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Shorter Period (shorter + period)
Selected AbstractsEstablishment of a chick embryo model for analyzing liver development and a search for candidate genesDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 6 2005Yuji Yokouchi The liver plays a crucial role in metabolism. There is considerable interest in how the liver develops, as such knowledge could prove of importance in regenerative medicine. However, our understanding of liver development remains somewhat limited. We have developed a model system using the chick embryo that is cost effective and is easy to manipulate experimentally. We performed four fundamental studies: (i) construction of an atlas of the developing chick liver; (ii) identification of differentiation marker genes in the developing chick embryo; (iii) development of germ-layer specific electroporation; and (iv) establishment of organ culture from the developing chick liver. Using this system, we have been able to demonstrate the functions of candidate genes within a shorter period and in a more cost-effective manner. In parallel with the establishment of this system, we examined the expression patterns of genes known to be required for organ development in the developing chick embryo in order to identify genes also involved in liver development. To date, we have found sixteen genes that are expressed in the developing chick liver (GELD, genes expressed in liver development). This knowledge will be fundamental to the establishment of the basic technology for engineering liver tissue in the future. [source] Behavior of moment-resisting frame structures subjected to near-fault ground motionsEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 6 2004Babak Alavi Abstract Near-fault ground motions impose large demands on structures compared to ,ordinary' ground motions. Recordings suggest that near-fault ground motions with ,forward' directivity are characterized by a large pulse, which is mostly orientated perpendicular to the fault. This study is intended to provide quantitative knowledge on important response characteristics of elastic and inelastic frame structures subjected to near-fault ground motions. Generic frame models are used to represent MDOF structures. Near-fault ground motions are represented by equivalent pulses, which have a comparable effect on structural response, but whose characteristics are defined by a small number of parameters. The results demonstrate that structures with a period longer than the pulse period respond very differently from structures with a shorter period. For the former, early yielding occurs in higher stories but the high ductility demands migrate to the bottom stories as the ground motion becomes more severe. For the latter, the maximum demand always occurs in the bottom stories. Preliminary regression equations are proposed that relate the parameters of the equivalent pulse to magnitude and distance. The equivalent pulse concept is used to estimate the base shear strength required to limit story ductility demands to specific target values. Copyright © 2004 John Wiley & Sons, Ltd. [source] Interventions with injection drug users in UkraineADDICTION, Issue 11 2009Robert E. Booth ABSTRACT Aims To assess the effectiveness of a brief human immunodeficiency virus (HIV) testing and counseling intervention compared to a more time-consuming and expensive street-based intervention with injection drug users (IDUs). Design Cross-over experimental design in which 900 IDUs were recruited, followed by a ,wash-out' period with no recruitment, a reversal of intervention assignment areas and an additional recruitment of 900 IDUs with baseline and 6-month follow-up assessments. Setting Kiev, Odessa and Makeevka/Donesk Ukraine. Participants A total of 1798 IDUs. Measurements HIV testing and audio computer-assisted self-interview (ACASI) data on socio-demographics, drug use and injection and sex-related risk behaviors. Findings Participants in both conditions reduced their injection and sex risks significantly; however, there was little difference in outcomes between conditions. IDUs who knew they were HIV-infected at baseline were significantly more likely to practice safe sex than those unaware or HIV-negative; those who first learned that they were infected at baseline changed their safe sex practices significantly more than those who already knew that they were infected at baseline and those who were HIV-negative. Younger IDUs and those injecting for a shorter period of time reported higher injection and sex risk behaviors following interventions. Conclusions Awareness of HIV infection by street-recruited drug injectors is associated with reduced sex risks. Additional interventions are required for younger IDUs and those injecting for shorter periods of time. [source] Autotomy-induced life history plasticity in band-legged ground cricket Dianemobius nigrofasciatusENTOMOLOGICAL SCIENCE, Issue 1 2010Nobuhiro MATSUOKA Abstract Crickets can autotomize their limbs when attacked by predators. This enables them to escape death, but imposes a short-term cost on their escape speed and a long-term cost on their future mating ability. Therefore, adaptive response compensated for the cost of autotomy might be advantageous for autotomized individuals. In the present study, we examined whether autotomy induced life history plasticities compensating for the future cost in the band-legged ground cricket Dianemobius nigrofasciatus. Life history traits of D. nigrofasciatus were compared between autotomized and intact individuals. The developmental time and head width of the individuals that were autotomized as fourth instar nymphs were significantly shorter and smaller, respectively, than those of intact individuals. However, the adult longevity, number of eggs laid and oviposition schedule did not vary between autotomized and intact individuals. In addition, there was no difference between individuals autotomized at the fourth instar and adult stages in these three traits. Early maturation in the autotomized individuals might be advantageous through reducing the risk of predation owing to the shorter period in nymphal stages. The cost of small body size in the autotomized females might not be so great because of no significant difference in fecundity between autotomized and intact individuals. However, the cost of small body size was unclear in the autotomized males because in general larger males were preferred by females. These results indicated autotomy-induced life history that might reduce the cost of autotomy. [source] Contrasting Patch Residence Strategy in Two Species of Sit-and-Wait Foragers Under the Same Environment: A Constraint by Life History?ETHOLOGY, Issue 2 2005Tadashi Miyashita The present study explored the significance of life history constraints on patch residence strategy by using two congeneric web spider species living in the same habitat. Nephila maculata had a large body size but had a shorter developmental period compared with N. clavata, indicating that N. maculata should have a greater foraging efficiency to reach maturity and reproduce. Residence time at web-sites in N. maculata was shorter than that in N. clavata, irrespective of the season. However, supplementation of food to N. maculata increased residence time, suggesting that it searches web-sites with higher prey intake. Investment of web materials, an important trait influencing web relocation frequency, was not greater in N. maculata. In addition, microhabitat and prey size did not differ significantly after controlling for the effect of body size. Because N. maculata needs to attain a large body size in a shorter period of time, this species appears to take a risk of moving patches to seek high quality web-sites. [source] A field test of imaging properties of rotational invariants of the magnetotelluric impedance tensorGEOPHYSICAL PROSPECTING, Issue 3 2005László Szarka ABSTRACT A part of the Békés Basin (an extensional sub-basin of the Pannonian Basin, where the basement under thick Pannonian sediments is well known from deep boreholes and from seismic measurements, and where many magnetotelluric (MT) soundings have been carried out for frequencies ranging from 1 to 10,3 Hz) was selected as a test area to assess the imaging performances of various apparent-resistivity definitions computed with rotational invariants of either the real part of the complex impedance tensor, or its imaginary part, or both. A comparison (based on earlier 3D numerical studies) has been made between the magnetotelluric images obtained in this way and the depths to the high-resistivity basement, as known from boreholes and seismic investigations. The correlation coefficient between the series of basement depth values at 39 MT sites and the apparent-resistivity values was found to be stronger and high correlation appeared at a shorter period when it was computed with apparent resistivities based on the real tensor rather than with apparent resistivities based on the imaginary tensor. In the light of our studies, ,ReZ and the impedance phase seem to be more informative than any other combination of magnetotelluric interpretation parameters. [source] Insects in a warmer world: ecological, physiological and life-history responses of true bugs (Heteroptera) to climate changeGLOBAL CHANGE BIOLOGY, Issue 8 2007DMITRY L. MUSOLIN Abstract Focusing on the southern green stink bug, Nezara viridula (Pentatomidae), in central Japan the effects of climate change on true bugs (Insecta: Heteroptera) are reviewed. In the early 1960s, the northern edge of the species's distribution was in Wakayama Prefecture (34.1°N) and distribution was limited by the +5°C coldest month (January) mean temperature isothermal line. By 2000, N. viridula was recorded 70 km further north (in Osaka, 34.7°N). Historical climate data were used to reveal possible causes of the northward range expansion. The increase of mean and lowest winter month temperatures by 1,2°C in Osaka from the 1950s to the 1990s improved potential overwintering conditions for N. viridula. This promoted northward range expansion of the species. In Osaka, adult diapause in N. viridula is induced after mid-September, much later than in other local seed-feeding heteropterans. This late diapause induction results in late-season ineffective reproduction: some females start oviposition in autumn when the progeny have no chance of attaining adulthood and surviving winter. Both reproductive adults and the progeny die. A period from mid-September to early November represents a phenological mismatch: diapause is not yet induced in all adults, but it is already too late to start reproduction. Females that do not start reproduction but enter diapause in September have reduced postdiapause reproductive performance: they live for a shorter period, have a shorter period of oviposition and produce fewer eggs in smaller egg masses compared with females that emerge and enter diapause later in autumn. To some extent, N. viridula remains maladapted to Osaka environmental conditions. Ecological perspectives on establishment in recently colonized areas are discussed. A review of available data suggests that terrestrial and aquatic Heteroptera species respond to climate change by shifting their distribution ranges, changing abundance, phenology, voltinism, physiology, behaviour, and community structure. Expected responses of Heteroptera to further climate warming are discussed under scenarios of slight (<2°C) and substantial (>2°C) temperature increase. [source] Survival to discharge among patients treated with CRRTHEMODIALYSIS INTERNATIONAL, Issue 1 2005R. Wald Continuous renal replacement therapy (CRRT) is widely used in critically ill patients with acute renal failure (ARF). The survival of patients who require CRRT and the factors predicting their outcomes are not well defined. We sought to identify clinical features to predict survival in patients treated with CRRT. We reviewed the charts of all patients who received CRRT at the Toronto General Hospital during the year 2002. Our cohort (n = 85) represented 97% of patients treated with this modality in 3 critical care units. We identified demographic variables, underlying diagnoses, transplantation status, location (medical-surgical, coronary or cardiovascular surgery intensive care units), CRRT duration, baseline creatinine clearance (CrCl), and presence of oliguria (<400 ml/d) on the day of CRRT initiation. The principal outcome was survival to hospital discharge. Among those alive at discharge, we assessed whether there was an ongoing need for renal replacement therapy. Greater than one-third (38%, 32/85) of patients survived to hospital discharge. Three (9%) of the survivors remained dialysis-dependent at the time of discharge. Survivors were younger than non-survivors (mean age 56 vs 60 y.), were on CRRT for a shorter duration (7 vs 13 d.), and had a higher baseline CrCl (79 vs 68 ml/min). Patient survival varied among different critical care units (medical surgical 33%, coronary 38%, and cardiovascular surgery 45%). Multivariable logistic regression revealed that shorter duration of CRRT, non-oliguria, and baseline CrCl > 60 ml/min were independently associated with survival to hospital discharge (p < 0.05). Critically ill patients with ARF who require CRRT continue to have high in-hospital mortality. A shorter period of CRRT dependence, non-oliguria, and higher baseline renal function may predict a more favorable prognosis. The majority of CRRT patients who survive their critical illness are independent from dialysis at the time of hospital discharge. [source] Mate choice in Pied Flycatchers Ficedula hypoleuca: can females use song to find high-quality males and territories?IBIS, Issue 1 2003Helene M. Lampe High-quality male Pied Flycatchers Ficedula hypoleuca (defined by brighter plumage, better condition and more experience) have previously been shown to have larger syllable repertoires and greater song versatility than males of inferior quality. Thus, by preferring more complex songs, females could choose a high-quality male. Females may also use song as a cue to find a high-quality territory since early arriving males may obtain the best territories and these males have more complex songs than late-arriving males. We found that males with more complex songs had a greater chance of becoming paired and stayed unpaired for a shorter period than males with less elaborate songs. When controlling for arrival order, however, only strophe versatility was still correlated with pairing order. Males defending popular territories had more complex and longer songs and were also in better body condition than males in less popular territories. A multiple logistic regression showed that song length was important in explaining whether a male defended a popular nestbox or not. Thus, male arrival time seems to be important in deciding the quality of a male's territory, which in turn explains female choice. However, song quality seems to add important information. Thus, females could find both high-quality males and high-quality territories by using song cues during mate choice. [source] Zircon sensitive high mass-resolution ion microprobe U,Pb and fission-track ages for gabbros and sheeted dykes of the Taitao ophiolite, Southern Chile, and their tectonic implicationsISLAND ARC, Issue 1 2006Ryo Anma Abstract The Late Miocene,Pliocene Taitao ophiolite is composed of a complete sequence of classic oceanic lithosphere and is exposed approximately 50 km southeast of the Chile triple junction, where the Chile Ridge subducts beneath the South American Plate. Gabbros and ultramafic rocks are folded into a complex pattern, but only evidence for block rotation has been reported in the overriding sheeted dyke complex. In the present study, sensitive high mass-resolution ion microprobe U,Pb and fission-track dating methods were applied to zircon crystals separated from gabbros and sheeted dykes. Two sets of radiometric ages of gabbros range between 5.9 ± 0.4 and 5.6 ± 0.1 Ma. These ages coincide within their error ranges and imply rapid intrusion and cooling of gabbros. The U,Pb age of a dacite dyke intruded into the sheeted dyke complex was determined to be 5.2 ± 0.2 Ma. These data indicate that the magmas of the Taitao ophiolite were formed during the 6 Ma Chile Ridge collision event and emplaced in a shorter period than previously thought. A short segment of the Chile Mid-oceanic Ridge must have been emplaced during the 6 Ma event. [source] Breeding in high-elevation habitat results in shift to slower life-history strategy within a single speciesJOURNAL OF ANIMAL ECOLOGY, Issue 2 2009H. Bears Summary 1Elevational gradients create environmental variation that is hypothesized to promote variation in life-history strategies. We tested whether differences in life-history strategies were associated with elevation in a songbird, the dark-eyed junco (Junco hyemalis; Aves; A.O.U. 1998). 2We monitored birds in four replicated sites per elevation, at 2000 m a.s.l. (high elevation) and 1000 m a.s.l. (low elevation), in the Rocky Mountains of Canada. 3Over 5 years, we measured the following traits and vital rates: egg-laying schedules, morphological indicators of reproductive stage, seasonal reproductive success, indicators of competitive class (age, size, arrival time), and survival rates. 4We found two main patterns: with an increase in breeding elevation, dark-eyed juncos delayed the development of structures necessary for reproduction (e.g. cloacal protuberance in males) and reduced the duration of their reproductive period to less than half of the time used by low-elevation birds; and 5Juncos at high-elevation sites had 55,61% lower annual reproductive success and 15 to 20% higher survival rates. While adult juncos at high elevations produced fewer offspring, those offspring were in better condition. Proportions of age and size classes in high- compared to low-elevation populations were similar, suggesting that a life-history trade-off is present, rather than competition forcing inferior competitors to breed in a peripheral habitat. The apparent trade-off between reproduction and survival corresponded to a shorter period of favourable weather and available food in high- compared to low-elevation habitats. 6Thus, elevation had a strong influence on life-history characteristics of a single species over a short spatial distance, suggesting a shift in life history from a high reproductive strategy at lower elevations to a high survivor strategy at high elevations. 7This is the first paper to show a shift in avian life-history strategies along an elevational gradient (in both genders, of multiple age classes) when region (latitude) and phylogenetic histories are controlled for. [source] A retrospective review of the outcome of plasma exchange and aggressive medical therapy in antibody mediated rejection of renal allografts: A single center experienceJOURNAL OF CLINICAL APHERESIS, Issue 6 2008Wisam Al-Badr Abstract Antibody-mediated rejection (AMR) has been recognized as a major cause of renal allograft loss. Protocols using plasma exchange (PE) to reverse rejection have mixed results. Methods: A retrospective chart review was performed to determine the clinical response to PE inpatients with AMR of renal allograft. A good response to treatment was defined as a decline in serum creatinine (SCr) to within 25% above the prerejection value or discontinuation of dialysis with a SCr <2 mg/dl within 3 months of discharge from the hospital and disappearance of donor-specific alloantibodies (DSA). Results: Twenty-two patients, treated with PE for biopsy proven AMR with or without acute-cellular rejection (ACR), were included in the study. Sixty-four percent of patients had concurrent AMR and ACR. Fifty-two percent of all patients had a good response to antirejection therapy, whereas 63% of patients with only AMR and 46% of patients with both AMR and ACR had a good response. Good response to PE did not correlate with the number of plasma volumes exchanged (P = 0.09), but correlated with a shorter period from transplantation to the rejection episode (P = 0.002). Conclusion: Only a shorter interval between transplantation and the acute rejection episode correlated with a good response to PE. J. Clin. Apheresis, 2008. © 2008 Wiley-Liss, Inc. [source] A systematic review of professional support interventions for breastfeedingJOURNAL OF CLINICAL NURSING, Issue 9 2008Leena Hannula PhD Objectives., The objectives of this systematic review were first, to describe how breastfeeding is professionally supported during pregnancy, at maternity hospitals and during the postnatal period. Secondly, to find out how effective interventions are in supporting breastfeeding. Background., Breastfeeding is an effective way to promote the health of infants. In many countries, the rates for breastfeeding remain lower than recommended. Many studies have examined breastfeeding promotion interventions; some of them are successful and some fail. It is important to find effective combinations of support. Design. Systematic review. Methods., Search of CINAHL, Medline and Cochrane Central Register databases were conducted for data collection. The search was limited to articles published in Finnish, Swedish and English between the year 2000 and March 2006, focusing on breastfeeding and breastfeeding support interventions. Two reviewers independently analysed 36 articles in the final analysis. Results., Interventions expanding from pregnancy to the intrapartum period and throughout the postnatal period were more effective than interventions concentrating on a shorter period. In addition, intervention packages using various methods of education and support from well-trained professionals are more effective than interventions concentrating on a single method. Conclusions., During pregnancy, the effective interventions were interactive, involving mothers in conversation. The Baby Friendly Hospital Initiative (BFHI) as well as practical hands off -teaching, when combined with support and encouragement, were effective approaches. Postnatally effective were home visits, telephone support and breastfeeding centres combined with peer support. Relevance to clinical practice., Professionals need breastfeeding education and support of their organisations to act as breastfeeding supporters. The BFHI -programme is effective and it would be wise to include the core components of the programme in breastfeeding promotion interventions. Mothers benefit from breastfeeding encouragement and guidance that supports their self-efficacy and feelings of being capable and empowered, and is tailored to their individual needs. [source] Prevalence and associated factors of pneumonia in patients with vegetative state in TaiwanJOURNAL OF CLINICAL NURSING, Issue 7 2008Li-Chan Lin PhD Aims., The aim of this study was to investigate the prevalence rate and influencing factors of pneumonia associated with long-term tube feeding in special care units for patients with persistent vegetative states (PVS) in Taiwan. Background., Pneumonia is a significant cause of morbidity, hospitalization and mortality in the nursing home population. Tube feeding has been found as a risk factor for the occurrence of pneumonia. Methods., Two hundred sixty subjects were chosen from three hospital-based special care units for patients with PVS and 10 nursing facilities for persons in PVS in Taiwan. All subjects, who were diagnosed with PVS, received either financial aid for institutional care or were means-tested from The Bureau of Social Welfare of cities and counties in Taiwan. Data were collected through chart review and observations. Results., The prevalence rate of pneumonia in nursing facilities for patients with PVS was 14·2%. The prevalence rate of tube-feeding in nursing facilities for PVS was 91·2%. The mean duration of tube-feeding was 73·21 SD 55·33 months. A total of 90·4% was fed with a nasogastric (NG) tube. Having a lower intake of food and fluids daily and having been institutionalized for a shorter period were three dominant factors associated with the occurrence of pneumonia. Conclusion., Research findings reveal that the incidence of pneumonia is higher in patients who do not receive adequate food and water. Continuing in-service training to improve caregivers' knowledge and skill in providing care to patients in PVS and monitoring their skills in feeding is needed to decrease the occurrence of pneumonia in this population. Relevance to clinical practice., Staff needs to be taught to monitor laboratory data and signs and symptoms of malnutrition and hydration deficit, and also be alert to early indicators of pneumonia in patients with PVS. [source] Latitudinal population differentiation in phenology, life history and flower morphology in the perennial herb Lythrum salicariaJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 6 2002K. Olsson Abstract In plants with a wide distribution, phenological characters can be expected to vary clinally along climatic gradients, whereas other characters important for adaptation to local biotic and abiotic factors may vary in a more mosaic fashion. We used common-garden experiments and controlled crosses to examine population differentiation in phenology, life history and morphology in the perennial herb Lythrum salicaria along a latitudinal transect through Sweden (57°N to 66°N). Northern populations initiated growth and flowering earlier, flowered for a shorter period, were shorter, produced more and larger winter buds, and were older at first reproduction than southern populations. Flower morphology varied significantly among populations, but was, with the exception of calyx length, not significantly related to latitude of origin. Survival in the common garden (at 63°49,N) was positively correlated with latitude of origin and the size and number of winter buds produced in the preceding year. The results suggest that the among-population differences in phenology and life history have evolved in response to latitudinal variation in length of the growing season. Further studies are required to determine whether population differentiation in flower morphology is maintained by selection. [source] Prognostic factors of long-term CD4+count-guided interruption of antiretroviral treatmentJOURNAL OF MEDICAL VIROLOGY, Issue 3 2009L. Sarmati Abstract Aim of the study was to determine predictors of the duration of antiretroviral treatment interruption in patients infected with HIV. This pilot prospective, open-label, multicenter trial comprised 62 HIV-seropositive subjects who decided voluntarily to interrupt therapy after two or more years of successful HAART. The primary end-point was the time to patients being free of therapy before reaching a CD4+ cell count ,350/µl. Fifteen of 62 patients remained in treatment interruption for more than 180 days. Patients restarting therapy had higher HIV-DNA levels (P,=,0.05), were treated more frequently with NNRTI-drugs (P,=,0.02), had a shorter period of HAART (P,=,0.046), and lower CD4+ cell counts after day 14 of interruption of treatment (P,=,0.04). Multivariate regression analysis showed that less than 323 baseline proviral HIV-DNA cp/106 PBMCs and more than 564 CD4 cells/µl at day 14 after interruption were associated independently with a reduced risk of restarting treatment (P,=,0.041 and P,=,0.012, respectively). A score based on CD4+ cell counts at nadir, at baseline, at week 2 of treatment interruption, and on baseline HIV-DNA values can identify patients with a prolonged period free safely of treatment. J. Med. Virol. 81:481,487, 2009. © 2009 Wiley-Liss, Inc. [source] Cows milk consumption in constipation and anal fissure in infants and young childrenJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 5 2003F And Objective: To examine daily cows milk consumption and duration of breastfeeding in infants and young children with anal fissure and constipation. Methods: Two groups of 30 consecutive children aged between 4 months and 3 years were evaluated retrospectively. Group I comprised children with chronic constipation and anal fissure in whom surgical causes were excluded, and group II comprised normal children. The daily consumption of cows milk, duration of breastfeeding and other clinical features of the children were investigated Results: The mean daily consumption of cows milk was significantly higher in group I (756 mL, range 200,1500 mL) than group II (253 mL, range 0,1000 mL) (P < 0.001). Group I children were breastfed for a significantly shorter period (5.8 months, range 0,18 months) than group II (10.1 months, range 2,24 months) (P < 0.006). The odds ratios for the two factors , children consuming more than 200 mL of cows milk per day (25 children in group I, 11 children in group II) and breastfeeding for less than 4 months (16 children in group I, 5 children in group II) , were calculated to be 8.6 (95% confidence interval [CI]: 0.23,0.74, P = 0.0005) and 5.7 (95% CI: 0.37,0.66, P = 0.007), respectively. Conclusions: Infants and young children with chronic constipation and anal fissure may consume larger amounts of cows milk than children with a normal bowel habit. Additionally, shorter duration of breastfeeding and early bottle feeding with cows milk may play a role in the development of constipation and anal fissure in infants and young children. [source] Serum Free Sialic Acid as a Marker of Alcohol AbuseALCOHOLISM, Issue 6 2007Lech Chrostek Background: Previous studies have shown that serum total sialic acid (TSA) concentration significantly increases during alcohol abuse. Chronic ethanol consumption impairs glycosylation of many proteins. The increased desialylation rate of serum glycoproteins is one of the effects of alcohol abuse. The aim of this study was to investigate the diagnostic value of free sialic acid (FSA) as a marker of alcohol abuse. Methods: We determined serum FSA concentrations in the group of 156 alcoholic subjects and 35 healthy control subjects by means of a modification of the thiobarbituric acid method. The alcoholic group was divided into subgroups according to their history of abuse. Results: The FSA concentration was significantly higher in alcoholic subjects than in healthy controls. The subjects who consumed alcohol for longer than a week showed significantly higher FSA level than those who consumed alcohol for a shorter period. The serum FSA concentration was significantly higher in alcoholic subjects with elevated markers of liver dysfunction. The diagnostic accuracy of FSA was high, although it did not differ from TSA, and was limited by its low sensitivity. Conclusions: This study shows that FSA concentration in the sera of alcoholic subjects is increased. The low diagnostic sensitivity is accompanied by high specificity, however the accuracy is high and similar to the accuracy of TSA. Free sialic acid does not seem to be a better marker of alcohol abuse than TSA and current markers. [source] Toxicokinetics and recovery studies of dicamba dimethyl amine salt in goats following single oral administrationJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 2 2010Madhusudan Mukherjee Abstract BACKGROUND: Toxicokinetics and recovery studies of dicamba dimethyl amine salt (DDAS) were conducted to obtain more information about its toxicity and tissue retention in farm animals. RESULTS: The minimum oral toxic dose level of DDAS was determined as 1400 mg kg,1 body weight. In the toxicokinetic study, blood DDAS concentration of 55.6 ± 0.59 µg mL,1 (mean ± standard error) was detected at 0.08 h, which peaked to 102.3 ± 5.03 µg mL,1 at 0.25 h, and declined to a minimum of 4.1 ± 0.06 µg mL,1 at 36 h. In recovery studies, DDAS concentration in urine began to increase significantly (P < 0.05) from 12 h, peaked at 24 h and declined from 48 h onwards. Maximum excretion through faeces was at 24 h and was complete by 144 h. The residual level in tissues decreased significantly (P < 0.05) on day 7 as compared to day 4. In histopathological studies, cellular alterations in lungs, liver, kidney, adrenal gland and spleen were found. CONCLUSION: DDAS persists in the body for a shorter period and its major excretory route is through urine. DDAS has lower affinity to accumulate in tissues, and intensity of cellular alterations is not severe after single-dose oral administration. Copyright © 2009 Society of Chemical Industry [source] Upper midline incision for living donor right hepatectomyLIVER TRANSPLANTATION, Issue 2 2009Seong Hoon Kim Innovations and refinements in the techniques of living donor right hepatectomy (LDRH) have been made over the past decades, but the type and size of abdominal incision have been at a standstill since its inception. We introduce herein the upper midline incision for LDRH using the standard open technique. A prospective case-matched study was conducted on 23 consecutive donors who underwent LDRH under a supraumbilical upper midline incision (I group) from February to May 2008. These donors were matched 1:1 to 23 right liver donors with a conventional J-shaped incision (J group) according to age, gender, and body mass index. Under the mean incision length of 13.5 cm, LDRH was successfully completed in all 23 donors without extension of the incision, with a mean operative time of 232.3 ± 29.2 minutes. No donors required blood transfusion during surgery. There were 2 cases of postoperative bleeding immediately controlled under the same incision and a case of pleural effusion. All donors fully recovered and returned to their previous activities. All grafts have been functioning well. Compared with the J group, the I group had a shorter operative time, a shorter period of analgesic use, and, after discharge, infrequent complaints of wound pain. This upper midline incision, even without laparoscopic assistance, can be used for LDRH with less pain and without impairing safety, reproducibility, or effectivity, allowing the seemingly insufficient incision to be recommended to the transplant centers that are practicing living donor liver transplantation. Liver Transpl 15:193,198, 2009. © 2009 AASLD. [source] Birth-related factors and doctor-diagnosed wheezing and allergic sensitization in early childhoodALLERGY, Issue 9 2010L. Keski-Nisula To cite this article: Keski-Nisula L, Karvonen A, Pfefferle PI, Renz H, Büchele G, Pekkanen J. Birth-related factors and doctor-diagnosed wheezing and allergic sensitization in early childhood. Allergy 2010; 65: 1116,1125. Abstract Background:, To investigate the associations between clinical obstetric factors during birth and doctor-diagnosed wheezing and allergic sensitization during early childhood. Methods:, We followed 410 Finnish women from late pregnancy until 18 months age of their children. All children were delivered at term. Doctor-diagnosed wheezing among children was established by questionnaires, while specific immunoglobulin E antibodies to inhalant and food allergens were measured in 388 children at 1 year of age. Data on maternal obstetric variables were recorded at the time of delivery. Results:, Children of mothers with longer duration of ruptured fetal membranes before birth had significantly higher risk of doctor-diagnosed wheezing during early childhood compared to those children with shorter period of ruptured fetal membranes (III vs I quartile; aOR 6.65, 95% CI 1.99,22.18; P < 0.002 and IV vs I quartile; aOR 3.88, 95% CI 1.05,14.36, P < 0.043). Children who were born by Cesarean delivery had significantly less allergic sensitization at the age of 1 year compared to those who were born by vaginal route (16.0%vs 32.2%; aOR 0.34, 95% CI 0.14,0.80; P < 0.013). Furthermore, allergic sensitization tended to be more common in children with longer duration of labor before birth. No other birth-related obstetric factors, such as induction, the type of fetal membrane rupture during birth or quality of amniotic fluid were associated significantly with the examined outcomes. Conclusion:, The longer duration of the ruptured fetal membranes possibly reflected the higher risk of intrapartum infection at birth, and further increased the risk of doctor-diagnosed wheezing among offspring. [source] Social facilitation affects longevity and lifetime reproductive success in a self-fertilizing land snailOIKOS, Issue 3 2000Bruno Baur Factors that reduce the reproductive output of self-fertilizing hermaphrodites are receiving increasing attention. The combined effects of reduced fecundity of selfing parents and inbreeding depression of the progeny have been referred to as self-fertilization depression. In isolated freshwater snails the reproductive output of selfing individuals also decreases due to the lack of social facilitation (absence of a conspecific). We examined the effect of social facilitation on lifetime reproductive success (number of young produced and longevity) over two generations in the simultaneously hermaphroditic land snail Balea perversa. In a parallel study we showed that B. perversa kept singly and in pairs reproduced exclusively by self-fertilization. In the parent generation, snails kept singly produced less offspring than snails kept in pairs. The difference in lifetime number of young was mainly due to differences in adult life span. Snails of the two groups did not differ in reproductive rate (number of young produced per 100 d of reproductive life) and hatchling size. In the offspring generation, snails kept singly did not differ from individuals kept in pairs in the lifetime number of young and hatchling survival. As in the parent generation, snails kept singly reproduced during a shorter period than snails kept in pairs. However, the shorter reproductive life span of snails kept singly was compensated for by a slightly (but not significantly) higher reproductive rate which resulted in a similar number of offspring produced for both groups. In both generations, snails of the two groups did not differ in size at first reproduction, adult growth rate and size at death. These findings suggest that social facilitation may affect longevity in selfing B. perversa. [source] Comparison of three methods in surgical treatment of pilonidal diseaseANZ JOURNAL OF SURGERY, Issue 6 2001Hasan Aydede Background: The present study was designed to compare three methods that are still used for the surgical treatment of pilonidal disease: marsupialization, primary midline closure and skin flaps. Methods: One hundred and one out of a total of 203 pilonidal disease patients underwent excision and marsupialization, while 82 patients had excision and primary closure and the remaining 20 were treated with excision and skin flaps. The minimum and maximum follow-up periods for the aforementioned surgical methods were 4 and 5 years, respectively. All patients were reviewed for in-hospital stay, return to work, wound infection and recurrence rates. Student's t -test and Fisher's exact test were used for statistical analysis. Results: Average hospital stays for marsupialization, primary closure and skin flaps were 2.84 ± 0.13, 2.62 ± 0.12 and 5.95 ± 0.52 days, respectively. Hospital stay for the skin flaps method was longer than that for the other two methods. The average time to return to work after marsupialization was 5.42 ± 0.08 weeks; but the time needed to return to work after undergoing the primary closure or the skin flaps methods was much shorter: 2.15 ± 0.05 and 2.90 ± 0.20 weeks, respectively (P < 0.001). There was no difference in wound infection rate (P = 1.000) or recurrence rates. Conclusion: The fact that there were no differences in terms of wound infection or recurrence rates between the three groups, and the relatively shorter period for returning to work, emphasize the usefulness of the excision and repair techniques in the surgical treatment of pilonidal disease. [source] Gender Differences in Publication among University Professors in Canada,CANADIAN REVIEW OF SOCIOLOGY/REVUE CANADIENNE DE SOCIOLOGIE, Issue 2 2002M. Reza Nakhaie Cet article analyse un important sondage à l'échelle canadienne et aborde la probématique de la productivité: pourquoi les professeures d'université publient-elles moins que leurs collégues hommes ? Les résultats montrent que, dans l'ensemble, les femmes ont publié moins que les hommes , et ce, de manière significative ,, à la fois durant leur carrière et au cours des trois années qui ont précédé le sondage. Cependant, des analyses multivariables révèlent que des différences s'avèrent plus prononcées dans les données touchant la carrière que dans celles de la courte période. La plus grande différence entre les hommes et les femmes a trait au fait de publier dans une revue à comité de lecture ou sans, et s'applique à toute leur carrière. Enfin, des différences se laissent expliquer par des différences de rang, d'années depuis l'obtention du doctorat, la discipline, le type d'université ainsi que le temps consacré a la recherche. Des problèmes d'évaluation des prédicteurs de la productivité en recherche sont discutés. This paper analyses a large Canadian national survey of professors and tackles the "productivity puzzle" as to why female scientists publish less than male scientists. Results show that, in aggregate, Canadian female professors have published significantly less than their male counterparts, both over their lifetimes and during the three years before the survey. However, multivariate analyses reveal that gender differences in publication are more pronounced in the lifetime data than in the data for the shorter period. Much of the difference in publication between men and women of the academy is in refereed and non-refereed articles and reports over their career. Finally, gender differences in publication are largely accounted for by differences in rank, years since PhD, discipline, type of university and time set aside for research. Problems of assessing predictors of research productivity are discussed. [source] THE SOCIAL ECOLOGY OF VIOLENCE AGAINST WOMEN,CRIMINOLOGY, Issue 2 2004JANET L. LAURITSEN Despite more than three decades of research on the topic of violence against women, the relative contribution of individual, family and community factors to victimization risk remains unknown. We use self-report data from the Area-Identified National Crime Victimization Survey to study the correlates of stranger, nonstranger and intimate,partner violence against women. Regardless of victim-offender relationship, we find that the risk for victimization is highest among young, single women with children, particularly those who have lived in the current home for relatively shorter periods. Area family and age composition appear to have stronger direct relationships with women's violence than poverty or racial composition measures. We also find there to be more similarities than differences in the individual, family, and community correlates of stranger, nonstranger and intimate partner violence. We discuss these findings as part of the growing body of multilevel literature on violence and on violence against women. [source] Correlation model for spatially distributed ground-motion intensitiesEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 15 2009Nirmal Jayaram Abstract Risk assessment of spatially distributed building portfolios or infrastructure systems requires quantification of the joint occurrence of ground-motion intensities at several sites, during the same earthquake. The ground-motion models that are used for site-specific hazard analysis do not provide information on the spatial correlation between ground-motion intensities, which is required for the joint prediction of intensities at multiple sites. Moreover, researchers who have previously computed these correlations using observed ground-motion recordings differ in their estimates of spatial correlation. In this paper, ground motions observed during seven past earthquakes are used to estimate correlations between spatially distributed spectral accelerations at various spectral periods. Geostatistical tools are used to quantify and express the observed correlations in a standard format. The estimated correlation model is also compared with previously published results, and apparent discrepancies among the previous results are explained. The analysis shows that the spatial correlation reduces with increasing separation between the sites of interest. The rate of decay of correlation typically decreases with increasing spectral acceleration period. At periods longer than 2,s, the correlations were similar for all the earthquake ground motions considered. At shorter periods, however, the correlations were found to be related to the local-site conditions (as indicated by site Vs30 values) at the ground-motion recording stations. The research work also investigates the assumption of isotropy used in developing the spatial correlation models. It is seen using the Northridge and Chi-Chi earthquake time histories that the isotropy assumption is reasonable at both long and short periods. Based on the factors identified as influencing the spatial correlation, a model is developed that can be used to select appropriate correlation estimates for use in practical risk assessment problems. Copyright © 2009 John Wiley & Sons, Ltd. [source] Interventions with injection drug users in UkraineADDICTION, Issue 11 2009Robert E. Booth ABSTRACT Aims To assess the effectiveness of a brief human immunodeficiency virus (HIV) testing and counseling intervention compared to a more time-consuming and expensive street-based intervention with injection drug users (IDUs). Design Cross-over experimental design in which 900 IDUs were recruited, followed by a ,wash-out' period with no recruitment, a reversal of intervention assignment areas and an additional recruitment of 900 IDUs with baseline and 6-month follow-up assessments. Setting Kiev, Odessa and Makeevka/Donesk Ukraine. Participants A total of 1798 IDUs. Measurements HIV testing and audio computer-assisted self-interview (ACASI) data on socio-demographics, drug use and injection and sex-related risk behaviors. Findings Participants in both conditions reduced their injection and sex risks significantly; however, there was little difference in outcomes between conditions. IDUs who knew they were HIV-infected at baseline were significantly more likely to practice safe sex than those unaware or HIV-negative; those who first learned that they were infected at baseline changed their safe sex practices significantly more than those who already knew that they were infected at baseline and those who were HIV-negative. Younger IDUs and those injecting for a shorter period of time reported higher injection and sex risk behaviors following interventions. Conclusions Awareness of HIV infection by street-recruited drug injectors is associated with reduced sex risks. Additional interventions are required for younger IDUs and those injecting for shorter periods of time. [source] Dynamical effects of the statistical structure of annual rainfall on dryland vegetationGLOBAL CHANGE BIOLOGY, Issue 5 2006CHRISTOPHER A. WILLIAMS Abstract In this study, we extend a model of daily dryland dynamics by parameterizing a modified version of a minimalistic annual model to examine how the statistical structure of annual rainfall and grazing intensity interact to influence dryland vegetation. With a Monte Carlo approach, an ensemble outcome provides a statistical description of likely dryland vegetation dynamics responding to variations in rainfall structure and grazing intensity. Results suggest that increased rainfall variability decreases the average and increases the variability of grass cover leading to more frequent degradation of the grass resource. Vegetation of drier regions is found to be more sensitive to interannual variability in rainfall. Concentrating this variability into an organized periodic mode further decreases the mean and increases the variability of grass cover. Hence, a shift toward lower, more variable, or more inter-annually correlated annual rainfall will likely lead to a general decrease in the grass resource and increased dryland vulnerability to degradation. Higher grazing intensity or lower annual rainfall both lead to more frequent and longer duration degradation of the grass condition. We note an interesting interaction in the response of grass biomass to grazing intensity and rainfall variability, where increased rainfall variability leads to longer duration degradation for low grazing, but shorter periods of degradation for high grazing. Once grass reaches a degraded condition, we find that woody vegetation strongly suppresses recovery even if successive rainfall is high. Overall, these findings suggest that the projected increase in interannual rainfall variability will likely decrease grass cover and potentially lead to more frequent, longer lasting degradation of dryland vegetation, particularly if enhanced rainfall variability is concentrated in long period (e.g. decadal) modes. [source] Lactational State Modifies Alcohol Pharmacokinetics in WomenALCOHOLISM, Issue 6 2007Marta Yanina Pepino Background: Given the physiological adaptations of the digestive system during lactation, the present study tested the hypothesis that lactation alters alcohol pharmacokinetics. Methods: Lactating women who were exclusively breastfeeding a 2- to 5-month-old infant and 2 control groups of nonlactating women were studied. The first control group consisted of women who were exclusively formula-feeding similarly aged infants, whereas the other consisted of women who had never given birth. A within-subjects design study was conducted such that women drank a 0.4 g/kg dose of alcohol following a 12-hour overnight fast during one test session (fasted condition) or 60 minutes after consuming a standard breakfast during the other (fed condition). Blood alcohol concentration (BAC) levels and mood states were obtained at fixed intervals before and after alcohol consumption. Results: Under both conditions, the resultant BAC levels at each time point were significantly lower and the area under the blood alcohol time curve were significantly smaller in lactating women when compared with the 2 groups of nonlactating women. That such changes were due to lactation per se and not due to recent parturient events was suggested by the finding that alcohol pharmacokinetics of nonlactating mothers, who were tested at a similar time postpartum, were no different from women who had never given birth. Despite lower BAC levels in lactating mothers, there were no significant differences among the 3 groups of women in the stimulant effects of alcohol. However, lactating women did differ in the sedative effects of alcohol when compared with nulliparous but not formula-feeding mothers. That is, both groups of parous women felt sedated for shorter periods of time when compared with nulliparous women. Conclusions: The systemic availability of alcohol was diminished during lactation. However, the reduced availability of alcohol in lactating women did not result in corresponding changes in the subjective effects of alcohol. [source] Variability in red supergiant stars: pulsations, long secondary periods and convection noiseMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2006L. L. Kiss ABSTRACT We study the brightness variations of galactic red supergiant stars using long-term visual light curves collected by the American Association of Variable Star Observers over the last century. The full sample contains 48 red semiregular or irregular variable stars, with a mean time-span of observations of 61 yr. We determine periods and period variability from analyses of power density spectra and time,frequency distributions. We find two significant periods in 18 stars. Most of these periods fall into two distinct groups, ranging from a few hundred to a few thousand days. Theoretical models imply fundamental, first and possibly second overtone mode pulsations for the shorter periods. Periods greater than 1000 d form a parallel period,luminosity relation that is similar to the long secondary periods of the asymptotic giant branch stars. A number of individual power spectra shows a single mode resolved into multiple peaks under a Lorentzian envelope, which we interpret as evidence for stochastic oscillations, presumably caused by the interplay of convection and pulsations. We find a strong 1/f noise component in the power spectra that is remarkably similar in almost all stars of the sample. This behaviour fits the picture of irregular photometric variability caused by large convection cells, analogous to the granulation background seen in the Sun. [source] | ||||||||||||||||||||||