Selective Destruction (selective + destruction)

Distribution by Scientific Domains

Selected Abstracts

Cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results from a Pig Model

BACKGROUND Liposuction is one of the most frequently performed cosmetic procedures in the United States, but its cost and downtime has led to the development of noninvasive approaches for adipose tissue reduction. OBJECTIVE To determine whether noninvasive controlled and selective destruction of fat cells (Cryolipolysis) can selectively damage subcutaneous fat without causing damage to the overlying skin or rise in lipid levels. METHODS Three Yucatan pigs underwent Cryolipolysis at 22 sites: 20 at cooling intensity factor (CIF) index 24.5 (,43.8 mW/cm2), one at CIF 24.9 (,44.7 mW/cm2), and one at CIF 25.4 (,45.6 mW/cm2). Treated areas were evaluated using photography, ultrasound, and gross and microscopic pathology. Lipids were at various times points. One additional pig underwent Cryolipolysis at various days before euthanasia. RESULTS The treatments resulted in a significant reduction in the superficial fat layer without damage to the overlying skin. An inflammatory response triggered by cold-induced apoptosis of adipocytes preceded the reduction in the fat layer. Evaluation of lipids over a 3-month period following treatment demonstrated that cholesterol and triglyceride values remained normal. CONCLUSIONS Cryolipolysis is worthy of further study because it has been shown to significantly decrease subcutaneous fat and change body contour without causing damage to the overlying skin and surrounding structures or deleterious changes in blood lipids. [source]

Prospects of photosensitization in control of pathogenic and harmful micro-organisms

Z. Luksien
Summary Photosensitization is a treatment involving the interaction of the two nontoxic factors, photoactive compound and visible light, which in the presence of oxygen results in the selective destruction of the target cell. Different micro-organisms, such as multidrug-resistant bacteria, yeasts, microfungi and viruses, are susceptible to this treatment. Therefore, a photosensitization phenomenon might open a new avenue for the development of nonthermal, effective and ecologically friendly antimicrobial technology, which might be applied for food safety. [source]

Simultaneous optical coherent control of excitonic and biexcitonic polarization in a ZnSe quantum well

Tobias Voss
Abstract The optical coherent-control technique is used to study biexcitonic effects in the four-wave-mixing signal of a ZnSe single quantum well. The signal is analyzed in both directions 2k1 , k2 and 2k2 , k1 which are not equivalent if a pulse pair is applied from direction k1 to achieve coherent control of the induced polarization. It is shown that the coherent control enables a selective enhancement or suppression of the contribution at the exciton and biexciton resonance to the signal, respectively, but only for certain sequences of the excitation pulses. Further, the suppression of exciton-biexciton beats in the signal as a function of tdel by a selective destruction of the biexciton polarization is demonstrated. [source]

Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson's disease

Xin Zhao
Abstract The dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) replicates many of the pathological hallmarks of Parkinson's disease (PD) in mice via selective destruction of dopamine neurons of the substantia nigra and striatum. Although MPTP has been widely used to study downstream effects following the degeneration of dopaminergic neurons, the underlying mechanisms of MPTP action remain poorly understood. To determine the underlying mechanisms of MPTP action at the protein level, a 2-DE-based proteomics approach was used to evaluate the changes in protein expression in substantia nigra and striatal tissue in C57BL/6 mice after MPTP administration. We identified nine proteins that were markedly altered and are likely to be involved in mitochondrial function, heat shock protein activity, and which contribute enzyme activities for energy metabolism and protein degradation. [source]

Synovial ablation in a rabbit rheumatoid arthritis model using photodynamic therapy

Andrew D. Beischer
Background: At present there is no ideal minimally invasive method for ablating inflamed synovium in joints that has been unres­ponsive to optimal medical management in patients with rheumatoid arthritis. The aim of this study was to determine whether photo­dynamic therapy could be used for this purpose. Methods: In a rabbit knee model of rheumatoid arthritis the pharmacokinetics of the photosensitizer Haematoporphyrin Derivative (HpD) into periarticular tissues and blood was measured following intravenous injection of HpD. The second phase of the study was to determine the histological effect of HpD activation by 63 nm light delivered via an intra-articular optic fibre using a dye pumped KTP-YAG laser. The light dose was varied from 0,200 joule/cm2. Results: Pharmacokinetic studies determined that inflamed synovium rapidly accumulated HpD, with peak levels being reached 12 h following intravenous injection. The ratio of HpD uptake into inflamed synovium versus peri-articular quadriceps muscle was found to be 22.8. Histological examination of the treated knees indicated that selective destruction of inflamed synovium was achieved at light doses 100 joules/cm2 and above. No significant effect was observed on normal intra-articular tissues. Conclusion: We have demonstrated that the first generation photosensitizer HpD selectively accumulates within inflamed ­synovium. Activation of HpD by intra-articular light administration resulted in selective ablation of the inflamed synovium. These findings indicate that PDT offers potential as a new selective, minimally invasive synovectomy technique. [source]