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Science Research (science + research)
Kinds of Science Research Selected AbstractsThe European Science Foundation Promotes Excellence in Materials Science ResearchADVANCED MATERIALS, Issue 10-11 2009Antonella di Trapani The European Science Foundation (ESF) with its 34,year history in funding scientific networking activities that span across European borders has been the instigator of several programs within the field of materials science. The main results of these programs have made a real impact in the field, and are contributing to a new class of researchers that will be the leaders of the European Research Area. [source] Reflections on Family and Consumer Sciences Research at the End of the Millennium: An Introduction and Editorial NoteFAMILY & CONSUMER SCIENCES RESEARCH JOURNAL, Issue 2 2001Wendy L. Way Editor No abstract is available for this article. [source] Towards an integrated GIS-based coastal forecast workflowCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 14 2008Gabrielle Allen Abstract The SURA Coastal Ocean Observing and Prediction (SCOOP) program is using geographical information system (GIS) technologies to visualize and integrate distributed data sources from across the United States and Canada. Hydrodynamic models are run at different sites on a developing multi-institutional computational Grid. Some of these predictive simulations of storm surge and wind waves are triggered by tropical and subtropical cyclones in the Atlantic and the Gulf of Mexico. Model predictions and observational data need to be merged and visualized in a geospatial context for a variety of analyses and applications. A data archive at LSU aggregates the model outputs from multiple sources, and a data-driven workflow triggers remotely performed conversion of a subset of model predictions to georeferenced data sets, which are then delivered to a Web Map Service located at Texas A&M University. Other nodes in the distributed system aggregate the observational data. This paper describes the use of GIS within the SCOOP program for the 2005 hurricane season, along with details of the data-driven distributed dataflow and workflow, which results in geospatial products. We also focus on future plans related to the complimentary use of GIS and Grid technologies in the SCOOP program, through which we hope to provide a wider range of tools that can enhance the tools and capabilities of earth science research and hazard planning. Copyright © 2008 John Wiley & Sons, Ltd. [source] Beyond Biogeography: a Framework for Involving the Public in Planning of U.S. Marine Protected AreasCONSERVATION BIOLOGY, Issue 5 2005TRACEY MORIN DALTON control de áreas marinas protegidas; intervención de usufructuarios; manejo basado en ecosistemas; participación del público Abstract:,Planning of marine protected areas (MPAs) is highlighted in the conservation literature but is not explored in much detail. Many researchers acknowledge the importance of involving the public in MPA planning, but there is limited guidance on how to do this in an effective manner. I present a framework for involving the public in planning of U.S. MPAs. Derived from empirically and theoretically based research on public participation in U.S. natural resource management, this framework is composed of factors that influence the success of participatory processes: active participant involvement, complete information exchange, fair decision making, efficient administration, and positive participant interactions. Processes incorporating these factors will produce decisions that are more likely to be supported by stakeholders, meet management objectives, and fulfill conservation goals. This framework contributes to the MPA social science literature and responds to calls in the conservation literature to increase the use of social science research to inform conservation decision making. Resumen:,La planificación de áreas marinas protegidas (AMP) resalta en la literatura de conservación pero no es explorada en mucho detalle. Muchos investigadores reconocen la importancia de involucrar al público en la planificación de AMP, pero las directrices para hacerlo de manera efectiva es limitada. Presento un marco para involucrar al público en la planificación de AMP en E.U.A. Este marco, derivado de investigación empírica y teórica de la participación del público en el manejo de recursos naturales en E.U.A., esta compuesto por factores que influyen en el éxito de procesos participativos: intervención activa de usufructuarios; intercambio completo de información; toma de decisiones justas; administración eficiente e interacciones positivas de participantes. Los procesos que incorporan estos factores producirán decisiones que tendrán más posibilidades de ser apoyadas por los usufructuarios, de alcanzar objetivos de manejo y cumplir metas de conservación. Este marco contribuye a la literatura de ciencias sociales de AMP y responde a llamados en la literatura de conservación para incrementar el uso de investigación de ciencias sociales para proporcionar información a la toma de decisiones de conservación. [source] GOOD GIFTS FOR THE COMMON GOOD: Blood and Bioethics in the Market of Genetic ResearchCULTURAL ANTHROPOLOGY, Issue 3 2007DEEPA S. REDDY This article is based on ethnographic fieldwork conducted with the Indian community in Houston, as part of a NIH,NHGRI-sponsored ethics study and sample collection initiative entitled "Indian and Hindu Perspectives on Genetic Variation Research." At the heart of this research is one central exchange,blood samples donated for genetic research,that draws both the Indian community and a community of researchers into an encounter with bioethics. I consider the meanings that come to be associated with blood donation as it passes through various hands, agendas, and associated ethical filters on its way to the lab bench: how and why blood is solicited, how the giving and taking of blood is rationalized, how blood as material substance is alienated, processed, documented, and made available for the promised ends of basic science research. Examining corporeal substances and asking what sorts of gifts and problems these represent, I argue, sheds some light on two imbricated tensions expressed by a community of Indians, on the one hand, and of geneticists and basic science researchers, on the other hand: that gifts ought to be free (but are not), and that science ought to be pure (but is not). In this article, I explore how experiences of bioethics are variously shaped by the histories and habits of Indic giving, prior sample collection controversies, commitments to "good science" and the common "good of humanity," and negotiations of the sites where research findings circulate. [source] A Pride of Museums in the Desert: Saudi Arabia and the "Gift of Friendship" ExhibitionCURATOR THE MUSEUM JOURNAL, Issue 1 2005John Coppola ABSTRACT The task of developing and presenting an exhibition at the King Abdul Aziz Historical Center in Riyadh, Saudi Arabia illustrates the challenges of museum work in a global environment filled with widely differing social, cultural, political, and professional norms. The exhibition, The Gift of Friendship, was largely drawn from the collections of the Franklin D. Roosevelt Library, in New York State. Saudi Arabia and its neighboring countries view museums as a source of national pride and public engagement, and frequently draw on Western expertise in building them. There are implications for exhibition development and interpretation in a society undergoing rapid modernization, but also one noted for an aversion to social science research. A postscript looks at museum trends in Oman, after 9/11 and the Iraq war. [source] Ethical, Legal, and Social Dimensions of Epilepsy GeneticsEPILEPSIA, Issue 10 2006Sara Shostak Summary:,Purpose: Emerging genetic information and the availability of genetic testing has the potential to increase understanding of the disease and improve clinical management of some types of epilepsy. However, genetic testing is also likely to raise significant ethical, legal, and social issues for people with epilepsy, their family members, and their health care providers. We review the genetic and social dimensions of epilepsy relevant to understanding the complex questions raised by epilepsy genetics. Methods: We reviewed two literatures: (a) research on the genetics of epilepsy, and (b) social science research on the social experience and social consequences of epilepsy. For each, we note key empiric findings and discuss their implications with regard to the consequences of emerging genetic information about epilepsy. We also briefly review available principles and guidelines from professional and advocacy groups that might help to direct efforts to ascertain and address the ethical, legal, and social dimensions of genetic testing for epilepsy. Results: Genetic information about epilepsy may pose significant challenges for people with epilepsy and their family members. Although some general resources are available for navigating this complex new terrain, no guidelines specific to epilepsy have yet been developed to assist people with epilepsy, their family members, or their health care providers. Conclusions: Research is needed on the ethical, legal, and social concerns raised by genetic research on epilepsy and the advent of genetic testing. This research should include the perspectives of people with epilepsy and their family members, as well as those of health care professionals, policymakers, and bioethicists. [source] Evolutions, Revolutions and Trends in Biomaterials Science , A Perspective,ADVANCED ENGINEERING MATERIALS, Issue 12 2007D. Jandt Abstract Despite a number of shortcomings biomaterials for implants have not changed much during the last decades. Yet, there is a revolution ongoing in fundamental biomaterials science research, which introduces new concepts and may help to answer a number of open questions. Bioactive and biomimetic nanomaterials in zero, one or two dimensions may be at the brink of transfer to clinical testing and application. These materials will in the future intervene actively in biological processes, such as protein adsorption, cell binding and growth. [source] Influence of Race on Household Residential UtilityGEOGRAPHICAL ANALYSIS, Issue 3 2000M William Sermons Residential location choice models are an important tool employed by urban geographers, planners, and transportation engineers for understanding household residential location behavior and for predicting future residential location activity. Racial segregation and residential racial preferences have been studied extensively using a variety of analysis techniques in social science research, but racial preferences have generally not been adequately incorporated into residential location choice models. This research develops residential location choice model specifications with a variety of alternative methods of addressing racial preferences in residential location decisions. The research tests whether social class, family structure, and in-group racial preferences are sufficient to explain household sensitivity to neighborhood racial composition. The importance of the interaction between the proportion of in-group race neighbors and other-race neighbors is also evaluated. Models for the San Francisco Bay metropolitan area are estimated and evidence of significant avoidance behavior by households of all races is found. The results suggest that social class differences, family structure differences, and in-group racial preferences alone are not sufficient to explain household residential racial preference and that households of all races practice racial avoidance behavior. Particularly pronounced avoidance of black neighbors by Asian households, Hispanic neighbors by black households, and Asian neighbors by white households are found. Evidence of a decrease in household racial avoidance intensity in neighborhoods with large numbers of own-race neighbors is also found. [source] The Necessity of Studio Art as a Site and Source for Dissertation ResearchINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 1 2008Kristin Baxter The issue raised by the authors in this article question why studio art continues to be ignored as a site and source for research in art education. The necessity of the field to be able to participate within the research community in addressing cultural, social, educational and political concerns is acknowledged. It is argued, however, that the exclusive use of methods of inquiry that align with the conventions of social science research has been done at the expense of fully appreciating the capacity of artistic research undertaken in studio contexts. This tendency is especially prevalent in doctoral research in higher education. Three accounts of dissertation research are given that incorporate studio activity as a central agency of inquiry in conceptualising and theorising issues. Each highlights the capacity of art practice to reveal insights that are a consequence of what the researcher did in the studio setting as issues, ideas and interpretive stances emerged, and problems were re-conceptualised. What is different in these accounts from more mainstream approaches to research is the readiness to accept that constructing new knowledge is a creative and critical process. [source] The use and application of Rose's theory of lesson drawing in peripheral areas of ScotlandINTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 2 2003Robert Nash Abstract This article looks at Rose's theory of lesson drawing and its possible use and application in social science research. It identifies the contingencies necessary for its application and also identifies how a lesson may be transferred between cases. The use and viability of Rose's theory of lesson drawing is evaluated. The lesson drawing approach would be appropriate to most comparative social science research. It lends itself to tourism research and the establishment of circumstances in which lessons can be imported or exported between regions or countries. It recently has been used in a comparative study of islands and lesson drawing. Copyright © 2003 John Wiley & Sons, Ltd. [source] The science commons in life science research: structure, function, and value of access to genetic diversityINTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 188 2006Robert Cook-Deegan Innovation in the life sciences depends on how much information is produced as well as how widely and easily it is shared. Policies governing the science commons , or alternative, more restricted informational spaces , determine how widely and quickly information is distributed. The purpose of this paper is to highlight why the science commons matters and to analyse its structure and function. The main lesson from our analysis is that both the characteristics of the physical resources (from genes to microbes, plants and animals) and the norms and beliefs of the different research communities , think of the Bermuda rules in the human genome case or the Belem declaration for bioprospecting , matter in the institutional choices made when organising the science commons. We also show that the science commons contributes to solving some of the collective action dilemmas that arise in the production of knowledge in Pasteur's Quadrant, when information is both scientifically important and practically applicable. We show the importance of two of these dilemmas for the life sciences, which we call respectively the diffusion,innovation dilemma (how readily innovation diffuses) and the exploration,exploitation dilemma (when application requires collective action). [source] Accounting for Corruption: Economic Structure, Democracy, and TradeINTERNATIONAL STUDIES QUARTERLY, Issue 1 2000Wayne Sandholtz Though corruption poses fundamental challenges to both democratic governance and market economies, political science research has only recently begun to address corruption in a comparative context. In this article we explain variation in the perceived level of corruption (defined as the misuse of public office for private gain) across fifty countries. We propose a set of hypotheses that explain variation in corruption levels in terms of domestic political-economic structure, democratic norms, integration into the international economy, and Protestant religious affiliation. Levels of corruption, we propose, are higher: (1) the lower the average income level, (2) the greater the extent of state control of the economy, (3) the weaker are democratic norms and institutions, (4) the lower the degree of integration in the world economy, and (5) the lower the share of the population with Protestant religious affiliation. The data analysis broadly confirms our predictions: in the multivariate regression, each of the independent variables is significant in the direction we expect. [source] Paternal Involvement with Children: The Influence of Gender IdeologiesJOURNAL OF MARRIAGE AND FAMILY, Issue 1 2004Ronald E. Bulanda Although prior social science research has established the ability of gender ideologies to influence the domestic division of labor, it has neglected to disentangle their potentially unique influence on paternal involvement with children. Past research examining the influence of gender ideology on parenting behaviors does not acknowledge potential differences that may result from accounting for each parent's gender ideology. Using both waves of the National Survey of Families and Households (N = 1,088), I assess the effect of both mother's and father's gender ideology on two measures of paternal involvement. Whereas egalitarian fathers demonstrate greater involvement than traditional fathers, mother's gender ideology failed to predict paternal involvement. Egalitarian mothers do not appear to negotiate greater father involvement successfully. [source] Solid-phase biotinylation of antibodies,JOURNAL OF MOLECULAR RECOGNITION, Issue 3 2004Elizabeth Strachan Abstract Biotinylation is an established method of labeling antibody molecules for several applications in life science research. Antibody functional groups such as amines, cis hydroxyls in carbohydrates or sulfhydryls may be modified with a variety of biotinylation reagents. Solution-based biotinylation is accomplished by incubating antibody in an appropriate buffered solution with biotinylation reagent. Unreacted biotinylation reagent must be removed via dialysis, diafiltration or desalting. Disadvantages of the solution-based approach include dilution and loss of antibody during post-reaction purification steps, and difficulty in biotinylation and recovery of small amounts of antibody. Solid-phase antibody biotinylation exploits the affinity of mammalian IgG-class antibodies for nickel IMAC (immobilized metal affinity chromatography) supports. In this method, antibody is immobilized on a nickel-chelated chromatography support and derivitized on-column. Excess reagents are easily washed away following reaction, and biotinylated IgG molecule is recovered under mild elution conditions. Successful solid phase labeling of antibodies through both amine and sulfhydryl groups is reported, in both column and mini-spin column formats. Human or goat IgG was bound to a Ni-IDA support. For sulfhydryl labeling, native disulfide bonds were reduced with TCEP, and reduced IgG was biotinylated with maleimide,PEO2 biotin. For amine labeling, immobilized human IgG was incubated with a solution of NHS,PEO4 biotin. Biotinylated IgG was eluted from the columns using a buffered 0.2,M imidazole solution and characterized by ELISA, HABA/avidin assay, probing with a streptavidin,alkaline phosphatase conjugate, and binding to a monomeric avidin column. The solid phase protocol for sulfhydryl labeling is significantly shorter than the corresponding solution phase method. Biotinylation in solid phase is convenient, efficient and easily applicable to small amounts of antibody (e.g. 100,,g). Antibody biotinylated on-column was found to be equivalent in stability and antigen-recognition ability to antibody biotinylated in solution. Solid-phase methods utilizing Ni-IDA resin have potential for labeling nucleic acids, histidine-rich proteins and recombinant proteins containing polyhistidine purification tags, and may also be applicable for other affinity systems and labels. Copyright © 2004 John Wiley & Sons, Ltd. [source] Influence of obstetric factors on the yield of mononuclear cells, CD34+ cell count and volume of placental/umbilical cord bloodJOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (ELECTRONIC), Issue 1 2010Atsuko Omori Abstract Aim:, Placental/umbilical cord blood (CB) has been used increasingly not only for transplantations, but also in the field of life science research. However, little information is available on the biological characteristics of CB units collected in rural areas because no medical facilities are affiliated with CB banks. Little attention has been paid to the collection of CB units in rural areas compared to CB collected in metropolitan areas. CB is a precious source for life science research due to the recent low birth rate in Japan. Therefore, to efficiently utilize CB units, the purpose of the present study was to investigate the optimum obstetric factors associated with a higher yield of mononuclear/CD34+ cells per CB unit. Methods:, CB units were collected at a single hospital (Hirosaki National Hospital). A total of 126 CB units from 105 vaginal deliveries and 21 cesarean section deliveries were available for cell separation within 24 h. Mononuclear low-density (LD) cells were separated using Ficoll-Paque and then processed for CD34+ cell enrichment using magnetic cell sorting. Associations between the maternal/neonatal factors and the yield of LD/CD34+ cells were analyzed. Results:, Despite the larger net weight of CB collected from cesarean section deliveries, the total number of LD cells collected from vaginal deliveries was significantly higher than that collected from cesarean section deliveries. The total number of LD cells per CB unit from primigravidae was significantly higher compared with that collected from from multigravidae. Conclusion:, CB units from vaginal deliveries of primigravidae may be more favorable because they contain a higher yield of mononuclear cells. [source] The role of entrepreneurial activities in academic pharmaceutical science researchJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 6 2010Audra L. Stinchcomb Abstract Academic pharmaceutical science research is expanding further and further from the University setting to encompass the for-profit private company setting. This parallels the National Institutes of Health momentum to include multiple funding opportunities for University and private company collaboration. It has been recognized that the nonprofit and for-profit combination research model can accelerate the commercialization of pharmaceutical products, and therefore more efficiently improve human health. Entrepreneurial activities require unique considerations in the University environment, but can be modeled after the commercialization expansion of the academic healthcare enterprise. Challenges and barriers exist to starting a company as an entrepreneurial faculty member, but the rewards to one's personal and professional lives are incomparable. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 2532,2537, 2010 [source] Disciplinary differences and undergraduates' information-seeking behaviorJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 8 2002Ethelene Whitmire This study applied the Biglan model of disciplinary differences to the information-seeking behavior patterns of 5,175 undergraduates responding to questions on the College Student Experiences Questionnaire (CSEQ). The Biglan model categorizes academic disciplines along three dimensions: (1) hard-soft, (2) pure-applied, and (3) life,nonlife systems. Using t -tests, this model proved to be valid for distinguishing differences in undergraduates' information-seeking behavior patterns among various academic disciplines. The results indicate that the Biglan model has implications for the redesign of academic library services and use as a valid theoretical framework for future library and information science research. [source] The Legal Context of School Violence: The Effectiveness of Federal, State, and Local Law Enforcement Efforts to Reduce Gun Violence in SchoolsLAW & POLICY, Issue 3 2001Richard E. Redding In the wake of recent school shootings, communities and legislatures are searching for law enforcement solutions to the perceived epidemic of school violence. A variety of legal measures have been debated and proposed. These include: the enactment of tougher gun control laws and more vigorous federal and local enforcement of existing gun control laws; the enactment of laws imposing civil or criminal liability on parents for their children's violent behavior; the establishment of specialized courts and prosecution strategies for handling juveniles who are charged with weapons offenses; stricter enforcement of school disciplinary codes; reform of the Individuals with Disabilities Education Act to make it easier to expel students for weapons violations; and greater use of alternative schools as placements for students who are charged with weapons violations. This article provides a legal and empirical analysis of proposed legislation in these areas as informed by social science research on the patterns of school violence, gun acquisition by juveniles, and the effectiveness of various laws and law enforcement measures. It proposes and discusses recommendations for legal reform. While efforts to reduce school violence will be most effective at the state and local levels, the United States federal government has an important role to play, particularly in federal-state partnerships aimed at disrupting illegal gun markets, and through the formulation of national standards and guidelines. These standards and guidelines are for the enforcement of existing laws; inter-agency law enforcement cooperation and information-sharing (particularly using computer-based analysis); effective school discipline and alternative educational settings for disruptive youth; and psycho-educational interventions designed to detect and prevent school violence in the first place. [source] The Diffusion of Rights: From Law on the Books to Organizational Rights PracticesLAW & SOCIETY REVIEW, Issue 3 2006Jeb Barnes How does law change society? To gain new leverage on this long-standing question, this article draws on two lines of research that often ignore each other: political science research on the mobilization of law, and sociological research on the diffusion of organizational practices. Our insights stem from six case studies of diverse organizations' responses to the accommodation provisions in the Americans with Disabilities Act and related state laws. We found that different modes of exposure to the law combined with organizational attributes to produce distinct "rights practices",styles of standard operating procedures and informal routines that reflect the understanding of legal requirements within an organization. The diversity of the organizational responses challenges simple dichotomies between compliance/noncompliance, change through deterrence/change through norms, and mobilization/nonmobilization, and it underscores the importance of combining political science and sociological perspectives on law and social change. [source] Biodegradable Polylactide and Its Nanocomposites: Opening a New Dimension for Plastics and CompositesMACROMOLECULAR RAPID COMMUNICATIONS, Issue 14 2003Suprakas Sinha Ray Abstract The academic and industrial aspects of the preparation, characterization, mechanical and materials properties, crystallization behavior, melt rheology, and foam processing of pure polylactide (PLA) and PLA/layered silicate nanocomposites are described in this feature article. Recently, these materials have attracted considerable interest in polymer science research. PLA is linear aliphatic thermoplastic polyester and is made from agricultural products. Hectorite and montmorillonite are among the most commonly used smectite-type layered silicates for the preparation of nanocomposites. Smectites are a valuable mineral class for industrial applications because of their high cation exchange capacities, surface area, surface reactivity, adsorptive properties, and, in the case of hectorite, high viscosity, and transparency in solution. In their pristine form, they are hydrophilic in nature, and this property makes them very difficult to disperse into a polymer matrix. The most common way to overcome this difficulty is to replace interlayer cations with quaternized ammonium or phosphonium cations, preferably with long alkyl chains. In general, polymer/layered silicate nanocomposites are of three different types: (1) intercalated nanocomposites, in which insertion of polymer chains into the layered silicate structure occurs in a crystallographically regular fashion, regardless of polymer to layered silicate ratio, with a repeat distance of few nanometer; (2) flocculated nanocomposites, in which intercalated and stacked silicate layers are sometimes flocculated due to the hydroxylated edge,edge interactions between the silicate layers; (3) exfoliated nanocomposites, in which individual silicate layers are uniformly distributed in the polymer matrix by average distances that totally depend on the layered silicate loading. This new family of composite materials frequently exhibits remarkable improvements in its material properties when compared with those of virgin PLA. Improved properties can include a high storage modulus both in the solid and melt states, increased flexural properties, a decrease in gas permeability, increased heat distortion temperature, an increase in the rate of biodegradability of pure PLA, and so forth. Illustration of the biodegradability of PLA and various nanocomposites. [source] On the timing characteristics of the apparent diffusion coefficient contrast in fMRIMAGNETIC RESONANCE IN MEDICINE, Issue 2 2002Stacey L. Gangstead Abstract For the past 10 years, functional MRI (fMRI) has seen rapid progress in both clinical and basic science research. Most of the imaging techniques are based on the blood oxygenation level-dependent (BOLD) contrast which arises from the field perturbation of the paramagnetic deoxyhemoglobin due to the mismatch between the local oxygen demand and delivery. Because the changes of oxygenation level take place mostly in the veins, the dominant signal sources of the BOLD signal are intra- and extravascular proton pools of the veins. Perfusion imaging methods, developed parallel to the BOLD technique, seek to quantify the blood flow and perfusion. Recently, perfusion imaging using arterial spin tagging methods have been used to study brain function by investigating the changes of the blood flow and perfusion during brain activation, thereby generating an alternative contrast mechanism to the functional brain imaging. Since most of these methods require tagging pulse and wait time for blood to be delivered to the imaged slice, the temporal resolution may not be optimal. Dynamic intravoxel incoherent motion (IVIM) weighting schemes using apparent diffusion coefficient (ADC) contrast were suggested to image the relative changes of the in-plane blood flow during brain function. In this report, it was demonstrated that, in addition to the spatial discrepancies of the activated areas, the time course based on the ADC contrast consistently precedes that from the BOLD contrast with timing offset on the order of 1 sec. Since arterial networks would have different spatial locations and preceding temporal characters, the findings in this report are indicative that the ADC contrast is sensitive to the arterial blood flow changes. Magn Reson Med 48:385,388, 2002. © 2002 Wiley-Liss, Inc. [source] Liquid chromatography combined with mass spectrometry for 13C isotopic analysis in life science researchMASS SPECTROMETRY REVIEWS, Issue 6 2007Jean-Philippe Godin Abstract Among the different disciplines covered by mass spectrometry, measurement of 13C/12C isotopic ratio crosses a large section of disciplines from a tool revealing the origin of compounds to more recent approaches such as metabolomics and proteomics. Isotope ratio mass spectrometry (IRMS) and molecular mass spectrometry (MS) are the two most mature techniques for 13C isotopic analysis of compounds, respectively, for high and low-isotopic precision. For the sample introduction, the coupling of gas chromatography (GC) to either IRMS or MS is state of the art technique for targeted isotopic analysis of volatile analytes. However, liquid chromatography (LC) also needs to be considered as a tool for the sample introduction into IRMS or MS for 13C isotopic analyses of non-volatile analytes at natural abundance as well as for 13C-labeled compounds. This review presents the past and the current processes used to perform 13C isotopic analysis in combination with LC. It gives particular attention to the combination of LC with IRMS which started in the 1990's with the moving wire transport, then subsequently moved to the chemical reaction interface (CRI) and was made commercially available in 2004 with the wet chemical oxidation interface (LC-IRMS). The LC-IRMS method development is also discussed in this review, including the possible approaches for increasing selectivity and efficiency, for example, using a 100% aqueous mobile phase for the LC separation. In addition, applications for measuring 13C isotopic enrichments using atmospheric pressure LC-MS instruments with a quadrupole, a time-of-flight, and an ion trap analyzer are also discussed as well as a LC-ICPMS using a prototype instrument with two quadrupoles. © 2007 Wiley Periodicals, Inc., Mass Spec Rev 26:751,774, 2007 [source] Quantitative research for nonprofit managementNONPROFIT MANAGEMENT & LEADERSHIP, Issue 4 2006Wolfgang Bielefeld Although the literature on organizational management has burgeoned recently, it has focused primarily on for-profit organizations. Moreover, widely published management prescriptions are often faddish in nature. It is risky for nonprofit managers to uncritically adopt these prescriptions. Not only may they be inappropriate for the Nonprofit setting, they may also be based on inadequate research. The nonprofit sector needs to develop its own research agenda and distribute usable findings to nonprofit managers. This process is in its infancy. While research on the nonprofit sector has been vigorous over the last few decades, most of it has focused on philanthropy or the delineation of the sector's dimensions. It is vitally important that management practices in the Nonprofit sector be based on sound, useful research. Given the nature of social science research, much of this will be quantitative research. In this article, I lay out some basic parameters of quantitative research and discuss its relevance to and utility for nonprofit management. [source] Characterization of de novo transcriptome for waterhemp (Amaranthus tuberculatus) using GS-FLX 454 pyrosequencing and its application for studies of herbicide target-site genesPEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 10 2010Chance W Riggins Abstract BACKGROUND: Waterhemp is a model for weed genomics research in part because it possesses many interesting biological characteristics, rapidly evolves resistance to herbicides and has a solid foundation of previous genetics work. To develop further the genomics resources for waterhemp, the transcriptome was sequenced using Roche GS-FLX 454 pyrosequencing technology. RESULTS: Pyrosequencing produced 483 225 raw reads, which, after quality control and assembly, yielded 44 469 unigenes (contigs + singletons). A total of 49% of these unigenes displayed highly significant similarities to Arabidopsis proteins and were subsequently grouped into gene ontology categories. Blast searches against public and custom databases helped in identifying and obtaining preliminary sequence data for all of the major target-site genes for which waterhemp has documented resistance. Moreover, sequence data for two other herbicide targets [4-hydroxyphenylpyruvate dioxygenase (HPPD) and glutamine synthetase], where resistance has not yet been reported in any plant, were also investigated in waterhemp and six related weedy Amaranthus species. CONCLUSION: These results demonstrate the enormous value of 454 sequencing for gene discovery and polymorphism detection in a major weed species and its relatives. Furthermore, the merging of the 454 transcriptome data with results from a previous whole genome 454 sequencing experiment has made it possible to establish a valuable genomic resource for weed science research. Copyright © 2010 Society of Chemical Industry [source] Research and Moral Law: Ethics and the Social Science Research RelationPOLAR: POLITICAL AND LEGAL ANTHROPOLOGY REVIEW, Issue 2 2007Amy Swiffen This paper explores the ethics of social science research by taking the Canadian context as a case study of the increasing formalization of ethics review procedures in North America. Based on a biomedical model of harm prevention, all university research involving humans in Canada, regardless of discipline, must pass through an ethics board review. I read the official ethics policy document governing review procedures for human research in Canada and use two examples of criticism of such policy as entry points to identify and explore a limit in understandings of social research ethics. This limit is reached when ethics policy is criticized on the basis of the incompatibility of a general rule applied to a particular research situation. Using concepts from the ethical philosophies of Kant and Lacan, I move beyond the question of the application of general rules to particular research situations and push research ethics into different territory, where neither general rules nor the notion of particularity can be relied on to ground ethical action. In this other terrain, radical responsibility and unguaranteed decision are the only signposts. [source] Anti-corruption: What Do We Know?POLITICAL STUDIES REVIEW, Issue 2 2007Research on Preventing Corruption in the Post-communist World This review assesses the anti-corruption literature in a first attempt to identify systematically significant trends so far and challenges remaining to future political science research. Research on anti-corruption is a young métier. While reflecting on the field at large, the review focuses on two issues that have been central to its development: the role of post-communist Eastern Europe and of civil society involvement. Organised in a chronological way, the review distinguishes and discusses four phases, in order to trace how scholars have addressed these two issues in the context of a rapid evolution of anti-corruption debates, ongoing transformations in Eastern Europe and increasing insight into the controversial matter of anti-corruption efforts. It considers four crucial periods: (1) earlier scholarly debates on corruption (pre-1990s); (2) initial anti-corruption debates (1990s); (3) a period of reorientation (early 2000s); and (4) latest anti-corruption debates (mid-2000s). Changing perspectives on anti-corruption in relation to post-communism and civil society involvement are discussed for each of the four phases in order to delineate the different research trajectories. This leads to the conclusion that future research, while addressing the theory deficit, needs to take account of increasingly complex conceptual challenges posed by the (interrelated) changes in international and domestic governance. [source] Social capital and information science researchPROCEEDINGS OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE & TECHNOLOGY (ELECTRONIC), Issue 1 2007Catherine A. Johnson (moderator, presenter) The concept of social capital has become a popular area of research in many social science fields, including public policy, political science, economics, community development, sociology, anthropology, and education. Increasingly, it has been used as the conceptual framework for research in the area of information studies including such topics as knowledge integration (Bhandar, Pan & Tan, 2007), knowledge sharing (Huysman & Wulf, 2006), access to information by the homeless (Hersberger, 2003), community informatics (Williams and Durrance, in press), and information seeking behavior (Johnson, in press). The concept has an ideological foundation in the theories of Pierre Bourdieu (1980), with two divergent approaches to its study emerging during the last two decades: one focusing on social capital as a collective asset and the other regarding it as an individual asset. The main proponent of the first approach is political scientist Robert Putnam who defines social capital as inhering in the "dense networks of social interaction" which foster "sturdy norms of generalized reciprocity and encourage the emergence of social trust" (Putnam, 1995, p. 66). Social network analysts, on the other hand, view social capital as resources to which individuals have access through their social relationships. Nan Lin, who is the main proponent of this approach, defines social capital as "resources embedded in a social structure which are accessed and/or mobilized in purposive actions" (Lin, 2001a, p. 12). While the concept of social capital may be operationalized differently depending on the point of view of the researcher, its value to information science research is in providing a framework within which to understand the relationship between social structure and information access. Participants in this panel will discuss social capital from various vantage points, including the role of social capital in solidifying power relationships, the effect of recent government policies on reducing social capital, and the relationship between social capital and the use of libraries and information technology. The intent of the panel is to clarify the meaning(s) of social capital and to demonstrate how the concept may be used in information science research. [source] Mapping the intellectual impact of library and information science research through citations: A tale of two databases , Scopus and Web of SciencePROCEEDINGS OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE & TECHNOLOGY (ELECTRONIC), Issue 1 2007Lokman I. Meho This study uses citations to a group of 42 LIS faculty members to examine the differences between Scopus and WoS in mapping the faculties' intellectual impact, focusing on the sources of their citations by universities, journals, and countries. The study also examines the effects of adding Scopus data on results obtained from WoS. Findings show that while Scopus does not significantly influence the rankings of the top citing journals, institutions, or countries, the database is necessary to use in addition to WoS in order to accurately map the intellectual impact of the faculty members examined and identify more correctly the extent of their research influence on the wider scientific community. [source] Project-as-practice: In search of project management research that mattersPROJECT MANAGEMENT JOURNAL, Issue 1 2010Tomas Blomquist Abstract Research on projects is not only an immature field of research, but it is also insubstantial when it comes to understanding what occurs in projects. This article contributes to making project management research matter to the academic as well as to the practitioner by developing a project-as-practice approach, in alignment with the ongoing debate in social science research. The article outlines a framework and argues that there are two major challenges to the researcher and also suggests how these challenges can be met. Underlying notions of the practice approach are outlined to ensure a development of the project-as-practice approach that makes project management research matter! [source] | |||||||||||||||||||||||||||||||||||||||||||