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Secondary Role (secondary + role)
Selected AbstractsInterpreting clinical trials of diabetic dyslipidaemia: new insightsDIABETES OBESITY & METABOLISM, Issue 3 2009A. S. Wierzbicki Current treatment guidelines highlight the importance of aggressive lipid-modifying therapy in reducing cardiovascular risk in patients with type 2 diabetes. Statins are established as the cornerstone of dyslipidaemia management in diabetic patients, based on their efficacy in lowering levels of low-density lipoprotein cholesterol (LDL-C). However, statins fail to address the high residual cardiovascular risk in treated patients, some of which may be attributable to low HDL cholesterol (HDL-C) and elevated triglycerides and to a preponderance of small, dense LDL particles, indicating the need for further intervention. Fibrates are effective against all components of atherogenic dyslipidaemia associated with type 2 diabetes. Clinical studies, most notably the Fenofibrate Intervention and Event Lowering in Diabetes, indicate that fibrates, most likely in combination with a statin, have a secondary role in reducing cardiovascular risk in patients with type 2 diabetes, particularly in those without prior cardiovascular disease or patients with low HDL-C. Results are awaited from the ongoing Action to Control Cardiovascular Risk in Diabetes trial to fully evaluate the outcome benefits of this combination strategy. [source] CAFTA, CAMPAIGN CONTRIBUTIONS, AND THE ROLE OF SPECIAL INTERESTSECONOMICS & POLITICS, Issue 3 2010JAMES M. DEVAULT This paper analyzes the passage of the Central American Free Trade Agreement (CAFTA) in 2005, paying particular attention to the role of campaign contributions. The CAFTA vote is significant in that the context in which it occurred was one in which campaign contributions were more likely to influence votes. By more carefully identifying the special interest groups actively involved in the CAFTA debate, I provide a more accurate assessment of the impact of the contributions made by these groups. I use instrumental variables to control for the potential endogeneity of campaign contributions and find that these contributions played at best a secondary role in determining the outcome of the CAFTA vote in the U.S. House of Representatives. [source] PERSPECTIVE: GENETIC ASSIMILATION AND A POSSIBLE EVOLUTIONARY PARADOX: CAN MACROEVOLUTION SOMETIMES BE SO FAST AS TO PASS US BY?EVOLUTION, Issue 7 2003Massimo Pigliucci Abstract., The idea of genetic assimilation, that environmentally induced phenotypes may become genetically fixed and no longer require the original environmental stimulus, has had varied success through time in evolutionary biology research. Proposed by Waddington in the 1940s, it became an area of active empirical research mostly thanks to the efforts of its inventor and his collaborators. It was then attacked as of minor importance during the "hardening" of the neo-Darwinian synthesis and was relegated to a secondary role for decades. Recently, several papers have appeared, mostly independently of each other, to explore the likelihood of genetic assimilation as a biological phenomenon and its potential importance to our understanding of evolution. In this article we briefly trace the history of the concept and then discuss theoretical models that have newly employed genetic assimilation in a variety of contexts. We propose a typical scenario of evolution of genetic assimilation via an intermediate stage of phenotypic plasticity and present potential examples of the same. We also discuss a conceptual map of current and future lines of research aimed at exploring the actual relevance of genetic assimilation for evolutionary biology. [source] The expansion of mechanistic and organismic diversity associated with non-ribosomal peptidesFEMS MICROBIOLOGY LETTERS, Issue 2 2000Michelle C Moffitt Abstract Non-ribosomal peptides are a group of secondary metabolites with a wide range of bioactivities, produced by prokaryotes and lower eukaryotes. Recently, non-ribosomal synthesis has been detected in diverse microorganisms, including the myxobacteria and cyanobacteria. Peptides biosynthesized non-ribosomally may often play a primary or secondary role in the producing organism. Non-ribosomal peptides are often small in size and contain unusual or modified amino acids. Biosynthesis occurs via large modular enzyme complexes, with each module responsible for the activation and thiolation of each amino acid, followed by peptide bond formation between activated amino acids. Modules may also be responsible for the enzymatic modification of the substrate amino acid. Recent analysis of biosynthetic gene clusters has identified novel integrated, mixed and hybrid enzyme systems. These diverse mechanisms of biosynthesis result in the wide variety of non-ribosomal peptide structures and bioactivities seen today. Knowledge of these biosynthetic systems is rapidly increasing and methods of genetically engineering these systems are being developed. In the future, this may lead to rational drug design through combinatorial biosynthesis of these enzyme systems. [source] Coastal and ancient harbour geoarchaeologyGEOLOGY TODAY, Issue 1 2010N. Marriner What roles have human impacts and natural processes had in shaping the evolution of Mediterranean coastlines during the Holocene? Where, when and how did societies transform the coastal zone? At what scales and rhythms did these changes take place? What can ancient harbour sediments tell us about human-environment interactions? During the past 20 years, geoarchaeological research in the Mediterranean has attempted to understand the interplay between culture and nature, and more particularly how environments and processes have played a role in Holocene human occupation of the coastal zone. This approach has drawn on the multidisciplinary study of sediments, as archives of information, to attempt to differentiate between anthropogenic and natural factors, the latter, we argue, having played an increasingly secondary role with time. Three important spatial scales of analysis have emerged, local, regional and Mediterranean, all of which are outlined here. [source] Subducted slabs and lateral viscosity variations: effects on the long-wavelength geoidGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 2 2009Nicola Tosi SUMMARY The characteristic broad local maxima exhibited by the long-wavelength geoid over subduction zones are investigated with a numerical model of mantle flow. In a spherical axisymmetric geometry, a synthetic model of buoyancy driven subduction is used to test the effects on the geoid caused by the depth of penetration of the lithosphere into the mantle, by the viscosity stratification and by lateral viscosity variations (LVV) in the lithosphere, upper and lower mantle. The presence of anomalous slab density in the lower mantle guarantees geoid amplitudes comparable with the observations, favouring the picture of slabs that penetrate the transition zone and sink into the deep mantle. The viscosity of the lower mantle controls the long-wavelength geoid to the first order, ensuring a clear positive signal when it is at least 30-times greater than the upper-mantle viscosity. The presence of LVV in the lithosphere, in the form of weak plate margins, helps to increase the contribution of the surface topography, causing a pronounced reduction of the geoid. Localized LVV associated with the cold slab play a secondary role if they are in the upper mantle. On the other hand, highly viscous slabs in the lower mantle exert a large influence on the geoid. They cause its amplitude to increase dramatically, way beyond the values typically observed over subduction zones. Long-wavelength flow becomes less vigorous as the slab viscosity increases. Deformation in the upper mantle becomes more localized and power is transferred to short wavelengths, causing the long-wavelength surface topography to diminish and the total geoid to increase. Slabs may be then weakened in the lower mantle or retain their high viscosity while other mechanisms act to lower the geoid. It is shown that a phase change from perovskite to post-perovskite above the core,mantle boundary can cause the geoid to reduce significantly, thereby helping to reconcile models and observations. [source] Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress,induced caspase-12 activationHEPATOLOGY, Issue 3 2002Qing Xie Activation of death receptors and mitochondrial damage are well-described common apoptotic pathways. Recently, a novel pathway via endoplasmic reticulum (ER) stress has been reported. We assessed the role of tauroursodeoxycholic acid (TUDCA) in inhibition of caspase-12 activation and its effect on calcium homeostasis in an ER stress-induced model of apoptosis. The human liver-derived cell line, Huh7, was treated with thapsigargin (TG) to induce ER stress. Typical morphologic changes of ER stress preceded development of apoptotic changes, including DNA fragmentation and cleavage of poly (adenosine diphosphate-ribose) polymerase (PARP), as well as activation of caspase-3 and -7. Elevation of intracellular calcium levels without loss of mitochondrial membrane potential (MMP) was shown using Fluo-3/Fura-red labeling and flow cytometry, and confirmed by induction of Bip/GRP78, a calcium-dependent chaperon of ER lumen. These changes were accompanied by procaspase-12 processing. TUDCA abolished TG-induced markers of ER stress; reduced calcium efflux, induction of Bip/GRP78, and caspase-12 activation; and subsequently inhibited activation of effector caspases and apoptosis. In conclusion, we propose that mitochondria play a secondary role in ER-mediated apoptosis and that TUDCA prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. This novel mechanism of TUDCA action suggests new intervention methods for ER stress-induced liver disease. [source] Spring northward retreat of Eurasian snow cover relevant to seasonal and interannual variations of atmospheric circulationINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 6 2003Hiroaki Ueda Abstract An observational study is made of the seasonal and interannual variations of spring snow-disappearance over the Eurasian continent and the circulation mechanisms causing those variations. The spring northward retreat of the snow boundary over the East European Plain (EEP) between 30 and 60° E is faster (0.4° per day) than to the east of the Ural Mountain range (0.3° per day). These migrations of the snow boundary lag behind the appearance of the surface air temperature 0 °C by about 1 to 5 pentads. The analyses of the atmospheric heat and moisture budgets showed that the seasonal intrusion of warm air associated with southwesterly winds is primarily responsible for the rapid snowmelt in March and April over the EEP. In addition, the adiabatic heating of descending air plays a secondary role in the snowmelt in mid-March. On an interannual time scale, horizontal warm advection also plays an essential role in the spring northward retreat of snow cover extent. The present study confirms the previous finding that the surface air temperature anomalies, produced during the seasonal snow-disappearance period, diminished in May, suggesting a weak dynamical linkage between the EEP snow cover and Asian summer monsoon. Copyright © 2003 Royal Meteorological Society [source] Consumer morality in times of economic hardship: evidence from the European Social SurveyINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 2 2010*Article first published online: 1 FEB 2010, Cláudia Abreu Lopes Abstract Crimes of everyday life, often referred to as unfair or unethical practices committed in the marketplace by those who see themselves and are seen as respectable citizens, have burgeoned as a result of the transformations in the European economy in the late 20th century, namely the transition to neo-liberal markets and the emergence of consumer society. A ,cornucopia of new criminal opportunities' has given rise to a new range of crimes such as ripping software, making false insurance claims or paying cash on hand to circumvent taxes. These shady behaviours (legal or not) are part of people's experience, albeit they are collectively regarded as morally dubious. Taken collectively, crimes of everyday life are indicators of the moral stage of a particular society and therefore a valuable instrument for social and political analysis. This paper addresses the question of whether and under which conditions feelings of economic hardship trigger crimes of everyday life. A multilevel theoretical and empirical perspective that integrates theories stemming from political science, sociology, and social psychology is adopted. I start by exploring the embeddedness of economic morality in social institutions, followed by an elaboration of the concept of market anomie to account for deviant behaviour in the marketplace, to finally step down to the examination of the correspondence between social attitudes and consumer behaviour, as postulated by the Theory of Planned Behaviour. The empirical study relies on micro data from the European Social Survey (ESS) (Round 2) and attempts to model, for each country, a formative measure of crimes of everyday life based on socio-demographic variables and the current economic situation, as it is perceived by the individual (taken as a measure of relative deprivation). The resultant country-specific regression coefficients are mapped onto the broader economic and normative context of 23 European countries. The results reveal that crimes of everyday life are driven by feelings of economic hardship only in countries where normative factors dictate their deviance. In countries where fraudulent behaviour is more generalized, inner motivations to offend play a secondary role as the more privileged consumers are more likely to commit fraud as they interact more often with the market. In turn, normative aspects result from a dynamic interplay of cultural and economic factors. As the economy grows faster, the tendency to offend in the market becomes more visible, but only in countries whose gross domestic product (GDP) stands above the European average. In countries with low GDP, the normative landscape is shaped by cultural factors that seem to obfuscate the power of economic factors favourable to consumer fraud. [source] Performance assessment under field conditions of a rapid immunological test for transgenic soybeansINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 4 2001John Fagan Summary Current market conditions and food regulations make it necessary for international and domestic participants in the agrifood industry to structure supply chains that control the content of genetically modified (GM) material in their products. Tests to detect and/or quantify GM components represent an important tool in maintaining such supply systems. This study assesses the field performance of kits that employ lateral flow immuno-technology to detect soybeans GM to be resistant to the herbicide glyphosate. Operators at 23 grain-handling facilities were paid to conduct analyses on a series of blinded samples containing defined proportions of conventional and transgenic soybeans. The observed rate of false positives was 6.7% in an experiment in which the highest level of GM material was 1% and 22.3% in a second experiment in which the highest level of GM material was 10%. This difference may be attributed to increased risk of cross-contamination with the higher level of transgenic material used in the second study. Samples containing 0.01% GM material were reported as genetically modified 6.70% of the time, while samples containing 0.1, 0.5 and 1% GM material were classified as genetically modified 29.5, 67.7 and 68.2% of the time, respectively. Thus, the frequencies of false negatives were 93.3, 70.5, 33.3 and 31.8% for samples containing 0.01, 0.1, 0.5 and 1.0% GM material. Samples containing 10% GM material were correctly reported as genetically modified in all cases. These results lead to the conclusion that the kit under study is useful in screening for lots of soybeans that contain high levels of GM material, but that, as a field tool, it is not effective in monitoring for GM material at the level of 1.0% or lower. Statistical and immunochemical analyses were carried out in order to assess the relative contributions of various factors to the error observed in these studies. These analyses indicated that limitations in operator performance, not defects in test kit materials, were the primary contributors, while sample size may play a secondary role. As both operator performance and sample size are independent of the specific characteristics of the test kit used in this study, it appears justifiable to generalize conclusions obtained here to other similar test systems. [source] German Interests in European Monetary IntegrationJCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 1 2002Karl Kaltenthaler This article explores the sources of the German govermnent's position on European monetary integration since the first attempt at monetary union. I argue that German policy on European monetary integration was, until after EMU, driven by German foreign policy elites' perception that integration could be used to achieve their primary geo-political goal, embedding Germany in European institutions to dismantle the security dilemma with its European neighbours, particularly with France. After the signing of the Maastricht Treaty, this situation was reversed, as domestic economic interests and state financial authorities have taken the lead in shaping Germany's policy on European monetary integration, with foreign policy elites playing a secondary role. Thus German policy has come to resemble more the policies of other European monetary union member states, in that domestic economic concerns have taken precedence over geo-political interests in the making of policy on European monetary integration. [source] The seasonal abundance of blowflies infesting drying fish in south-west IndiaJOURNAL OF APPLIED ECOLOGY, Issue 2 2001R. Wall Summary 1Blowfly infestation of sun-drying fish is a major economic problem in many developing countries of Asia, Africa and the Pacific. To consider the ecology of infestation, adult and larval blowfly populations were monitored between 27 October 1997 and 27 April 1999 at a fish landing and drying site, approximately 5 km north of Calicut, in Kerala state on the coast of south-west India. 2During the 548-day sampling period, a total of 96 953 adult Diptera was collected from 16 sticky targets, placed inside and outside eight fish-storage sheds. Of these, 91 912 (95%) were Chrysomya megacephala, 3719 (4%) were other Calliphoridae and 1322 (1%) were other species, largely Sarcophagidae. 3The population of C. megacephala showed pronounced seasonal fluctuations in response to climate, particularly relative humidity. Significantly shorter-frequency fluctuations within fish-processing sheds were also evident, the periodicity of which corresponded approximately to C. megacephala generation cycles. Spatial variation in C. megacephala abundance was evident within the site, higher populations occurring closest to the beach and numbers declining with distance inland. 4The pattern of drying fish infestation by C. megacephala broadly followed changes in the density of adult flies and the seasonal change in weather, with peaks during the monsoon and troughs in the dry hot periods. High relative humidity played a significant but secondary role in increasing infestation. 5Quantification of the relationship between larval infestation and percentage fish loss suggests that, given the infestation levels observed, between 10% and 60% post-harvest wet weight losses would be expected in the monsoon period, depending on the species of fish landed. 6The study emphasizes the importance of developing a clear understanding of the basic ecology and spatial and temporal dynamics of an insect pest, prior to the design or implementation of any pest management programme. [source] Climatic limits for the present distribution of beech (Fagus L.) species in the worldJOURNAL OF BIOGEOGRAPHY, Issue 10 2006Jingyun Fang Abstract Aim, Beech (Fagus L., Fagaceae) species are representative trees of temperate deciduous broadleaf forests in the Northern Hemisphere. We focus on the distributional limits of beech species, in particular on identifying climatic factors associated with their present range limits. Location, Beech species occur in East Asia, Europe and West Asia, and North America. We collated information on both the southern and northern range limits and the lower and upper elevational limits for beech species in each region. Methods, In total, 292 lower/southern limit and 310 upper/northern limit sites with available climatic data for all 11 extant beech species were collected by reviewing the literature, and 13 climatic variables were estimated for each site from climate normals at nearby stations. We used principal components analysis (PCA) to detect climatic variables most strongly associated with the distribution of beech species and to compare the climatic spaces for the different beech species. Results, Statistics for thermal and moisture climatic conditions at the lower/southern and upper/northern limits of all world beech species are presented. The first two PCA components accounted for 70% and 68% of the overall variance in lower/southern and upper/northern range limits, respectively. The first PCA axis represented a thermal gradient, and the second a moisture gradient associated with the world-wide distribution pattern of beech species. Among thermal variables, growing season warmth was most important for beech distribution, but winter low temperature (coldness and mean temperature for the coldest month) and climatic continentality were also coupled with beech occurrence. The moisture gradient, indicated by precipitation and moisture indices, showed regional differences. American beech had the widest thermal range, Japanese beeches the most narrow; European beeches occurred in the driest climate, Japanese beeches the most humid. Climatic spaces for Chinese beech species were between those of American and European species. Main conclusions, The distributional limits of beech species were primarily associated with thermal factors, but moisture regime also played a role. There were some regional differences in the climatic correlates of distribution. The growing season temperature regime was most important in explaining distribution of Chinese beeches, whilst their northward distribution was mainly limited by shortage of precipitation. In Japan, distribution limits of beech species were correlated with summer temperature, but the local dominance of beech was likely to be dependent on snowfall and winter low temperature. High summer temperature was probably a limiting factor for southward extension of American beech, while growing season warmth seemed critical for its northward distribution. Although the present distribution of beech species corresponded well to the contemporary climate in most areas, climatic factors could not account for some distributions, e. g., that of F. mexicana compared to its close relative F. grandifolia. It is likely that historical factors play a secondary role in determining the present distribution of beech species. The lack of F. grandifolia on the island of Newfoundland, Canada, may be due to inadequate growing season warmth. Similarly, the northerly distribution of beech in Britain has not reached its potential limit, perhaps due to insufficient time since deglaciation to expand its range. [source] Structural response of Caribbean dry forests to hurricane winds: a case study from Guánica Forest, Puerto RicoJOURNAL OF BIOGEOGRAPHY, Issue 3 2006Skip J. Van Bloem Abstract Aim, Tropical dry forests in the Caribbean have an uniquely short, shrubby structure with a high proportion of multiple-stemmed trees compared to dry forests elsewhere in the Neotropics. Previous studies have shown that this structure can arise without the loss of main stems from cutting, grazing, or other human intervention. The Caribbean has a high frequency of hurricanes, so wind may also influence forest stature. Furthermore, these forests also tend to grow on soils with low amounts of available phosphorus, which may also influence structure. The objective of this study was to assess the role of high winds in structuring dry forest, and to determine whether soil nutrient pools influence forest response following hurricane disturbance. Location, Guánica Forest, Puerto Rico. Methods, Over 2000 stems in five plots were sampled for hurricane effects within 1 week after Hurricane Georges impacted field sites in 1998. Sprout initiation, growth, and mortality were analysed for 1407 stems for 2 years after the hurricane. Soil nutrient pools were measured at the base of 456 stems to assess association between nutrients and sprout dynamics. Results, Direct effects of the hurricane were minimal, with stem mortality at < 2% and structural damage to stems at 13%, although damage was biased toward stems of larger diameter. Sprouting response was high , over 10 times as many trees had sprouts after the hurricane as before. The number of sprouts on a stem also increased significantly. Sprouting was common on stems that only suffered defoliation or had no visible effects from the hurricane. Sprout survival after 2 years was also high (> 86%). Soil nutrient pools had little effect on forest response as a whole, but phosphorus supply did influence sprout dynamics on four of the more common tree species. Main conclusions, Hurricanes are able to influence Caribbean tropical dry forest structure by reducing average stem diameter and basal area and generating significant sprouting responses. New sprouts, with ongoing survival, will maintain the high frequency of multi-stemmed trees found in this region. Sprouting is not limited to damaged stems, indicating that trees are responding to other aspects of high winds, such as short-term gravitational displacement or sway. Soil nutrients play a secondary role in sprouting dynamics of a subset of species. The short, shrubby forest structure common to the Caribbean can arise naturally as a response to hurricane winds. [source] Sex-specific selection and sexual size dimorphism in the waterstrider Aquarius remigisJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 2 2000Ferguson We estimated selection on adult body size for two generations in two populations of Aquarius remigis, as part of a long-term study of the adaptive significance of sexual size dimorphism (SSD). Net adult fitness was estimated from the following components: prereproductive survival, daily reproductive success (mating frequency or fecundity), and reproductive lifespan. Standardized selection gradients were estimated for total length and for thorax, abdomen, genital and mesofemur lengths. Although selection was generally weak and showed significant temporal and spatial heterogeneity, patterns were consistent with SSD. Prereproductive survival was strongly influenced by date of eclosion, but size (thorax and genital lengths in females; total and abdomen lengths in males) played a significant secondary role. Sexual selection favoured smaller males with longer external genitalia in one population. Net adult fitness was not significantly related to body size in females, but was negatively related to size (thorax and total length) in males. [source] Colonization by barnacles on fossil Clypeaster: an exceptional example of larval settlementLETHAIA, Issue 4 2008ANA G. SANTOS The presence of c. 1450 individuals of the balanid barnacle Balanus crenatus Bruguière encrusting the test of a clypeasteroid sea urchin from the Late Miocene of the Guadalquivir Basin (southwestern Spain) allows proposing a settlement pattern linked to the growth of the encrusting organism. The possible influence of dip angle was controlled by dividing the test into four concentric zones ranging from lowest margin to apex (0,15°, 15,30°, 30,50° and 0°). Contour diagrams were prepared to identify areas of highest barnacle density as well as size categories distribution in relationship to the pitch of the sea urchin test. The orientation of balanid tests was recorded and plotted on rose diagrams from 0° to 180°. Four size categories of barnacles were distinguished: (1) < 1 mm, (2) 1,2 mm, (3) 2,3 mm and (4) 3,4 mm; these correspond to a growth sequence ranging from post-larval forms to juveniles. Two areas of maximum settlement density are situated on the posterior margin of the test, on aboral as well as oral surfaces. The aboral surface shows the maximum number of barnacles. Two groups of individuals are defined on the basis of their location, that is, those encrusting the posterior medium part of the urchin, and those located on the anterior half. The results suggest that larval settlement was initially controlled by the availability of free space and afterwards by an intensification effect. Orientation and dip of the test may have played a secondary role in the settlement of the larvae. Substrate colonization seems to have been closely related to the biostratinomic history of the sea urchin test and although several scenarios are possible, our data are congruent with a synchronous settlement of both surfaces (aboral and oral) by one spat or several. [source] Model error and sequential data assimilation: A deterministic formulationTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 634 2008A. Carrassi Abstract Data assimilation schemes are confronted with the presence of model errors arising from the imperfect description of atmospheric dynamics. These errors are usually modelled on the basis of simple assumptions such as bias, white noise, and first-order Markov process. In the present work, a formulation of the sequential extended Kalman filter is proposed, based on recent findings on the universal deterministic behaviour of model errors in marked contrast with previous approaches. This new scheme is applied in the context of a spatially distributed system proposed by Lorenz. First, it is found that, for short times, the estimation error is accurately approximated by an evolution law in which the variance of the model error (assumed to be a deterministic process) evolves according to a quadratic law, in agreement with the theory. Moreover, the correlation with the initial condition error appears to play a secondary role in the short-time dynamics of the estimation error covariance. Second, the deterministic description of the model error evolution, incorporated into the classical extended Kalman filter equations, reveals that substantial improvements of the filter accuracy can be gained compared with the classical white-noise assumption. The universal short-time quadratic law for the evolution of the model error covariance matrix seems very promising for modelling estimation error dynamics in sequential data assimilation. Copyright © 2008 Royal Meteorological Society [source] Metapopulation viability of the marsupial Micoureus demerarae in small Atlantic forest fragments in south-eastern BrazilANIMAL CONSERVATION, Issue 3 2000Daniel Brito A population viability analysis (PVA) was carried out for populations of the arboreal didelphid Micoureus demerarae in eight small (1.5,15.0 ha) forest fragments in south-eastern Brazil. Analysis was based on field data obtained through demographic studies carried out since 1995. Populations are small, but connected by dispersing individuals, thus forming a metapopulation. Frequency of catastrophic fires was estimated from the Reserve's historical records. We used the computer package VORTEX for all analyses. All populations and the metapopulation were found to be endangered within 100 years (extinction probability > 0.98). A sensitivity analysis was run varying six parameters: three demographic (sex ratio, migration and mortality rates), two environmental (K, fire frequency) and one genetic (level of inbreeding depression). Genetics, K, mortality rates and sex ratio seemed to play major roles to population persistence, whereas catastrophes and migration rates had a secondary role. Among demographic factors, extinction rate was least sensitive to migration rate. Micoureus demerarae can be used as a model species, thus improving our knowledge of how extinction-prone populations of neotropical arboreal marsupials in forest fragments might be, and which management actions could decrease such risks. [source] Extensive astrocyte infection is prominent in human immunodeficiency virus,associated dementia,ANNALS OF NEUROLOGY, Issue 2 2009Melissa J. Churchill PhD Astrocyte infection with human immunodeficiency virus (HIV) is considered rare, so astrocytes are thought to play a secondary role in HIV neuropathogenesis. By combining double immunohistochemistry, laser capture microdissection, and highly sensitive multiplexed polymerase chain reaction to detect HIV DNA in single astrocytes in vivo, we showed that astrocyte infection is extensive in subjects with HIV-associated dementia, occurring in up to 19% of GFAP+ cells. In addition, astrocyte infection frequency correlated with the severity of neuropathological changes and proximity to perivascular macrophages. Our data indicate that astrocytes can be extensively infected with HIV, and suggest an important role for HIV-infected astrocytes in HIV neuropathogenesis. Ann Neurol 2009;66:253,258 [source] Spondylarthritis in HLA,B27/human ,2 -microglobulin,transgenic rats is not prevented by lack of CD8ARTHRITIS & RHEUMATISM, Issue 7 2009Joel D. Taurog Objective HLA,B27 predisposes to spondylarthritis by an unknown mechanism. A logical candidate mechanism is through recognition of B27 by CD8+ T cells. The purpose of this study was to examine the effects of a lack of CD8 on the spondylarthritis that develops in B27/human ,2 -microglobulin (Hu,2m),transgenic rats. Methods A missense mutation in the CD8a gene that causes a loss of CD8, expression was identified in offspring of a male Sprague-Dawley rat that had been treated with the mutagen N -ethyl- N -nitrosourea. The mutation was crossed into B27/Hu,2m-transgenic lines on the Lewis background. CD8a,/, and CD8a+/, progeny were compared on a mixed SD-LEW background as well as after at least 10 backcrosses to LEW rats. CD8 function was assessed by generating cytolytic T lymphocytes (CTLs) against allogeneic DA strain antigens. Results Homozygous mutant rats showed normal CD8a and CD8b messenger RNA levels but no detectable expression of either protein and an almost complete abrogation of the allogeneic CTL response. Two disease phenotypes previously observed in different B27/Hu,2m-transgenic lines also occurred in the respective CD8a,/, -transgenic rat lines. There was no significant difference in disease prevalence or severity between CD8a,/, rats and CD8a+/, rats. Conclusion All of the previously described disease manifestations in HLA,B27/Hu,2m-transgenic rats arise in the absence of any functional CD8+ T cells. It thus seems unlikely that classic T cell recognition of HLA,B27 is of primary importance in this animal model. The possibility of a secondary role of a CD8-dependent mechanism cannot be entirely excluded. [source] Morphological properties of isolated galaxies vs. isolation criteriaASTRONOMISCHE NACHRICHTEN, Issue 9-10 2009I.B. Vavilova Abstract We studied the morphological properties of isolated galaxies samples in dependence on the isolation parameter and properties of primary catalogs. With this aim we identified the samples of single and isolated galaxies from SDSS DR5 (Single and QIsol) with the 3D Voronoi tessellation method (Elyiv et al. 2009). We found that in comparison with other samples of isolated galaxies, the QIsol sample contains an excess of late-type galaxies, especially with a low luminosity and BCG/Im/Irr morphology. We also showed that the fractions of early type galaxies in QIsol SDSS DR5 sample and samples 2MIG (Karachentseva et al. 2010) and CIG (Karachentseva et al. 1973; Hernandez-Toledo et al. 2008) are in a good agreement (16,19 %), but Allam's (Allam et al. 2005) and Prada's (Prada et al. 2003) SDSS DR1 samples show a higher excess of the early type galaxies that can be explained by the selection criteria and morphology definition method. We found a weak relation between isolation parameter and color index for the Single sample that may indicate that even in the low dense environment the morphology density relation is observed. We conclude that morphological properties of the resulting sample of isolated galaxies are highly dependent on the primary catalogue from which the galaxies were selected. Moreover, the selection criterion is also important but plays a secondary role in the resulting morphological content, color indices distribution and other parameters of the isolated galaxy samples. Only four galaxies are common in the 2MIG, QIsol, and CIG samples, namely UGC5184, UGC6121, UGC8495, and UGC9598, that allows to consider them as really most isolated galaxies (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] The tectonic regime along the Andes: Present-day and Mesozoic regimesGEOLOGICAL JOURNAL, Issue 1 2010Victor A. Ramos Abstract The analyses of the main parameters controlling the present Chile-type and Marianas-type tectonic settings developed along the eastern Pacific region show four different tectonic regimes: (1) a nearly neutral regime in the Oregon subduction zone; (2) major extensional regimes as the Nicaragua subduction zone developed in continental crust; (3) a Marianas setting in the Sandwich subduction zone with ocean floored back-arc basin with a unique west-dipping subduction zone and (4) the classic and dominant Chile-type under compression. The magmatic, structural and sedimentary behaviours of these four settings are discussed to understand the past tectonic regimes in the Mesozoic Andes based on their present geological and tectonic characteristics. The evaluation of the different parameters that governed the past and present tectonic regimes indicates that absolute motion of the upper plate relative to the hotspot frame and the consequent trench roll-back velocity are the first order parameters that control the deformation. Locally, the influences of the trench fill, linked to the dominant climate in the forearc, and the age of the subducted oceanic crust, have secondary roles. Ridge collisions of seismic and seismic oceanic ridges as well as fracture zone collisions have also a local outcome, and may produce an increase in coupling that reinforces compressional deformation. Local strain variations in the past and present Andes are not related with changes in the relative convergence rate, which is less important than the absolute motion relative to the Pacific hotspot frame, or changes in the thermal state of the upper plate. Changes in the slab dip, mainly those linked to steepening subduction zones, produce significant variations in the thermal state, that are important to generate extreme deformation in the foreland. Copyright © 2009 John Wiley & Sons, Ltd. [source] The Insulin-like Growth Factor System: a Key Determinant Role in the Growth and Selection of Ovarian Follicles?REPRODUCTION IN DOMESTIC ANIMALS, Issue 4 2003A Comparative Species Study Contents The aim of the present paper is to make a comparative study of the expression of the elements of the insulin-like growth factor (IGF) system in different mammalian species and thus illuminate their potential role in the process of ovarian folliculogenesis in mammals. In most mammalian species, IGFs and IGFBPs (in particular IGFBP-2 and IGFBP-4) are considered, respectively, as stimulators and inhibitors of follicular growth and maturation. In mammalian species, IGFs might play a key role in sensitizing ovarian granulosa cells to FSH action during terminal follicular growth. Concentrations of IGFBP-2 and IGFBP-4 in follicular fluid strongly decrease and increase during follicular growth and atresia, respectively, leading to an increase and a decrease in IGF bioavailability, respectively. The decrease in these IGFBPs is because of a decrease in mRNA expression (IGFBP-2) and an increase in proteolytic degradation by PAPP-A in follicular fluid (IGFBP-2, IGFBP-4 and IGFBP-5), and likely participates in the selection of dominant follicles. In contrast, levels and/or sites of expression of IGF-I, IGF-II, IGFBP-4, IGFBP-5 and type II receptor in follicular cells strongly differ between mammalian species, suggesting that these phenomena might play species-specific or secondary roles in ovarian folliculogenesis. [source] | ||||||||||||||||||||||||||||||||||