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Sharp Distinction (sharp + distinction)
Selected AbstractsDefining and classifying periodontitis: need for a paradigm shift?EUROPEAN JOURNAL OF ORAL SCIENCES, Issue 1 2003Vibeke Baelum The past two decades have witnessed a large number of proposals for the classification of periodontitis. These proposals are all founded in an essentialistic disease concept, according to which periodontitis is a link between the causes and the signs and symptoms of periodontitis. Essentialistic definitions are necessarily rather imprecise and thereby subject to multiple interpretations. Consequently, it remains unknown to what extent current knowledge regarding ,different' forms of periodontitis is based on the ,same' type of patients. However, periodontitis is a syndrome, the clinical manifestations of which may come in all sizes. Thereby, periodontitis has no diagnostic truth, just as there is no natural basis for a sharp distinction between health and disease or between ,different' forms of periodontitis. Recognition of these facts and adoption of a nominalistic approach to the definition of periodontitis is needed to provide a rational framework for the development of a classification system that meets the needs of both clinicians and scientists. [source] FELLOW CITIZENS AND IMPERIAL SUBJECTS: CONQUEST AND SOVEREIGNTY IN EUROPE'S OVERSEAS EMPIRESHISTORY AND THEORY, Issue 4 2005ANTHONY PAGDEN ABSTRACT This article traces the association between the European overseas empires and the concept of sovereignty, arguing that, ever since the days of Cicero,if not earlier,Europeans had clung to the idea that there was a close association between a people and the territory it happened to occupy. This made it necessary to think of an "empire" as a unity,an "immense body," to use Tacitus's phrase,that would embrace all its subjects under a single sovereign. By the end of the eighteenth century it had become possible, in this way, to speak of "empires of liberty" that would operate for the ultimate benefit of all their "citizens," freeing them from previous tyrannical rulers and bringing them under the protection of more benign regimes. In such empires sovereignty could only ever be, as it had become in Europe, undivided. The collapse of Europe's "first" empires in the Americas, however, was followed rapidly by Napoleon's attempt to create a new kind of Empire in Europe. The ultimate, and costly, failure of this project led many, Benjamin Constant among them, to believe that the age of empires was now over and had been replaced by the age of commerce. But what in fact succeeded Napoleon was the modern European state system, which attempted not to replace empire by trade, as Constant had hoped, but to create a new kind of empire, one that sought to minimize domination and settlement, and to make a sharp distinction between imperial ruler and imperial subject. In this kind of empire, sovereignty could only be "divided." Various kinds of divided rule were thus devised in the nineteenth century. Far, however, from being an improvement on the past, this ultimately resulted in,or at least contributed greatly to,the emergence of the largely fictional and inevitably unstable societies that after the final collapse of the European empires became the new states of the "developing world." [source] A Reevaluation of the New York Court of Appeals: The Home, the Market, and Labor, 1885-1905LAW & SOCIAL INQUIRY, Issue 3 2002Felice Batlan Closely examining a range of New York Court of Appeals police-power cases during the period 1885 to 1905, this article demonstrates that the New York Court had a long history of accepting and continually expanding the police power. In these police-power cases, one finds the court grappling with an evolving sense of how to balance the concept of and need for a well-regulated society against the rights of an individual in an increasingly complex and interconnected world, as well as a tenacious refusal to abandon Victorian bourgeois norms regarding the dichotomy between the home and workplace. By contextualizing and historicizing New York Court of Appeals cases, the article challenges the dominant historiographical interpretations about late-nineteenth-century law. Moving away from a paradigm that labels the court conservative or liberal, formalist or realist, it argues that the court participated in creating a regulatory state while also employing a reasoning that adopted a sharp distinction between the market and the site of the domestic. [source] BEALER ON THE AUTONOMY OF PHILOSOPHICAL AND SCIENTIFIC KNOWLEDGEMETAPHILOSOPHY, Issue 1 2007MICHAEL J. SHAFFER Abstract: In a series of influential articles, George Bealer argues for the autonomy of philosophical knowledge on the basis that philosophically known truths must be necessary truths. The main point of his argument is that the truths investigated by the sciences are contingent truths to be discovered a posteriori by observation, while the truths of philosophy are necessary truths to be discovered a priori by intuition. The project of assimilating philosophy to the sciences is supposed to be rendered illegitimate by the more or less sharp distinction in these characteristic methods and its modal basis. In this article Bealer's particular way of drawing the distinction between philosophy and science is challenged in a novel manner, and thereby philosophical naturalism is further defended. [source] Localizations of intracellular calcium and Ca2+ -ATPase in hamster spermatogenic cells and spermatozoaMICROSCOPY RESEARCH AND TECHNIQUE, Issue 8 2006H.L. Feng Abstract Calcium plays a predominant role regulating many functional processes of spermatogenesis and fertilization. The purpose of the present study is to define the exact location of calcium as well as examine the role it plays during spermatogenesis and sperm capacitation. Testes and epididymides were obtained from adult healthy male hamsters. Spermatozoa were incubated with modified Tyrode's medium up to 4 h at 37°C for sperm capacitation in vitro. Samples of the testes and sperm cells were analyzed by cytochemical techniques to determine the location of calcium and Ca2+ -ATPase and the percentage of acrosome reactions under light and electron microscopy. The data showed that (1) Sertoli cells exhibited numerous calcium precipitates as large, round, electron-dense bodies distributed throughout the cytoplasm and the mitochondrial matrix. Fine calcium precipitates existed in fewer numbers in the intracellular storage sites of spermatogonia and primary spermatocytes, in sharp distinction to secondary spermatocyte and spermatids, which showed an abundance of large and round calcium precipitates, especially in the mitochondrial matrix of spermatids. More calcium deposits were distributed in the plasma membrane (PM), acrosome membrane, and matrices of the acrosome and mitochondria following capacitation; (2) Ca2+ -ATPase was found in the endoplasmic reticulum system and PM of noncapacitated spermatozoa as well as Sertoli cells. Capacitated spermatozoa showed a weak signal. These results suggest that the presence of calcium in spermatogenic cells might play a role in cell growth and differentiation during spermatogenesis. The Ca2+ -ATPase function may be inhibited during capacitation, leading to an increase in acrosomal calcium level and triggering of acrosomal exocytosis. Microsc. Res. Tech., 2006. © 2006 Wiley-Liss, Inc. [source] Risk, Ritual and PerformanceTHE JOURNAL OF THE ROYAL ANTHROPOLOGICAL INSTITUTE, Issue 1 2000Leo Howe Performance approaches to the interpretation of ritual highlight process, presence, strategy and uniqueness. They are often favourably contrasted to textual approaches said to emphasize meaning, structure and stability. However, this sharp distinction can be maintained only by ignoring the notion of inscription, which is central to text. Inscription is a political process which involves risk, strategy and struggle. Moreover, commonly performance approaches neglect questions of risk in ritual action. Ritual is often seen as suppressing risk, but many rituals are events involving high risk. This article considers various Balinese rituals in which risk is a prominent feature, and suggests ways in which a focus on risk may aid our understanding of ritual. [source] On the Meaning of Words and Dinosaur Bones: Lexical Knowledge Without a LexiconCOGNITIVE SCIENCE - A MULTIDISCIPLINARY JOURNAL, Issue 4 2009Jeffrey L. Elman Abstract Although for many years a sharp distinction has been made in language research between rules and words,with primary interest on rules,this distinction is now blurred in many theories. If anything, the focus of attention has shifted in recent years in favor of words. Results from many different areas of language research suggest that the lexicon is representationally rich, that it is the source of much productive behavior, and that lexically specific information plays a critical and early role in the interpretation of grammatical structure. But how much information can or should be placed in the lexicon? This is the question I address here. I review a set of studies whose results indicate that event knowledge plays a significant role in early stages of sentence processing and structural analysis. This poses a conundrum for traditional views of the lexicon. Either the lexicon must be expanded to include factors that do not plausibly seem to belong there; or else virtually all information about word meaning is removed, leaving the lexicon impoverished. I suggest a third alternative, which provides a way to account for lexical knowledge without a mental lexicon. [source] Differential sensitivity to apoptosis between the human small and large intestinal mucosae: Linkage with segment-specific regulation of Bcl-2 homologs and involvement of signaling pathways,JOURNAL OF CELLULAR BIOCHEMISTRY, Issue 2 2001Rémy Gauthier Abstract The small and large intestines differ in their expression profiles of Bcl-2 homologs. Intestinal segment-specific Bcl-2 homolog expression profiles are acquired as early as by mid-gestation (18,20 weeks) in man. In the present study, we examined the question whether such distinctions underlie segment-specific control mechanisms of intestinal cell survival. Using mid-gestation human jejunum and colon organotypic cultures, we analyzed the impact of growth factors (namely insulin; 10 ,g/ml) and pharmacological compounds that inhibit signal transduction molecules/pathways (namely tyrosine kinases, Fak, PI3-K/Akt, and MEK/Erk) on cell survival and Bcl-2 homolog expression (anti-apoptotic: Bcl-2, Bcl-XL, Mcl-1; pro-apoptotic: Bax, Bak, Bad). The relative activation levels of p125Fak, p42Erk-2, and p57Akt were analyzed as well. Herein, we report that (1) the inhibition of signal transduction molecules/pathways revealed striking differences in their impact on cell survival in the jejunum and colon (e.g., the inhibition of p125Fak induced apoptosis with a significantly greater extent in the jejunum [,43%] than in the colon [,24%]); (2) sharp distinctions between the two segments were noted in the modulatory effects of the various treatments on Bcl-2 homolog steady-state levels (e.g., inhibition of tyrosine kinase activities in the jejunum down-regulated all anti-apoptotics analyzed while increasing Bax, whereas the same treatment in the colon down-regulated Bcl-XL only and increased all pro-apoptotics); and (3) in addition to their differential impact on cell survival and Bcl-2 homolog expression, the MEK/Erk and PI3-K/Akt pathways were found to be distinctively regulated in the jejunum and colon mucosae (e.g., insulin in the jejunum increased p42Erk-2 activation without affecting that of p57Akt, whereas the sa e treatment in the colon decreased p42Erk-2 activation while increasing that of p57Akt). Altogether, these data show that intestinal cell survival is characterized by segment-specific susceptibilities to apoptosis, which are in turn linked with segmental distinctions in the involvement of signaling pathways and the regulation of Bcl-2 homolog steady-state levels. Therefore, these indicate that cell survival is subject to segment-specific control mechanisms along the proximal-distal axis of the intestine. J. Cell. Biochem. 82: 339,355, 2001. © 2001 Wiley-Liss, Inc. [source] | |||||||||||||