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Simultaneous Changes (simultaneous + change)
Selected AbstractsModelling the hydrologic effects of dynamic land-use change using a distributed hydrologic model and a spatial land-use allocation modelHYDROLOGICAL PROCESSES, Issue 18 2010Hone-Jay Chu Abstract This study develops a novel approach for modelling and examining the impacts of time,space land-use changes on hydrological components. The approach uses an empirical land-use change allocation model (CLUE-s) and a distributed hydrological model (DHSVM) to examine various land-use change scenarios in the Wu-Tu watershed in northern Taiwan. The study also uses a generalized likelihood uncertainty estimation approach to quantify the parameter uncertainty of the distributed hydrological model. The results indicate that various land-use policies,such as no change, dynamic change and simultaneous change,have different levels of impact on simulating the spatial distributions of hydrological components in the watershed study. Peak flow rates under simultaneous and dynamic land-use changes are 5·71% and 2·77%, respectively, greater than the rate under the no land-use change scenario. Using dynamic land-use changes to assess the effect of land-use changes on hydrological components is more practical and feasible than using simultaneous land-use change and no land-use change scenarios. Furthermore, land-use change is a spatial dynamic process that can lead to significant changes in the distributions of ground water and soil moisture. The spatial distributions of land-use changes influence hydrological processes, such as the ground water level of whole areas, particularly in the downstream watershed. Copyright © 2010 John Wiley & Sons, Ltd. [source] Cortisol levels and measures of body composition in middle-aged and older menCLINICAL ENDOCRINOLOGY, Issue 1 2007Thomas G. Travison Summary Introduction, Similarities in the symptomatic expressions of excess adiposity and hypercortisolaemic conditions suggest that elevated glucocorticoid exposure may influence the pathogenesis of obesity. Circulating cortisol levels are not typically elevated in obese subjects, but data from large prospective samples are rare. We undertook an analysis to determine both cross-sectional and longitudinal associations between body composition and serum cortisol concentrations in a randomly chosen group of 999 community-dwelling men, aged 40,79 years. Methods, Data were obtained from the two follow-up waves of the Massachusetts Male Ageing Study (T2: 1995,97; T3: 2002,04). Partial correlation and multivariate regression analyses were used to estimate cross-sectional (T2) and longitudinal associations between serum cortisol concentrations and a range of measures of subjects' body composition, including weight, body mass index (BMI), waist circumference (WC), waist-to-hip girth ratio (WHR), and percentage body fat (measured by bioelectrical impedance at T3); similar analyses were conducted to assess the association between change (T2 to T3) in serum cortisol and simultaneous change in body composition parameters. Results, We observed weak negative associations between cortisol concentrations and all body composition parameters, with the exception of percentage body fat. Longitudinal results demonstrated similar relationships but associations were of lesser magnitude. T2 cortisol concentrations were not associated with change in body composition over time, whereas T2 body size was positively associated with longitudinal changes in cortisol concentrations, providing limited evidence that weight change drives changes in cortisol concentrations, rather than vice versa. Results were unchanged when age and other covariate effects were controlled. Conclusions, Circulating cortisol concentrations are somewhat lower in obese than in nonobese community-dwelling men. There is some evidence that excess adiposity presages increases in cortisol concentrations, rather than the reverse. However, this observation should be greeted with caution, as age-related weight loss , and not gain , was associated with simultaneous increases in serum cortisol concentrations. [source] Decadal changes in the link between El Niño and springtime North Atlantic oscillation and European,North African rainfallINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 11 2003Peter Knippertz Abstract The link between El Niño,southern oscillation (ENSO) variability in boreal winter (represented by the NIÑO3 index, i.e. East Pacific sea-surface temperature anomalies) and the large-scale circulation and weather conditions over Europe,northwest Africa in spring is explored, considering station reports of precipitation, sea-level pressure (SLP) anomalies and two North Atlantic oscillation (NAO) indices. It is found that these relations have undergone consistent and simultaneous changes in the 20th century. Three characteristic periods can be identified. During 1900,25 and 1962,87, positive NIÑO3 index values are associated with enhanced precipitation over central Europe and reduced rainfall in southern Europe and northern Africa. The ENSO influence on precipitation over Scotland and Norway is small. The rainfall anomalies can be explained from the advective and dynamical implications of a north,south dipole in SLP correlations (warm ENSO events followed by low pressure in northern Europe and high pressure over the Mediterranean Sea,North Africa). This dipole hardly projects on the commonly used NAO centres (Iceland and Azores/Gibraltar) and thus ENSO,NAO correlations are insignificant. During 1931,56 the NIÑO3 index reveals little influence on precipitation over the Iberian Peninsula and Morocco, but there are large negative correlations with precipitation over Scotland and Norway. This is related to an alteration of the NIÑO3,SLP correlation pattern, which implies high pressure over northern Europe and low pressure over central Europe after warm events, and thus a virtually inverted dipole with respect to the other two periods. The large westward extension of the dipole leads to a significant NAO,NIÑO3 correlation of r = ,0.5. These alterations were accompanied by substantial large-scale circulation changes during the period 1931,56, as revealed by anomalously high pressure and dry conditions over central,western Europe, a change in precipitation-producing SLP patterns for Morocco and an anomalously low number of positive NAO and NIÑO3 index values. It is left for discussion as to whether the decadal variations described are due to a change in the physics of the teleconnection or to stochastic fluctuations. Copyright © 2003 Royal Meteorological Society [source] Effect of temperature on the chromatographic retention of ionizable compounds.JOURNAL OF SEPARATION SCIENCE, JSS, Issue 6-7 2008Abstract We propose a general simple equation for accurately predicting the retention factors of ionizable compounds upon simultaneous changes in mobile phase pH and column temperature at a given hydroorganic solvent composition. Only four independent experiments provide the input data: retention factors measured in two pH buffered mobile phases at extreme acidic and basic pH values (e. g., at least ± 2 pH units far from the analyte pKa) and at two column temperatures. The equations, derived from the basic thermodynamics of the acid,base equilibria, additionally require the knowledge of the solute pKa and enthalpies of acid,base dissociation of both the solute and the buffer components in the hydroorganic solvent mixture. The performance of the predictive model is corroborated with the comparison between theoretical and experimental retention factors of several weak acids and bases of important pharmacological activity, in mobile phases containing different buffer solutions prepared in 25% w/w ACN in water and at several temperatures. [source] Rapid and Precise Release from Nano-Tracted Poly(N -isopropylacrylamide) Hydrogels Containing Linear Poly(acrylic acid)MACROMOLECULAR BIOSCIENCE, Issue 11 2006Taka-aki Asoh Abstract Summary: We investigated the rapid and precise molecular release from hydrogels in response to dual stimuli. To achieve precise on/off drug release using thermoresponsive poly(N -isopropylacrylamide) hydrogels, we prepared nano-structured semi-IPNs, which consisted of thermosensitive PNIPAAm networks penetrated by pH-responsive poly(acrylic acid) (PAAc) linear chains and perforated to create nano-tracts as a molecular pathway. The present nano-tracted semi-IPNs show a rapid deswelling response to both temperature and pH. Model drug releases were investigated when simultaneous changes in temperature and pH were applied. We observed that the cationic drug was rapidly released and then abruptly discontinued from the nano-tracted semi-IPNs in response to the dual stimuli, and clear release and stopping cycles were repeatedly observed on successive steps. Moreover, the release rates and amount of drug released were controllable by the deswelling speed of the gels and the PAAc content inside the gels. This novel release system using the nano-tracted semi-IPNs may be useful for the high performance, pulsed release of molecules. Release profiles of MB from semi-IPNs at pH,=,5.5, 20,°C (white region) and pH,=,2, 40,°C (gray region). [source] Disperse distribution of cationic amino acids on hydrophilic surface of helical wheel enhances antimicrobial peptide activityBIOTECHNOLOGY & BIOENGINEERING, Issue 2 2010Young Soo Kim Abstract The antimicrobial action of amphipathic antimicrobial peptides (AMPs) generally depends on perturbation of the bacterial membrane via electrostatic interactions promoting initial binding to the surface and hydrophobic interactions for pore formation into the membrane. Several studies have focused on the structure,activity relationship (SAR) of AMPs by modulation of structural parameters. However, modulation of one parameter commonly induces simultaneous changes in other parameters, making it difficult to investigate the specific influence of a single variable. In the present work, we investigated the distribution effect of cationic amino acids on the hydrophilic surface of the helical wheel using model AMPs composed of only lysine (K) and leucine (L) as representative cationic and hydrophobic residues, respectively, under conditions in which other parameters are fixed. Based on SAR analyses of ,-helical KL model AMPs displaying different cationic distributions, we propose that the dispersity of cationic amino acids on the hydrophilic surface is a factor that contributes to the antimicrobial activity of AMP. Moreover, antimicrobial activity is enhanced by rearrangement of cationic amino acids to promote dispersed distribution. We confirmed the cationic distribution effect using natural AMP-derived ,-helical CRAMP18 and its analogs. Our data show that accumulation of lysine shifts in the CRAMP18 analog leads to higher dispersion, and subsequently to improved antimicrobial activity. Therefore, we propose that the cationic distribution effect can be applied for the rational redesign of amino acid sequences to improve the antimicrobial activities of natural ,-helical AMPs, in combination with regulation of other known structural parameters. Biotechnol. Bioeng. 2010;107: 216,223. © 2010 Wiley Periodicals, Inc. [source] Modeling and Optimization of Photosynthetic Hydrogen Gas Production by Green Alga Chlamydomonas reinhardtii in Sulfur-Deprived CircumstanceBIOTECHNOLOGY PROGRESS, Issue 2 2006Ji Hye Jo Biological hydrogen production by the green alga Chlamydomonas reinhardtii under sulfur-deprived conditions has attracted great interest due to the fundamental and practical importance of the process. The photosynthetic hydrogen production rate is dependent on various factors such as strain type, nutrient composition, temperature, pH, and light intensity. In this study, physicochemical factors affecting biological hydrogen production by C. reinhardtii were evaluated with response surface methodology (RSM). First, the maximum specific growth rate of the alga associated with simultaneous changes of ammonium, phosphate, and sulfate concentrations in the culture medium were investigated. The optimum conditions were determined as NH4+ 8.00 mM, PO43, 1.11 mM, and SO42, 0.79 mM in Tris-acetate-phosphate (TAP) medium. The maximum specific growth rate with the optimum nutrient concentrations was 0.0373 h,1. Then, the hydrogen production rate of C. reinhardtii under sulfur-deprivation conditions was investigated by simultaneously changing two nutrient concentrations and pH in the medium. The maximum hydrogen production was 2.152 mL of H2 for a 10-mL culture of alga with density of 6 × 106 cells mL,1 for 96 h under conditions of NH4+ 9.20 mM, PO43, 2.09 mM, and pH 7.00. The obtained hydrogen production rate was approximately 1.55 times higher than that with the typical TAP medium under sulfur deficiency. [source] | ||||||||||