific traits. Genes that display signs of weak negative selection have also been identified and could represent candidate loci for complex genomic disorders. Here, we review recent progress in comparing the human and chimpanzee genomes and discuss how the differences detected have improved our understanding of the evolution of the human genome. Hum Mutat 28(2), 99,130, 2007. © 2006 Wiley-Liss, Inc. [source] Analysis of the glucocerebrosidase gene and mutation profile in 144 Italian gaucher patients,,HUMAN MUTATION, Issue 3 2002Mirella Filocamo Abstract Gaucher disease (GD), the most prevalent lysosomal storage disease characterized by a remarkable degree of clinical variability, results from deleterious mutations in the glucocerebrosidase gene (GBA). In this paper we report the molecular characterization of 144 unrelated Italian GD patients with the three types of the disease. The allelic frequencies of Italians are reported and the mutation profile is analyzed. Besides the common N370S, L444P, RecNciI, G202R, IVS2+1G>A, D409H, F213I mutations, the different molecular strategies, used for the mutation detection, identified the rare N107L, R131C, R170C, R170P, N188S, S196P, R285C, R285H, W312C, D399N, A446P, IVS10-1G>A, Rec,55, total gene deletion, as well as 12 mutant alleles that were exclusively present in the Italian population until now: the previously reported R353G, N370S+S488P mosaicism, IVS8(-11delC)-14T>A), Rec I, Y418C, and the seven novel alleles D127X, P159T, V214X, T231R, L354X, H451R, and G202R+M361I. The wide phenotypic differences observed within the genotypic groups as well as between siblings implicate a significant contribution of other modifying genetic and/or non-genetic factors and claim a comprehensive valuation of the patient including clinical., biochemical and molecular investigations for prognosis, appropriate interventive therapy and reliable genetic counseling. © 2002 Wiley-Liss, Inc. [source] The effect of particle shape and grain-scale properties of shale: A micromechanics approachINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 11 2010J. A. Ortega Abstract Traditional approaches for modeling the anisotropic elasticity response of the highly heterogeneous clay fabric in shale have mainly resorted to geometric factors such as definitions of particles shapes and orientations. However, predictive models based on these approaches have been mostly validated using macroscopic elasticity data. The recent implementation of instrumented indentation aimed at probing nano-scale mechanical behaviors has provided a new context for characterizing and modeling the anisotropy of the porous clay in shale. Nanoindentation experimental data revealed the significant contribution of the intrinsic anisotropy of the solid clay to the measured elastic response. In this investigation, we evaluate both the effects of geometric factors and of the intrinsic anisotropic elasticity of the solid clay phase on the observed anisotropy of shale at multiple length scales through the development of a comprehensive theoretical micromechanics approach. It was found that among various combinations of these sources of anisotropy, the elastic response of the clay fabric represented as a granular ensemble of aligned effective clay particles with spherical morphology and anisotropic elasticity compares satisfactorily to nanoindentation and ultrasonic pulse velocity measurements at nano- and macroscopic length scales, respectively. Other combinations of sources of anisotropy could yield comparable predictions, particularly at macroscopic scales, at the expense of requiring additional experimental data to characterize the morphology and orientations of particles. Copyright © 2009 John Wiley & Sons, Ltd. [source] The N(4S) + N2O(X,1,) reactionINTERNATIONAL JOURNAL OF CHEMICAL KINETICS, Issue 6 2001Abel Fernandez The title reaction, which is spin-forbidden for N2(X1,) + NO(X2,) production, has been studied from 960 to 1130 K in a high-temperature photochemistry reactor. No reaction could be observed, indicating k < 1 × 10,15 cm3 molecule,1 s,1. It is concluded that there is no significant contribution from the spin-allowed exothermic path leading to N2(X1,) + NO(a4,). © 2001 John Wiley & Sons, Inc. Int J Chem Kinet 33: 387,389, 2001 [source] On the interannual wintertime rainfall variability in the Southern AndesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 5 2010M. H. González Abstract The paper concentrates on the analysis of the interannual variability of wintertime rainfall in the Southern Andes. Besides the socio-economic relevance of the region, mainly associated with hydroelectric energy production, the study of the climate variability in that area has not received as much attention as others along the Andes. The results show that winter rainfall explains the largest percentage of regional total annuals. A principal component analysis (PCA) of the winter rainfall anomalies showed that the regional year-to-year variability is mostly explained by three leading patterns. While one of them is significantly associated with both the El Niño Southern Oscillation (ENSO), and the Southern Annular Mode (SAM), the other two patterns are significantly related to interannual changes of the sea surface temperature (SST) anomalies in the tropical Indian Ocean. Specifically, changes in the ocean surface conditions at both tropical basins induce in the atmospheric circulation the generation of Rossby wave trains that extend along the South Pacific towards South America, and alter the circulation at the region under study. The relationship between variability in the Indian Ocean and the Andes climate variability has not been previously addressed. Therefore, this result makes a significant contribution to the identification of the sources of predictability in South America with relevant consequences for future applications in seasonal predictions. Copyright © 2009 Royal Meteorological Society [source] Quantifying random measurement errors in Voluntary Observing Ships' meteorological observationsINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 7 2005Elizabeth C. Kent Abstract Estimates of the random measurement error contained in surface meteorological observations from Voluntary Observing Ships (VOS) have been made on a 30° area grid each month for the period 1970 to 2002. Random measurement errors are calculated for all the basic meteorological variables: surface pressure, wind speed, air temperature, humidity and sea-surface temperature. The random errors vary with space and time, the quality assurance applied and the types of instrument used to make the observations. The estimates of random measurement error are compared with estimates of total observational error, which includes uncertainty due both to measurement errors and to observational sampling. In tropical regions the measurement error makes a significant contribution to the total observational error in a single observation, but in higher latitudes the sampling error can be much larger. Copyright © 2005 Royal Meteorological Society [source] Serum paraoxonase and arylesterase activities for the evaluation of patients with chronic hepatitisINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 7 2008M. Aslan Summary The sensitivity of standard biochemical tests for liver function is low and insufficient for a reliable determination of the presence or absence of liver disease. The aim of the present study was to investigate serum paraoxonase and arylesterase activities and lipid hydroperoxide (LOOH) levels, and to find out that whether the measurement of serum paraoxonase and arylesterase activities would be useful as an index of liver function status in chronic hepatitis (CH). Fourty-four patients with CH (24 CHB and 20 CHC) and 38 controls were enrolled. Serum paraoxonase and arylesterase activities were detected spectrophotometrically. LOOH levels were measured by the FOX-2 assay. Serum paraoxonase and arylesterase activities were significantly lower in patients with CH than controls (p < 0.001 for both), while LOOH levels were significantly higher (p < 0.001). Paraoxonase and arylesterase activities were inversely correlated with LOOH levels (r = ,0.394, p < 0.05; r =,0.362, p < 0.05, respectively). Fibrosis scores of CH patients were significantly correlated with paraoxonase and arylesterase activities and LOOH levels (r =,0.276, p < 0.05; r = ,0.583, p < 0.001 and r = 0.562, p < 0.001, respectively). Our results indicated that decrease in the activities paraoxonase and arylesterase may play a role in the pathogenesis of CH. In addition, serum paraoxonase and arylesterase activities measurement may add a significant contribution to the liver function tests. [source] | ||||||||||||||||||||||||||||||||||||||||