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Situ Assembly (situ + assembly)

Distribution by Scientific Domains

Chemistry	100%

Selected Abstracts

Titelbild: In Situ Assembly and Screening of Enzyme Inhibitors with Surface-Tension Microarrays (Angew. Chem.

ANGEWANDTE CHEMIE, Issue 41 2009
41/2009)
Die Bildung von Regentropfen auf einer Blattoberfläche spiegelt eine wesentliche Eigenschaft von Wasser wider: die hohe Oberflächenspannung. Eine künstliche Anordnung sehr einheitlicher Tropfen lässt sich auf einer lithographisch bemusterten Glasoberfläche mit einer differenziellen Oberflächenenergie erzeugen. M.,Y. Balakirev et,al. schildern in der Zuschrift auf S.,7775,ff. die Verwendung dieser Tropfen für die Synthese kleiner Moleküle in Lösung und die anschließende quantitative Hochdurchsatzanalyse der Enzymkinetik. [source]

In Situ Assembly and Screening of Enzyme Inhibitors with Surface-Tension Microarrays,

ANGEWANDTE CHEMIE, Issue 41 2009
Laurent Mugherli Dr.
Hunderte von Reaktionen wurden bei einer neuartigen Synthese im Submikroliter-Maßstab parallel in Tropfen durchgeführt, die durch differenzielle Oberflächenspannung auf einem Glasträger gehalten wurden. Dieser ,Oberflächenspannungs-Mikroarray" wurde genutzt, um Tausende von Phenylboronsäurederivaten aufzubauen und gegen die NS3/4A-Protease des Hepatitis-C-Virus zu testen. Mehrere hochwirksame Inhibitoren des Enzyms wurden identifiziert. [source]

Control of Drug Release through the In Situ Assembly of Stimuli-Responsive Ordered Mesoporous Silica with Magnetic Particles

CHEMPHYSCHEM, Issue 17 2007
Shenmin Zhu Dr.
Abstract A site-selective controlled delivery system for controlled drug release is fabricated through the in situ assembly of stimuli-responsive ordered SBA-15 and magnetic particles. This approach is based on the formation of ordered mesoporous silica with magnetic particles formed from Fe(CO)5 via the surfactant-template sol-gel method and control of transport through polymerization of N-isopropyl acrylamide inside the pores. Hydrophobic Fe(CO)5 acts as a swelling agent as well as being the source of the magnetic particles. The obtained system demonstrates a high pore diameter (7.1 nm) and pore volume (0.41 cm3,g,1), which improves drug storage for relatively large molecules. Controlled drug release through the porous network is demonstrated by measuring the uptake and release of ibuprofen (IBU). The delivery system displays a high IBU storage capacity of 71.5 wt,%, which is almost twice as large as the highest value based on SBA-15 ever reported. In vitro testing of IBU loading and release exhibits a pronounced transition at around 32,°C, indicating a typical thermosensitive controlled release. [source]

Fabrication of Cobalt and Cobalt Oxide/Graphene Composites: Towards High-Performance Anode Materials for Lithium Ion Batteries

CHEMSUSCHEM CHEMISTRY AND SUSTAINABILITY, ENERGY & MATERIALS, Issue 2 2010
Shubin Yang Dr.
Pave a way to high-performance anode materials: Organic metal/graphene composites are fabricated through an in,situ assembly of disc-shaped phthalocyanine molecules with graphene sheets during the chemical reduction of graphite oxide, which enables a homogenous dispersion of Co and Co3O4 nanoparticles in the sheets after simple pyrolysis and oxidation. The resulting Co3O4/graphene composites exhibit remarkable lithium storage performance. [source]