			Home About us Contact

Shares Similarities (share + similarity)

Distribution by Scientific Domains

Psychology	50%

Selected Abstracts

Eating Disorder Not Otherwise Specified

INTERNATIONAL JOURNAL OF EATING DISORDERS, Issue S3 2007
You have free access to this content
Abstract Objective: This study sought to characterize a large number of adult outpatients diagnosed with eating disorder not otherwise specified (EDNOS). Method: The sample consisted of 1,449 patients who were classified as anorexia nervosa (AN), bulimia nervosa (BN), or assigned to one of six EDNOS categories. Eating disorder groups were compared on demographic features, symptom frequencies, and psychological functioning. Results: Forty percent of the sample was categorized as EDNOS. A subgroup of purging only patients closely resembled the BN purging subtype. Although EDNOS subthreshold BN patients reported less psychopathology than full syndrome BN they, nevertheless, displayed clinical levels of disturbance. Patients who binge-eat once a week demonstrate a profile of psychological functioning similar to those who binge eat twice a week. Conclusion: Consistent with previous research, in this sample there were subgroups embedded in the EDNOS category that both share similarities with and differ from full syndrome BN. Int J Eat Disord 2007 © 2007 by Wiley Periodicals, Inc. [source]

A question for DSM-V: which better predicts persistent conduct disorder , delinquent acts or conduct symptoms?

CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 1 2002
Jeffrey D. Burke PhD
Background Conduct disorder (CD), a psychiatric index of antisocial behaviour, shares similarities with delinquency, a criminological index. This study sought to examine which factors in childhood predict a repeated diagnosis of CD in adolescence, and whether self-reported delinquent acts enhance the utility of symptoms of CD in predicting later persistent CD. Method Longitudinal data used in this paper come from a clinic-referred sample of 177 boys, along with their parents and teachers, who were assessed using a structured clinical interview. The boys also reported on their delinquent behaviours, as well as a broad range of other family and life events. Results Before age 13, 77 boys met criteria for CD according to their parent, 69 according to their own report, and 36 reported three or more delinquent acts. Forty-eight boys (29%) met criteria for CD three or more times between 13 and 17. In childhood, delinquency overlapped, but was distinct from CD. Both were present in 28 cases, while 41 cases had CD without delinquency, and eight had delinquency without CD. When tested as predictors of later persistent CD, child-reported CD was the strongest predictor of later persistent CD, but self-reported delinquency was stronger than parent-reported CD. A final model of significant predictors included child-reported CD, delinquency, poor child communication with parents, and maternal prenatal smoking. Conclusions It appears that delinquency does add uniquely to the prediction of persistent CD. It may be useful to expand the diagnostic criteria for CD accordingly. Copyright © 2002 Whurr Publishers Ltd. [source]

Potential roles for BMP and Pax genes in the development of iris smooth muscle

DEVELOPMENTAL DYNAMICS, Issue 2 2005
Abbie M. Jensen
Abstract The embryonic optic cup generates four types of tissue: neural retina, pigmented epithelium, ciliary epithelium, and iris smooth muscle. Remarkably little attention has focused on the development of the iris smooth muscle since Lewis ([1903] J. Am. Anat. 2:405,416) described its origins from the anterior rim of the optic cup neuroepithelium. As an initial step toward understanding iris smooth muscle development, I first determined the spatial and temporal pattern of the development of the iris smooth muscle in the chick by using the HNK1 antibody, which labels developing iris smooth muscle. HNK1 labeling shows that iris smooth muscle development is correlated in time and space with the development of the ciliary epithelial folds. Second, because neural crest is the only other neural tissue that has been shown to generate smooth muscle (Le Lievre and Le Douarin [1975] J. Embryo. Exp. Morphol. 34:125,154), I sought to determine whether iris smooth muscle development shares similarities with neural crest development. Two members of the BMP superfamily, BMP4 and BMP7, which may regulate neural crest development, are highly expressed by cells at the site of iris smooth muscle generation. Third, because humans and mice that are heterozygous for Pax6 mutations have no irides (Hill et al. [1991] Nature 354:522,525; Hanson et al. [1994] Nat. Genet. 6:168,173), I determined the expression of Pax6. I also examined the expression of Pax3 in the developing anterior optic cup. The developing iris smooth muscle coexpresses Pax6 and Pax3. I suggest that some of the eye defects caused by mutations in Pax6, BMP4, and BMP7 may be due to abnormal iris smooth muscle. Developmental Dynamics 232:385,392, 2005. © 2004 Wiley-Liss, Inc. [source]

The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat

PEDIATRIC DIABETES, Issue 1 2004
Jadranka Popovic
Abstract:, Background:, Autoimmune diabetes of the diabetes-resistant biobreeding (DRBB) rat shares similarities with diabetes in humans and has stages of diabetes that can be controlled and compared. FTY720 is an immunomodulator that has been efficacious in transplant and autoimmune models without inducing an immunosuppressed state. We determined the stages of diabetes that are affected by FTY720 in the DRBB rat. Methods:, Autoimmune diabetes was induced with RT6.1 T-cell-depleting antibody and polyIC starting at 4 weeks of age. FTY720 (1 mg/kg/d) was started at day 0, 5, 7, and 14 following the start of depletion. The rats that did not develop diabetes were maintained for 60 d following the last dose of FTY720 before undergoing a second course of depletion. Results:, FTY720 starting at day 0, 5, 7, and 14 of depletion prevented diabetes in 100, 100, 50, and 20% of the DRBB rats compared to 0% of the control rats. The surviving rats in the 5-, 7-, and 14-d groups developed diabetes after FTY720 treatment was stopped. Histological examination indicated insulitis in the control rats between day 7 and 11 of depletion and end-stage insulitis by day 18 of depletion compared to negligible insulitis in rats without diabetes. Redepletion in the surviving day 0 rats resulted in development of diabetes in 25% of these rats compared to none of the age-matched controls. Summary:, FTY720 can prevent autoimmune diabetes, if administered before and/or during stimulation and expansion of the autoreactive T cells or in the early stages of insulitis. The effectiveness diminishes with each successive stage of diabetes. [source]