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Second Analysis (second + analysis)
Selected AbstractsCaloric restriction for longevity: II,The systematic neglect of behavioural and psychological outcomes in animal researchEUROPEAN EATING DISORDERS REVIEW, Issue 6 2004Kelly M. Vitousek Abstract Research on caloric restriction for longevity (CRL) has generated hundreds of articles on the physiology of food deprivation, yet almost no data on consequences in other domains. The first paper in this series outlined the generally positive physical effects of CRL; the second analyses the meagre and sometimes disturbing record of research on behaviour, cognition and affect. The available evidence suggests that nutrient-dense CRL in animals,just like nutrient-poor semi-starvation in people,is associated with a number of adverse effects. Changes include abnormal food-related behaviour, heightened aggression and diminished sexual activity. Studies of learning and memory in underfed rodents yield inconsistent findings; no information is available on cognitive effects in primates. To date, the CRL field has ignored other variables that are crucial to the human case and known to be disrupted by chronic hunger, including sociability, curiosity and emotionality. Promotion of CRL for people is irresponsible in the absence of more reassuring data on the full range of expected outcomes. Eating disorder specialists should be contributing to scientific and public discussions of this increasingly prominent paradigm. Copyright © 2004 John Wiley & Sons, Ltd and Eating Disorders Association. [source] Changes in serum leptin concentrations in overweight Japanese men after exerciseDIABETES OBESITY & METABOLISM, Issue 5 2004N. Miyatake Aim:, To investigate the link between serum leptin concentrations and exercise. Design:, Cross-sectional and longitudinal studies of an exercise intervention. Subjects:, 110 Japanese overweight men aged 32,59 years were recruited. At baseline, the average body mass index (BMI) was 28.5 ± 2.5 kg/m2. From this group, we used data of 36 overweight men (BMI, 28.9 ± 2.3) for a 1-year exercise programme. Measurements:, Leptin was measured at baseline and after 1 year. Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography (CT) scanning at umbilical levels. Anthropometric parameters, aerobic exercise level, muscle strength and flexibility were also investigated at baseline and after 1 year. Results:, In the first analysis, using cross-sectional data, leptin was significantly correlated with total body fat (r = 0.760, p < 0.01), V (r = 0.383, p < 0.01) and S (r = 0.617, p < 0.01) areas. In the second analysis, using longitudinal data, leptin was significantly reduced after 1 year (pre 6.7 ± 4.0 ng/ml vs. post 5.1 ± 3.1 ng/ml, p < 0.01). Results showed that steps per day were increased, and aerobic exercise level, weight-bearing index (WBI) and insulin resistance were significantly improved. Although, there was a positive correlation between , leptin(positive changes in leptin after 1 year) and anthropometric measurements such as , body weight, , BMI and , body fat, leptin/body weight, leptin/BMI and leptin/body fat ratios were significantly reduced during exercise intervention. Conclusion:, The present study indicated exercise significantly lowers serum leptin concentrations, and thus it may improve the leptin resistance observed in overweight Japanese men. [source] On the relationship between dynamic visual and auditory processing and literacy skills; results from a large primary-school studyDYSLEXIA, Issue 4 2002Joel B. Talcott Abstract Three hundred and fifty randomly selected primary school children completed a psychometric and psychophysical test battery to ascertain relationships between reading ability and sensitivity to dynamic visual and auditory stimuli. The first analysis examined whether sensitivity to visual coherent motion and auditory frequency resolution differed between groups of children with different literacy and cognitive skills. For both tasks, a main effect of literacy group was found in the absence of a main effect for intelligence or an interaction between these factors. To assess the potential confounding effects of attention, a second analysis of the frequency discrimination data was conducted with performance on catch trials entered as a covariate. Significant effects for both the covariate and literacy skill was found, but again there was no main effect of intelligence, nor was there an interaction between intelligence and literacy skill. Regression analyses were conducted to determine the magnitude of the relationship between sensory and literacy skills in the entire sample. Both visual motion sensitivity and auditory sensitivity to frequency differences were robust predictors of children's literacy skills and their orthographic and phonological skills. Copyright © 2002 John Wiley & Sons, Ltd. [source] Missing persons in the study of groupsJOURNAL OF ORGANIZATIONAL BEHAVIOR, Issue 1 2005Thomas A. Timmerman This research examined relationships between team-level variables with various patterns of individual non-response. In the first analysis, professional basketball teams (n,=,389) were used to study the relationship between team cooperation and team performance. In the second analysis, the same teams were used to study the relationship between team experience and team performance. In the third analysis, professional baseball teams (n,=,1984) were used to study the relationship between team experience and team performance. Individuals were deleted from the complete data sets to simulate three different types of non-response that might be encountered in organizational group or team research. In all three analyses, team-level relationships were attenuated as individual members were deleted randomly. Team-level relationships were also generally reduced as individuals were deleted as a function of their level of participation with the team. The overall amount of variance explained, however, showed a pronounced curvilinear effect. Namely, in all three analyses, the variance explained in team performance peaked when 30,40,per,cent of the low-participation members were deleted. Finally, in the first analysis, relationships were also attenuated as the least cooperative members were deleted from the data set. The results demonstrate the need for researchers to understand the diverse effects of various types of non-response in team and group research. Copyright © 2005 John Wiley & Sons, Ltd. [source] For richer or for poorer: Marriage as an antipoverty strategyJOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 4 2002Adam Thomas This study examines the effects of changes in family structure on children's economic well-being. An initial shift-share analysis indicates that, had the proportion of children living in female-headed families remained constant since 1970, the 1998 child poverty rate would have been 4.4 percentage points lower than its actual 1998 level of 18.3 percent. The March 1999 Current Population Survey is then used to conduct a second analysis in which marriages are simulated between single mothers and demographically similar, unrelated males. The microsimulation analysis addresses some of the shortcomings of the shift-share approach by making it possible to account for the possibility of a shortage of marriageable men, to control for unobservable differences between married men and women and their unmarried counterparts, and to measure directly the effects of increases in marriage on the economic well-being of children. Results from the microsimulation analysis suggest that, had the proportion of children living in female-headed families remained constant since 1970, the child poverty rate would have been 3.4 percentage points lower than its actual 1998 level. Among children whose mother participated in a simulated marriage, the poverty rate would have fallen by almost two-thirds. © 2002 by the Association for Public Policy Analysis and Management. [source] QTL for resistance to Salmonella carrier state confirmed in both experimental and commercial chicken linesANIMAL GENETICS, Issue 5 2009F. Calenge Summary The ability of chickens to carry Salmonella without displaying disease symptoms is responsible for Salmonella propagation in poultry stocks and for subsequent human contamination through the consumption of contaminated eggs or meat. The selection of animals more resistant to carrier state might be a way to decrease the propagation of Salmonella in poultry stocks and its transmission to humans. Five QTL controlling variation for resistance to carrier state in a chicken F2 progeny derived from the White Leghorn inbred lines N and 61 had been previously identified using a selective genotyping approach. Here, a second analysis on the whole progeny was performed, which led to the confirmation of two QTL on chromosomes 2 and 16. To assess the utility of these genomic regions for selection in commercial lines, we tested them together with other QTL identified in an [N×61] × N backcross progeny and with the candidate genes SLC11A1 and TLR4. We used a commercial line divergently selected for either low or high carrier-state resistance both in young chicks and in adult hens. In divergent chick lines, one QTL on chromosome 1 and one in the SLC11A1 region were significantly associated with carrier-state resistance variations; in divergent adult lines, one QTL located in the major histocompatibility complex on chromosome 16 and one in the SLC11A1 region were involved in these variations. Genetic studies conducted on experimental lines can therefore be of potential interest for marker-assisted selection in commercial lines. [source] A three-centre experience of orthotopic neobladder reconstruction after radical cystectomy: revisiting the initial experience, and results in 104 patientsBJU INTERNATIONAL, Issue 5 2009Jon-Paul Meyer OBJECTIVE To assess, in a retrospective three-centre series, a second analysis of the initial experience and results of patients undergoing radical cystectomy (RC) and orthotopic neobladder reconstruction (ONR) after an additional 4 years of follow-up. PATIENTS AND METHODS The medical records of 104 suitable consecutive patients undergoing RC and ONR between June 1994 and April 2003 were reviewed retrospectively. The complications, mortality, continence and cancer control rates were all recorded. RESULTS The median (range) follow-up was 88 (52,156) months; 90 patients had reconstruction with a ,Studer' neobladder, 12 with a Hautmann W pouch and 2 with a ,T pouch' ileal neobladder. There were 24 early complications, and one death after surgery. There were 32 late complications. The daytime continence rate was 98% and the nocturnal continence rate was 76%. Ten patients required intermittent self-catheterization (ISC). In all, 30 patients had local and/or distant recurrences, all of whom died. Seven patients died from other causes. CONCLUSIONS ONR provides excellent long-term continence rates and both acceptable complication and mortality rates. Suitable patients undergoing RC should be offered ONR. [source] Fertility preservation in young women with epithelial ovarian cancerCANCER, Issue 18 2009Jason D. Wright MD Abstract BACKGROUND: Surgical management of ovarian cancer consists of hysterectomy with bilateral oophorectomy. In young women, this results in the loss of reproductive function and estrogen deprivation. In the current study, the authors examined the safety of fertility-conserving surgery in premenopausal women with epithelial ovarian cancers. METHODS: Women aged ,50 years with stage IA or IC epithelial ovarian cancer who were registered in the Surveillance, Epidemiology, and End Results database were examined. Patients who underwent bilateral oophorectomy were compared with those who underwent ovarian conservation. A second analysis examined uterine conservation versus hysterectomy. Multivariate Poisson regression models were developed to describe predictors of fertility preservation. Survival was examined using Cox proportional hazards models and the Kaplan-Meier method. RESULTS: In total, 1186 women, including 754 women (64%) who underwent bilateral oophorectomy and 432 women (36%) who underwent ovarian preservation, were identified. Younger age, later year of diagnosis, and residence in the eastern or western United States were associated with ovarian preservation (P < .05 for all). Women with endometrioid and clear cell histologies and stage IC disease were less likely to have ovarian conservation (P < .05). In a Cox model, ovarian preservation had no effect on survival (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.39-1.20). Young age, later year of diagnosis, residence in the eastern or western United States, single women, mucinous tumors, and patients with stage IA disease were more likely to have uterine preservation (P < .05 for all). In a multivariate model, uterine preservation had no effect on survival (HR, 0.87; 95% CI, 0.62-1.22). CONCLUSIONS: Ovarian and uterine-conserving surgery were safe in young women who had stage IA and IC epithelial ovarian cancer. Cancer 2009. © 2009 American Cancer Society. [source] | ||||||||||||||||