Home About us Contact
|
Home About us Contact | ||
|
|
||
Several Constraints (several + constraint)
Selected AbstractsThe challenge of public sector reform in EC accession countries: reflections from the Baltics, especially LatviaPUBLIC ADMINISTRATION & DEVELOPMENT, Issue 4 2004Colin Jacobs This article considers some of the key issues in reforming the public sector in Central and Eastern Europe (CEE). Drawing on the experience of donor funded projects, some conclusions are drawn about the process of public sector reform with particular reference to Latvia. In particular, it is argued that the process will take time but strategic choices need to be made in the absence of obvious demands from within the country. Several constraints are noted which together constitute formidable barriers to progress. However, the results of work to date provide some optimism for pilot approaches to strategic budgeting in reformist ministries. A simple checklist is used as a yardstick for progress in the main areas of public administration reform. Copyright © 2004 John Wiley & Sons, Ltd. [source] Hypotheses for the origin and early evolution of triterpenoid cyclasesGEOBIOLOGY, Issue 1 2007W. W. FISCHER ABSTRACT Hopanes and steranes are found almost universally in the sedimentary rock record where they often are used as proxies for aerobic organisms, metabolisms, and environments. In order to interpret ancient lipid signatures confidently we require a complementary understanding of how these modern biochemical pathways evolved since their conception. For example, generally it has been assumed that hopanoid biosynthesis was an evolutionary predecessor to steroid biosynthesis. Here we re-evaluate this assumption. Using a combined phylogenetic and biochemical perspective, we address the evolution of polycyclic triterpenoid biosynthesis and suggest several constraints on using these molecules as aerobic biomarkers. Amino acid sequence data show that the enzymes responsible for polycyclic triterpenoid biosynthesis (i.e. squalene and 2,3-oxidosqualene cyclases) are homologous. Numerous conserved domains correspond to active sites in the enzymes that are required to complete the complex cyclization reaction. From these sites we develop an evolutionary analysis of three independent characters to explain the evolution of the major classes of polycyclic triterpenoids. These characters are: (i) the number of unfavourable anti-Markovnikov ring closures, (ii) all-chair (CCC) or chair-boat-chair (CBC) substrate conformation, and (iii) the choice between squalene and 2,3-oxidosqualene as the substrate. We use these characters to construct four competing phylogenies to describe the evolution of polycyclic triterpenoid biosynthesis. The analysis suggests that malabaricanoids would be the most ancient polycyclic triterpenoids. The two most parsimonious evolutionary trees are the ones in which hopanoid and steroid cyclases diverged from a common ancestor. The transition from a CCC- to CBC-fold marks the major divergence in the evolution of these pathways, and it is diagnosable in the geological record. However, this transition does not require the simultaneous adoption of the aerobic substrate, 2,3-oxidosqualene, because these characters are controlled by independent parts of the enzyme. [source] PARADES, PUBLIC SPACE, AND PROPAGANDA: THE NAZI CULTURE PARADES IN MUNICHGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 4 2008Joshua Hagen ABSTRACT. As the birthplace of the Nazi Party and the official Capital of the Movement, Munich assumed a high profile within the party's propaganda apparatus. While Berlin became the political and foreign policy centre of Hitler's Reich and Nuremberg the site of massive displays of national power during the annual party rallies, national and local party leaders launched a series of cultural initiatives to showcase Munich as the Capital of German Art. Munich hosted numerous festivals proclaiming a rebirth of German art and culture, as well as the regime's supposedly peaceful intentions for domestic and international audiences. To help achieve these goals, Nazi leaders staged a series of extravagant parades in Munich celebrating German cultural achievements. The parades provided an opportunity for the regime to monopolize Munich's public spaces through performances of its particular vision of German history, culture and national belonging. While such mass public spectacles had obvious propaganda potential, several constraints, most prominently Munich's existing spatial layout, limited the parades' effectiveness. [source] Tourism in Dubai: overcoming barriers to destination developmentINTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 2 2006Joan C. Henderson Abstract The Middle East as a whole attracts comparatively few visitors, and political events in the current century have generated new uncertainties and tensions which seem likely to further discourage tourists and investors. Additional barriers relate to poor accessibility, a perceived lack of conventional attractions and limited promotion. Despite these apparently unfavourable circumstances, international tourism has been adopted by the Dubai authorities as a core element in a programme of economic diversification. They have invested heavily in expensive facilities, as well as undertaken extensive marketing, and the outcome has been strong growth in tourism. There are great expectations of the future, reflected in the setting of very high arrival targets. However, there are also several constraints that might inhibit progress, with a need to review strategies. The experience of Dubai thus serves to illustrate factors that are critical to destination development, major impediments and approaches to overcoming these. Copyright © 2006 John Wiley &Sons, Ltd. [source] Verification process and its application to network traffic simulation modelsJOURNAL OF ADVANCED TRANSPORTATION, Issue 3 2002Ryota Horiguchi This paper summarizes a standardized verification process for network traffic simulation models. After the general introduction of philosophy of verification, we explain detailed processes of the verification and its application to several well-known simulation models. "Verification" here means several examination tests of simulation models using virtual data on a simple network so as to confirm their fundamental functions. In the course of model development, the developers have to examine whether the model performance is consistent with the specifications that they intend and also with the well-authorized traffic engineering theory. Because of several constraints in putting the model specifications into the computer programming such as discretizing of time and space and simplifying vehicle behaviors to some degree, the intended model specifications may not be fully achieved in a computer. Therefore, we strongly recommend the verification before applying the models to a real network. [source] Transferable intermolecular potentials for carboxylic acids and their phase behaviorAICHE JOURNAL, Issue 2 2010Amir Vahid Abstract Transferable step potentials are characterized for 39 carboxylic acids. The reference potential is treated with discontinuous molecular dynamics, including detailed molecular structure. Thermodynamic perturbation theory is used to interpret the simulation results and to provide an efficient basis for molecular modeling and characterization of the attractive forces. Four steps are used for representation of the attractive forces with only the first and last steps varied independently. The two middle steps are interpolated such that each site type is characterized by three parameters: the diameter, ,, the depth of the inner well, ,1, and the depth of the outer well, ,4. The depths of the attractive wells are optimized to fit experimental vapor pressure and liquid density data. Generally, the vapor pressure is correlated to an overall 43% average absolute deviation (% AAD) and the liquid density to 5% AAD. The deviations tend to be largest for the higher molecular weight acids. These deviations are larger than the errors previously encountered in characterizing organic compounds, but carboxylic acids present exceptional challenges owing to their peculiar dimerization behavior. Simultaneous correlation of vapor pressure, vapor compressibility factor, and phase equilibria of water + carboxylic acids place several constraints on the nature of the potential model, with the parameters of the present model representing a reasonable tradeoff. In other words, our model represents minimal deviations for vapor pressure, vapor compressibility factor, and phase equilibria of all acids simultaneously while varying the parameters ,, ,1, ,4, ,CC(dimerizing site bonding energy), ,AD(acceptor-donor bonding energy), and KHB(hydrogen bonding volume) for the acid O and OH site types. The present model is characterized by one acceptor and one dimerizing site on the carbonyl oxygen and one acceptor and one donor site on the hydroxyl oxygen. The acceptor and donor are capable of interacting with water while the dimerizing site is not. With this model, the saturated vapor compressibility factor of acids with seven or fewer carbons is near 0.5 while higher carbon ratios lead to a compressibility factor approaching 1.0. To compensate for the high vapor pressure deviations of the transferable potential model, a correction is introduced to customize the molecule-molecule self interaction energy. This adaptation results in deviations of 3.1% for vapor pressure of the pure acid database. To validate the behavior of the model for carboxylic acids in mixtures, 33 binary solutions were considered. Acids in this database ranged from formic to hexadecanoic. The average absolute deviation in bubble pressure for aqueous acid systems is 4.4%, 10.5% for acid + acid systems, and 4.7% for acid + n-alkane systems without a customized interaction correction. When applying the correction, deviations were 2.4% for aqueous systems, 2% for acid systems, and 2.8% for acid + n-alkane systems. © 2009 American Institute of Chemical Engineers AIChE J, 2010 [source] Competition between Eurasian otter Lutra lutra and American mink Mustela vison probed by niche shiftOIKOS, Issue 1 2004Laura Bonesi Interspecific competition is one of several constraints that might prevent an individual from maximising its energy intake. When an interspecific competitor is introduced, an individual is often forced to shift its diet according to the intensity of the competitive pressure. In this paper, we explore whether the introduced American mink (Mustela vison Schreber) shifts its diet when the density of its potential competitor, the Eurasian otter (Lutra lutra L.), is increased. We compared the diets of otter and mink at the same location but at two moments in time when the relative densities of these two species were different while controlling for the abundance of aquatic prey. Mink and otters are semi-aquatic mammals belonging to the same guild of mustelids and otters are expected to be the dominant competitor because they are larger and better at hunting underwater. The diets of otters and mink overlap to a great extent but while otters specialise mainly on aquatic prey, mink are able to exploit both aquatic and terrestrial prey. These observations prompted the hypothesis investigated in this work that at higher otter densities the diet of mink should change to include a higher proportion of terrestrial items. This hypothesis was supported by the data and at higher otter densities mink diet was observed to consist of a higher proportion of mammals and birds while fewer fish were present, although this pattern was present only in winter while no changes were observed in spring. Meanwhile the diet of otters remained basically unchanged. In the second part of the study, we investigated whether niche breadth and niche overlap between otter and mink changed at different otter densities. We found that niche overlap declined as the density of otters increased, in agreement with the prediction of habitat selection theory. [source] Trajectory optimization involving sloshing mediaOPTIMAL CONTROL APPLICATIONS AND METHODS, Issue 1 2002Harald Leonpacher Abstract This paper is concerned with the optimization of the transport motion of an open topped fluid filled container within a warehouse environment. In particular, optimal trajectories of the motion of the driver,container system in two-dimensional space will be investigated via numerical solutions of the model equations using sequential quadratic programming. The fluid and the mechanical facility that moves the container are subject to several constraints. The objective of the optimization is the time to transport the container from an initial position to its final destination within the warehouse. Optimization criteria are investigated to control the movement of the fluid within the container. The systems of ordinary and partial differential equations, representing the dynamics of the models are solved numerically using a direct shooting method. The resulting non-linear programming problem is solved using sequential quadratic programming (SQP). Copyright © 2002 John Wiley & Sons, Ltd. [source] Noninvasive Activity-based Control of an Implantable Rotary Blood Pump: Comparative Software Simulation StudyARTIFICIAL ORGANS, Issue 2 2010Dean M. Karantonis Abstract A control algorithm for an implantable centrifugal rotary blood pump (RBP) based on a noninvasive indicator of the implant recipient's activity level has been proposed and evaluated in a software simulation environment. An activity level index (ALI),derived from a noninvasive estimate of heart rate and the output of a triaxial accelerometer,forms the noninvasive indicator of metabolic energy expenditure. Pump speed is then varied linearly according to the ALI within a defined range. This ALI-based control module operates within a hierarchical multiobjective framework, which imposes several constraints on the operating region, such as minimum flow and minimum speed amplitude thresholds. Three class IV heart failure (HF) cases of varying severity were simulated under rest and exercise conditions, and a comparison with other popular RBP control strategies was performed. Pump flow increases of 2.54, 1.94, and 1.15 L/min were achieved for the three HF cases, from rest to exercise. Compared with constant speed control, this represents a relative flow change of 30.3, 19.8, and ,15.4%, respectively. Simulations of the proposed control algorithm exhibited the effective intervention of each constraint, resulting in an improved flow response and the maintenance of a safe operating condition, compared with other control modes. [source] | |||||||||||||