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Selected AbstractsCloning of vertebrate Protogenin (Prtg) and comparative expression analysis during axis elongationDEVELOPMENTAL DYNAMICS, Issue 10 2006Christine Vesque Abstract A murine cDNA encoding Protogenin, which belongs to the DCC/Neogenin family, was cloned in a screen performed to identify novel cDNAs regionally expressed in the neural plate. Isolation of the putative zebrafish orthologues allowed a comparative analysis of the expression patterns of Protogenin genes during embryogenesis in different vertebrate species. From mid-gastrulation to early somite stages, Protogenin expression is restricted to posterior neural plate and mesoderm, with an anterior limit at the level of the rhombencephalon in mouse, chicken, and zebrafish. During somitogenesis, the expression profiles in the three species share features in the neural tube but present also species-specific characteristics. The initiation of Protogenin expression just before somitogenesis and its maintenance in the neural tube and paraxial mesoderm during this process suggest a conserved role in axis elongation. Developmental Dynamics 235:2836,2844, 2006. © 2006 Wiley-Liss, Inc. [source] Nevi with site-related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic siteJOURNAL OF CUTANEOUS PATHOLOGY, Issue 10 2008Gregory A. Hosler A subset of melanocytic nevi share features with melanoma and nevi with architectural disorder but are biologically inert and to date do not appear to portend an increased risk for the development of malignancy. These benign nevi with certain atypical histologic features cluster among specific anatomic sites and are thus designated nevi with site-related atypia. We categorize these lesions into four main groups: acral, genital, special site and conjunctival, based on anatomy and relative prevalence of specific atypical histologic features. As the literature and our recognition of these lesions continue to grow, our understanding of their biology has not kept pace. [source] Kaposi's sarcoma , still an enigmaJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 4 2003P Babál ABSTRACT Kaposi's sarcoma (KS) is an unusual neoplasm that has proved to be an enigma in many ways since its original description in 1872. KS, a vascular tumour that is otherwise rare, is at present the most common neoplasm in patients with AIDS. The lesions contain spindle cells that share features with endothelial cells and smooth muscle cells and are in all likelihood primitive mesenchymal cells that can form vascular channels. These cells are monoclonal in origin indicating therefore that KS is a neoplasm. The presence of a novel type of human herpes virus, KS herpesvirus (KSHV) also called human herpesvirus type 8 (HHV8) in KS lesions support a viral ethiology. KS may be mistaken in the skin for an inflammatory or other lesion, thus skin biopsy is important for correct diagnosis, with the use of immunohistochemistry or molecular biology if needed. Radiation or interferon alpha dominate in the therapeutic approaches. [source] Generalization Across Segments in Second Language Consonant IdentificationLANGUAGE LEARNING, Issue 1 2009Kenneth J. De Jong This article examines the extent of differences between second language (L2) learners in their abilities to identify L2 consonants and provides evidence for linguistic generalization from one consonant to other consonants. It distinguishes among different sorts of models of the relationship between segments: (a) segmentally specific models in which each segment is treated separately and (b) generalized featural models in which segments that share features are treated as a group. It also examines (c) ordered models in which one segment might rely on another previously existing one. The article presents the results of an experiment with 40 Korean learners of English identifying English obstruents in different prosodic locations, and it examines the pattern of variation in perceptual accuracy across the listeners. Results indicate that manner perception varies from person to person as a unit, regardless of the segment, suggesting a single generalized featural skill. Voicing identification, however, does not vary as a unit across the different prosodic positions, suggesting different skills that are applicable to different prosodic positions and are acquired separately. There is also evidence for an implicational relationship between pairs of segments that differ in markedness, providing some evidence for an ordered model; however, such patterns are not pervasive across different contrasts. [source] ORIGINAL ARTICLE: Identification of Toll-Like Receptors in the Rat (Rattus norvegicus): Messenger RNA Expression in the Male Reproductive Tract Under Conditions of Androgen VariationAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 4 2009Barnali Biswas Problem, Although the majority of Toll-like receptors (TLRs) are reported in many species, some of them are not yet described in the rat. Further, factors that govern Tlr expression in the male reproductive tract have received little attention. We attempt to identify and characterize Tlrs in the rat and determine the expression profile under conditions that affect male reproductive tract gene expression. Method of study, Rat Tlr5, Tlr10, and Tlr11 transcript sequences were submitted to GenBank and in silico characterization carried out using bioinformatics tools. RT-PCR analyses using gene specific primers for rat Tlr1,13 were carried out with RNA isolated from reproductive tract tissues of various experimental groups. Results,Tlr5, Tlr10, and Tlr11 identified in this study share features that are characteristic of the known TLRs. Abundant Tlr expression was observed in the male reproductive tract of adult and developing rats. Further, Tlr expression was also observed in the epididymides of androgen ablated rats. Conclusion,Tlr5, Tlr10, and Tlr11 are ubiquitously expressed in the rat. Tlrs seem to be expressed during male reproductive tract development and under conditions of androgen ablation, suggesting the preparedness of the male reproductive tract to detect an infection under all conditions of androgen status. [source] | ||||||||||