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Several Data (several + data)
Selected AbstractsEvidence for vesicular glutamate transporter synapses onto gonadotropin-releasing hormone and other neurons in the rat medial preoptic areaEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 12 2003J. Kiss Abstract The medial preoptic area is a key structure in the control of reproduction. Several data suggest that excitatory amino acids are involved in the regulation of this function and the major site of this action is the medial preoptic region. Data concerning the neuromorphology of the glutamatergic innervation of the medial preoptic area are fragmentary. The present investigations were focused on: (i) the morphology of the vesicular glutamate transporter 1 (VGluT1)- and vesicular glutamate transporter 2 (VGluT2)-immunoreactive nerve terminals, which are considered to be specific to presumed glutamatergic neuronal elements, in the medial preoptic area of rat; and (ii) the relationship between these glutamate transporter-positive endings and the gonadotropin-releasing hormone (GnRH) neurons in the region. Single- and double-label immunocytochemistry was used at the light and electron microscopic level. There was a weak to moderate density of VGluT1- and a moderate to intense density of VGluT2-immunoreactive elements in the medial preoptic area. Electron microscopy revealed that both VGluT1- and VGluT2-immunoreactive boutons made asymmetric type synaptic contacts with unlabelled neurons. VGluT2-labelled, but not VGluT1-labelled, axon terminals established asymmetric synaptic contacts on GnRH-immunostained neurons, mainly on their dendrites. The present findings are the first electron microscopic examinations on the glutamatergic innervation of the rat medial preoptic area. They provide direct neuromorphological evidence for the existence of direct glutamatergic innervation of GnRH and other neurons in the rat medial preoptic area. [source] Magma flow in the East Greenland dyke swarm inferred from study of anisotropy of magnetic susceptibility: magmatic growth of a volcanic marginGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 2 2004Jean-Paul Callot SUMMARY Volcanic passive margins (VPMs) are characterized by large volumes of melt emplaced within the lithosphere during break-up processes. Several data and a recently proposed conceptual model of volcanic margin development suggest that VPMs are fed from localized crustal zones of magma storage, underlying large polygenetic volcanoes localized above diapir-like instabilities of the asthenosphere. We investigated the magma flow pattern within the coast-parallel dyke swarm of the East Greenland VPM, which is the only outcropping VPM, over a distance of 125 km. The 44 sampled dykes are representative of the successive families of intrusions. Igneous petrofabrics are constrained by the measurements of the anisotropy of magnetic susceptibility. The magnetic fabrics are of medium to low anisotropy (P, < 1.08) and show moderately oblate ellipsoids (T > 0). Flow-related fabrics are recorded in 75 per cent of the sampled dykes. We infer the flow directions from the imbrication geometry of the magnetic foliation planes at the dyke margins, and check the results by measuring the preferred orientation of plagioclase in thin sections cut in the magnetic principal planes. Due to probable fabric superposition, the magnetic lineation represents the zone axis for the distribution of magnetic foliation plane. We obtained 23 reliable flow directions that are predominantly horizontal and directed away from identified crustal reservoirs. This flow pattern supports the proposed model of VPM growth, and emphasizes the localized nature of the magma sources in the mantle. The entire flood basalt sequence appears to have been fed by a restricted number of crustal reservoirs and associated dyke swarms. [source] Missense mutations of human homeoboxes: A reviewHUMAN MUTATION, Issue 5 2001Angela V. D'Elia Abstract The homeodomain (encoded by the homeobox) is the DNA-binding domain of a large variety of transcriptional regulators involved in controlling cell fate decisions and development. Mutations of homeobox-containing genes cause several diseases in humans. A variety of missense mutations giving rise to human diseases have been described. These mutations are an excellent model to better understand homeodomain molecular functions. To this end, homeobox missense mutations giving rise to human diseases are reviewed. Seventy-four independent homeobox mutations have been observed in 17 different genes. In the same genes, 30 missense mutations outside the homeobox have been observed, indicating that the homeodomain is more easily affected by single amino acids changes than the rest of the protein. Most missense mutations have dominant effects. Several data indicate that dominance is mostly due to haploinsufficiency. Among proteins having the homeodomain as the only DNA-binding domain, three "hot spot" regions can be delineated: 1) at codon encoding for Arg5; 2) at codon encoding for Arg31; and 3) at codons encoding for amino acids of recognition helix. In the latter, mutations at codons encoding for Arg residues at positions 52 and 53 are prevalent. In the recognition helix, Arg residues at positions 52 and 53 establish contacts with phosphates in the DNA backbone. Missense mutations of amino acids that contribute to sequence discrimination (such as those at positions 50 and 54) are present only in a minority of cases. Similar data have been obtained when missense mutations of proteins possessing an additional DNA-binding domain have been analyzed. The only exception is observed in the POU1F1 (PIT1) homeodomain, in which Arg58 is a "hot spot" for mutations, but is not involved in DNA recognition. Hum Mutat 18:361,374, 2001. © 2001 Wiley-Liss, Inc. [source] Sexual differences and effect of photoperiod on melatonin receptor in avian brainMICROSCOPY RESEARCH AND TECHNIQUE, Issue 1 2001Nicoletta Aste Abstract Several data suggest that melatonin may influence avian reproduction by acting at the level of the hypothalamic-hypophisial-gonadal axis, and/or on neural circuits controlling reproductive behaviours. The action of melatonin is exerted through specific receptors whose distribution and pharmacological properties have been extensively investigated. This review will focus on the distribution, sexual dimorphism, and dependence upon the photoperiod of melatonin binding sites in avian species with a special emphasis on Japanese quail. Melatonin receptors are widely distributed in avian brain. They are mostly present in the visual pathways of all the investigated species and in the song controlling nuclei of oscine birds. Sexual dimorphism of melatonin binding sites (higher density in males than in females) was detected in some telencephalic nuclei of songbirds, in the visual pathways, and in the preoptic area of quail. The last region plays a key role in the activation of male quail copulatory behaviour and it hosts a large population of gonadotropin-releasing hormone-containing neurons. Sexual dimorphism of melatonin-binding sites in the above-mentioned regions suggests a differential role for this hormone in the modulation of visual perception, gonadotropin production, and seasonally activated behaviours in male and female quail. Further studies are necessary to understand interrelationships among photic cues, gonadal steroids, density, and sexually dimorphic distribution of melatonin receptors. Microsc. Res. Tech. 55:37,47, 2001. © 2001 Wiley-Liss, Inc. [source] Accelerating Ray Tracing using Constrained TetrahedralizationsCOMPUTER GRAPHICS FORUM, Issue 4 2008Ares Lagae Abstract In this paper we introduce the constrained tetrahedralization as a new acceleration structure for ray tracing. A constrained tetrahedralization of a scene is a tetrahedralization that respects the faces of the scene geometry. The closest intersection of a ray with a scene is found by traversing this tetrahedralization along the ray, one tetrahedron at a time. We show that constrained tetrahedralizations are a viable alternative to current acceleration structures, and that they have a number of unique properties that set them apart from other acceleration structures: constrained tetrahedralizations are not hierarchical yet adaptive; the complexity of traversing them is a function of local geometric complexity rather than global geometric complexity; constrained tetrahedralizations support deforming geometry without any effort; and they have the potential to unify several data structures currently used in global illumination. [source] | ||||||||||