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Second Application (second + application)

Distribution by Scientific Domains

Medical Sciences	57%

Selected Abstracts

Sodium Hydroxide Chemical Matricectomy for the Treatment of Ingrown Toenails: Comparison of Three Different Application Periods

DERMATOLOGIC SURGERY, Issue 7 2005
Pelin Kocyigit MD
Objective Sodium hydroxide matricectomy is a successful method for the treatment of ingrown toenails. This study was designed to evaluate the optimal sodium hydroxide application period providing high success rates with minimal postoperative morbidity. Materials and Methods Sixty-six patients with 225 ingrown nail edges were treated in three groups receiving 30-second, 1-minute, and 2-minute applications of sodium hydroxide. Each patient was reviewed postoperatively for pain, drainage, and tissue damage. The median long-term follow-up period was 14 months. Results The success rate of the therapy was 70.9% in the first group, 92.7% in the second group, and 94.4% in the third group. In all groups, about half of the patients experienced minimal pain within 48 hours following the operation, but only in the third group, 20% of the patients had minimal pain, which continued about 1 week. Drainage and tissue damage were minimal or mild in all groups and disappeared within 3 weeks in the first and second groups but were prolonged to 6 weeks in the third group. conclusion The success rate of 30-second application is significantly lower than 1-minute and 2-minute applications. Although the success rates of the latter two procedures are similar, the prolonged healing time is the disadvantage of the 2-minute application. We conclude that 1-minute application of 10% sodium hydroxide is simple, safe, and highly effective for the treatment of ingrown nails. [source]

Value-at-risk for long and short trading positions

JOURNAL OF APPLIED ECONOMETRICS, Issue 6 2003
Pierre Giot
In this paper we model Value-at-Risk (VaR) for daily asset returns using a collection of parametric univariate and multivariate models of the ARCH class based on the skewed Student distribution. We show that models that rely on a symmetric density distribution for the error term underperform with respect to skewed density models when the left and right tails of the distribution of returns must be modelled. Thus, VaR for traders having both long and short positions is not adequately modelled using usual normal or Student distributions. We suggest using an APARCH model based on the skewed Student distribution (combined with a time-varying correlation in the multivariate case) to fully take into account the fat left and right tails of the returns distribution. This allows for an adequate modelling of large returns defined on long and short trading positions. The performances of the univariate models are assessed on daily data for three international stock indexes and three US stocks of the Dow Jones index. In a second application, we consider a portfolio of three US stocks and model its long and short VaR using a multivariate skewed Student density. Copyright © 2003 John Wiley & Sons, Ltd. [source]

Does diagnostic sonography alter thyroid and parathyroid hormone levels?

JOURNAL OF CLINICAL ULTRASOUND, Issue 1 2008
Erdinc Serin MD
Abstract Purpose To investigate possible alterations in the levels of thyroid and parathyroid hormones (PTHs) and thyroglobulin (TG) in healthy individuals following diagnostic sonographic examination of the thyroid gland. Methods Thirty healthy women with no pathologic findings underwent sonographic examination, followed 6 weeks later by a second examination involving a probe-only application (PA) with the ultrasound scanner switched off. Duration times were identical for both examinations. Blood was drawn before and after the 2 applications. Thyroid hormone, PTH, and TG levels before and after the 2 applications were compared, and the difference between the variations for each parameter in the first and second applications was assessed. Blood samples were taken before and after the sonographic examination and the PA, and the serum concentrations of sensitive thyrotropin, total and free thyroxine, total and free tri-iodothyronine, TG, and PTH were measured. The pre- and post-examination levels of the hormones for the 2 applications were then compared and the difference between the variations for each parameter in the first and second application was then assessed. Results The only significant variations observed were in the TG levels after PA and PTH levels after both sonographic examination and PA. The comparison between the 2 difference values revealed no significant difference except for PTH. Conclusion This preliminary report on the possible influence of sonographic examination of the thyroid on the serum levels of thyroid and parathyroid hormones suggests that gland secretions such as PTH may be affected by external factors, including ultrasound. Clinicians should be aware of alterations in hormone levels by external factors. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2008 [source]

Teachers' support with ad-hoc collaborative networks

JOURNAL OF COMPUTER ASSISTED LEARNING, Issue 3 2005
C. Cortez
Abstract Efforts to improve the educational process must focus on those most responsible for implementing it: the teachers. It is with them in mind that we propose a face-to-face computer-supported collaborative learning system that uses wirelessly networked hand-held computers to create an environment for helping students assimilate and transfer educational content. Two applications of this system are presented in this paper. The first involves the use of the system by students, transforming classroom dynamics and enabling collaboration and interaction between the students and the teacher. In the second application, the system is used to help teachers update their knowledge of subject content and exchange methodological strategies. [source]

Principal component analysis of landmarks from reversible images

JOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES C (APPLIED STATISTICS), Issue 1 2004
C. M. Theobald
Summary., We consider the use of principal component analysis to summarize the variation in labelled landmark data for images which are reversible in the sense that a mirror image may be defined for each image and the original and mirror images may be regarded as equally representative of the population. We examine the effect of including the original and mirror images on a principal component analysis based on the landmark co-ordinates. The inclusion of mirror images is found to lead to a simplified interpretation in which some components measure asymmetry in the images and the remainder depend symmetrically on pairs of co-ordinates. This is illustrated on shape variation in carrots. A second application is to the segmentation of X-ray computed tomography images of sheep to locate the inner boundary of the carcass. It is found that image boundaries can be identified more accurately by modelling them with principal components, and that including mirror images can offer a further improvement in accuracy. Similar arguments apply when a population of images is thought to be invariant under a rotation and may also be relevant when a principal component analysis is applied to descriptive statistics such as Fourier sums. [source]

"One-pot" Synthesis of 1-Vinyl-2-pyrrolidone with Protic Functional Groups in 3-Position

MACROMOLECULAR CHEMISTRY AND PHYSICS, Issue 22 2009
Mónica Pérez Perrino
Abstract A synthetic route that allows modification of 1-vinyl-2-pyrrolidone with an alcohol or thiol group in its 3-position in a one-pot reaction without using protecting groups is described. The strategy used to achieve this goal is the reaction of the carboxamide anion of 1-vinyl-2-pyrrolidone with cyclic precursors of these functionalities. It is furthermore shown that VP-monomers functionalized with OH groups are suitable for the preparation of the corresponding copolymers with pure VP. As a second application of the new compounds, we also describe the synthesis of the first asymmetric crosslinker based on VP. [source]

Two constructive embedding-extension theorems with applications to continuity principles and to Banach-Mazur computability

MLQ- MATHEMATICAL LOGIC QUARTERLY, Issue 4-5 2004
Andrej Bauer
Abstract We prove two embedding and extension theorems in the context of the constructive theory of metric spaces. The first states that Cantor space embeds in any inhabited complete separable metric space (CSM) without isolated points, X, in such a way that every sequentially continuous function from Cantor space to , extends to a sequentially continuous function from X to ,. The second asserts an analogous property for Baire space relative to any inhabited locally non-compact CSM. Both results rely on having careful constructive formulations of the concepts involved. As a first application, we derive new relationships between "continuity principles" asserting that all functions between specified metric spaces are pointwise continuous. In particular, we give conditions that imply the failure of the continuity principle "all functions from X to , are continuous", when X is an inhabited CSM without isolated points, and when X is an inhabited locally non-compact CSM. One situation in which the latter case applies is in models based on "domain realizability", in which the failure of the continuity principle for any inhabited locally non-compact CSM, X, generalizes a result previously obtained by Escardó and Streicher in the special case X = C[0, 1]. As a second application, we show that, when the notion of inhabited complete separable metric space without isolated points is interpreted in a recursion-theoretic setting, then, for any such space X, there exists a Banach-Mazur computable function from X to the computable real numbers that is not Markov computable. This generalizes a result obtained by Hertling in the special case that X is the space of computable real numbers. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]

Evaluation of a Navigation System for ENT with Surgical Efficiency Criteria,

THE LARYNGOSCOPE, Issue 4 2006
Gero Strau MD
Abstract The aim of this study is the evaluation of a navigation system (NaviBase) for ENT surgery. For this purpose, a new methodology for the evaluation of surgical and ergonomic system properties has been developed. The practicability of the evaluation instruments will be examined using the example of the overall assessment of the system in comparison with the current surgical standard and with other systems using clinical efficiency criteria. The evaluation is based on 102 ENT surgical applications; of these, 89 were functional endoscopic sinus surgeries (FESS). The evaluation of surgical and ergonomic performance factors was performed by seven ENT surgeons. To evaluate surgical system properties, the Level of Quality (LOQ) in 89 cases of the FESS was determined. It compares the existing information of the surgeon with that of the navigation system on a scale of 0 to 100 and with a mean value of 50 and places it in a relationship to the clinical impact. The intraoperative change of the planned surgical strategy (Change of Surgical Strategy) was documented. The ergonomic factors of the system with the categories of Overall Confidence (Trust), awareness of the situation (Situation Awareness), influence on the operating team, requirements for specific skills (Skill Set Requirement), and cognitive load (Workload Shift) were recorded for all surgical procedures as Level of Reliance (LOR). In the evaluation of the surgical system properties, an average evaluation of the quality of the information, as an LOQ of 63.59, resulted. Every second application of the navigation system (47.9%), on average, led to a change in the surgical strategy. An extension/enhancement of the indication of the endonasal approach through the use of the navigation system was shown in 7 of 102 (6.8%) cases. The completion of the resection in the FESS was rated by 74% of group I and 11% of group II as better in comparison with the standard approach. Total confidence shows a positive evaluation of 3.35 in the LOR. To supplement the evaluation of the navigation system, the technical parameters were included. The maximum deviation, Amax, of the displayed position of the reference value amounted to 1.93 mm. The average deviation was at 1.29 mm with an SD above all values, sd, of 0.29. The subsequent economic evaluation resulted in an effective average extra expenditure of time of 1.35 minutes per case. The overall evaluation of the system imparts application-relevant information beyond the technical details and permits comparability between different assistance systems. [source]

Long-lasting contractile action and the inhibitory action of cupric ions on ileal longitudinal muscle

AUTONOMIC & AUTACOID PHARMACOLOGY, Issue 4 2004
K. Miyazaki
Summary 1 Cupric ions (Cu2+), at concentrations above 0.03 mm, induced a progressive increase in the tonic contraction of guinea-pig ileal longitudinal muscle. Maximal contraction of 0.1 mm Cu2+ attained a level above that of the 60-mm K+ -induced tonic response, within 20 min of application. The tension induced by Cu2+ persisted for more than several hours. Tetrodotoxin (3 × 10,6 m) had no effect on the contraction induced by 0.1 mm Cu2+. 2 After incubation in a Ca2+ -free medium, the ileal response to 0.1 mm Cu2+ was lost. Nifedipine, a L-type Ca2+ channel blocker, dose-dependently inhibited contractions induced by Cu2+. 3 As the duration of the first application of 0.1 mm Cu2+ increased above 30 min, after washing with normal medium, the contractile response to a second application of 0.1 mm Cu2+ decreased gradually. After 150 min of the first application of 0.1 mm Cu2+, a second application of Cu2+ could not evoke any contraction. 4 After the application of 0.1 mm Cu2+ for 150 min, when muscles were washed with a medium containing 1 mm EDTA, the response to 0.1 mm Cu2+ returned to a greater extent in the normal Ca2+ medium. 5 In conclusion, Cu2+ (0.1 mm) induced a maximal ileal tension above that of the K-induced tonic response within 20 min. The ileal contraction to Cu2+ persisted for more than several hours and depended on extracellular Ca2+ concentrations. It is possible that a part of Cu2+, bound to a EDTA-inaccessible site, also has a tension inhibitory effect. [source]

The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries

BRITISH JOURNAL OF PHARMACOLOGY, Issue 1 2009
NN Huynh
Background and purpose:, Arginase and nitric oxide (NO) synthase share the common substrate L-arginine, and arginase inhibition is proposed to increase NO production by increasing intracellular levels of L-arginine. Many different inhibitors are used, and here we have examined the effects of these inhibitors on vascular tissue. Experimental approach:, Each arginase inhibitor was assessed by its effects on isolated rings of aorta and mesenteric arteries from rats by: (i) their ability to preserve the tolerance to repeated applications of the endothelium-dependent agonist acetylcholine (ACh); and (ii) their direct vasorelaxant effect. Key results:, In both vessel types, tolerance (defined as a reduced response upon second application) to ACh was reversed with addition of L-arginine, (S)-(2-boronethyl)-L-cysteine HCl (BEC) or NG -Hydroxy-L-arginine (L-NOHA). On the other hand, N, -hydroxy-nor-L-arginine (nor-NOHA) significantly augmented the response to ACh, an effect that was partially reversed with L-arginine. No effect on tolerance to ACh was observed with L-valine, nor-valine or D,L, ,-difluoromethylornithine (DFMO). BEC, L-NOHA and nor-NOHA elicited endothelium-independent vasorelaxation in both endothelium intact and denuded aorta while L-valine, DFMO and nor-valine did not. Conclusions and implications:, BEC and L-NOHA, but not nor-NOHA, L-valine, DFMO or nor-valine, significantly reversed tolerance to ACh possibly conserving L-arginine levels and therefore increasing NO bioavailability. However, both BEC and L-NOHA caused endothelium-independent vasorelaxation in rat aorta, suggesting that these inhibitors have a role beyond arginase inhibition alone. Our data thus questions the interpretation of many studies using these antagonists as specific arginase inhibitors in the vasculature, without verification with other methods. [source]

Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro

BRITISH JOURNAL OF PHARMACOLOGY, Issue 4 2007
E M Jarvie
Background and purpose: Motilin or 5-HT4 receptor agonists stimulate gastrointestinal motility. Differences in activity are suggested but direct comparisons are few. A method was devised to directly compare the gastric prokinetic activities of motilin, the motilin receptor agonist, erythromycin, and the 5-HT4 receptor agonist, tegaserod. Experimental approach: Gastric prokinetic-like activity was assessed by measuring the ability to facilitate cholinergically-mediated contractions evoked by electrical field stimulation (EFS) in rabbit isolated stomach. Comparisons were made between potency, maximal activity and duration of responses. Key results: Rabbit motilin (r.motilin) 0.003,0.3,M, [Nle13]motilin 0.003,0.3,M, erythromycin 0.3,10,M and tegaserod 0.1,10,M caused concentration , dependent potentiation of EFS-evoked contractions. The potency ranking was r.motilin = [Nle13]motilin > tegaserod > erythromycin. The Emax ranking was r.motilin = [Nle13]motilin = erythromycin > tegaserod. Responses to r.motilin and [Nle13]motilin faded rapidly (t1/2 9 and 11 min, respectively) whereas those to erythromycin and tegaserod were maintained longer (t1/2 24 and 28 min). The difference did not appear to be due to peptide degradation. A second application of [Nle13]motilin was excitatory after 60 min contact and fade of the initial response (responses to 0.03 and 0.1,M [Nle13]motilin were not different from those caused by the first application). Conclusions and implications: Prokinetic-like activities of the 5-HT4 agonist tegaserod and the motilin receptor agonists were compared by measuring changes in cholinergically-mediated contractions. This novel approach highlighted important differences between classes (greater Emax of motilin, compared with tegaserod) and for the first time, within each class (short t1/2 for motilin, compared with erythromycin). British Journal of Pharmacology (2007) 150, 455,462. doi:10.1038/sj.bjp.0707118 [source]

Laser Microbeams and Optical Tweezers in Ageing Research

CHEMPHYSCHEM, Issue 1 2009
Paulius Grigaravi
Abstract We show how a technique developed within the framework of physics and physical chemistry,in a true interdisciplinary approach,can answer questions in life sciences that are not solvable by using other techniques. Herein, we focus on blood-pressure regulation and DNA repair in ageing studies. Laser microbeams and optical tweezers are now established tools in many fields of science, particularly in the life sciences. A short glimpse is given on the wide field of non-age-research applications in life sciences. Then, optical tweezers are used to show that exerting a vertical pressure on cells representing the inner lining of blood vessels results in bursts of NO liberation concomitant with large changes in cell morphology. Repeated treatment of such human umbilical vein endothelial cells (HUVEC) results in stiffening, a hallmark of manifest high blood pressure, a disease primarily of the elderly. As a second application in ageing research, a laser microbeam is used to induce, with high spatial and temporal resolution, DNA damages in the nuclei of U2OS human osteosarcoma cells. A pairwise study of the recruitment kinetics of different DNA repair proteins reveals that DNA repair starts with non-homologous end joining (NHEJ), a repair pathway, and may only after several minutes switch to the error-free homologous recombination repair (HRR) pathway. Since DNA damages,when incorrectly repaired,accumulate with time, laser microbeams are becoming well-used tools in ageing research. [source]

Respiratory Effect of Prolonged Electrical Weapon Application on Human Volunteers

ACADEMIC EMERGENCY MEDICINE, Issue 3 2007
Jeffrey D. Ho MD
Background: Conducted electrical weapons (CEWs) are used by law enforcement to subdue combative subjects. Occasionally, subjects will die after a CEW has been used on them. It is theorized that CEWs may contribute to these deaths by impairing respiration. Objectives: To examine the respiratory effects of CEWs. Methods: Human volunteers received a 15-second application of electrical current from a CEW while wearing a respiratory measurement device. Common respiratory parameters were collected before, during, and after exposure. Health histories and demographic information were also collected. Results: Fifty-two subjects were analyzed. Thirty-four underwent a 15-second continuous exposure, and 18 underwent three 5-second burst exposures. In the continuous application group, the baseline mean tidal volume of 1.1 L increased to 1.8 L during application, the baseline end-tidal CO2 level went from 40.5 mm Hg to 37.3 mm Hg after exposure, the baseline end-tidal oxygen level went from 118.7 mm Hg to 121.3 mm Hg after exposure, and the baseline respiratory rate went from 15.9 breaths/min to 16.4 breaths/min after exposure. In the 5-second burst group, the baseline mean tidal volume increased to 1.85 L during application, the baseline end-tidal CO2 level went from 40.9 mm Hg to 39.1 mm Hg after exposure, the baseline end-tidal oxygen level went from 123.1 mm Hg to 127.0 mm Hg after exposure, and the baseline respiratory rate went from 13.8 breaths/min to 14.6 breaths/min after exposure. Conclusions: Prolonged CEW application did not impair respiratory parameters in this population of volunteers. Further study is recommended to validate these findings in other populations. [source]