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Se Content (se + content)
Selected AbstractsAssociation of heavy metals with metallothionein and other proteins in hepatic cytosol of marine mammals and seabirdsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 8 2004Tokutaka Ikemoto Abstract Distribution of Cu, Zn, Cd, Ag, Hg, and Se were determined in hepatocytosol of northern fur seals (Callorhinus ursinus), black-footed albatrosses (Diomedea nigripes), and Dall's porpoises (Phocoenoides dalli). Copper, Zn, and Cd were accumulated preferentially in metallothionein (MT) fraction and their contents in MT fraction increased with the amounts in the hepatocytosol. Silver was bound to both high-molecular-weight substances (HMWS) and MT in the hepatocytosol for all three species, whereas the distribution of Ag in the cytosol was different among the three species. In northern fur seals, Ag mainly was bound to MT, whereas it mainly was associated with HMWS in Dall's porpoises. In contrast, Ag was distributed almost equally in both HMWS and MT for black-footed albatrosses. Mercury content in HMWS and Se content in HMWS and low-molecular-weight substances (LMWS) increased with their contents in hepatocytosol for all the three species. A significant positive correlation was found between Se and Hg contents in high-molecular weight (HMW) fraction in cytosol. The molar ratio of Hg and Se was close to unity in HMW fraction of the specimens with high Hg concentration in cytosol, implying that the Hg,Se complex was bound to the HMWS. Analysis of metals in the hepatocytosol by high-performance liquid chromatography/inductively coupled plasma,mass spectrometry (HPLC/ICP-MS) suggests that multiple isoforms of MT are present in hepatocytosol of the three species and that the metal profiles in hepatocytosols are different among the species. To our knowledge, this is the first report on the association of Ag with HMWS and MT in hepatocytosol of marine mammals and seabirds. Also, distribution and interaction of Hg and Se were investigated for the first time in hepatocytosol of the higher trophic marine animals. [source] Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China,INTERNATIONAL JOURNAL OF CANCER, Issue 4 2005Lori C. Sakoda Abstract Selenium (Se) is an essential trace mineral with known anticarcinogenic properties in humans. However, few studies have examined the association between Se nutrient status and risk of liver cancer. We conducted a nested case-control study comparing the Se content in toenail clippings of 166 individuals (154 men, 12 women) with hepatocellular carcinoma (HCC) to 394 healthy controls (360 men, 34 women) in Haimen City, China, where HCC is a leading cause of mortality. Toenail Se concentration was measured by inductively coupled plasma-optical emission spectroscopy. Median toenail Se was lower for HCC cases than controls (p = 0.03). Adjusted odds ratios and 95% confidence intervals for HCC mortality by increasing quartile of toenail Se were 1.00 (reference), 0.58 (0.32,1.03), 0.83 (0.48,1.42) and 0.50 (0.28,0.90), with a marginally significant trend in risk observed (p for trend = 0.06). This inverse association appeared stronger among those who did not consume alcohol and among women. Future studies are needed to examine the interrelationship between Se, viral hepatitis infection and HCC in order to better understand the etiologic mechanisms involved and evaluate the true chemopreventive potential of Se compounds for liver diseases. © 2005 Wiley-Liss, Inc. [source] Selenium supplementation and selenium status of dairy cows fed diets based on grass, grass silage or maize silageJOURNAL OF ANIMAL PHYSIOLOGY AND NUTRITION, Issue 3-4 2002M. GIERUS In three separate trial series (TS) the effect of diet composition on selenium (Se) status of dairy cows were investigated. Diets were formulated based mainly on grass (TS1), grass silage (TS2) or maize silage (TS3) with different levels of Se supplementation. Each TS comprised a total of 30 dairy cows and contained one treatment group without Se supplementation (control) and two groups with increasing levels of Se supplementation (levels 1 and 2). Selenium was administered as Na-selenite. The control groups of the different TS showed a very low Se supply of 38,54 ,g Se/kg DM. At level 1 the Se supply was increased to 102,165 ,g Se/kg DM and at level 2 was 294,373 ,g Se/kg DM. After completion of the 6-week trials the average plasma Se concentration of the control cows (without Se supplementation) across all TS was 21.5 ,g/l; this increased significantly following Se supplementation, to 37.7 ,g/l at level 1 and 61.5 ,g/l at level 2. The plasma glutathione peroxidase (GSH-Px) activity of the control cows averaged 67 U/l, rising considerably after supplementation at level 1 to a value of 101 U/l, but showed little further increase at level 2 with a mean value of 120 U/l. By contrast, the average Se content of the milk was unchanged in the control and level 1 groups at 10.5 ,g/kg and 10.9 ,g/kg, respectively, and only increased markedly after supplementation at level 2 to a mean value of 15.1 ,g/kg. The diet based on maize silage, while having a similar Se content as the grass and grass silage-based diets, resulted in a slightly improved Se status, which is due to a higher Se intake from soybean meal. [source] Selenium Content of Venison, Squirrel, and Beef Purchased or Produced in Ohio, a Low Selenium Region of the United StatesJOURNAL OF FOOD SCIENCE, Issue 1 2002D.H. HolbenArticle first published online: 20 JUL 200 ABSTRACT: The selenium (Se) content (AOAC fluorometric method) of: 1) raw and cooked venison, squirrel, and beef from a low selenium region of the United States and 2) nonregion-raised beef was assessed and compared by region, species, and gender. For both raw and cooked meats, the Se content of venison was not different from region-raised beef (p > .05), and their contents were generally less than squirrel, which was less than nonregion-raised beef (p < .05). Gender and age did not influence Se content of the meats. Field-dressed weight did not affect Se content of deer, and antler size did not impact Se content of meat from male deer. [source] Determination of selenium concentration in rice and the effect of foliar application of Se-enriched fertiliser or sodium selenite on the selenium content of riceJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 8 2002Qiuhui Hu Abstract Atomic fluorescence spectrophotometry was used to determine the selenium (Se) concentration in 30 rice products of different species from Southern China. The Se level ranged from 0.015 to 0.046,µg,g,1. Considering the average daily individual consumption of rice products in Southern China, the average dietary intake of Se supplied by this source is only 6,18,µg,day,1 for an adult. This low Se intake from rice products is mainly responsible for the low total Se intake of inhabitants in Southern China. Foliar spraying of Se-enriched fertiliser or sodium selenite with 14,18,g Se,ha,1 in the heading stage of rice growth increased the Se content to 0.178,0.421,µg,g,1 in rice products. The concentration and amount of Se-enriched fertiliser can be varied to achieve an optimum concentration of Se in rice products. The authors suggest that these Se-enriched rice products can contribute an increase in Se intake of 50,100,µg,day,1 on average if their Se concentration is controlled in the region of 0.15,0.50,µg,g,1. © 2002 Society of Chemical Industry [source] | |||||||||||||