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Serious Errors (serious + error)
Selected AbstractsVortex surface method: some numerical problems of the potential calculationINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 8 2001T. Belamri Abstract The singularities method is used to analyze the flow around an isolated profile or through a plane cascade. In this paper, a numerical study has been developed in order to discuss the accuracy of solutions. The aims of this study are summarized as follows: (1) to expose the elements that influence the method,precision in the geometrical profile definition, trailing-edge geometry, smoothing problems, number of discretization points, precision of calculation, etc.; (2) to provide an accurate solution for these different problems. For example, some profiles, obtained by the Joukowski transformation, present, in spite of an analytical definition, a crossing of the suction and pressure sides at the trailing edge. This crossing causes a serious error in the velocity field computation. A new procedure to solve this problem is presented. Copyright © 2001 John Wiley & Sons, Ltd. [source] Haemoglobinometry in general practiceINTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 6 2003S. M. Lewis Summary Haemoglobinometry as a primary point-of-care test is well established. This study was undertaken to assess whether haemoglobinometry by itself provides an adequate haematological screening procedure in general practice. In a series of 500 sequential blood counts received by the central hospital laboratory from local doctors, 405 (81%) had a normal haemoglobin. Full blood counts on these samples showed 15% with one or more blood count parameters outside 2SD of normal reference values, including increased MCV, low MCV with low MCH and MCHC, leucocytosis with neutrophilia, a few cases with neutropenia, lymphopenia, monocytosis or eosinophilia. When the limits were set at 3SD, these abnormalities were found in only 7.6% of the cases. Calculation of test utility gave a positive predictive value of 0.83, a negative predictive value of 0.85, with a likelihood ratio of 14.3 and an overall diagnostic reliability of 84%. It was concluded that haemoglobin alone is a valuable primary screening test and a full blood count is required only when anaemia is present or when the patient's history and clinical signs indicate the need for such further investigation. Using this protocol it is unlikely that any serious error will be made in diagnosing a clinically significant condition; the main limitation is failure to diagnose pre-anaemic iron deficiency. [source] The embedded ion method: A new approach to the electrostatic description of crystal lattice effects in chemical shielding calculationsCONCEPTS IN MAGNETIC RESONANCE, Issue 5 2006Dirk Stueber Abstract The nuclear magnetic shielding anisotropy of NMR active nuclei is highly sensitive to the nuclear electronic environment. Hence, measurements of the nuclear magnetic shielding anisotropy represent a powerful tool in the elucidation of molecular structure for a wide variety of materials. Quantum mechanical ab initio nuclear magnetic shielding calculations effectively complement the experimental NMR data by revealing additional structural information. The accuracy and capacity of these calculations has been improved considerably in recent years. However, the inherent problem of the limitation in the size of the systems that may be studied due to the relatively demanding computational requirements largely remains. Accordingly, ab initio shielding calculations have been performed predominantly on isolated molecules, neglecting the molecular environment. This approach is sufficient for neutral nonpolar systems, but leads to serious errors in the shielding calculations on polar and ionic systems. Conducting ab initio shielding calculations on clusters of molecules (i.e., including the nearest neighbor interactions) has improved the accuracy of the calculations in many cases. Other methods of simulating crystal lattice effects in shielding calculations that have been developed include the electrostatic representation of the crystal lattice using point charge arrays, full ab initio methods, ab initio methods under periodic boundary conditions, and hybrid ab initio/molecular dynamics methods. The embedded ion method (EIM) discussed here follows the electrostatic approach. The method mimics the intermolecular and interionic interactions experienced by a subject molecule or cluster in a given crystal in quantum mechanical shielding calculations with a large finite, periodic, and self-consistent array of point charges. The point charge arrays in the EIM are generated using the Ewald summation method and embed the molecule or ion of interest for which the ab initio shielding calculations are performed. The accuracy with which the EIM reproduces experimental nuclear magnetic shift tensor principal values, the sensitivity of the EIM to the parameters defining the point charge arrays, as well as the strengths and limitations of the EIM in comparison with other methods that include crystal lattice effects in chemical shielding calculations, are presented. © 2006 Wiley Periodicals, Inc. Concepts Magn Reson Part A 28A: 347,368, 2006 [source] Mortgage Terminations, Heterogeneity and the Exercise of Mortgage OptionsECONOMETRICA, Issue 2 2000Yongheng Deng As applied to the behavior of homeowners with mortgages, option theory predicts that mortgage prepayment or default will be exercised if the call or put option is ,in the money' by some specific amount. Our analysis: tests the extent to which the option approach can explain default and prepayment behavior; evaluates the practical importance of modeling both options simultaneously; and models the unobserved heterogeneity of borrowers in the home mortgage market. The paper presents a unified model of the competing risks of mortgage termination by prepayment and default, considering the two hazards as dependent competing risks that are estimated jointly. It also accounts for the unobserved heterogeneity among borrowers, and estimates the unobserved heterogeneity simultaneously with the parameters and baseline hazards associated with prepayment and default functions. Our results show that the option model, in its most straightforward version, does a good job of explaining default and prepayment, but it is not enough by itself. The simultaneity of the options is very important empirically in explaining behavior. The results also show that there exists significant heterogeneity among mortgage borrowers. Ignoring this heterogeneity results in serious errors in estimating the prepayment behavior of homeowners. [source] Combined Confocal Microscopy and Stereology: a Highly Efficient and Unbiased Approach to Quantitative Structural Measurement in TissuesEXPERIMENTAL PHYSIOLOGY, Issue 6 2002Katherine Howell Understanding the relationship of the structure of organs to their function is a key component of integrative physiological research. The structure of the organs of the body is not constant but changes, both during growth and development and under conditions of sustained stress (e.g. high altitude exposure and disease). Recently, powerful new techniques have become available in molecular biology, which promise to provide novel insights into the mechanisms and consequences of these altered structure-function relationships. Conventionally structure-function relationships are studied by microscopic examination of tissue sections. However, drawing conclusions about the three-dimensional structure of an organ based on this two-dimensional information frequently leads to serious errors. The techniques of stereology allow precise and accurate quantification of structural features within three-dimensional organs that relate in a meaningful way to integrated function. For example, knowledge of changes in the total surface area of the capillary endothelium in an organ can be related directly to changes in fluid filtration and permeability, or knowledge of total vessel length and mean radius allows deductions about vascular resistance. Confocal microscopy adds enormously to the power of stereological approaches. It reduces the difficulties and labour involved in obtaining suitable images. Moreover, when used in conjunction with new analytical software, it allows convenient application of stereology to small samples and those in which it is essential to maintain a specific orientation for interpretation. The information obtained will allow us to examine in a quantitative manner the altered structure-function relationships produced by manipulation of single genes and regulatory pathways in whole organisms. [source] Medication errors in older people with mental health problems: a reviewINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 6 2008Ian D Maidment Abstract Objective To review and summarise published data on medication errors in older people with mental health problems. Methods A systematic review was conducted to identify studies that investigated medication errors in older people with mental health problems. MEDLINE, EMBASE, PHARMLINE, COCHRANE COLLABORATION and PsycINFO were searched electronically. Any studies identified were scrutinized for further references. The title, abstract or full text was systematically reviewed for relevance. Results Data were extracted from eight studies. In total, information about 728 errors (459 administration, 248 prescribing, 7 dispensing, 12 transcribing, 2 unclassified) was available. The dataset related almost exclusively to inpatients, frequently involved non-psychotropics, and the majority of the errors were not serious. Conclusions Due to methodology issues it was impossible to calculate overall error rates. Future research should concentrate on serious errors within community settings, and clarify potential risk factors. Copyright © 2007 John Wiley & Sons, Ltd. [source] Comparing mass-consistent atmospheric moisture budgets on an irregular grid: An Arctic exampleTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 592 2003M. Göber Abstract We present a method to minimize the effects of different resolution and mass imbalance when comparing atmospheric energy and water budgets from different datasets. Sizeable differences between re-analysis- and radiosonde-based atmospheric budgets had been found in earlier studies and it had been suspected that the different resolutions of the datasets strongly contributes to these discrepancies. Furthermore, most studies so far had used mass-imbalanced wind fields, which can lead to serious errors. We balance the wind field by using a variational modification algorithm combined with a finite-element discretization which allows the use of data on a grid defined by the radiosonde network. This method permits the computation of flux divergences in integral form and gives a consistent numerical method to get a mass-balanced wind field with minimum modifications. Applying this method to Arctic radiosonde and re-analysis data on the same grid leads to a better agreement with respect to the horizontal distribution and the mean annual cycle of the moisture flux convergence. The constraint of mass balance on the wind field leads to a greatly reduced and more realistic variability in space and time. However, a systematic difference of about 20% remains between the estimate based on a re-analysis dataset sampled only on the coarse grid of the radiosonde network and an estimate based on the use of the full, fine grid of the re-analysis. These systematic differences can be significantly reduced by creating a simulated radiosonde dataset from the re-analysis with doubled resolution. We undertake an extensive analysis of the uncertainty of the estimates originating from the choices made in the specification of the algorithm. Based solely on radiosonde data, which are likely to result in a low bias, we estimate the net water gain of the Arctic atmosphere as 164 ± 10 mm yr,1 (0.45 ± 0.03 mm d,1) for 1979,93. Copyright © 2003 Royal Meteorological Society. [source] Prescription errors in UK critical care unitsANAESTHESIA, Issue 12 2004S. A. Ridley Summary Drug prescription errors are a common cause of adverse incidents and may be largely preventable. The incidence of prescription errors in UK critical care units is unknown. The aim of this study was to collect data about prescription errors and so calculate the incidence and variation of errors nationally. Twenty-four critical care units took part in the study for a 4-week period. The total numbers of new and re-written prescriptions were recorded daily. Errors were classified according to the nature of the error. Over the 4-week period, 21 589 new prescriptions (or 15.3 new prescriptions per patient) were written. Eighty-five per cent (18 448 prescriptions) were error free, but 3141 (15%) prescriptions had one or more errors (2.2 erroneous prescriptions per patient, or 145.5 erroneous prescriptions per 1000 new prescriptions). The five most common incorrect prescriptions were for potassium chloride (10.2% errors), heparin (5.3%), magnesium sulphate (5.2%), paracetamol (3.2%) and propofol (3.1%). Most of the errors were minor or would have had no adverse effects but 618 (19.6%) errors were considered significant, serious or potentially life threatening. Four categories (not writing the order according to the British National Formulary recommendations, an ambiguous medication order, non-standard nomenclature and writing illegibly) accounted for 47.9% of all errors. Although prescription rates (and error rates) in critical care appear higher than elsewhere in hospital, the number of potentially serious errors is similar to other areas of high-risk practice. [source] Beitrag zur Berechnung der Durchbiegung von Stahlbetonbauteilen und Kritik an der ÖNORM B 4700BAUTECHNIK, Issue 5 2008Zivilingenieur für Bauwesen i. R. Friedrich Schäfer Dipl.-Ing. Im Folgenden wird eine Berechnung der Durchbiegung des Stahlbetons angegeben. Diese unterscheidet sich gegenüber früheren Durchbiegungsberechnungen der ÖNORM B4700 , Stahlbetontragwerke (EUROCODE-nahe Berechnung, Bemessung und konstruktive Durchbildung) , und ÖNORM B4200/8 dadurch, dass unter anderem Versuchsresultate berücksichtigt und die Vorgänge wirklichkeitsnah erfasst werden. Die nach den oben genannten ÖNORMEN berechneten und überhöhten Tragwerke in Österreich sind nach Jahrzehnten noch überhöht. Dies kann unter anderem als Indiz für eine falsche Durchbiegungsberechnung angesehen werden. Es wird daher empfohlen, die in der ÖNORM B4700 , Stahlbetontragwerke , angegebene Berechnungsmethode der Durchbiegung des Stahlbetons erstens aus der Norm zu entfernen, da diese, wie wir zeigen werden, nicht richtig ist; zweitens sich wie in der DIN 1045 auf eine Angabe der Schlankheiten zu beschränken und eventuell die Durchbiegung nach den hier angegebenen Überlegungen zu berechnen und drittens diese dem Bauingenieur zu überlassen und auf diese Weise auch die Qualen der Bauingenieure zu beenden. Da die Normen auch den Stand der Technik darstellen und eingehalten werden müssen, stellt dies zusätzlich ein rechtliches Problem dar. Wie gezeigt wird, beinhaltet die angegebene Methode der Berechnung der Durchbiegung in der ÖNORM B4700 schon im Ansatz schwere Gedankenfehler und falsche Voraussetzungen. A contribution to the calculation of the deflection of reinforced concrete members. Stated below you will find a calculation of the deflection of reinforced concrete. It differs from former calculations of the deflection according to the Austrian standard ÖNORM B4700 , reinforced concrete structures (EUROCODE-based calculation, dimensioning and constructive design) , and Austrian standard ÖNORM B4200/8 in that it takes into consideration, among others, the results of tests and represents the processes realistically. The load-bearing structures in Austria which were calculated according to the above-mentioned Austrian standards and feature a precamber still have a camber after decades. This may be regarded, among others, as an indication for an incorrect calculation of the deflection. It is therefore requested that the calculation method for the deflection of reinforced concrete specified in ÖNORM B4700 , reinforced concrete structures , firstly, be removed from this standard because it is not correct, as will be shown; secondly, restrict itself to stating the slendernesses, as is the case with DIN 1045, and to calculate the deflection according to the considerations contained in this paper, for example; and thirdly, to leave the calculation method to the structural engineers, which would also put an end to their anguish. Since the standards also represent the state of the art and have to be observed, this additionally poses a legal problem. As will be shown, the method for calculating the deflection according to ÖNORM B4700 contains serious errors of thought and wrong presuppositions in its basic approach, already. [source] | |||||||||||||