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Selected AbstractsPotential manipulation of endothelial progenitor cells in diabetes and its complicationsDIABETES OBESITY & METABOLISM, Issue 7 2010G. P. Fadini Diabetes mellitus increases cardiovascular risk through its negative impact on vascular endothelium. Although glucotoxicity and lipotoxicity account for endothelial cell damage, endothelial repair is also affected by diabetes. Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial homoeostasis and in the process of new vessel formation. For these reasons, EPCs are thought to have a protective impact within the cardiovascular system. In addition, EPCs appear to modulate the functioning of other organs, providing neurotropic signals and promoting repair of the glomerular endothelium. The exact mechanisms by which EPCs provide cardiovascular protection are unknown and the definition of EPCs is not standardized. Notwithstanding these limitations, the literature consistently indicates that EPCs are altered in type 1 and type 2 diabetes and in virtually all diabetic complications. Moreover, experimental models suggest that EPC-based therapies might help prevent or reverse the features of end-organ complications. This identifies EPCs as having a novel pathogenic role in diabetes and being a potential therapeutic target. Several ways of favourably modulating EPCs have been identified, including lifestyle intervention, commonly used medications and cell-based approaches. Herein, we provide a comprehensive overview of EPC pathophysiology and the potential for EPC modulation in diabetes. [source] Examining the use of subsidies for the abatement of greenhouse gas emissions through experimental simulationsENVIRONMENTAL POLICY AND GOVERNANCE, Issue 4 2006Lars E. Olsson Abstract A market experiment was designed to empirically investigate the potential effectiveness of a governmental subsidy system to reduce sales and therefore production of environmentally harmful products. The important issue of whether the subsidy system preserves competitiveness was also examined. In the experiment two levels of a subsidy for unsold units were compared with no subsidy. To simulate the way in which subsidy levels may vary across time in real markets, the effects of high and low uncertainty regarding the subsidy level were also investigated. The results showed that subsidies, whether known and fixed or uncertain and varying, did not erode competition but nevertheless led to higher prices, which resulted in fewer sales. In the control condition a price war resulting in decreasing prices and increasing sales were observed. Several ways in which the proposed subsidy system may be implemented in the transport sector and other sectors are discussed. It is suggested that subsidies may make the adjustment process toward sustainable production less costly for the regulated parties. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment. [source] A Privileged Status for Male Infant-Directed Speech in Infants of Depressed Mothers?INFANCY, Issue 2 2010Role of Father Involvement Prior research showed that 5- to 13-month-old infants of chronically depressed mothers did not learn to associate a segment of infant-directed speech produced by their own mothers or an unfamiliar nondepressed mother with a smiling female face, but showed better-than-normal learning when a segment of infant-directed speech produced by an unfamiliar nondepressed father signaled the face. Here, learning in response to an unfamiliar nondepressed father's infant-directed speech was studied as a function both of the mother's depression and marital status, a proxy measure of father involvement. Infants of unmarried mothers on average did not show significant learning in response to the unfamiliar nondepressed father's infant-directed speech. Infants of married mothers showed significant learning in response to male infant-directed speech, and infants of depressed, married mothers showed significantly stronger learning in response to that stimulus than did infants of nondepressed, married mothers. Several ways in which father involvement may positively or negatively affect infant responsiveness to male infant-directed speech are discussed. [source] k-space analysis of point-resolved spectroscopy (PRESS) with regard to spurious echoes in in vivo1H MRSNMR IN BIOMEDICINE, Issue 2 2009G. Starck Abstract The spurious echo artefact, not uncommon in 1H MRS in the brain, comes from refocusing outer volume signal. Application of MRS in small volumes in susceptibility-affected regions often results in large shim gradients. The artefact problem is accentuated when the global effect of the shim gradient shifts the water resonance outside the water suppression band in the outer volume. This scenario brings the issue of spurious echoes once again to the fore. In this paper, spurious signals of the point-resolved spectroscopy (PRESS) sequence are analysed using the concept of k-space. This new approach facilitates a more geometrical view of the problem, well suited for studying the effect of gradient spoiling and refocusing of signal. Several spoiling options are shown, and the probability of the global effects of shimming being a primary cause of the artefact is discussed. Fourier transform analysis of realistic slice profiles, combined with the k-space description of spurious echoes, shows that unsuppressed water signal in outer regions greatly increases the demands on spoiling. Gradient spoiling adequate for artefact suppression at a given size of MRS volume may not be sufficient at a smaller size. Several ways to improve PRESS measurements with regard to suppression of spurious signal are discussed. Copyright © 2008 John Wiley & Sons, Ltd. [source] The relevance of international consortia in studies on the pathogenesis of type 1 diabetes: the role of ET1DGNDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 3 2006Flemming Pociot Abstract The Type 1 Diabetes Genetics Consortium (T1DGC), funded September 2002, is a collaborative effort to develop resources for the purpose of identifying risk genes for type 1 diabetes. One of the aims is to establish a renewable resource of DNA on 2500 affected sib-pair families. Regional networks have been established and in continental Europe, the European Type 1 Diabetes Genetics Network (ET1DGN) is responsible for identifying and collecting families. Most European countries have shown interest in this study and many have started recruiting families. The consortium is open to participation and there are several ways one can participate as a member of the consortium. ET1DGN suggests going beyond the tasks of T1DGC and establishing a well-organized network for additional and future studies in Europe. Copyright © 2005 John Wiley & Sons, Ltd. [source] Diabetes mellitus and alcoholDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 4 2004Albert van de Wiel Abstract Alcohol influences glucose metabolism in several ways in diabetic patients as well as in non-diabetic patients. Since alcohol inhibits both gluconeogenesis and glycogenolysis, its acute intake without food may provoke hypoglycaemia, especially in cases of depleted glycogen stores and in combination with sulphonylurea. Consumed with a meal including carbohydrates, it is the preferred fuel, which may initially lead to somewhat higher blood glucose levels and hence an insulin response in type 2 diabetic patients. Depending on the nature of the carbohydrates in the meal, this may be followed by reactive hypoglycaemia. Moderate consumption of alcohol is associated with a reduced risk of atherosclerotic disorders. Diabetic patients benefit from this favourable effect as much as non-diabetic patients. Apart from effects on lipid metabolism, haemostatic balance and blood pressure, alcohol improves insulin sensitivity. This improvement of insulin sensitivity may also be responsible for the lower incidence of type 2 diabetes mellitus reported to be associated with light-to-moderate drinking. In case of moderate and sensible use, risks of disturbances in glycaemic control, weight and blood pressure are limited. Excessive intake of alcohol, however, may not only cause loss of metabolic control, but also annihilate the favourable effects on the cardiovascular system. Copyright © 2004 John Wiley & Sons, Ltd. [source] Reconstructing ancestral ecologies: challenges and possible solutionsDIVERSITY AND DISTRIBUTIONS, Issue 1 2006Christopher R. Hardy ABSTRACT There are several ways to extract information about the evolutionary ecology of clades from their phylogenies. Of these, character state optimization and ,ancestor reconstruction' are perhaps the most widely used despite their being fraught with assumptions and potential pitfalls. Requirements for robust inferences of ancestral traits in general (i.e. those applicable to all types of characters) include accurate and robust phylogenetic hypotheses, complete species-level sampling and the appropriate choice of optimality criterion. Ecological characters, however, also require careful consideration of methods for accounting for intraspecific variability. Such methods include ,Presence Coding' and ,Polymorphism Coding' for discrete ecological characters, and ,Range Coding' and ,MaxMin Coding' for continuously variable characters. Ultimately, however, historical inferences such as these are, as with phylogenetic inference itself, associated with a degree of uncertainty. Statistically based uncertainty estimates are available within the context of model-based inference (e.g. maximum likelihood and Bayesian); however, these measures are only as reliable as the chosen model is appropriate. Although generally thought to preclude the possibility of measuring relative uncertainty or support for alternative possible reconstructions, certain useful non-statistical support measures (i.e. ,Sharkey support' and ,Parsimony support') are applicable to parsimony reconstructions. [source] T-type calcium channels: an emerging therapeutic target for the treatment of painDRUG DEVELOPMENT RESEARCH, Issue 4 2006Terrance P. Snutch Abstract It has become generally accepted that presynaptic high voltage,activated N-type calcium channels located in the spinal dorsal horn are a validated clinical target for therapeutic interventions associated with severe intractable pain. Low voltage,activated (T-type) calcium channels play a number of critical roles in nervous system function, including controlling thalamocortical bursting behaviours and the generation of spike wave discharges associated with slow wave sleep patterns. There is a growing body of evidence that T-type calcium channels also contribute in several ways to both acute and neuropathic nociceptive behaviours. In the one instance, the Cav3.1 T-type channel isoform likely contributes an anti-nociceptive function in thalamocortical central signalling, possibly through the activation of inhibitory nRT neurons. In another instance, the Cav3.2 T-type calcium channel subtype acts at the level of primary afferents in a strongly pro-nociceptive manner in both acute and neuropathic models. While a number of classes of existing clinical agents non-selectively block T-type calcium channels, there are no subtype-specific drugs yet available. The development of agents selectively targeting peripheral Cav3.2 T-type calcium channels may represent an attractive new avenue for therapeutic intervention. Drug Dev. Res. 67:404,415, 2006. © 2006 Wiley-Liss, Inc. [source] An Extended Analytical Approach to Credit Risk ManagementECONOMIC NOTES, Issue 2 2002Alexandre Kurth Among the ,reduced form models' for measuring the credit risk of a bank's portfolio is CreditRisk+, which provides a closed,form solution for calculating the portfolio loss distribution based on an actuarial approach. The limitations of this model are well known, but they are often misinterpreted as being deeply embedded within the model. Dismantling the mathematical components of the model allows one to modify and extend it in several ways while remaining within an analytical approach. One of the most unattractive features is the orthogonality of the background factors or sectors as it hinders any resemblance to real,world macroeconomic indexes or industrial sectors and geographical areas. Among other extensions, which we mention briefly, we present in more detail how the original model can be amended to consider correlations among default risk sectors and among severity risk segments. These extensions are applied to real,life data, based on mortality rate data produced by the Italian Central Bank. (J.E.L.: C00, C51). [source] Chemical mass balance when an unknown source existsENVIRONMETRICS, Issue 8 2004Nobuhisa Kashiwagi Abstract A chemical mass balance method is proposed for the case where the existence of an unknown source is suspected. In general, when the existence of an unknown source is assumed in statistical receptor modeling, unknown quantities such as the composition of an unknown source and the contributions of assumed sources become unidentifiable. To estimate these unknown quantities avoiding the identification problem, a Bayes model for chemical mass balance is constructed in the form of composition without using prior knowledge on the unknown quantities except for natural constraints. The covariance of ambient observations given in the form of composition is defined in several ways. Markov chain Monte Carlo is used for evaluating the posterior means and variances of the unknown quantities as well as the likelihood for the proposed model. The likelihood is used for selecting the best fit covariance model. A simulation study is carried out to check the performance of the proposed method. Copyright © 2004 John Wiley & Sons, Ltd. [source] New Insights into the Clinical Management of Partial EpilepsiesEPILEPSIA, Issue S5 2000Prof. Edouard Hirsch Summary The diagnosis, treatment, and prognosis of seizure disorders depend on the correct identification of epileptic syndromes. Partial epilepsies are heterogeneous and can be divided into idiopathic, cryptogenic, and symptomatic epilepsies. The most common of the idiopathic localization-related epilepsies is benign epilepsy with rolandic or centrotemporal spikes (BECTS). Seizures remain rare and the use of antiepileptic drug (AED) treatment in all patients does not appear justified. Children who present with some of the electroclinical characteristics of BECTS may also display severe unusual neurologic, neuropsychological, or atypical symptoms. In some cases, carbamazepine has been implicated as a triggering factor. Primary reading epilepsy and idiopathic occipital lobe epilepsies with photosensitivity are examples of an overlap between idiopathic localization-related and generalized epilepsies and respond well to sodium valproate. Autosomal dominant nocturnal frontal lobe epilepsy and benign familial infantile convulsions are recently described syndromes, differing in several ways from classical idiopathic localization-related epileptic syndromes. In cryptogenic or symptomatic epilepsy, the topography of the epileptogenic zone might influence drug efficacy. An individualized approach to AED selection, tailored to each patient's needs, should be used. Resistance of seizures to antiepileptic therapy may be due to diagnostic and/or treatment error or may be the result of noncompliance. Increasing the dosage, discontinuation or replacement of a drug, or addition of a second drug is indicated in truly resistant cases. The use of more than two AEDs rarely optimizes seizure control, and in some cases reduction of treatment may improve seizure control while lessening side effects. EEG-video assessment of patients with refractory epilepsy is important. Indications for and timing of epilepsy surgery should be reconsidered. Surgical therapy should probably be used more often and earlier than it is at present. [source] 2,5-Disubstituted Pyrrolidines as Chiral Auxiliaries in Radical Reactions: A Theoretical ApproachEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 25 2010Miglena K. Georgieva Abstract The radical addition to amides derived from chiral 2,5-disubstituted pyrrolidines has been theoretically studied by the use of density functional methods and the results compared with known experimental data. The results agree quite well with those obtained experimentally and allow the full rationalization of the factors influencing the diastereoselectivity. Steric effects are the main factors determining the selectivity, but electronic interactions can also be very important when the attacking alkene is ,,,-conjugated, as in acrylic esters or acrylamides. Additions at the ,- and ,-positions of the amide chain in the auxiliary are subject to different rules, with the former usually yielding high diastereoselectivities both experimentally and theoretically, whereas the latter is theoretically predicted to occur with low selectivity. We fully rationalize these two opposite behaviours and suggest several ways to circumvent this limitation, thus strongly increasing the interest of this type of structure as chiral auxiliaries in radical reactions. [source] The Function of the Proportionality Principle in EU LawEUROPEAN LAW JOURNAL, Issue 2 2010Tor-Inge Harbo In this article the author assesses the proportionality principle in EU law from a legal theoretical and constitutional perspective with the aim of discovering the function of the principle. Having first discussed the implications of the proportionality principle being a general principle of law, and what function it has,namely to secure legitimacy for judicial decisions,the author suggests that there are several ways in which the principle can be interpreted. There is, nevertheless, a limit to this interpretation determined by the proposed function of the principle. In the third part of the article, the European Court of Justice's (ECJ's) interpretation of the principle is assessed. The assessment clearly shows that the ECJ is interpreting the principle in different distinguishable ways. The question could, however, be raised as to whether the ECJ in some areas is interpreting the principle in a way that undermines the very function of it. [source] HETEROSIS AND OUTBREEDING DEPRESSION IN DESCENDANTS OF NATURAL IMMIGRANTS TO AN INBRED POPULATION OF SONG SPARROWS (MELOSPIZA MELODIA)EVOLUTION, Issue 1 2002Amy B. Marr Abstract We studied heterosis and outbreeding depression among immigrants and their descendants in a population of song sparrows on Mandarte Island, Canada. Using data spanning 19 generations, we compared survival, seasonal reproductive success, and lifetime reproductive success of immigrants, natives (birds with resident-hatched parents and grandparents), and their offspring (F1s, birds with an immigrant and a native parent, and F2s, birds with an immigrant grandparent and resident-hatched grandparent in each of their maternal and paternal lines). Lifetime reproductive success of immigrants was no worse than that of natives, but other measures of performance differed in several ways. Immigrant females laid later and showed a tendency to lay fewer clutches, but had relatively high success raising offspring per egg produced. The few immigrant males survived well but were less likely to breed than native males of the same age that were alive in the same year. Female F1s laid earlier than expected based on the average for immigrant and native females, and adult male F1s were more likely to breed than expected based on the average for immigrant and native males. The performance differences between immigrant and native females and between F1s and the average of immigrants and natives are consistent with the hypothesis that immigrants were disadvantaged by a lack of site experience and that immigrant offspring benefited from heterosis. However, we could not exclude the possibility that immigrants had a different strategy for optimizing reproductive success or that they experienced ecological compensation for life-history parameters. For example, the offspring of immigrants may have survived well because immigrants laid later and produced fewer clutches, thereby raising offspring during a period of milder climatic conditions. Although sample sizes were small, we found large performance differences between F1s and F2s, which suggested that either heterosis was associated with epistasis in F1s, that F2s experienced outbreeding depression, or that both phenomena occurred. These findings indicate that the performance of dispersers may be affected more by fine-scale genetic differentiation than previously assumed in this and comparable systems. [source] ORIGINAL ARTICLE: Implications of fisheries-induced evolution for stock rebuilding and recoveryEVOLUTIONARY APPLICATIONS (ELECTRONIC), Issue 3 2009Katja Enberg Abstract Worldwide depletion of fish stocks has led fisheries managers to become increasingly concerned about rebuilding and recovery planning. To succeed, factors affecting recovery dynamics need to be understood, including the role of fisheries-induced evolution. Here we investigate a stock's response to fishing followed by a harvest moratorium by analyzing an individual-based evolutionary model parameterized for Atlantic cod Gadus morhua from its northern range, representative of long-lived, late-maturing species. The model allows evolution of life-history processes including maturation, reproduction, and growth. It also incorporates environmental variability, phenotypic plasticity, and density-dependent feedbacks. Fisheries-induced evolution affects recovery in several ways. The first decades of recovery were dominated by demographic and density-dependent processes. Biomass rebuilding was only lightly influenced by fisheries-induced evolution, whereas other stock characteristics such as maturation age, spawning stock biomass, and recruitment were substantially affected, recovering to new demographic equilibria below their preharvest levels. This is because genetic traits took thousands of years to evolve back to preharvest levels, indicating that natural selection driving recovery of these traits is weaker than fisheries-induced selection was. Our results strengthen the case for proactive management of fisheries-induced evolution, as the restoration of genetic traits altered by fishing is slow and may even be impractical. [source] Molecular determinants of UV-induced immunosuppressionEXPERIMENTAL DERMATOLOGY, Issue 2002Agatha Schwarz Abstract: It is almost three decades ago that it was discovered that ultraviolet radiation (UV) can compromise the immune system. UV suppresses immune responses in several ways. It inhibits the function of antigen-presenting cells, induces T cells with suppressor activity and induces the release of immunosuppressive cytokines. The latter phenomenon is mainly responsible for systemic immunosuppression. Although UV can also target cytoplasmic and cell membrane components, UV-induced DNA damage has been recognized as the most important molecular structure in mediating UV-induced immunosuppression. Recently, it was observed that interleukin-12 (IL-12), which antagonizes UV-induced immunosuppression, can accelerate the removal of UV-induced DNA lesions, probably via inducing DNA repair. Hence, it is tempting to speculate that the activity of IL-12 to reduce UV-induced immunosuppression may be due at least partially to this new biological activity of IL-12. [source] A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac Purkinje single cellsEXPERIMENTAL PHYSIOLOGY, Issue 1 2007Mario Vassalle The action potential of Purkinje fibres is markedly shortened by tetrodotoxin, suggesting the possibility that a slowly inactivating sodium current might flow during the plateau. The aim of the present experiments was to investigate, in canine cardiac Purkinje single cells by means of a whole cell patch clamp technique, whether a sodium current slowly inactivates at less negative potentials and (if so) some of its distinctive characteristics. The results showed that a 500 ms depolarizing step from a holding potential of ,90 mV to ,50 mV induced the fast inward current INa (labelled here INa1). With steps to ,40 mV or less negative values, a slowly decaying component (tentatively labelled here INa2) appeared, which peaked at ,30 to ,20 mV and decayed slowly and incompletely during the 500 ms steps. The INa2 was present also during steps to ,10 mV, but then the transient outward current (Ito) appeared. When the holding potential (Vh) was decreased to ,60 to ,50 mV, INa2 disappeared even if a small INa1 might still be present. Tetrodotoxin (30 ,m), lignocaine (100 ,m) and cadmium (0.2 mm; but not manganese, 1 mm) blocked INa2. During fast depolarizing ramps, the rapid inactivation of INa1 was followed by a negative slope region. During repolarizing ramps, a region of positive slope was present, whereas INa1 was absent. At less negative values of Vh, the amplitude of the negative and positive slopes became gradually smaller. Gradually faster ramps increased the magnitude of the negative slope, and tetrodotoxin (30 ,m) reduced or abolished it. Thus, Purkinje cells have a slowly decaying inward current owing to Na+ entry (INa2) that is different in several ways from the fast INa1 and that appears important for the duration of the plateau. [source] Fragments of Economic Accountability and Trade PolicyFOREIGN POLICY ANALYSIS, Issue 2 2007RYAN KENNEDY While there has been a prodigious amount of literature on trade policy written in the past two decades, very little of that literature has dealt with countries in economic transition or nondemocratic regimes. There has also been a lack of work dealing with state interests in trade policy beyond realpolitik discussions of national security. This article seeks to fill some of these gaps through a study of two samples: one of liberalization in 25 post-Communist countries between the years 1991 and 1999 and the other of 124 countries from around the world in 1997. The study concludes that a key element in the choice between free trade and protectionism is the level of "fragmentation of economic accountability." Such fragmentation consists of two major components: (1) the existence of a strong capitalist class that is independent of the government; and (2) the dispersion of political power among actors both inside and outside the government. Where the government is more accountable to a wide range of interests, policies are more likely to be aligned with market mechanisms, encouraging the adoption of reforms, including the liberalization of trade policy. This article builds on the conclusions of Frye and Mansfield in several ways: (1) it embeds political fragmentation into a larger theoretical framework of economic accountability of government institutions; (2) it introduces the importance of state ownership in shaping government interests; (3) it introduces an idea of social, not just institutional, accountability; and (4) it proposes a statist view of trade policy that is lacking in the present literature. [source] Integrating geochemistry and micromorphology to interpret feature use at Dust Cave, a Paleo-Indian through middle-archaic site in Northwest AlabamaGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 3 2006Lara K. Homsey The authors develop an integrated method using geochemistry and micromorphology to examine the use of archaeological features at Dust Cave, a Paleo-Indian through Middle Archaic (10,650,3600 cal. B.C.) site in northwest Alabama. Samples analyzed using ICP-AES for aluminum (Al), barium (Ba), calcium (Ca), iron (Fe), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), phosphorous (P), strontium (Sr), sulfur (S), and zinc (Zn) and suggest that cultural features differ chemically from geogenic sediments in several ways: (a) K-means cluster analyses indicate that features of known origin and suspected features of the same origin cluster together, thereby allowing for a preliminary separation into discrete functionalities; (b) phosphorus serves as an indicator of human occupation intensity; and (c) Sr/Ca and K/P ratios help identify anthropogenic materials. Micromorphological observations allow for a finer subdivision of feature types and help highlight postdepositional processes affecting cave sediments, and interpretation of activity at the site. These findings show that feature diversity and occupation intensity increased through time, peaking during the Middle Archaic. © 2006 Wiley Periodicals, Inc. [source] MATTER(S) OF INTEREST: ARTEFACTS, SPACING AND TIMINGGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 1 2007Tim Schwanen ABSTRACT. This paper argues that time-geography can make a contribution to contemporary ,rematerialized' geographies, because the interconnections among social processes, human corporeality and inanimate material artefacts within the landscape were among Hägerstrand's central concerns. Time-geography needs none the less to be extended in several ways to make it more reconcilable with current thinking about materiality in geography. The possibility of combining Hägerstrand's framework with notions from (post) actor-network approaches is therefore explored. It is suggested that concepts and notions from the latter may contribute to the advancement of the conceptualization of action at a distance and agency in general in time-geography, as well as the incorporation of the immaterial realm into space,time diagrams. The resulting materially heterogeneous time-geography is a framework for studying the spacing and timing of different material entities that is sensitive to the role of artefacts and their local connectedness with other material forms. Some of its elements are illustrated briefly through an empirical study of the roles played by a few mundane artefacts in working parents ,coping with child-care responsibilities on working days. The case study suggest that these artefacts not only enable goal fulfilment and routinization but also result in further spacing and timing practices, and can introduce uncertainty and novelty to existing orders. [source] German Exchange Rate Exposure at DAX and Aggregate Levels, International Trade and the Role of Exchange Rate Adjustment CostsGERMAN ECONOMIC REVIEW, Issue 3 2007Horst Entorf Exchange rate exposure; macroeconomic risks; financial panel econometrics Abstract. This article analyses value changes of German stock market companies in response to movements of the US dollar. The approach followed in this work extends the standard means of measuring exchange rate exposure in several ways, e.g. by using multifactor modelling instead of augmented Capital Asset Pricing Model, application of moving window panel regressions and orthogonalization of overall market risk vis-à-vis currency risk. A further innovation lies in testing the theoretical implications of exchange rate adjustment costs (hedging costs) for firm values and economic exposure. Based on time series and panel data of German Deutsche Aktien Xchange companies, Deutsche Mark/dollar rates and macroeconomic factors, we find a rather unstable, time-variant exposure of German stock market companies. Dollar sensitivity is positively affected by the ratio of exports/gross domestic product (GDP) and negatively affected by imports/GDP. Moreover, as expected from theoretical findings, firm values and exchange rate exposure are significantly reduced by adjustment costs depending on the distance of the exchange rate from the expected long-run mean. [source] Increase of granzyme B-positive cells in ascitic fluid of patients with spontaneous bacterial peritonitisHEPATOLOGY RESEARCH, Issue 4 2008Alessandro Perrella Spontaneous bacterial peritonitis (SBP) occurs as a direct consequence of bacteria entering ascitic fluid (AF) from the intestinal lumen trough in several ways, including the hematogenous and mesenteric lymph nodes route. There are few studies on the cytokine profile of ascitic-derived mononuclear cells of patients with SBP, particularly on granzyme B (GZB). The aim of the present study was to verify whether patients with SBP have GZB-positive cells, whether they are increased in patients with aseptic ascites, and their trend after antibiotic treatment. We enrolled 36 consecutive patients (24 males and 12 females) with SBP on histologically-proven hepatitis C virus cirrhosis (group A) and 20 patients (11 males and nine females with ascites, but without evidences of SBP (group B). The diagnosis of SBP was made according to the following criteria: positive colture in AF or blood (at least two cultures) and neutrophils in AF (>250 mL polymorphonuclear leukocytes). For these patients we used ELISpot to assay GZB production on purified mononuclear cells in ascitesand peripheral blood, coupled with tumor necrosis factor-, tested using ELISA. A non-parametric statistical analysis was used to assess significant differences and correlations. We found positive culture in all of the patients with SBP (80% Escherichia coli; 20% Enterococcus faecium). Furthermore, the patients in group A had a higher number of GZB spot-forming colonies than the patients in group B (P < 0.001). GZB-positive cells were lower in the peripheral blood than those found in the AF of patients with SBP, while no differences were found between blood and AF in group B. Furthermore, after antibiotic treatment, GZB was reduced in the patients with SBP (P < 0.05). In conclusion, GZB may be an important mediator of the immune response towards bacteria in AF and could be used as a diagnostic tool. [source] If the Armada Had Landed: A Reappraisal of England's Defences in 1588HISTORY, Issue 311 2008NEIL YOUNGER The defeat of the Spanish Armada in 1588 stands as one of the greatest triumphs of Elizabeth I's reign, but, the success of the navy notwithstanding, received wisdom presents the land defences as woefully inadequate. This article shows that the existing picture of the English preparations is flawed in several ways and that they were better organized, more efficient and more willing than has been recognized. The privy council was called upon to deploy limited forces to defend a long coastline against an unpredictable attacker, and the evidence shows that they contrived to maximize the effectiveness of the available resources whilst balancing the calls of military practicality, financial necessity and political constraints. An assessment is also made of the response from the counties, using the mobilization as a test case of the structures put in place by the Elizabethan regime to deal with such an emergency. [source] Factors That Affect Understanding of Social Responsibility Accounting,ACCOUNTING PERSPECTIVES, Issue 1 2005IRENE M. GORDON ABSTRACT Many social responsibility/sustainable development (SR/SD) issues affecting accounting policies and standards will have to be addressed by present and future accountants. This paper investigates qualitative factors that may impede the learning of, and attitudes toward, SR/SD. While Gordon (1998) examined exposure to SR/SD, the present study contributes to the literature in several ways. First, to overcome one of the limitations of Gordon's study, noted by her, matched pair responses (n = 198) to pre- and post-study questionnaires are employed in this study. These responses are analyzed using t-statistics, cluster analysis, and multivariate analysis. Second, three factors not previously examined that may affect learning of SR/SD (number of economics courses taken, gender, and grade point average) are explored in this paper. The positive conclusion is that exposure to SR/SD had more influence on learning, understanding, and attitudes than did pre-existing demographic and educational background variables with the exception of grade point average. As a surrogate for intelligence or ability to learn, grade point average was found to be highly significant in a multivariate model. An appreciation that ability to learn affects understanding and attitudes is important for instructors in both continuing professional education and university/college accounting. [source] ICOADS release 2.1 data and productsINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 7 2005Steven J. Worley Abstract The International Comprehensive Ocean,Atmosphere Data Set (ICOADS), release 2.1 (1784,2002), is the largest available set of in situ marine observations. Observations from ships include instrument measurements and visual estimates, and data from moored and drifting buoys are exclusively instrumental. The ICOADS collection is constructed from many diverse data sources, and made inhomogeneous by the changes in observing systems and recording practices used throughout the period of record, which is over two centuries. Nevertheless, it is a key reference data set that documents the long-term environmental state, provides input to a variety of critical climate and other research applications, and serves as a basis for many associated products and analyses. The observational database is augmented with higher level ICOADS data products. The observed data are synthesized to products by computing statistical summaries, on a monthly basis, for samples within 2° latitude × 2° longitude and 1° × 1° boxes beginning in 1800 and 1960 respectively. For each resolution the summaries are computed using two different data mixtures and quality control criteria. This partially controls and contrasts the effects of changing observing systems and accounts for periods with greater climate variability. The ICOADS observations and products are freely distributed worldwide. The standard ICOADS release is supplemented in several ways; additional summaries are produced using experimental quality control, additional observations are made available in advance of their formal blending into a release, and metadata that define recent ships' physical characteristics and instruments are available. Copyright © 2005 Royal Meteorological Society [source] On the application of forking nodes to product-form queueing networks,INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 2 2008Essia H. Elhafsi Abstract We define a ,forking node' as a service centre with one input feeding two outputs (each served by its own queue) under the control of an internal path-selection (PS) policy. We assume that both outputs lead to paths through which a packet reaches its final destination. However, the mean downstream delays on the two paths may be different and the PS policy should favour the path with the lower downstream delay. Using simulation, we compare the performance of this system under a variety of random, deterministic, state-dependent PS policies, including threshold-based and join-shortest-queue with bias (JSQ + b). We show that JSQ + b has better performance than the other alternatives. Moreover, if the input process to the forking node is Poisson, standard time series analysis techniques show that its two outputs are very close to being independent Poisson processes. Thus, if we find an accurate and efficient ,offline' analytical performance model for JSQ + b forking node, we can extend the applicability of product-form queueing networks to include such forking nodes. For this reason, we present several ways of modelling the performance of a JSQ + b node, using bounds, and compare their results on example networks. We establish a closed-form expression relating the bias b and the delays of the downstream paths. Copyright © 2007 John Wiley & Sons, Ltd. [source] Dental hygienists' work environment: motivating, facilitating, but also tryingINTERNATIONAL JOURNAL OF DENTAL HYGIENE, Issue 3 2010A Candell To cite this article: Int J Dent Hygiene,8, 2010; 204,212 DOI: 10.1111/j.1601-5037.2009.00420.x Candell A, Engström M. Dental hygienists' work environment: motivating, facilitating, but also trying Abstract:, The aim of the present study was to describe dental hygienists' experiences of their physical and psychosocial work environment. The study was descriptive in design and used a qualitative approach. Eleven dental hygienists participated in the study and data were collected during spring 2008 using semi-structured interviews. The material was analysed using qualitative content analysis. The results showed that the dental hygienists experienced their work environment as motivating and facilitating, but at the same time as trying. The three categories revealed a theme: Being controlled in a modern environment characterized by good relationships. Motivating factors were the good relationship with co-workers, managers and patients, seeing the results of your work, having your own responsibility and making your own decisions. The new, pleasant and modern clinics, good cooperation between co-workers and varying duties were described as facilitating factors. The trying factors, as described by the dental hygienists, were above all being controlled by time limits or by some elements of the work, such as teamwork. The dental hygienists also felt stress because appointments were too-short. To conclude, the participants described their work environment as trying in several ways, despite the modern clinics and good relationships. [source] Fixing minimum wage levels in developing countries: Common failures and remediesINTERNATIONAL LABOUR REVIEW, Issue 1 2008Catherine SAGET Abstract. Some developing countries have set their minimum wages too high or too low to constitute a meaningful constraint on employers. The article compares minimum wages worldwide, proposes several ways of measuring them in developing countries and discusses whether they are effective thresholds in those countries. The second part of the article considers the institutional factors leading countries to set minimum wages at extreme levels. The author concludes that the minimum wage is used as a policy instrument to several ends , wage negotiation, deflation and social dialogue , which results in the absence of a wage floor, weak collective bargaining, or non-compliance. [source] Preferences and the Democratic PeaceINTERNATIONAL STUDIES QUARTERLY, Issue 2 2000Erik Gartzke A debate exists over whether (and to what degree) the democratic peace is explained by joint democracy or by a lack of motives for conflict between states that happen to be democratic. Gartzke (1998) applies expected utility theory to the democratic peace and shows that an index of states' preference similarity based on United Nations General Assembly roll-call votes (affinity) accounts for much of the lack of militarized interstate disputes (MIDs) between democracies. Oneal and Russett (1997b, 1998, 1999) respond by arguing that UN voting is itself a function of regime type,that democracy ,causes'affinity. Oneal and Russett seek to demonstrate their thesis by regressing affinity on democracy and other variables from a standard model of the democratic peace. I replicate results reported by Oneal and Russett and then extend the analysis in several ways. I find that the residuals from Oneal and Russett's regression of affinity remain highly significant as a predictor of the absence of MIDs. Further, significance for democracy is shown to be fragile and subject to variable construction, model specification, and the choice of estimation procedure. [source] False Promises: The Tobacco Industry, "Low Tar" Cigarettes, and Older SmokersJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9 2008Janine K. Cataldo RN To investigate the role of the tobacco industry in marketing to and sustaining tobacco addiction among older smokers and aging baby boomers, We performed archival searches of electronic archives of internal tobacco company documents using a snowball sampling approach. Analysis was done using iterative and comparative review of documents, classification by themes, and a hermeneutic interpretive approach to develop a case study. Based on extensive marketing research, tobacco companies aggressively targeted older smokers and sought to prevent them from quitting. Innovative marketing approaches were used. "Low tar" cigarettes were developed in response to the health concerns of older smokers, despite industry knowledge that such products had no health advantage and did not help smokers quit. Tobacco industry activities influence the context of cessation for older smokers in several ways. Through marketing "low tar" or "light" cigarettes to older smokers "at risk" of quitting, the industry contributes to the illusion that such cigarettes are safer, although "light" cigarettes may make it harder for addicted smokers to quit. Through targeted mailings of coupons and incentives, the industry discourages older smokers from quitting. Through rhetoric aimed at convincing addicted smokers that they alone are responsible for their smoking, the industry contributes to self-blame, a documented barrier to cessation. Educating practitioners, older smokers, and families about the tobacco industry's influence may decrease the tendency to "blame the victim," thereby enhancing the likelihood of older adults receiving tobacco addiction treatment. Comprehensive tobacco control measures must include a focus on older smokers. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||