Home About us Contact
|
Home About us Contact | ||
|
|
||
Scalable Method (scalable + method)
Selected AbstractsA Facile, Low-Cost, and Scalable Method of Selective Etching of Semiconducting Single-Walled Carbon Nanotubes by a Gas ReactionADVANCED MATERIALS, Issue 7 2009Hongliang Zhang A facile, scalable, and low-cost gas-treatment method for selectively etching semiconductor single-walled carbon nanotubes (SWNTs) is developed. Using SO3 gas as the etchant at a temperature of 400 °C, semiconductor SWNTs can be selectively and efficiently removed, and after this gas treatment samples enriched with metallic SWNTs can be obtained. [source] Site-Selective Self-Assembly of Colloidal Photonic CrystalsADVANCED FUNCTIONAL MATERIALS, Issue 8 2009Sanna Arpiainen Abstract A scalable method for site-selective, directed self-assembly of colloidal opals on topologically patterned substrates is presented. Here, such substrate contains optical waveguides which couple to the colloidal crystal. The site-selectivity is achieved by a capillary network, whereas the self-assembly process is based on controlled solvent evaporation. In the deposition process, a suspension of colloidal microspheres is dispensed on the substrate and driven into the desired crystallization sites by capillary flow. The method has been applied to realize colloidal crystals from monodisperse dielectric spheres with diameters ranging from 290 to 890,nm. The method can be implemented in an industrial wafer-scale process. [source] A General Approach to the Synthesis of ,2 -Amino Acid Derivatives via Highly Efficient Catalytic Asymmetric Hydrogenation of ,-AminomethylacrylatesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 9 2010Yujuan Guo Abstract A new strategy was developed for the synthesis of a valuable class of ,-aminomethylacrylates via the Baylis,Hillman reaction of different aldehydes with methyl acrylate followed by acetylation of the resulting allylic alcohols and SN2,-type amination of the allylic acetates. Asymmetric hydrogenation of these diverse olefinic precursors using rhodium(Et-Duphos) catalysts provided the corresponding ,2 -amino acid derivatives with excellent enantioselectivities and exceedingly high reactivities (up to >99.5% ee and S/C=10,000). The first hydrogenation of (Z)-configurated substrates was studied for the synthesis of ,2 -amino acid derivatives. The high influence of the substrate geometry and steric hindrance on the reactivity and enantioselectivity was also disclosed for this reaction. This protocol provides a highly practical, facile and scalable method for the preparation of optically pure ,2 -amino acids and their derivatives under mild reaction conditions. [source] A fast, scalable method for the parallel evaluation of distance-limited pairwise particle interactionsJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 13 2005David E. Shaw Abstract Classical molecular dynamics simulations of biological macromolecules in explicitly modeled solvent typically require the evaluation of interactions between all pairs of atoms separated by no more than some distance R, with more distant interactions handled using some less expensive method. Performing such simulations for periods on the order of a millisecond is likely to require the use of massive parallelism. The extent to which such simulations can be efficiently parallelized, however, has historically been limited by the time required for interprocessor communication. This article introduces a new method for the parallel evaluation of distance-limited pairwise particle interactions that significantly reduces the amount of data transferred between processors by comparison with traditional methods. Specifically, the amount of data transferred into and out of a given processor scales as O(R3/2p,1/2), where p is the number of processors, and with constant factors that should yield a substantial performance advantage in practice. © 2005 Wiley Periodicals, Inc. J Comput Chem 26: 1318,1328, 2005 [source] Efficient and scalable method for scaling up cell free protein synthesis in batch modeBIOTECHNOLOGY & BIOENGINEERING, Issue 4 2005Alexei M. Voloshin A novel method for general cell free system scale-up in batch mode was applied to expression of E. coli chloramphenicol acetyl transferase (CAT) and a GMCSF-scFv fusion protein being developed as a B-cell lymphoma vaccine candidate (GLH). Performance of two different E. coli based cell-free systems was evaluated using the new scale-up approach. Reaction volumes from 15 to 500 µL were tested for both products and both reaction systems. In each case, the new scale-up method preserved total, soluble, and active volumetric yields of GLH and CAT at every reaction volume. At the 500 µL reaction volume, the PANOx SP system produced 560,±,36 µg/mL of active CAT and 99,±,10 µg/mL of active GLH protein using the new thin film approach whereas 500 µL test tube reactions produced 250,±,42 µg/mL and 72,±,7 µg/mL of active CAT and GLH respectively. Similarly, 500 µL cell-free synthesis reactions with the Cytomim system produced 481,±,38 µg/mL of active CAT and 109,±,15 µg/mL active GLH respectively in thin films compared to 29,±,7 µg/mL of active CAT and 5,±,2 µg/mL of active GLH protein in 500 µL test tube reactions. The new thin film approach improves oxygen supply for the Cytomim system, and increases the availability of hydrophobic surfaces. Analysis suggests that these surfaces provide significant benefit for protein expression and folding. We believe that this approach provides a general reaction scale-up technology that will be suitable for any protein target, cell free system, and reaction volume. © 2005 Wiley Periodicals, Inc. [source] | |||||||||||||