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Short Period (short + period)
Kinds of Short Period Selected AbstractsHistopathologic Maturation of Juvenile Xanthogranuloma in a Short PeriodPEDIATRIC DERMATOLOGY, Issue 2 2001Yumiko Kubota M.D. The initial biopsy specimen showed a dense collection of small histiocytes as evidenced by CD68 staining without either lipidization or giant cell formation, admixed with a small number of lymphocytes. On the other hand, sections from the excised specimen obtained 2 weeks after the initial biopsy from the same site showed a mixed proliferation of abundant foam cells together with Touton giant cells, some small histiocytes, and small numbers of lymphocytes and eosinophils. Mitotic figures were fewer in the excised nodule than in the initial biopsy specimen. Fascicles of spindle-shaped cells arranged in a vague storiform pattern were additionally found in the deep portion of the nodule. Our case findings suggest that xanthomatization of the JXG could have been accelerated by the inflammation associated with the biopsy, based on the histopathologic fact that the change from an early phase to a mature form occurred within the very short period of 2 weeks. [source] Short periods of prenatal stress affect growth, behaviour and hypothalamo,pituitary,adrenal axis activity in male guinea pig offspringTHE JOURNAL OF PHYSIOLOGY, Issue 3 2005Amita Kapoor Prenatal stress can have profound long-term influences on physiological function throughout the course of life. We hypothesized that focused periods of moderate prenatal stress at discrete time points in late gestation have differential effects on hypothalamo,pituitary,adrenal (HPA) axis function in adult guinea pig offspring, and that changes in HPA axis function will be associated with modification of anxiety-related behaviour. Pregnant guinea pigs were exposed to a strobe light for 2 h on gestational days (GD) 50, 51, 52 (PS50) or 60, 61, 62 (PS60) (gestation length ,70 days). A control group was left undisturbed throughout pregnancy. Behaviour was assessed in male offspring on postnatal day (PND)25 and PND70 by measurement of ambulatory activity and thigmotaxis (wall-seeking behaviour) in a novel open field environment. Subsequent to behavioural testing, male offspring were cannulated (PND75) to evaluate basal and activated HPA axis function. Body weight was significantly decreased in adult PS50 and PS60 offspring and this effect was apparent soon after weaning. The brain-to-body-weight ratio was significantly increased in adult PS50 males. Basal plasma cortisol levels were elevated in PS50 male offspring throughout the 24 h sampling period compared with controls. In response to an ACTH challenge and to exposure to an acute stressor, PS60 male offspring exhibited elevated plasma cortisol responses. Plasma testosterone concentrations were strikingly decreased in PS50 offspring. Thigmotaxis in the novel environment was increased in PS50 male offspring at PND25 and PND70, suggesting increased anxiety in these animals. In conclusion, prenatal stress during critical windows of neuroendocrine development programs growth, HPA axis function, and stress-related behaviour in adult male guinea pig offspring. Further, the nature of the effect is dependant on the timing of the maternal stress during pregnancy. [source] Differential effects of glucose on agonist-induced relaxations in human mesenteric and subcutaneous arteriesBRITISH JOURNAL OF PHARMACOLOGY, Issue 3 2008A MacKenzie Background and purpose: Acute periods of hyperglycaemia are strongly associated with vascular disorder, yet the specific effects of high glucose on human blood vessel function are not fully understood. In this study we (1) characterized the endothelial-dependent relaxation of two similarly sized but anatomically distinct human arteries to two different agonists and (2) determined how these responses are modified by acute exposure to high glucose. Experimental approach: Ring segments of human mesenteric and subcutaneous arteries were mounted in a wire myograph. Relaxations to acetylcholine and bradykinin were determined in a control (5 mM) and high glucose (20 mM) environment over a 2 and 6 h incubation period. Key results: Bradykinin-induced relaxation in both sets of vessels was mediated entirely by EDHF whilst that generated by acetylcholine, though principally generated by EDHF, also had contribution from prostacyclin and possibly nitric oxide in mesenteric and subcutaneous vessels, respectively. A 2-h incubation of high glucose impaired bradykinin-induced relaxation of subcutaneous vessels whilst, in contrast, the relaxation generated by bradykinin in mesenteric vessels was enhanced at the same time point. High glucose significantly augmented the relaxation generated by acetylcholine in mesenteric and subcutaneous vessels at a 2 and 6 h incubation point, respectively. Conclusions and implications: Short periods of high glucose exert a variable influence on endothelial function in human isolated blood vessels that is dependent on factors of time, agonist-used and vessel studied. This has implications for how we view the effects of acute hyperglycaemia found in patients with diabetes mellitus as well as other conditions. British Journal of Pharmacology (2008) 153, 480,487; doi:10.1038/sj.bjp.0707592; published online 26 November 2007 [source] Calyculin-A, an inhibitor for protein phosphatases, induces cortical contraction in unfertilized sea urchin eggsCYTOSKELETON, Issue 4 2001Yukako Asano Abstract When an unfertilized sea urchin egg was exposed to calyculin-A (CL-A), an inhibitor of protein phosphatases, for a short period and then lysed, the cortex contracted to exclude cytoplasm and became a cup-shaped mass. We call the contracted cortex "actin cup" since actin filaments were major structural components. Electron microscopic observation revealed that the cup consisted of inner electron-dense layer, middle microfilamentous layer, and outermost granular region. Microfilaments were heavily accumulated in the inner electron-dense layer. The middle layer also contained numerous microfilaments, which were determined to be actin filaments by myosin S1 decoration, and they were aligned so that their barbed ends directed toward the outermost region. Myosin II, Arp2, Arp3, and spectrin were concentrated in the actin cup. Immuno-electron microscopy revealed that myosin II was localized to the electron-dense layer. We further found that the cortical tension of the egg increased just after application of CL-A and reached maximum within 10 min. Cytochalasin B or butanedione monoxime blocked the contraction, which suggested that both actin filaments and myosin ATPase activity were required for the contraction. Myosin regulatory light chain (MRLC) in the actin cup was shown to be phosphorylated at the activation sites Ser-19 and Thr-18, by immunoblotting with anti-phosphoepitope antibodies. The phosphorylation of MRLC was also confirmed by a 32P in vivo labeling experiment. The CL-A-induced cortical contraction may be a good model system for studying the mechanism of cytokinesis. Cell Motil. Cytoskeleton 48:245,261, 2001. © 2001 Wiley-Liss, Inc. [source] A Case of Foul Genital Odor Treated with Botulinum Toxin ADERMATOLOGIC SURGERY, Issue 9 2004Jae-Bong Lee MD Background. Genital odor is an uncommon condition characterized by an offensive and malodorous smell in the genital area. Although the etiology of foul genital odor is multifactorial, an important cause is sweat secretion and decomposition of sweat components by bacteria. Different methods are effective in reducing body odor secondary to bromhidrosis. Conservative methods only act for a short period of time, and more invasive surgical methods carry risk of complications or are inapplicable for the genital region. Methods. A patient with localized foul odor in the genital hair bearing area was treated with botulinum toxin A. Results. Botulinum toxin A was effective in creating an odorless and anhydrous response in the genital region, and no major adverse effects were noted during a follow-up of 9 months after injection. Conclusion. Local injection of botulinum toxin A appears to be a useful treatment for foul genital odor related to sweat glands activity. [source] The changing prevalence of diagnosed diabetes and its associated vascular complications in a large region of the UK*DIABETIC MEDICINE, Issue 6 2010C. L. Morgan Diabet. Med. 27, 673,678 (2010) Abstract Aims, To characterize the prevalence of diabetes in a large health district in 2004 and compare it with a previous estimate made in 1996. Methods, The study population comprised the resident population of Cardiff and the Vale of Glamorgan. Routine record linkage was used to identify patients from various sources of hospital and mortality data. Patients with diabetes were identified according to biochemistry test results, coding on routine data or attendance at a diabetes-related clinic. Diabetes-related complications were ascribed according to coding on routine data. Results, It was possible to identify 17 088 people with diabetes alive on 1 January 2005. Of these patients, 9064 (53.0%) were male and 8024 (47.0%) were female. Mean age (± sd) was 59.6 ± 18.9 years for males and 61.2 ± 20.4 years for females. The crude prevalence of diabetes in 2005 was 3.9% (3.4% adjusted) compared with 2.5% in 1996 (2.3% adjusted). With the exception of females aged , 75 years, the prevalence of diabetes increased in all age- and sex-specific subgroups. Within the 2005 cohort, over two-thirds has no recorded complications compared with approximately one half of the 1996 cohort. The prevalence of individual complications decreased, with the exception of renal complications. Conclusions, The prevalence of identified diabetes appears to have increased substantially over a relatively short period of 9 years to 2004. The increase in prevalence was 46%, with an increase in numbers of patients with diabetes of 53%. A number of factors are likely to have contributed to this, including an increase in case ascertainment. [source] Pulmonary Artery Dissection: Echocardiographic Findings and DiagnosisECHOCARDIOGRAPHY, Issue 4 2003Daniel Areco Pulmonary artery dissection is a rare but life-threatening event, predisposing to sudden cardiac death or cardiogenic shock. It is often associated with underlying congenital disorders predisposing to pulmonary hypertension. Rarely, it is diagnosed by echocardiography or other image techniques. We present a case report of a pulmonary artery dissection, diagnosed primarily by echocardiography. The patient died soon after refusing any interventional approach after a short period under medication. (ECHOCARDIOGRAPHY, Volume 20, May 2003) [source] Wedged between bottom-up and top-down processes: aphids on tansyECOLOGICAL ENTOMOLOGY, Issue 1 2004Bernhard Stadler Abstract., 1. Many species of aphids exploit a single host-plant species and have to cope with changing environmental conditions. They often vary greatly in abundance even when feeding on the same host. In a field experiment, the bottom-up (plant quality/patch type frequency) and top-down (ant attendance/predation) effects on the abundance of four species of aphids feeding on tansy (Tanacetum vulgare) were tested using a full factorial design. In addition, a model was used to examine these patch characteristics for their relative effects on the population dynamics and abundance of different aphid species. 2. Aphid numbers changed significantly depending on the quality of the host plant and the presence/absence of attending ants. The obligate myrmecophile, Metopeurum fuscoviride, was abundant on high-quality plants, while on poor quality plants or on plants without attending ants these aphids did not survive until the end of the experiment. The facultative myrmecophiles, Aphis fabae and Brachycaudus cardui, and the unattended aphid species, Macrosiphoniella tanacetaria, all reached similar peak population densities, but M. tanacetaria did best in poor quality patches. 3. Natural enemies reduced aphid numbers, but those species feeding on high-quality plants survived longer than those on poor-quality plants, which existed only for a short period of time, especially when associated with ants. Losses due to migration of winged morphs and mortality caused by parasitoids were insignificant. 4. Varying the frequency of different patch types in a model indicates that different degrees of associations with ants are favoured in different environments. If the proportion of high-quality patches in a habitat is large, obligate myrmecophiles do best. On increasing the number of poor-quality patches, unattended species become more abundant. 5. The results suggest that, in spite of large species specific differences in growth rates, degree of myrmecophily or life cycle features, the temporal and spatial variability in top-down and bottom-up forces differentially affects aphid species and allows the simultaneous exploitation of a shared host-plant species. [source] European Monetary Union: the dark sides of a major successECONOMIC POLICY, Issue 46 2006Charles Wyplosz SUMMARY European monetary union THE DARK SIDES OF A MAJOR SUCCESS This paper revisits the debates that have surrounded the launch of a unique experience: the adoption of a common currency among developed countries. A striking aspect of this history is that, pressed by what they correctly identified as a window of opportunity, policy-makers crafted this complex project in a short period of time, largely eschewing inputs from the academic profession. Academic research, in turn, developed its own views, which turned out to be critical of some ley orientations, yet it generally recognizes that, in the end, the launch of the euro has been a major success. Over time, many of the academic criticisms have been taken on board, but not yet fully. The monetary strategy has been slightly amended, but it remains the subject of disagreements between the European Central Bank and monetary economists. Events have confirmed that the Stability and Growth Pact was ill-designed; its reformulation goes some way to address some of the concerns but not all of them. Its ability to deliver fiscal discipline is in doubt. Another look at the experiment highlights the gap between the principles laid out by those who designed the monetary union and the pragmatism that has prevailed thereafter. The resulting tension between principles and actions sometimes obscures the fact that the Eurosystem has acted wisely so far. The widespread perception that monetary policy is not as transparent as it should be and suffers from a lack of adequate democratic accountability is not just annoying. The general public, including politicians, sometimes blames the Eurosystem for Europe's poor growth performance since the adoption of the euro. This is unfair and could dangerously undermine the monetary union if the Eurosystem were to become the scapegoat for the slow and incomplete reforms that are needed to revigorate the euro area's economies. , Charles Wyplosz [source] Phytosanitary measures in the European Union: a call for more dynamic risk management allowing more focus on real pest risks Case study: Potato spindle tuber viroid (PSTVd) on ornamental Solanaceae in EuropeEPPO BULLETIN, Issue 3 2008M. B. De Hoop After fifteen years of harmonisation of phytosanitary measures in the European Union, today's legislation has become increasingly stagnant, complex and detailed. The recent finding of Potato spindle tuber viroid in ornamental plants in the Netherlands and other Member States illustrates the struggle to take prompt emergency measures when specific knowledge is not available. It is proposed that the European Commission should take the initiative to organise the process of pest risk analysis from beginning to end. In addition, the Commission should have budgets at their disposal for instantaneous research to generate the required data and fill in knowledge gaps. Such policy enables evaluation of emergency measures and implementation of permanent requirements on the basis of scientific data within a short period, thereby creating a dynamic legislation that focuses on real pest risks. [source] Why do Both Parents Incubate in the Kentish Plover?ETHOLOGY, Issue 8 2003András Kosztolányi Incubation by both parents is a common parental behaviour in many avian species. Biparental incubation is expected if the survival prospects of offspring are greatly raised by shared care, relative to the costs incurred by each parent. We investigated this proposition in the Kentish plover Charadrius alexandrinus, in which both parents incubate the clutch, but one parent (either the male or the female) usually deserts after hatching of the eggs. We carried out a mate-removal and food supplementation experiment to reveal both the role of the sexes and food abundance in maintaining biparental incubation by removing either the male or the female from the nest for a short period of time. In some nests we provided supplementary food for the parent that remained at the nest to reduce the costs of incubation, whereas other nests were left unsupplemented. Although males spent more time on incubation after their mate had been removed, females' incubation did not change. Notwithstanding the increased male incubation, total nest attentiveness was lower at uniparental nests than at biparental controls. However, incubation behaviour was not influenced by food supplementation. We conclude that offspring desertion during incubation is apparently costly in the Kentish plover, and this cost cannot be ameliorated with supplementary food. [source] Helminths, allergic disorders and IgE-mediated immune responses: Where do we stand?EUROPEAN JOURNAL OF IMMUNOLOGY, Issue 5 2007Klaus Abstract Th2 responses induced by allergens or helminths share many common features. However, allergen-specific IgE can almost always be detected in atopic patients, whereas helminth-specific IgE is often not detectable and anaphylaxis often occurs in atopy but not helminth infections. This may be due to T regulatory responses induced by the helminths or the lack of helminth-specific IgE. Alternatively non-specific IgE induced by the helminths may protect from mast cell or basophil degranulation by saturating IgE binding sites. Both of these mechanisms have been implicated to be involved in helminth-induced protection from allergic responses. An article in the current issue of the European Journal of Immunology describes the generation of an anti- Nippostrongylus brasiliensis -specific IgE antibody which was used to identify a novel N. brasiliensis antigen (Nb-Ag1). The authors demonstrated that Nb-Ag1 specific IgE could only be detected for a short period of time during infection, and that these levels were sufficient to prime mast cells thereby leading to active cutaneous anaphylaxis after the application of Nb-Ag1. This is the first report clearly showing that a low level of helminth-specific IgE, transiently produced, is able to induce mast cell degranulation in the presence of large amounts of polyclonal IgE. See accompanying article: http://dx.doi/10.1002/eji.200737135 [source] Influence of shear flow on polymorphic behavior and microstructural development during palm oil crystallizationEUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, Issue 3 2009Veerle De Graef Abstract The influence of shear on the crystallization of palm oil was studied at four different crystallization temperatures (18, 20, 22 and 25,°C). Time-resolved X-ray analyses were carried out to study the effect of continuous shear on the crystallization kinetics of the fat. Rheological measurements were used to assess the effect of a shear step on crystallization, and finally polarized light microscopy was used to follow changes in microstructure due to the applied initial shear step. It was shown that shear enhanced the primary crystallization, even when low shear rates were applied for a short period. Furthermore, a shear step prior to crystallization without shear has a marked influence on the microstructural development. [source] Automated ultrasound-assisted method for the determination of the oxidative stability of virgin olive oilEUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, Issue 2 2007José Platero-López Abstract A fast and automated method is proposed for determining the oxidative stability of virgin olive oil by using ultrasound. The ultrasound microprobe (3,mm in diameter) was directly immersed into the olive oil sample contained in a test tube. The most influential variables in the oxidation process, namely pulse amplitude, duty cycle, irradiation time, and sample amount, were optimized. The oil absorbance at 270,nm was continuously monitored by oil recirculation through a 0.1-mm path length flow cell connected to a fiber optic microspectrometer. This short path length allowed the direct monitoring of absorbance without needing any sample dilution. The ultrasound energy was applied during 35,min, and the resulting increase in absorbance was continuously monitored. The difference between the final and the initial absorbance at 270,nm of a set of virgin olive oil samples was closely correlated with their oxidative stability calculated by the Rancimat method (R2,=,0.9915). The resulting equation enabled the prediction of the oxidative stability of virgin olive oil in a short period of time (35,min), by using a simple, inexpensive, automatic and easy-to-use system. [source] Percolation characteristics of a water-repellent sandy forest soilEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 1 2008G. Wessolek Summary In a tracer experiment TDR transect measurements were made to study percolation behaviour in a 120-year-old pine stand (Pinus sylvestris) on a water-repellent sandy soil (Haplic Arenosol). The experiment (with potassium iodide) showed an 80% labelling of the total flow in organic layers, whereas the area of transport in the mineral soil was sharply reduced to 12,30%. The average diameters of these preferential flow paths were about 8,15 cm. The TDR measurements indicate a homogeneous flow only for a short period from February until April. At this time of the year preferential flow is insignificant, because the soil is at approximately field capacity and not repellent to water. During summer (May to September) the soil dries out, and most precipitation results in preferential flow during this period. For any daily rainfall exceeding 10 mm, water infiltrates down to 1 m depth in the soil, which nevertheless, is still within the root zone. This kind of deep percolation results in the subsoil's wetting to field capacity (pF 1.8) earlier than the topsoil. A one-dimensional numerical model (SWAP) was used to simulate mean water balance with hydraulic functions with and without a water-repellency term. From the results of our tracer experiment we showed that the de-watering process in spring could be simulated well using the traditional piston flow concept, while the rewetting behaviour could be described more realistically using the mobile,immobile concept for water repellency. [source] EVOLUTION OF WOLBACHIA-INDUCED CYTOPLASMIC INCOMPATIBILITY IN DROSOPHILA SIMULANS AND D. SECHELLIAEVOLUTION, Issue 9 2002Sylvain Charlat Abstract., The intracellular bacterium Wolbachia invades arthropod host populations through various mechanisms, the most common of which being cytoplasmic incompatibility (CI). CI involves elevated embryo mortality when infected males mate with uninfected females or females infected with different, incompatible Wolbachia strains. The present study focuses on this phenomenon in two Drosophila species: D. simulans and D. sechellia. Drosophila simulans populations are infected by several Wolbachia strains, including w Ha and w No. Drosophila sechellia is infected by only two Wolbachia: w Sh and w Sn. In both Drosophila species, double infections with Wolbachia are found. As indicated by several molecular markers, w Ha is closely related to w Sh, and w No to w Sn. Furthermore, the double infections in the two host species are associated with closely related mitochondrial haplotypes, namely si I (associated with w Ha and w No in D. simulans) and se (associated with w Sh and w Sn in D. sechellia). To test the theoretical prediction that Wolbachia compatibility types can diverge rapidly, we injected w Sh and w Sn into D. simulans, to compare their CI properties to those of their sister strains w Ha and w No, respectively, in the same host genetic background. We found that within each pair of sister strains CI levels were similar and that sister strains were fully compatible. We conclude that the short period for which the Wolbachia sister strains have been evolving separated from each other was not sufficient for their CI properties to diverge significantly. [source] Expression of Hoxa-11 and Hoxa-13 in the pectoral fin of a basal ray-finned fish, Polyodon spathula: implications for the origin of tetrapod limbsEVOLUTION AND DEVELOPMENT, Issue 3 2005Brian D. Metscher Summary Paleontological and anatomical evidence suggests that the autopodium (hand or foot) is a novel feature that distinguishes limbs from fins, while the upper and lower limb (stylopod and zeugopod) are homologous to parts of the sarcopterygian paired fins. In tetrapod limb development Hoxa-11 plays a key role in differentiating the lower limb and Hoxa-13 plays a key role in differentiating the autopodium. It is thus important to determine the ancestral functions of these genes in order to understand the developmental genetic changes that led to the origin of the tetrapod autopodium. In particular it is important to understand which features of gene expression are derived in tetrapods and which are ancestral in bony fishes. To address these questions we cloned and sequenced the Hoxa-11 and Hoxa-13 genes from the North American paddlefish, Polyodon spathula, a basal ray-finned fish that has a pectoral fin morphology resembling that of primitive bony fishes ancestral to the tetrapod lineage. Sequence analysis of these genes shows that they are not orthologous to the duplicated zebrafish and fugu genes. This implies that the paddlefish has not duplicated its HoxA cluster, unlike zebrafish and fugu. The expression of Hoxa-11 and Hoxa-13 in the pectoral fins shows two main phases: an early phase in which Hoxa-11 is expressed proximally and Hoxa-13 is expressed distally, and a later phase in which Hoxa-11 and Hoxa-13 broadly overlap in the distal mesenchyme of the fin bud but are absent in the proximal fin bud. Hence the distal polarity of Hoxa-13 expression seen in tetrapods is likely to be an ancestral feature of paired appendage development. The main difference in HoxA gene expression between fin and limb development is that in tetrapods (with the exception of newts) Hoxa-11 expression is suppressed by Hoxa-13 in the distal limb bud mesenchyme. There is, however, a short period of limb bud development where Hoxa-11 and Hoxa-13 overlap similarly to the late expression seen in zebrafish and paddlefish. We conclude that the early expression pattern in tetrapods is similar to that seen in late fin development and that the local exclusion by Hoxa-13 of Hoxa-11 from the distal limb bud is a derived feature of limb developmental regulation. [source] Human melanocytes can be isolated, propagated and expanded from plucked anagen hair folliclesEXPERIMENTAL DERMATOLOGY, Issue 6 2010Christina Dieckmann Please cite this paper as: Human melanocytes can be isolated, propagated and expanded from plucked anagen hair follicles. Experimental Dermatology 2010; 19: 543,545. Abstract:, Herein, we report a technically simple method for isolation and culture of human follicular melanocytes based on explant cultures of epilated hair follicles. This technique does not require any surgical intervention and allows the isolation and cultivation of follicular melanocytes from a comparatively small amount of raw material. Generally, 30,60 human anagen hair follicles have been plucked from the scalp of healthy donors and cultivated under low oxygen pressure (5%). After a short period of time cells of various types were growing out from the outer root sheath (ORS) of the hair follicles. Under the selected culture conditions, most of the cells other than melanocytes have been eliminated and a nearly 100% pure population of melanocytes has been achieved, as confirmed by immunohistochemical analyses for melanocyte-specific markers, for example, Tyrosinase-1, S-100 and premelanosomal antigens. These melanocytes derived from the ORS were proliferating for up to 2 months. [source] Indigenous Methodologies: Suggestions for Junior ResearchersGEOGRAPHICAL RESEARCH, Issue 1 2010NAOHIRO NAKAMURA Abstract Indigenous methodologies in geography have recently been developed to decolonise Western dominated paradigms. It has been argued that research which does not benefit Indigenous communities should not be conducted. However, Indigenous methodologies are not taught in many post-secondary institutions. Therefore, when they pursue Indigenous topics, many junior researchers are self-taught in these methodologies. However, these methodologies cannot be defined simply and they are too diverse to be learnt in a short period. In Japan, Indigenous peoples are not widely recognised and research on contemporary Indigenous issues is limited. The concept of Indigenous methodologies is rarely discussed. Because of this, Japanese researchers rarely identify their research as adopting an Indigenous methodology. Indigenous researchers are thereby discouraged from pursuing Indigenous methodologies. Furthermore, a methodology or a thesis statement used by researchers to reflect Indigenous perspectives often gets little support from Indigenous peoples. My master's research on the Ainu mirrored this situation. While Indigenous methodologies remain difficult to learn, junior researchers should not be discouraged from this form of engagement. Practical suggestions are therefore necessary to encourage their use and application. Based on my experience, I suggest that researchers approach Indigenous communities from a learning perspective. This would encourage open-mindedness and sensitivity. Researchers should also be prepared and willing to refine their research questions and to continue their literature searches after their fieldwork is completed. These strategies could limit misinterpretation and exploitation of Indigenous knowledges and peoples. [source] Insights into biaxial extensional tectonics: an examplefrom the Sand,kl, Graben, West Anatolia, TurkeyGEOLOGICAL JOURNAL, Issue 1 2003Mustafa Cihan Abstract West Anatolia, together with the Aegean Sea and the easternmost part of Europe, is one of the best examples of continental extensional tectonics. It is a complex area bounded by the Aegean,Cyprus Arc to the south and the North Anatolian Fault Zone (NAFZ) to the north. Within this complex and enigmatic framework, the Sand,kl, Graben (10,km wide, 30,km long) has formed at the eastern continuation of the Western Anatolian extensional province at the north-northwestward edge of the Isparta Angle. Recent studies have suggested that the horst,graben structures in West Anatolia formed in two distinct extensional phases. According to this model the first phase of extension commenced in the Early,Middle Miocene and the last, which is accepted as the onset of neotectonic regime, in Early Pliocene. However, it is controversial whether two-phase extension was separated by a short period of erosion or compression during Late Miocene,Early Pliocene. Both field observations and kinematic analysis imply that the Sand,kl, Graben has existed since the Late Pliocene, with biaxial extension on its margins which does not necessarily indicate rotation of regional stress distribution in time. Although the graben formed later in the neotectonic period, the commencement of extension in the area could be Early Pliocene (c. 5,Ma) following a severe but short time of erosion at the end of Late Miocene. The onset of the extensional regime might be due to the initiation of westward motion of Anatolian Platelet along the NAFZ that could be triggered by the higher rate of subduction at the east Aegean,Cyprus Arc in the south of the Aegean Sea. Copyright © 2003 John Wiley & Sons, Ltd. [source] Evaluating local hydrological modelling by temporal gravity observations and a gravimetric three-dimensional modelGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 1 2010M. Naujoks SUMMARY An approach for the evaluation of local hydrological modelling is presented: the deployment of temporal terrestrial gravity measurements and gravimetric 3-D modelling in addition to hydrological point observations. Of particular interest is to what extent such information can be used to improve the understanding of hydrological process dynamics and to evaluate hydrological models. Because temporal gravity data contain integral information about hydrological mass changes they can be considered as a valuable augmentation to traditional hydrological observations. On the other hand, hydrological effects need to be eliminated from high-quality gravity time-series because they interfere with small geodynamic signals. In areas with hilly topography and/or inhomogeneous subsoil, a simple reduction based on hydrological point measurements is usually not sufficient. For such situations, the underlying hydrological processes in the soil and the disaggregated bedrock need to be considered in their spatial and temporal dynamics to allow the development of a more sophisticated reduction. Regarding these issues interdisciplinary research has been carried out in the surroundings of the Geodynamic Observatory Moxa, Germany. At Moxa, hydrologically induced gravity variations of several 10 nm s,2 are observed by the stationarily operating superconducting gravimeter and by spatially distributed and repeated high-precision measurements with transportable relative instruments. In addition, hydrological parameters are monitored which serve as input for a local hydrological catchment model for the area of about 2 km2 around the observatory. From this model, spatial hydrological variations are gained in hourly time steps and included as density changes of the subsoil in a well-constrained gravimetric 3-D model to derive temporal modelled gravity variations. The gravity variations obtained from this combined modelling correspond very well to the observed hydrological gravity changes for both, short period and seasonal signals. From the modelling the amplitude of the impact on gravity of hydrological changes occurring in different distances to the gravimeter location can be inferred. Possible modifications on the local hydrological model are discussed to further improve the quality of the model. Furthermore, a successful reduction of local hydrological effects in the superconducting gravimeter data is developed. After this reduction global seasonal fluctuations are unmasked which are in correspondence to GRACE observations and to global hydrological models. [source] Prediction of thermal sensation based on simulation of temperature distribution in a vehicle cabinHEAT TRANSFER - ASIAN RESEARCH (FORMERLY HEAT TRANSFER-JAPANESE RESEARCH), Issue 3 2001Takuya Kataoka Abstract Thermal comfort in an automobile is predicted with numerical simulation. The flow field and temperature distribution are solved with a grid system based on many small cubic elements which are generated automatically with cabin and passenger configuration. Simulation of temperature is combined with simulation of cooling cycle and calculation of heat transfer at the wall including solar radiation to treat transient and actual driving conditions of the vehicle. In order to evaluate thermal comfort, transitional effective temperature is calculated from simulated thermal conditions and physiologic values which are calculated by a simple model of a human thermal system. This system can well predict thermal sensation of passengers in a short period of time. © 2001 Scripta Technica, Heat Trans Asian Res, 30(3): 195,212, 2001 [source] Efficient Regio- and Stereoselective Conversions of Oxiranes and Aziridines into , -(Nitrooxy)-Substituted Alcohols and Amines by Using Bismuth Nitrate,HELVETICA CHIMICA ACTA, Issue 1 2007Biswanath Das Abstract Oxiranes and aziridines efficiently undergo ring opening with bismuth nitrate at room temperature to furnish the corresponding , -(nitrooxy)-substituted alcohols and amines respectively. The conversions are highly regio- and stereoselective and afford the nitrooxy-compounds in excellent yields within a short period of time. [source] Long-term precipitation and slide activity in south-eastern Norway, autumn 2000HYDROLOGICAL PROCESSES, Issue 4 2008Christian Jaedicke Abstract In autumn 2000 high amounts of precipitation caused a large number of landslides in south-eastern Norway. The precipitation reached more than 400% of the normal monthly values in November. In addition to the precipitation, groundwater monitoring showed unusual high levels. High air temperatures in the mountains caused the precipitation to fall as rain instead of snow, causing additional runoff in the catchments. In this paper, 90 landslides are presented that were studied and evaluated by the Norwegian Geotechnical Institute (NGI) in the counties effected by the slide activity. The landslide database serves as start point for an analysis of the connection between slide activity and precipitation. The analysis shows a high variability of the observed precipitation just a few days before the slides. This variability decreases significantly around 50 days prior to the slides when the results stabilize at about 400% of normal precipitation in a 50-day period. Comparison of these results to long time observations gives an estimate of return periods for the precipitation events. The 53 days accumulated precipitation has the highest return period of 132 years. This suggests that the high landslide activity in autumn 2000 in south-eastern Norway was caused by a long-term infiltration of large amounts of precipitation rather than high rainfall intensities during a short period. Copyright © 2007 John Wiley & Sons, Ltd. [source] Remote sensing and GIS-based flood vulnerability assessment of human settlements: a case study of Gangetic West Bengal, IndiaHYDROLOGICAL PROCESSES, Issue 18 2005Joy Sanyal Abstract Flooding due to excessive rainfall in a short period of time is a frequent hazard in the flood plains of monsoon Asia. In late September 2000, a devastating flood stuck Gangetic West Bengal, India. This particular event has been selected for this study. Instead of following the conventional approach of flooded area delineation and overall damage estimation, this paper seeks to identify the rural settlements that are vulnerable to floods of a given magnitude. Vulnerability of a rural settlement is perceived as a function of two factors: the presence of deep flood water in and around the settlement and its proximity to an elevated area for temporary shelter during an extreme hydrological event. Landsat ETM+ images acquired on 30 September 2000 have been used to identify the non-flooded areas within the flooded zone. Particular effort has been made to differentiate land from water under cloud shadow. ASTER digital elevation data have been used to assess accuracy and rectify the classified image. The presence of large numbers of trees around rural settlements made it particularly difficult to extract the flooded areas from their spectral signatures in the visible and infrared bands. ERS-1 synthetic aperture radar data are found particularly useful for extracting the settlement areas surrounded by trees. Finally, all information extracted from satellite imageries are imported into ArcGIS, and spatial analysis is carried out to identify the settlements vulnerable to river inundation. Copyright © 2005 John Wiley & Sons, Ltd. [source] A validity and reliability study of assessment and screening for sustained withdrawal reaction in infancy: The Alarm Distress Baby scale,INFANT MENTAL HEALTH JOURNAL, Issue 5 2001Antoine Guedeney Sustained withdrawal behavior in infancy is an important alarm signal to draw attention to both organic and relationship disorders. A withdrawal scale, the Alarm Distress Baby scale (ADBB), for infants between 2 and 24 months of age was built. This article describes the construction of the scale and the assessment of its psychometric properties. The ADBB has good content validity, based on the advice of seven experts. The scale has good criterion validity: first, as a measure of the infant's withdrawal reaction, with a very good correlation between nurse and pediatrician on the ADBB (rs = 0.84), and second, as a screening procedure for detecting the developmental risk of the infant. The cutoff score of 5 with a sensitivity of 0.82 and a specificity of 0.78 was determined to be optimal for screening purposes. The scale has good construct validity, with good convergent validity with both the Spitz (1951) and the Herzog & Rathbun (1982) lists of symptoms of infant depression (rs = 0.61 and 0.60, respectively). Exploratory factor analysis showed two different factors, consistent with the scale's construct. Reliability was satisfactory with good internal consistency for both subscales (the Cronbach , = 0.80 for the first subscale and 0.79 for the second) and for the global scale (, = 0.83). The test-retest procedure showed good stability over time (rs = 0.90 and 0.84 for the two different raters). The scale could be used in different clinical settings, provided a sufficient level of social stimulation is given to the infant in a relatively brief period of time. The scale can be used by nurses and psychologists or by medical doctors after a short period of training. © 2001 Michigan Association for Infant Mental Health. [source] Variability of the recent climate of eastern AfricaINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 6 2004Carl J. Schreck III Abstract The primary objective of this study is to investigate the recent variability of the eastern African climate. The region of interest is also known as the Greater Horn of Africa (GHA), and comprises the countries of Burundi, Djibouti, Eritrea, Ethiopia, Kenya, Rwanda, Somalia, Sudan, Uganda, and Tanzania. The analysis was based primarily on the construction of empirical orthogonal functions (EOFs) of gauge rainfall data and on CPC Merged Analysis of Precipitation (CMAP) data, derived from a combination of rain-gauge observations and satellite estimates. The investigation is based on the period 1961,2001 for the ,short rains' season of eastern Africa of October through to December. The EOF analysis was supplemented by projection of National Centers for Environmental Prediction wind data onto the rainfall eigenmodes to understand the rainfall,circulation relationships. Furthermore, correlation and composite analyses have been performed with the Climatic Research Unit globally averaged surface-temperature time series to explore the potential relationship between the climate of eastern Africa and global warming. The most dominant mode of variability (EOF1) based on CMAP data over eastern Africa corresponds to El Nińo,southern oscillation (ENSO) climate variability. It is associated with above-normal rainfall amounts during the short rains throughout the entire region, except for Sudan. The corresponding anomalous low-level circulation is dominated by easterly inflow from the Indian Ocean, and to a lesser extent the Congo tropical rain forest, into the positive rainfall anomaly region that extends across most of eastern Africa. The easterly inflow into eastern Africa is part of diffluent outflow from the maritime continent during the warm ENSO events. The second eastern African EOF (trend mode) is associated with decadal variability. In distinct contrast from the ENSO mode pattern, the trend mode is characterized by positive rainfall anomalies over the northern sector of eastern Africa and opposite conditions over the southern sector. This rainfall trend mode eluded detection in previous studies that did not include recent decades of data, because the signal was still relatively weak. The wind projection onto this mode indicates that the primary flow that feeds the positive anomaly region over the northern part of eastern Africa emanates primarily from the rainfall-deficient southern region of eastern Africa and Sudan. Although we do not assign attribution of the trend mode to global warming (in part because of the relatively short period of analysis), the evidence, based on our results and previous studies, strongly suggests a potential connection. Copyright © 2004 Royal Meteorological Society. [source] Droughts and extreme events in regional daily Italian precipitation seriesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 5 2002Michele Brunetti Abstract This paper proposes a methodology to study daily precipitation series that include a significant proportion of missing data, without resorting to completion methods based on randomly generated numbers. It is applied to a data set consisting of 75 station records (1951,2000) covering the Italian territory. They are clustered by principal component analysis into six regions: the north-west, the northern part of the north-east, the southern part of the north-east, the centre, the south and the islands (i.e. Sicily and Sardinia). Complete annual and seasonal regional average series are obtained from the incomplete station records, and analysed for droughts and extreme precipitation events. Droughts are identified by means of two indicators: the longest dry period and the proportion of dry days. The most remarkable result is a systematic increase in winter droughts over all of Italy, especially in the north, due mainly to the very dry 1987,93 period. Extreme events are analysed considering 5 day regional totals. In this case, however, an attempt to search for a statistically significant trend is not successful because of the scarcity of events in such a short period. The reliability of the regional series is checked by computing some basic statistics concerning total precipitation, rainy days and precipitation intensity and comparing them with the same statistics computed for regional series obtained by station records completed with methods based on random number generators. Copyright © 2002 Royal Meteorological Society. [source] Nursing management of fever in children: A systematic reviewINTERNATIONAL JOURNAL OF NURSING PRACTICE, Issue 1 2003FRCNA, Robin Watts RN ABSTRACT Objectives:, The aim of the present review was to determine whether the best available evidence supports the types and timing of the various nursing interventions that are commonly used to reduce fever in non-critically-ill children, and to what extent the outcomes are influenced by these nursing actions. Methods:, Studies included were randomised or quasi-randomised controlled trials that involved non-critically-ill children with a fever aged between 3 months and 16 years. ,,The search strategy sought to identify both published and unpublished research reports in the English language and covered all major databases up to 1998. ,,The methodological quality of each study was assessed by two independent reviewers using a piloted critical appraisal checklist. ,,Despite all studies being randomised, heterogeneity precluded conduction of a meta-analysis; therefore, evidence was synthesised using narrative summaries. Results: Ten studies were assessed as being of sufficient quality to be included in the review. These studies addressed two of the intervention categories identified in the protocol: (i) administration of antipyretics (paracetamol); and (ii) direct cooling measures on the outcome measure (reduction of or prevention of increase in fever). The review found little benefit from sponging in temperate climates and usually at the expense of the child's comfort. There may be situations in high environmental temperatures and high humidity, or where there is a need for immediate temperature reduction, in which sponging may be warranted. Risks were identified when paracetamol was administered on a sustained basis over even a short period of time and above a relatively low total daily dosage. There was a lack of evidence to support the administration of antipyretics to reduce the incidence of febrile convulsions. There is a need for parental education that focuses on knowledge of the body's protective physiological responses and how to support these responses. Conclusion: The primary purpose for intervening when a child has a fever is to increase the child's comfort. This consideration should be weighed against any harm that might result from intervening. There was a lack of evidence to support the routine use of sponging. The administration of paracetamol should be used selectively and with caution. In summary, care needs to be individualised, based on current knowledge of the effectiveness and risks of interventions. [source] A double blind, randomized, placebo controlled study to evaluate the efficacy of erythromycin in patients with knee effusion due to osteoarthritisINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Issue 1 2009Shahram SADREDDINI Abstract Objective:, The efficacy of erythromycin in treatment of knee effusion due to osteoarthritis was evaluated. Method:, We assessed efficacy and safety of erythromycin during 16 weeks in patients enrolled in a randomized double-blind study. One hundred and eight patients with knee effusion due to osteoarthritis (OA) received 12-week courses of erythromycin or placebo allocated randomly, and were followed for 4 months. Acetaminophen 650 mg/day was used in both groups, while they received no other anti-inflammatory drugs (such as corticosteroid or nonsteroidal anti-inflammatory drugs) during the course of the study. Our patients were divided in two groups, erythromycin in doses of 200 mg four times per day was given to the first group (51 patients) over the first 3 months of the study and in the second group we used placebo with the same dosage and schedule (53 patients). Outcomes improvement for the erythromycin-treated group was assessed by a significantly higher mean score from baseline to the end of the trial, compared with placebo group. Patients were examined monthly during the treatment period. Measurement values included recording of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire subscales (pain, stiffness and function), range of motion and knee circumference. Results:, Erythromycin produced a higher response rate than placebo in treatment of knee effusion due to OA. Significant reduction in knee circumference (P < 0.0005) and pain (P < 0.001) with functional improvement (P < 0.0005) were seen. At the first month after treatment, 11.8% (6 patients) in erythromycin and 9.4% (5 patients) in placebo groups had 50% pain reduction, which was not significant (P = 0.75). At the fourth month, 50% reduction of pain was seen in 45.1% (23 patients) of the erythromycin and 11.3% (6 patients) of the placebo group. This was statistically significant (P < 0.0005). Erythromycin treatment was well tolerated and mild adverse events caused no discontinuation during the study. Conclusion:, This is a placebo-controlled study of macrolid efficacy on knee effusion due to OA in a short period. Results of this research showed the better efficacy of erythromycin in controlling effusion and pain with functional improvement in patients with knee effusion due to OA. 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