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Short Term (short + term)
Selected AbstractsOrthodontic loading of titanium miniplates in dogs: microradiographic and histological evaluationCLINICAL ORAL IMPLANTS RESEARCH, Issue 10 2008M. A. Cornelis Abstract Objectives: The objectives of this animal study were to evaluate if orthodontic loading has an impact on osseointegration of screws supporting miniplates, and to describe the histological components of the bone,screw interface. Materials and methods: Eighty orthodontic miniplates were placed in the jaws of 10 dogs. After 2 weeks, a 125 g force was applied between the miniplates of one upper quadrant of each dog and between those of the controlateral lower quadrant. The others, nonloaded miniplates, were considered as controls. Five dogs were sacrificed 7 weeks after implantation and the remaining five dogs after 29 weeks [Short Term (ST) and Long Term (LT) groups, respectively]. Fluorochromes were injected at implantation and at sacrifice. Jaw quadrants were dissected, embedded, cut into undecalcified transverse sections through the screws and finally submitted to microradiographic analysis to allow assessment of bone,implant contact (BIC) and bone volume/total volume (BV/TV). The sections were observed under UV light and stained in order to examine them under ordinary light. Results: Osseointegration occurred around 90/160 screws and consisted mainly in limited repair and remodelling processes of lamellar bone, without inflammation. Wide variations were observed in BIC and BV/TV, but without any significant difference, neither between the loaded and the nonloaded screws, nor according to the direction of load, whereas they were significantly higher in the LT than in the ST group. Nonosseointegrated screws were surrounded by fibrous tissue. Osteoblastic activity, when present in front of these screws, was not sufficient to achieve stability. Conclusions: Osseointegration underlying orthodontic anchorage was not affected by loading. BIC increased with time and varied according to implantation site. Particularly the tight-fitting screw insertion appeared crucial in determining the appropriate bone healing response. [source] Evaluation of Pimobendan and N-Terminal Probrain Natriuretic Peptide in the Treatment of Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease in DogsJOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 6 2009K.J. Atkinson Background: Pimobendan is a positive inotrope and vasodilator that may be useful in the treatment of pulmonary hypertension (PHT) secondary to degenerative mitral valve disease. Hypothesis: Pimobendan decreases the severity of PHT measured echocardiographically and improves quality-of-life scores. Changes in N-terminal probrain natriuretic peptide (NT-proBNP) concentrations will reflect improvement in severity of PHT. Animals: Ten client-owned dogs with peak tricuspid regurgitant flow velocity (TRFV) ,3.5 m/s. Methods: Prospective short-term, double-blinded, crossover design, with a long-term, open-label component. Short term, dogs were randomly allocated to receive either placebo or pimobendan (0.18,0.3 mg/kg PO q12 h) for 14 days. After a 1-week washout, they received the alternative treatment for 14 days, followed by pimobendan open-label for 8 weeks. Results: Short-term comparison: peak TRFV decreased in all dogs on pimobendan compared with placebo from a median of 4.40 (range, 3.2,5.6) to 3.75 (range, 2.4,4.8) m/s (P < .0001). NT-proBNP concentration decreased after treatment with pimobendan from a median of 2,143 (range, 450,3,981) to 1,329 (range, 123,2,411) pmol/L (P= .0009). All dogs improved their quality-of-life score (P= .006). In the long-term comparisons, peak TRFV decreased in all dogs from a median of 4.28 (range, 3.5,5.7) to 3.52 (range, 2.4,5.0) m/s (P < .0001). No significant changes in NT-proBNP or quality-of-life scores were detected. Conclusions and Clinical Importance: Pimobendan lowered severity of measurable PHT, improved quality-of-life scores, and decreased NT-proBNP concentrations short-term. Long term, only the reduction in TRFV was maintained. [source] Acute Adaptation to Volume Unloading of the Functional Single Ventricle in Children Undergoing Bidirectional Glenn AnastomosisCONGENITAL HEART DISEASE, Issue 2 2009Catherine Ikemba MD ABSTRACT Objective., Volume unloading of the functional single ventricle after a bidirectional Glenn anastomosis (BDG) prior to 1 year of age leads to improved global ventricular function as measured by the myocardial performance index (MPI), a Doppler-derived measurement of combined systolic and diastolic ventricular function. Systolic function remains unchanged after BDG according to previous studies; however, acute changes in global and diastolic function have not been previously investigated in this cohort. Our objective was to assess the short-term effects of the BDG on global ventricular function in patients with a functional single ventricle. Design., Echocardiograms to obtain MPI, isovolumic contraction time, and isovolumic relaxation time were performed at four time periods: in the operating room, in the operating room prior to BDG, shortly after separation from cardiopulmonary bypass, less than 24 hours postoperatively, and either prior to hospital discharge or at the first clinic follow-up visit. Results., Twenty-six patients were enrolled. There was significant ventricular dysfunction noted shortly after separation from cardiopulmonary bypass, median MPI 0.63 (0.39,0.81), that persisted in the short term postoperatively median MPI 0.50 (0.40,0.63). Isovolumic contraction time did not change, however, isovolumic relaxation time was significantly prolonged following BDG. Conclusion., In the postoperative patient after BDG, systolic function is preserved; however, there is evidence of diastolic and global ventricular dysfunction, at least in the short term. [source] Governing Emerging Stock Markets: legal vs administrative governanceCORPORATE GOVERNANCE, Issue 1 2005Katharina Pistor Transition economies face a fundamental dilemma. They need to develop financial markets, and yet they lack the ingredients it takes to do so. Recipes for legal governance mechanisms that have worked elsewhere, including reactive law enforcement by courts and proactive law enforcement by regulators, may not help in the short to medium term. Using evidence from stock market development in China and Russia, this paper suggests that at least in the short term, administrative governance may be a viable alternative to legal governance in emerging stock markets. [source] Psychotherapy for depression among children and adolescents: a systematic reviewACTA PSYCHIATRICA SCANDINAVICA, Issue 2 2007N. Watanabe Objective:, To examine the clinical benefit, the harm and the cost-effectiveness of psychotherapies in comparison with no treatment, waiting-list controls, attention-placebos, and treatment as usual in depressed youths. Method:, Meta-analyses were undertaken by using data from all relevant randomized-controlled trials identified by a comprehensive literature search. The primary outcome was relative risk (RR) of response. Results:, We identified 27 studies containing 35 comparisons and 1744 participants. At post-treatment, psychotherapy was significantly superior (RR = 1.39, 95% CI 1.18,1.65, P = 0.0001, number-needed to treat 4.3). There was an evidence of the existence of small study effects, including a publication bias (P < 0.001). The superiority of psychotherapy was no longer statistically significant (1.18 [0.94,1.47], P = 0.15) at 6-month follow-up. None of the studies reported adverse effects or cost-effectiveness outcomes. Conclusion:, Although the findings were biased by some small positive trials, psychotherapies appear to help depressed youths for the short term, but are no longer significantly favourable at 6-month follow-up. [source] Preschoolers continue to trust a more accurate informant 1 week after exposure to accuracy informationDEVELOPMENTAL SCIENCE, Issue 1 2009Kathleen Corriveau To determine whether children retain a preference for a previously accurate informant only in the short term or for long-term use, 3- and 4-year-old children were tested in two experiments. In both experiments, children were given accuracy information about two informants and were subsequently tested for their selective trust in the two informants (Experiment 1: immediately, 1 day and 1 week later; Experiment 2: immediately, 4 days and 1 week later). Both age groups preferred to trust the accurate informant not only immediately after receiving accuracy information but also at subsequent time-points. Children who were immediately able to explicitly identify the accurate informant were significantly more likely to seek and accept information from her 1 week later. However, even when they had not been asked to explicitly identify the accurate informant both age groups still maintained their preference for her. Thus, by 3 years of age, children spontaneously choose a previously accurate informant up to 1 week after exposure to information regarding her accuracy. [source] Managing childhood obesity: when lifestyle change is not enoughDIABETES OBESITY & METABOLISM, Issue 11 2010C. Hearnshaw The management of childhood obesity is a clinical dilemma. Paediatricians will see those children whose weight is at the severe end of the spectrum with obesity-related co-morbidities and for whom more intensive weight loss therapies may be appropriate. A literature review was performed (January 1995,January 2010) of the roles of pharmacotherapy or bariatric surgery in the management of childhood obesity. Three hundred and eighty-three abstracts were reviewed and 76 full-text articles were requested. Of these, 34 were excluded and a total of 21 pharmacotherapy papers and 22 papers on surgery were reviewed in detail. All studies involved adolescents. Pharmacotherapy: Most studies were small and of short duration, the notable exceptions being two large RCTs of sibutramine and orlistat. Sibutramine led to a mean estimated change in BMI from baseline of ,3.1 kg/m2 vs. ,0.3 kg/m2 for placebo over 12 months. Orlistat was also beneficial with a mean reduction in BMI of 0.55 vs. an increase of 0.31 kg/m2 in the placebo group at 12 months. Bariatric surgery: Most papers presented clinical observations and there were no randomised controlled trials (RCTs). Robust selection criteria were not used and ideal candidate selection remains unclear. Most papers showed a significant benefit of surgery in severely obese adolescents in the short term but long-term data were sparse. There were a surprisingly large number of papers examining the benefits of intensive weight management in obese adolescents. The study design of many was inadequate and the role of pharmacotherapy or surgery in childhood obesity remains unclear. [source] Obesity, bariatric surgery and type 2 diabetes,a systematic reviewDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 6 2004Cynthia V. Ferchak Abstract Obesity is endemic in the United States and is closely linked to the development of type 2 diabetes. Both obesity and diabetes are responsible for significant morbidity and mortality. Likewise, both conditions are resistant to treatment. Recent studies have evaluated prevention of type 2 diabetes through intensive lifestyle intervention, while others are examining the impact of bariatric surgery on type 2 diabetes. This article presents an overview of the impact of bariatric surgical and lifestyle interventions on the prevention and treatment of type 2 diabetes. Although studies using a variety of bariatric surgical techniques are included, the focus is on two interventions in particular: the Roux-en-Y gastric bypass and the laparoscopic silicone gastric banding procedure. Outcomes of these procedures are further contrasted with recent lifestyle intervention studies, in particular, the Diabetes Prevention Program study. Gastric bypass studies have been associated with a 99 to 100% prevention of diabetes in patients with IGT and an 80 to 90% clinical resolution of diagnosed early type 2 diabetes. Gastric banding procedures are associated with a lower median (50,60%) clinical remission of type 2 diabetes. Lifestyle intervention studies of obese and glucose-intolerant patients have achieved a 50% reduction in the progression of IGT to diabetes over the short term, with no reported resolution of the disease. Weight loss by any means in the obese patient appears to prevent progression to type 2 diabetes, at least in the short term. Furthermore, sustained weight loss through bariatric surgical intervention is associated both with prevention of progression of IGT and with clinical remission of early type 2 diabetes. Copyright © 2004 John Wiley & Sons, Ltd. [source] New potential treatments for protection of pancreatic B-cell function in Type 1 diabetesDIABETIC MEDICINE, Issue 11 2008S. Cernea Abstract Type 1 diabetes mellitus results from the progressive and specific autoimmune destruction of insulin-secreting pancreatic B-cells, which develops over a period of years and continues after the initial clinical presentation. The ultimate goal of therapeutic intervention is prevention or reversal of the disease by the arrest of autoimmunity and by preservation/restoration of B-cell mass and function. Recent clinical trials of antigen-specific or non-specific immune therapies have proved that modulation of islet specific autoimmunity in humans and prevention of insulin secretion loss in the short term after the onset of disease is achievable. The identification of suitable candidates for therapy, appropriate dosage and timing, specificity of intervention and the side-effect profile are crucial for the success of any approach. Considering the complexity of the disease, it is likely that a rationally designed approach of combined immune-based therapies that target suppression of B-cell specific autoreactivity and maintenance of immune tolerance, coupled with islet regeneration or replacement of the destroyed B-cell mass, will prove to be most effective in causing remission/reversal of disease in a durable fashion. [source] Early intervention with second-generation antipsychotics in first-episode psychosis: results of an 8-week naturalistic studyEARLY INTERVENTION IN PSYCHIATRY, Issue 1 2010Richard C. Josiassen Abstract Objective: The objective was to compare short-term effectiveness of aripiprazole with three other second-generation antipsychotics (SGAs) in the treatment of first-episode psychosis. Method: In a naturalistic, ,single-blind' design, 60 subjects experiencing their first psychotic episode were treated for 8 weeks with aripiprazole (n = 19), risperidone (n = 16), olanzapine (n = 14) or quetiapine (n = 11). Medication and dosing decisions were made by treating psychiatrists, constrained to once-a-day dosing, low initial doses and no clozapine. Weekly ratings were obtained using the Positive and Negative Syndrome Scale (PANSS), Simpson-Angus Rating Scale and Barnes Akathasia Rating Scale. Weight and vital signs were also collected weekly. Results: The group presented with severe psychotic symptoms (mean baseline PANSS total score of 105.2), which were reduced rapidly (P < 0.0005). The between-group and group by time interaction terms were non-significant. Similar reductions were seen across all PANSS sub-scales. At Week 1 the mean PANSS Activation Scale score was reduced more with olanzapine than in the other groups (P < 0.002). Few instances of extrapyramidal symptoms occurred; all were sporadic and did not require treatment. Group body weight increased by 7.3% over the study. Vital signs remained unchanged. Conclusions: Early intervention with low doses of four SGAs led to rapid symptom reduction in first-episode psychotic patients with severe psychopathology. Although no clear medication advantages were observed in the short term, longer duration studies with larger samples will be required for determining efficacy, rates of compliance, relapse prevention and diminished incidence of extrapyramidal signs and symptoms. [source] The rationale for early intervention in schizophrenia and related disordersEARLY INTERVENTION IN PSYCHIATRY, Issue 2009Merete Nordentoft Abstract Aim: To examine the rationale and evidence supporting an early intervention approach in schizophrenia. Methods: A selective literature review was conducted. Results: During the onset of schizophrenia, there is often a significant delay between the emergence of psychotic symptoms and the initiation of treatment. The average duration of untreated psychosis is around 1,2 years. During this period, brain function may continue to deteriorate and social networks can be irreversibly damaged. Studies have consistently linked longer duration of untreated psychosis with poorer outcomes and this relationship holds even after controlling for the potential confounding variable of premorbid functioning. In Norway, the early Treatment and Intervention in PSychosis study demonstrated that duration of untreated psychosis is amenable to intervention with the combination of educational campaigns and specialized early detection units substantially decreasing the period from onset of symptoms to treatment initiation. Furthermore, recent evidence from the randomized controlled OPUS and the Lambeth Early Onset trial studies have linked phase-specific early interventions to improved outcomes spanning symptoms, adherence to treatment, comorbid drug abuse, relapse and readmission. Some benefits persist after cessation of the intervention. Conclusions: Early intervention in schizophrenia is justified to reduce the negative personal and social impact of prolonged periods of untreated symptoms. Furthermore, phase-specific interventions are associated with improved outcomes, at least in the short term. Further research is needed to establish the optimum duration of such programmes. [source] A one-dimensional model for simulating armouring and erosion on hillslopes: 2.EARTH SURFACE PROCESSES AND LANDFORMS, Issue 10 2007Long term erosion, armouring predictions for two contrasting mine spoils Abstract This paper investigates the dynamics of soil armouring as a result of fluvial erosion for a non-cohesive sandy gravel spoil from the Ranger Mine, Australia, and a cohesive silt loam spoil from the Northparkes Mine, Australia, using a model for hillslope soil armouring. These long term predictions concentrate on the temporal and spatial changes of the spoil grading and erosion over 100,200 years for the flat cap regions (1,2%) and steep batter edges (10,30%) typically encountered on waste rock dumps. The existence of a significant rock fragment fraction in the Ranger spoil means that it armours readily, while Northparkes does not. For Ranger the waste rock showed reductions in (1) cumulative erosion of up to 81% from that obtained by extrapolating the initial erosion rate out 100 years and (2) the erosion/year by more than 10-fold. For Northparkes reductions were less marked, with the maximum reduction in erosion/year being 37% after 200 years. For Ranger the reductions were greatest and fastest for intermediate gradient hillslopes. For the steepest hillslopes the armouring decreased because the flow shear stresses were large enough to mobilize all material in the armour layer. Model uncertainty was assessed with probabilistic confidence limits demonstrating that these erodibility reductions were statistically significant. A commonly used hillslope erosion model (sediment flux = ,1 discharge m1 slope n1) was fitted to these predictions. The erodibility, ,1, and m1 decreased with time, which was consistent with our physical intuition about armouring. At Ranger the parameter m1 asymptoted to 1·5,1·6 while at Northparkes it asymptoted to 1·2,1·3. At Ranger transient spatial trends in armouring led to a short term (50,200 years in the future) reduction in n1, to below zero under certain circumstances, recovering to an asymptote of about 0·5,1. At Northparkes n1 asymptoted to about 0·6, with no negative transients predicted. The m1 and n1 parameters predicted for Ranger were shown to be consistent with field data from a 10-year-old armoured hillslope and consistent with published relationships between erodibility and rock content for natural hillslopes. Copyright © 2007 John Wiley & Sons, Ltd. [source] A systematic review of the effectiveness of smoking relapse prevention interventions for abstinent smokersADDICTION, Issue 8 2010Shade Agboola ABSTRACT Aims To carry out a systematic review of the effectiveness of relapse prevention interventions (RPIs) among abstinent smokers who had completed an initial course of treatment or who had abstained unassisted, pooling only outcome data from similar follow-up time points. Methods We used the same search strategy as was used in Cochrane reviews of RPIs to identify randomized trials of behavioural and pharmacological studies of smoking RPIs published up to July 2008. Abstinence from smoking was defined as either continuous abstinence or point prevalence abstinence, measured at three follow-up time points: short term (1,3 months post randomization), medium term (6,9 months) and long term (12,18 months). Abstinence among pregnant/postpartum women was also measured at delivery or the last follow-up prior to delivery. Random effect meta-analysis was used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI). Results Thirty-six studies randomizing abstainers were included. Self-help materials appeared to be effective in preventing relapse at long-term follow up in initially unaided quitters (pooled OR 1.52; 95% CI 1.15 to 2.01, I2 = 0%, NNT = 11, 3 studies). Other behavioural interventions for relapse prevention appeared effective in the short term only. There were positive results for the use of pharmacotherapies for relapse prevention. Bupropion was effective at long-term follow-up (pooled OR 1.49; 95% CI 1.10 to 2.01; I2 = 0%; NNT = 11; 4 studies). Nicotine replacement therapy (NRT) was effective at medium-term (pooled OR 1.56; 95% CI 1.16 to 2.11; I2 = 37%; NNT = 14; 4 trials) and long-term follow-ups (pooled OR 1.33; 95% CI 1.08 to 1.63; I2 = 0%; NNT = 20; 4 trials). Single trials of extended treatment of Varenicline and rimonabant were also found to be effective at short-term and medium-term follow-ups. Conclusions Self-help materials appear to prevent relapse in initially unaided quitters. Use of NRT, bupropion and varenicline appears to be effective in preventing relapse following an initial period of abstinence or an acute treatment episode. There is currently no good evidence that behavioural support prevents relapse after initial unaided abstinence or following an acute treatment period. [source] Atmospheric CO2 enrichment facilitates cation release from soilECOLOGY LETTERS, Issue 3 2010L. Cheng Ecology Letters (2010) 13: 284,291 Abstract Atmospheric CO2 enrichment generally stimulates plant photosynthesis and nutrient uptake, modifying the local and global cycling of bioactive elements. Although nutrient cations affect the long-term productivity and carbon balance of terrestrial ecosystems, little is known about the effect of CO2 enrichment on cation availability in soil. In this study, we present evidence for a novel mechanism of CO2 -enhancement of cation release from soil in rice agricultural systems. Elevated CO2 increased organic C allocation belowground and net H+ excretion from roots, and stimulated root and microbial respiration, reducing soil redox potential and increasing Fe2+ and Mn2+ in soil solutions. Increased H+, Fe2+, and Mn2+ promoted Ca2+ and Mg2+ release from soil cation exchange sites. These results indicate that over the short term, elevated CO2 may stimulate cation release from soil and enhance plant growth. Over the long-term, however, CO2 -induced cation release may facilitate cation losses and soil acidification, negatively feeding back to the productivity of terrestrial ecosystems. [source] "Offshoring": How big an issue?ECONOMIC OUTLOOK, Issue 3 2004Grant Colquhoun Spurred by the political debate in the US and several high-profile corporate moves, "offshoring" has become a lively topic of discussion. This paper by Grant Colquhoun, Keith Edmonds and David Goodger tries to put recent developments in context and argues that "offshoring" should be seen as part of a long-standing and largely beneficial trend of international specialisation. In the short term at least, the transfer of service sector activities abroad is likely to involve relatively small numbers of jobs when compared to overall UK employment and labour market turnover. However, specific areas , such as call centres, back office functions and software programming , are expected to be increasingly affected, impacting upon regions of the UK with heavy exposure to those activities and giving rise to adjustment costs. In contrast, retailing, hotels and catering and personal services could well benefit from the move of low value-added jobs abroad. Overall, the impact of "offshoring" on the UK economy in terms of output and productivity should be positive. [source] Randomized controlled trial of cognitive,behavioural therapy for coexisting depression and alcohol problems: short-term outcomeADDICTION, Issue 1 2010Amanda L. Baker ABSTRACT Aims Alcohol use disorders and depression co-occur frequently and are associated with poorer outcomes than when either condition occurs alone. The present study (Depression and Alcohol Integrated and Single-focused Interventions; DAISI) aimed to compare the effectiveness of brief intervention, single-focused and integrated psychological interventions for treatment of coexisting depression and alcohol use problems. Methods Participants (n = 284) with current depressive symptoms and hazardous alcohol use were assessed and randomly allocated to one of four individually delivered interventions: (i) a brief intervention only (single 90-minute session) with an integrated focus on depression and alcohol, or followed by a further nine 1-hour sessions with (ii) an alcohol focus; (iii) a depression focus; or (iv) an integrated focus. Follow-up assessments occurred 18 weeks after baseline. Results Compared with the brief intervention, 10 sessions were associated with greater reductions in average drinks per week, average drinking days per week and maximum consumption on 1 day. No difference in duration of treatment was found for depression outcomes. Compared with single-focused interventions, integrated treatment was associated with a greater reduction in drinking days and level of depression. For men, the alcohol-focused rather than depression-focused intervention was associated with a greater reduction in average drinks per day and drinks per week and an increased level of general functioning. Women showed greater improvements on each of these variables when they received depression-focused rather than alcohol-focused treatment. Conclusions Integrated treatment may be superior to single-focused treatment for coexisting depression and alcohol problems, at least in the short term. Gender differences between single-focused depression and alcohol treatments warrant further study. [source] Behavioral intervention to promote smoking cessation and prevent weight gain: a systematic review and meta-analysisADDICTION, Issue 9 2009Bonnie Spring ABSTRACT Aims The prospect of weight gain discourages many cigarette smokers from quitting. Practice guidelines offer varied advice about managing weight gain after quitting smoking, but no systematic review and meta-analysis have been available. We reviewed evidence to determine whether behavioral weight control intervention compromises smoking cessation attempts, and if it offers an effective way to reduce post-cessation weight gain. Methods We identified randomized controlled trials (RCTs) that compared combined smoking treatment and behavioral weight control to smoking treatment alone for adult smokers. English-language studies were identified through searches of PubMed, Ovid MEDLINE, CINAHL, EMBASE, PsycINFO and Cochrane Central Register of Controlled Trials. Of 779 articles identified and 35 potentially relevant RCTs screened, 10 met the criteria and were included in the meta-analysis. Results Patients who received both smoking treatment and weight treatment showed increased abstinence [odds ratio (OR) = 1.29, 95% confidence interval (CI) = 1.01, 1.64] and reduced weight gain (g = ,0.30, 95% CI = ,0.57, ,0.02) in the short term (<3 months) compared with patients who received smoking treatment alone. Differences in abstinence (OR = 1.23, 95% CI = 0.85, 1.79) and weight control (g = ,0.17, 95% CI = ,0.42, 0.07) were no longer significant in the long term (>6 months). Conclusions Findings provide no evidence that combining smoking treatment and behavioral weight control produces any harm and significant evidence of short-term benefit for both abstinence and weight control. However, the absence of long-term enhancement of either smoking cessation or weight control by the time-limited interventions studied to date provides insufficient basis to recommend societal expenditures on weight gain prevention treatment for patients who are quitting smoking. [source] Alcohol use trajectories among adults in an urban area after a disaster: evidence from a population-based cohort studyADDICTION, Issue 8 2008Magdalena Cerda ABSTRACT Alcohol use increased in the New York City (NYC) metropolitan area in the first months after the 11 September 2001 terrorist attacks. Aims To investigate alcohol use trajectories in the NYC metropolitan area in the 3 years after 11 September and examine the relative contributions of acute exposure to the attacks and ongoing stressors to these trajectories. Design We used a population-based cohort of adults recruited through a random-digit-dial telephone survey in 2002; participants completed three follow-up interviews over 30 months. Setting The NYC metropolitan area. Participants A total of 2752 non-institutionalized adult residents of NYC. Measurements We used growth mixture models to assess trajectories in levels of total alcohol consumption and bingeing in the past 30 days, and predictors of these trajectories. Findings We identified five trajectories of alcohol consumption levels and three bingeing trajectories. Predictors of higher levels of use over time included ongoing stressors, traumatic events and lower income. Ongoing exposure to stressors and low income also play a central role in bingeing trajectories. Conclusions While point-in-time mass traumatic events may matter in the short term, their contribution subsides over time. Accumulated stressors and traumatic events, in contrast, lead to higher levels of consumption among respondents already vulnerable to high alcohol use. Interventions to mitigate post-disaster stressors may have substantial benefit in reducing alcohol abuse in the medium- to long term. [source] Strategies of family farms to strengthen their resilienceENVIRONMENTAL POLICY AND GOVERNANCE, Issue 4 2010Ika Darnhofer Abstract Resilience thinking offers a framework to emphasize dynamics and interdependencies across time, space and domains. It is based on understanding social,ecological systems as complex, and future developments as unpredictable, thus emphasizing adaptive approaches to management. In this paper the four clusters of factors that have been identified as building resilience in large-scale social,ecological systems are applied at the farm level. Suggestions on how these factors could be operationalized at the farm level are derived from workshops held with family farmers in Austria. The results show that farmers understand change as unpredictable and unfolding, have a number of strategies to ensure the flexibility and adaptability of their farm and build extensive networks to diversify information and income sources. However, these strategies, while ensuring adaptability and transformability, compete for scarce resources. The farmers thus face trade-offs between strategies that ensure the adaptive capacity of their farm over the long term and those ensuring profitability over the short term. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment. [source] Wind power and ,the planning problem': the experience of WalesENVIRONMENTAL POLICY AND GOVERNANCE, Issue 5 2007Richard Cowell Abstract Across Europe, spatial planning has acquired an important role in steering wind power to more socially acceptable locations. However, the tendency for planning decisions to become a focus of opposition has also led to planning being represented as ,a problem' in meeting renewable energy targets. Using Jessop's dialectical relationship between modes and objects of governance, this paper seeks to understand why certain states are inclined to resolve ,the planning problem' for wind through strengthened national control. The case study is the Welsh Assembly Government's 2005 planning guidance on renewable energy, which superimposes centrally-determined ,Strategic Search Areas' for large-scale, onshore wind farm development onto local decision-making processes. Motivations for adopting this approach reflect the UK's centralizing planning culture, and beliefs that local planning processes will not yield sufficient sites to meet targets for wind power expansion. Responses to this planning guidance suggest that it may stabilizing the regulatory conditions for large-scale wind investment in the short term, in some parts of Wales, but faces a number of points of vulnerability in the longer term. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment. [source] Comparison of air quality management strategies of PM10, SO2, and NOx by an industrial source complex model in BeijingENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 1 2007Gaoxiang Ying Abstract The primary air pollutants in the Beijing urban area are fine particulate matter (PM10), sulfur dioxide (SO2), and nitrogen oxides (NOx). Using suitable emission factors for point, area, and line sources from 20 categories of industrial, commercial, domestic and traffic, total yearly mean emissions were estimated at 103.3 kton of PM10, 209.9 kton of SO2, and 225.4 kton of NOx in 1999. To abate this elevated air pollution, three air quality management schemes are adopted. After the implementation, the annual mean ground-level concentrations of air pollutants are predicted by an industrial source complex short term (ISCST3) dispersion model and compared by the geographic information system (GIS). The ISCST3 dispersion model is used by inputting emission inventory and meteorological data with 1 h temporal and 1 km × 1 km spatial resolution. The model validity is verified by its agreement with monitoring data from Beijing's Environmental Protection Bureau. Results indicate that the levels of PM10, SO2, and NOx in Beijing are improved gradually because of the adoption of these three control schemes. The predicted annual mean concentrations decreased from 90.63 to 67.28 ,g/m3 for PM10, 57.94 to 31.77 ,g/m3 for SO2, and 119.97 to 73.83 ,g/m3 for NOx, respectively. © 2007 American Institute of Chemical Engineers Environ Prog 26:33,42, 2007. [source] 4-nonylphenol-induced toxicity and apoptosis in Hydra attenuataENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 12 2005Sophie Pachura Abstract Effects of 4-nonylphenol (4-NP) onthe morphology and survival of the cnidarian Hydra attenuata were studied under acute exposure conditions. The lethal concentration value inducing 50% mortality after 96 h was 97.5 ± 20 ,g/L, whereas the lethal concentration value inducing 10% mortality after 96 h was 64 ± 25.5 ,g/L. The no-observed-effect concentration based on morphological criteria was less than 25 ,g/L. Hydra was one of the most sensitive freshwater invertebrate species behind the amphipod Hyalella azteca. Toxicity effects appeared rapidly and did not evolve substantially between 24 and 96 h of exposure. Induction of apoptosis was registered during the first hour of exposure to 4-NP at lethal concentrations, indicating rapid effects of the chemical. Abnormal increase of apoptosis may explain the acute toxicity of 4-NP in hydra. Results show that hydra viability is affected in the short term at 4-NP concentrations normally found in contaminated sites, but not at those concentrations reflecting lower levels of environmental contamination. [source] Smoothing splines for trend estimation and prediction in time seriesENVIRONMETRICS, Issue 3 2009Richard Morton Abstract We consider the use of generalized additive models with correlated errors for analysing trends in time series. The trend is represented as a smoothing spline so that it can be extrapolated. A method is proposed for choosing the smoothing parameter. It is based on the ability to predict a short term into the future. The choice not only addresses the purpose in hand, but also performs very well, and avoids the tendency to under-smooth or to interpolate the data that can occur with other data-driven methods used to choose the smoothing parameter. The method is applied to data from a chemical process and to stream salinity measurements. Copyright © 2008 John Wiley & Sons, Ltd. [source] Impact of severe epilepsy on development: Recovery potential after successful early epilepsy surgeryEPILEPSIA, Issue 7 2010Eliane Roulet-Perez Summary Purpose:, Epilepsy surgery in young children with focal lesions offers a unique opportunity to study the impact of severe seizures on cognitive development during a period of maximal brain plasticity, if immediate control can be obtained. We studied 11 children with early refractory epilepsy (median onset, 7.5 months) due to focal lesion who were rendered seizure-free after surgery performed before the age of 6 years. Methods:, The children were followed prospectively for a median of 5 years with serial neuropsychological assessments correlated with electroencephalography (EEG) and surgery-related variables. Results:, Short-term follow-up revealed rapid cognitive gains corresponding to cessation of intense and propagated epileptic activity [two with early catastrophic epilepsy; two with regression and continuous spike-waves during sleep (CSWS) or frontal seizures]; unchanged or slowed velocity of progress in six children (five with complex partial seizures and frontal or temporal cortical malformations). Longer-term follow-up showed stabilization of cognitive levels in the impaired range in most children and slow progress up to borderline level in two with initial gains. Discussion:, Cessation of epileptic activity after early surgery can be followed by substantial cognitive gains, but not in all children. In the short term, lack of catch-up may be explained by loss of retained function in the removed epileptogenic area; in the longer term, by decreased intellectual potential of genetic origin, irreversible epileptic damage to neural networks supporting cognitive functions, or reorganization plasticity after early focal lesions. Cognitive recovery has to be considered as a "bonus," which can be predicted in some specific circumstances. [source] Size-Dependent Mating Success at Various Nutritional States in the Yellow Dung FlyETHOLOGY, Issue 8 2008Wolf U. Blanckenhorn Mating success not only depends on genetic quality, but also equally on environmental factors, most prominently food availability. We investigated the interactive effects of nutritional state and body size on mating success and copula duration in yellow dung fly males (Scathophaga stercoraria; Diptera: Scathophagidae) of three body size selection lines in the laboratory in both non-competitive (single) and competitive (group) situations. Adults require protein and lipids from prey to reproduce, as well as sugars as an energy source for reproductive activity. We expected mating success to decrease with time because of sperm depletion (sugar treatment) and/or energy shortage (water treatment) relative to the control, prey plus sugar treatment. Based on physiological scaling, we also expected large-line males to become depleted either sooner because of their higher energy and sperm demands, or later because of their more efficient energy use. Average mating success indeed declined over a period of 5,7 d (or 5,15 potential copulations per male), but equally for all food treatments and body size classes. Surprisingly, water-fed and small-line males had the highest mating probability in the non-competitive setting, while in the competitive setting large-line males had the highest success. Energy-depleted males showed apparent terminal investment. Small males acquired females more readily but eventually lost them to larger males in the competitive situation. As shown before, copula duration was inversely related to body size and increased with copulation number, independent of food treatment. We conclude that sugar or prey shortage has little effect on mating success in the short term, and does not differentially affect males of different sizes. [source] Newborn human brain identifies repeated auditory feature conjunctions of low sequential probabilityEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 10 2004Timo Ruusuvirta Abstract Natural environments are usually composed of multiple sources for sounds. The sounds might physically differ from one another only as feature conjunctions, and several of them might occur repeatedly in the short term. Nevertheless, the detection of rare sounds requires the identification of the repeated ones. Adults have some limited ability to effortlessly identify repeated sounds in such acoustically complex environments, but the developmental onset of this finite ability is unknown. Sleeping newborn infants were presented with a repeated tone carrying six frequent (P = 0.15 each) and six rare (P ,0.017 each) conjunctions of its frequency, intensity and duration. Event-related potentials recorded from the infants' scalp were found to shift in amplitude towards positive polarity selectively in response to rare conjunctions. This finding suggests that humans are relatively hard-wired to preattentively identify repeated auditory feature conjunctions even when such conjunctions occur rarely among other similar ones. [source] Soil moisture, carbon and nitrogen dynamics following incorporation and surface application of labelled crop residues in soil columnsEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 6 2006F. Coppens Summary One way to increase the amount of carbon sequestered in agricultural land is to convert conventional tillage into no-tillage systems. This greatly affects the location of crop residues in soil. To investigate the impact of the location of residues on soil physical and biological properties and how the interactions between those properties influence the fate of carbon and nitrogen in soil, we did a laboratory experiment with repacked soil in columns. Doubly labelled 13C15N oilseed rape residues were incorporated in the 0,10 cm layer or left on the soil surface. The columns were incubated for 9 weeks at 20°C and were submitted to three cycles of drying and wetting, each of them induced by a rain simulator. The location of the residues affected the water dynamics and the distribution of C and N in the soil, which in turn influenced microbial activity and the decomposition rate of the added residues. After 9 weeks of'incubation, 18.4 ± 1.5% of the surface applied residue-C and 54.7 ± 1.3% of the incorporated residue-C was mineralized. We observed a nitrate accumulation of 10.7 mg N kg,1 with residues at the soil surface, 3.6 mg N kg,1 with incorporated residues and 6.3 mg N kg,1 without addition of fresh organic matter, which entailed net N mineralization in soil under mulch and immobilization of N with residue incorporation compared with the control soil. We concluded that application of oilseed rape residues at the soil surface increased the storage of fresh organic C in soil in the short term, compared with the incorporation treatment, but increased the risk of nitrate leaching. [source] Why the Open Method of Coordination Is Bad For You: A Letter to the EUEUROPEAN LAW JOURNAL, Issue 3 2007Vassilis Hatzopoulos Most writers explore the tentative outcomes of the method, since they lack a solid experimental background, against which to assess its actual effectiveness. Lately, however, some empirical studies have come to light. Among them, some fully discredit the OMC as a means of pursuing common policies at the EU level; while others recognise indirect effects, essentially at the national level of policy setting. On the basis of this assumption, i.e. that the OMC has only restricted direct effects in the short term and indirect effects in the medium to long term, the present article first puts forward a series of arguments against the current ,spread' of the OMC, and then offers some proposals on how to neutralise some of the identified shortfalls of the OMC. Despite the title of the article, the final conclusion is not for the demise of the OMC, but rather for its ,communautarisation'. It is put forward that both the application and the effects of the OMC should be more clearly defined and better integrated with the other pre-existing forms of cooperation, in accordance with basic requirements stemming from the Community legal order. [source] SOCIALITY IN THERIDIID SPIDERS: REPEATED ORIGINS OF AN EVOLUTIONARY DEAD ENDEVOLUTION, Issue 11 2006Ingi Agnarsson Abstract Evolutionary ,dead ends' result from traits that are selectively advantageous in the short term but ultimately result in lowered diversification rates of lineages. In spiders, 23 species scattered across eight families share a social system in which individuals live in colonies and cooperate in nest maintenance, prey capture, and brood care. Most of these species are inbred and have highly female-biased sex ratios. Here we show that in Theridiidae this social system originated eight to nine times independently among 11 to 12 species for a remarkable 18 to 19 origins across spiders. In Theridiidae, the origins cluster significantly in one clade marked by a possible preadaptation: extended maternal care. In most derivations, sociality is limited to isolated species: social species are sister to social species only thrice. To examine whether sociality in spiders represents an evolutionary dead end, we develop a test that compares the observed phylogenetic isolation of social species to the simulated evolution of social and non-social clades under equal diversification rates, and find that sociality in Theridiidae is significantly isolated. Because social clades are not in general smaller than their nonsocial sister clades, the spindly phylogenetic pattern,many tiny replicate social clades,may be explained by extinction rapid enough that a nonsocial sister group does not have time to diversify while the social lineage remains extant. In this case, this repeated origin and extinction of sociality suggests a conflict between the short-term benefits and long-term costs of inbred sociality. Although benefits of group living may initially outweigh costs of inbreeding (hence the replicate origins), in the long run the subdivision of the populations in relatively small and highly inbred colony lineages may result in higher extinction, thus an evolutionary dead end. [source] Genetic estimates of contemporary effective population size in an endangered butterfly indicate a possible role for genetic compensationEVOLUTIONARY APPLICATIONS (ELECTRONIC), Issue 1 2010Emily V. Saarinen Abstract The effective population size (Ne) is a critical evolutionary and conservation parameter that can indicate the adaptive potential of populations. Robust estimates of Ne of endangered taxa have been previously hampered by estimators that are sensitive to sample size. We estimated Ne on two remaining populations of the endangered Miami blue butterfly, a formerly widespread taxon in Florida. Our goal was to determine the consistency of various temporal and point estimators on inferring Ne and to determine the utility of this information for understanding the role of genetic stochasticity. We found that recently developed ,unbiased estimators' generally performed better than some older methods in that the former had more realistic Ne estimates and were more consistent with what is known about adult population size. Overall, Ne/N ratios based on census point counts were high. We suggest that this pattern may reflect genetic compensation caused by reduced reproductive variance due to breeding population size not being limited by resources. Assuming Ne and N are not heavily biased, it appears that the lack of gene flow between distant populations may be a greater genetic threat in the short term than the loss of heterozygosity due to inbreeding. [source] | ||||||||||||||||||||||||||||||||||||||||