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Distribution by Scientific Domains
Medical Sciences53%
Life Sciences14%
Humanities and Social Sciences9%
Earth and Environmental Science7%
Business, Economics, Finance and Accounting3%
Psychology3%
Engineering3%
Chemistry2%
4 Other Domains6%
Distribution within Medical Sciences
Dermatology7%
Pediatrics5%
Gastroenterology & Hepatology3%
47 Other Subdomains72%

Selected Abstracts

A dynamic admission control scheme to manage contention on shared computing resources

CONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 2 2009
Percival Xavier
Abstract A virtual organization is established when physical organizations collaborate to share their computing resources with the aim of serving each other when there is a likelihood of insufficient local resources during peak resource usage periods at any organization. Contention becomes a potential problem when a large number of requests, which can overwhelm the aggregate capacity of shared resources, are submitted from the participating organizations coincidentally at the same period. In particular, when a small number of requests that require large amounts of computing resources are admitted in place of a large number of requests that require less computing resources, the overall system performance, in terms of admission ratio, can deteriorate significantly. Hence, admission control is necessary to reduce resource oversubscription. Because domain-shared computing resources are likely to be combined to form a large-scale system, it is not possible to define a fixed admission policy solely based on the request's CPU and execution time requirements. In this paper, we introduce an admission control framework, based on a pricing model, for a multi-domain-shared computing infrastructure. The performance of the admission control framework is evaluated under different scenarios that contribute to the overall degree of competition for shared resources. The results are presented and analyzed in this paper. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Influence of Temporal Scale of Sampling on Detection of Relationships between Invasive Plants and the Diversity Patterns of Plants and Butterflies

CONSERVATION BIOLOGY, Issue 6 2004
RALPH MAC NALLY
But monitoring is often neglected because it can be expensive and time-consuming. Accordingly, it is valuable to determine whether the temporal extent of sampling alters the validity of inferences about the response of diversity measures to environmental variables affected by restoration actions. Non-native species alter ecosystems in undesirable ways, frequently homogenizing flora and fauna and extirpating local populations of native species. In the Mojave Desert, invasion of salt-cedar (Tamarix ramosissima Ledeb.) and human efforts to eradicate salt-cedar have altered vegetation structure, vegetation composition, and some measures of faunal diversity. We examined whether similar inferences about relationships between plants and butterflies in the Muddy River drainage (Nevada, U.S.A.) could have been obtained by sampling less intensively (fewer visits per site over the same period of time) or less extensively (equal frequency of visits but over a more limited period of time). We also tested whether rank order of butterfly species with respect to occurrence rate (proportion of sites occupied) would be reflected accurately in temporal subsamples. Temporal subsampling did not lead to erroneous inferences about the relative importance of six vegetation-based predictor variables on the species richness of butterflies. Regardless of the temporal scale of sampling, the species composition of butterflies was more similar in sites with similar species composition of plants. The rank order of occurrence of butterfly species in the temporal subsamples was highly correlated with the rank order of species occurrence in the full data set. Thus, similar inferences about associations between vegetation and butterflies and about relative occurrence rates of individual species of butterflies could be obtained by less intensive or extensive temporal sampling. If compromises between temporal intensity and extent of sampling must be made, our results suggest that maximizing temporal extent will better capture variation in biotic interactions and species occurrence. Resumen:,El monitoreo es un componente importante de los esfuerzos de restauración y de manejo adoptivo. Pero el monitoreo a menudo es desatendido porque puede ser costoso y consume tiempo. En consecuencia, es valioso determinar si la extensión temporal del muestreo altera la validez de inferencias sobre la respuesta de medidas de diversidad a variables ambientales afectadas por acciones de restauración. Las especies no nativas alteran a los ecosistemas de manera indeseable, frecuentemente homogenizan la flora y fauna y extirpan poblaciones locales de especies nativas. En el Desierto Mojave, la invasión de Tamarix ramosissima Ledeb. y los esfuerzos humanos para erradicarla han alterado la estructura y composición de la vegetación y algunas medidas de diversidad de fauna. Examinamos si se podían obtener inferencias similares sobre las relaciones entre plantas y mariposas en la cuenca Muddy River (Nevada, E.U.A.) muestreando menos intensivamente (menos visitas por sitio en el mismo período de tiempo) o menos extensivamente (igual frecuencia de visitas pero sobre un período de tiempo más limitado). También probamos si el orden jerárquico de especies de mariposas con respecto a la tasa de ocurrencia (proporción de sitios ocupados) se reflejaba con precisión en las submuestras temporales. El submuestreo temporal no condujo a inferencias erróneas acerca de la importancia relativa de seis variables predictivas basadas en vegetación sobre la riqueza de especies de mariposas. A pesar de la escala temporal del muestreo, la composición de especies de mariposas fue más similar en sitios con composición de especies de plantas similar. El orden jerárquico de ocurrencia de especies de mariposas en las muestras subtemporales estuvo muy correlacionado con el orden jerárquico de ocurrencia de especies en todo el conjunto de datos. Por lo tanto, se pudieron obtener inferencias similares de las asociaciones entre vegetación y mariposas y de las tasas de ocurrencia relativa de especies individuales de mariposas con muestreo temporal menos intensivo o extensivo. Si se deben hacer compromisos entre la intensidad y extensión de muestreo temporal, nuestros resultados sugieren que la maximización de la extensión temporal capturará la variación en interacciones bióticas y ocurrencia de especies más adecuadamente. [source]

Commercializing bycatch can push a fishery beyond economic extinction

CONSERVATION LETTERS, Issue 4 2010
Aaron Savio Lobo
Abstract Tropical bottom trawling is among the most destructive fishing practices, catching large quantities of bycatch, which are usually discarded. We used questionnaire surveys of trawl fishers to look at changes in catches over the last 30 years (1978,2008) along India's Coromandel Coast. We show that catches and income from target species have declined sharply over the last two decades. Meanwhile, costs of fishing have increased substantially and now almost exceed income from target species. Over the same period, bycatch (which was traditionally discarded) has now become increasingly marketable, being sold for local consumption, and as fish meal to supply the region's rapidly growing poultry industry. Without this income from bycatch, the fishery would scarcely be economically viable. While such a change in the use of bycatch is good news in terms of reducing waste and improving livelihoods, it is also responsible for pushing the Indian bottom trawl fishery beyond the economic extinction of its target species. [source]

INFLATION TARGETING AND THE ECONOMY: LESSONS FROM CANADA'S FIRST DECADE

CONTEMPORARY ECONOMIC POLICY, Issue 1 2001
C Freedman
Inflation targeting has become the centerpiece of the monetary policy framework in a number of industrial countries and emerging economies. The first part of this article examines the Canadian experience with inflation targeting since its introduction in early 1991 and various issues that require resolution in establishing such a framework. It also examines the way inflation targets deal with demand, price, and productivity shocks. The second part focuses on Canada's economic performance during the 1990s. Factors other than monetary policy - most notably private sector restructuring and the fiscal situation in the first half of the decade - played an important role in the sluggishness of the recovery from the recession of 1990,91. Trend growth in Canada during the 1990s was lower than in earlier periods and than U.S. trend growth over the same period. The article examines the role of such factors as productivity growth and participation rates in explaining the differences. I conclude that a good monetary policy is necessary but not sufficient for good economic outcomes. [source]

Characteristics of spousal homicide perpetrators: a study of all cases of spousal homicide in Sweden 1990,1999

CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2004
Professor Henrik Belfrage PhD
Background In Sweden 20 000 cases of assault against women are reported to the police every year. Method All data on the perpetrators of spousal homicide in Sweden between 1990 and 1999 were investigated (n = 164). A control group of all other perpetrators of homicide in Sweden during the same period, i.e. cases of homicide not committed in the context of spouse violence (n = 690) was used. All verdicts, as well as all material in the police investigations, including interviews with all of the police investigators, were analysed. Copies of police examinations of the suspects, and forensic reports from the autopsies, were also examined. Data on all registered criminality were collected from the National Police Register, and in cases where the perpetrators had been subject to forensic psychiatric examinations, those reports were obtained from the Swedish National Board of Forensic Medicine. In addition, the Psychopathy Checklist: Screening Version scores were rated from the forensic psychiatric examinations. Results There was a four times higher suicide rate among the spousal homicide perpetrators (24%, n = 40) compared with the perpetrators in the control-group (6%, n = 39, chi-squared = 55,42df = 1 , p < 0.001). Consequently, suicidal ideation must be considered as an important risk factor for spousal homicide. In 79% of the cases the spousal homicide perpetrators were subject to forensic psychiatric examinations. All except 5% were diagnosed with at least one psychiatric diagnosis, and 34% were sentenced to forensic psychiatric treatment. If it is assumed that the psychiatric morbidity was high in the 24% of the perpetrators who committed suicide, then 80% of all perpetrators of spouse homicide during the study period can be characterized as mentally disordered. ,Psychopathic' perpetrators, who generally are over-represented in most violent criminality, were comparatively uncommon. Only seven (4%) in the study group met the diagnostic criteria for psychopathy as measured with the PCL:SV. Discussion The group of spouse killers studied here fits the dysphoric/borderline group of spouse assaulters. This is a group that may benefit from treatment. Perhaps police officers could help identify this kind of spouse assaulter before a fatality occurs. Copyright © 2004 Whurr Publishers Ltd. [source]

Changes in patterns of excessive alcohol consumption in 25 years of high security hospital admissions from England and Wales

CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 1 2003
Celia McMahon
Background It is now generally acknowledged that alcohol abuse increases the risk of violence among people with major mental disorder. Studies in the 1980s and earlier, however, tended to report an inverse relationship between their alcohol use and violence. Aims A study was undertaken to test a hypothesis that among people with major mental disorder considered to pose a serious risk to others the likelihood of excessive alcohol consumption in a period leading up to a violent or dangerous act has increased over time. Methods Analysis was made of annual high security hospital admission cohort case register data of 1 January 1975 to 31 December 1999; alcohol use data were taken from interview and records, and problem drinking defined as consumption of alcohol in excess of 21 units per week during the 12 months prior to the index offence or act. Results There was a linear increase in the proportion of patients in five-year admission cohorts who had engaged in excessive alcohol consumption during the year prior to their index offence or act. The increase was steeper among women than men, but cut across all diagnosis and offending groups. It was strongly associated with increasing tendency to abuse illicit drugs. Conclusions The greater proportion of patients affected by excessive alcohol consumption occurred in spite of a reduction over the same period in admission of people in the diagnostic groups most likely to be implicated in substance misuse (personality disorder). This increased trend may simply reflect similar trends in the general population, but may also be associated with a lack of services or current consensus on appropriate treatment for patients whose mental illness is complicated by excessive alcohol use. Regardless, the trend suggests a growing need for ,dual diagnosis' services within and outside high security hospital. Copyright © 2003 Whurr Publishers Ltd. [source]

O-13 ENDOMETRIAL CARCINOMA DETECTED WITH SUREPATH LIQUID BASED CERVICAL CYTOLOGY: COMPARISON WITH CONVENTIONAL CERVICAL CYTOLOGY

CYTOPATHOLOGY, Issue 2006
C. J. Patel
Introduction:, Conventional Pap Smear (CPS) has had little impact on the detection of endometrial carcinoma (MC). Although Liquid Based Cytology (LBC) is replacing CPS in the UK, experience with identification of endometrial cancers with this is limited. A few studies of ThinPrep LBC show promise with reported increased detection rate, but to date, there has been no reported study of detection with SurePath LBC. Aim:, The purpose of this 2-year retrospective study was to compare the accuracy of the SurePath LBC with that of conventional smear in detecting endometrial cancers. Methods:, Our study group consisted of all SurePath cases of endometrial atypia/carcinoma diagnosed between 1st Jan 2004 and 31st Dec 2005, following 100% conversion of our laboratory to the SurePath system in 2001. Conventional smears reported over a 6-year period (1993,1998), comprised the control group. Histological follow up was obtained. Results:, Endometrial lesions were reported in 95 (0.07%) of 130352 SurePath LBC smears. These included 70 (0.053%) reports of endometrial atypia, 05 (0.003%) suspicious and 20 (0.015%) diagnostic of endometrial carcinoma. A total of 58 (0.014%) cases of 409495 CPS were diagnosed as endometrial carcinoma. Adequate histological follow up was available in 47 (49.5%) SurePath LBC and 52 (89.6%) conventional cases. In these, the positive predictive value (PPV) for endometrial carcinoma of SurePath LBC was 73.3% compared to 55.4% of CPS. The PPV for endometrial carcinoma of the atypical and suspicious LBC categories was 14.3% and 40% respectively. No categorisation as atypical or suspicious in the conventional study was available for comparison. The sensitivity of the SurePath LBC, calculated from retrograde analysis of histologically diagnosed endometrial cancers during the same period was 40%. Conclusion:, The SurePath LBC is at least an as accurate and sensitive method for detecting endometrial cancer as CPS. [source]

Changes in gravitational force cause changes in gene expression in the lens of developing zebrafish

DEVELOPMENTAL DYNAMICS, Issue 10 2006
Naoko Shimada
Abstract Gravity has been a constant physical factor during the evolution and development of life on Earth. We have been studying effects of simulated microgravity on gene expression in transgenic zebrafish embryos expressing gfp under the influence of gene-specific promoters. In this study, we assessed the effect of microgravity on the expression of the heat shock protein 70 (hsp70) gene in lens during development using transgenic zebrafish embryos expressing gfp under the control of hsp70 promoter/enhancer. Hsp70:gfp expression was up-regulated (45%) compared with controls during the developmental period that included the lens differentiation stage. This increase was lens specific, because the entire embryo showed only a 4% increase in gfp expression. Northern blot and in situ hybridization analysis indicated that the hsp70:gfp expression recapitulated endogenous hsp70 mRNA expression. Hypergravity exposure also increased hsp70 expression during the same period. In situ hybridization analysis for two lens-specific crystallin genes revealed that neither micro- nor hypergravity affected the expression level of ,B1 - crystallin, a non-hsp gene used as a marker for lens differentiation. However, hypergravity changed the expression level of ,A - crystallin, a member of the small hsp gene family. Terminal deoxynucleotidyl transferase,mediated deoxyuridinetriphosphate nick end-labeling (TUNEL) assay analysis showed that altered-gravity (,g) decreased apoptosis in lens during the same period and the decrease correlated with the up-regulation of hsp70 expression, suggesting that elimination of nuclei from differentiating lens fiber cells was suppressed probably through hsp70 up-regulation. These results support the idea that ,g influences hsp70 expression and differentiation in lens-specific and developmental period specific manners and that hsp family genes play a specific role in the response to ,g. Developmental Dynamics 235:2686,2694, 2006. © 2006 Wiley-Liss, Inc. [source]

Vaginocervical stimulation of Ewes induces the rapid formation of a new bond with an alien young without interfering with a previous bond

DEVELOPMENTAL PSYCHOBIOLOGY, Issue 6 2010
F. Lévy
Abstract Ewes form a selective olfactory memory for their lambs after 2,hr of mother,young interaction following parturition. Mothers will subsequently reject any strange lamb at suckling. The present study investigated whether artificial vaginocervical stimulation (VCS) allows the formation of a selective bond with an unfamiliar lamb and whether it interferes with the maintenance of the bond formed with the familiar lamb. At 2,hr postpartum, mothers were separated from their familiar lamb after having formed a selective bond with it and were given 10,min of mechanical VCS. In the "VCS,+,lamb" group (n,=,24) an unfamiliar lamb was left with the ewe for 2,hr whereas in the "VCS no lamb" group (n,=,26) the mother was left alone for the same period of time. Ewes of the "no VCS" group (n,=,14) did not receive any VCS. In the majority of animals of the "VCS,+,lamb" group (23/24) VCS induced a complete acceptance of the unfamiliar lamb without any disruption of the bond previously formed with the familiar lamb. VCS or 2,hr of separation did not disrupt the maintenance of the selective bond initially formed with the familiar lamb since all the ewes of the "VCS no lamb" and "no VCS" groups accepted it at suckling. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 537,544, 2010. [source]

Effects of neonatal novelty exposure on sexual behavior, fear, and stress-response in adult rats

DEVELOPMENTAL PSYCHOBIOLOGY, Issue 3 2007
Fernando Benetti
Abstract Environmental stimuli in early life may result in permanent behavioral and physiological changes. Present study evaluated the effects of exposing pups to a novel environment on behaviors (open-field test and sexual behavior) and prolactin stress-responses in adult male rats. Half of a litter was daily removed outside (OUT) from the nest and stimulated by handling for 3 min, while the other half remained inside (IN) the nest and was also handled for the same period during the first 10 days postpartum. Maternal behavior after all the pups were returned to the nest was not different between IN and OUT littermates. In adulthood, OUT males showed increased general and central locomotion activity in the open-field test, reduced sexual behavior, and attenuated prolactin secretion in response to restraint stress compared with the IN littermates. The repeated exposition of rat pups to a novel environment is a causal factor for the long-lasting behavioral and endocrine changes. The premature exposition of the pup to unfamiliar environments decreases fear and stress-response, and also reduces sexual behavior. We suggest that the absence of the odor of the mother may be crucial to explain the effects detected in adulthood. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 258,264, 2007. [source]

Postnatal stress in mice: Does "stressing" the mother have the same effect as "stressing" the pups?

DEVELOPMENTAL PSYCHOBIOLOGY, Issue 4 2004
A. Moles
Abstract Short- and long-term effects of brief maternal separation, maternal exposure to novel male odor, and standard rearing were compared in NMRI mice. The first condition consisted of 15 min of daily exposure of pups to clean bedding (CB), and the second condition consisted of 15 min of mothers' exposure to the odor of strange males (SM), for 14 days after birth starting from postnatal Day 1. Thus, both conditions entailed the same period of maternal separation. A control mother,offspring group was left undisturbed (nonhandled, N-H). Corticosterone levels of mothers and pups were measured at the end of the last manipulation session. Corticosterone levels were higher in SM mothers, differing from both those of CB and of control dams; CB pups showed the highest corticosterone levels in comparison with the pups belonging to the other groups. Maternal behavior observed as furthest as possible from the daily separation session did not differ among the three groups. The behavioral response to 0.5 mg/kg of apomorphine in 15-day-old pups was enhanced in both CB and SM animals, which suggests an alteration of dopaminergic functioning. Finally, adult CB and SM male mice showed an increase in the percentage of time and entries into the open arms of the plus-maze in comparison to nonhandled males. This study indicates that exposure to ecologically relevant stimuli elicited a stress response in lactating dams. This "social stress" brings about short- and long-term effects in the offspring, even in the absence of any direct manipulation of the pups. © 2004 Wiley Periodicals, Inc. Dev Psychobiol 44: 230,237, 2004. [source]

Social consumption of alcohol in adolescents with Type 1 diabetes is associated with increased glucose lability, but not hypoglycaemia

DIABETIC MEDICINE, Issue 8 2006
D. Ismail
Abstract Aims To determine the effects of social consumption of alcohol by diabetic adolescents on glycaemic control. Methods Fourteen (five male) patients aged > 16 years were recruited from the diabetes clinic at the Royal Children's Hospital. The continuous glucose monitoring system (CGMS) was attached at a weekend when alcohol consumption was planned for one night only. For each patient, the 12-h period from 18.00 h to 06.00 h for the night with alcohol consumption (study period) was compared with the same period with non-alcohol consumption (control period) either 24 h before or after the alcohol study night. Thus, each subject was his/her own control. Glycaemic outcomes calculated from continuous glucose monitoring included mean blood glucose (MBG), percentage of time spent at low glucose levels (CGMS < 4.0 mmol/l), normal glucose levels (CGMS 4.0,10.0 mmol/l) and high glucose levels (> 10.0 mmol/l) and continuous overall net glycaemic action (CONGA). Results The mean number of standard alcohol drinks consumed during the study period was 9.0 for males and 6.3 for females. There was no difference in percentage of time at high and normal glucose levels in the study and control periods. During the control period, there was a higher percentage of time with low glucose levels compared with the study period (P < 0.05). There was an increased level of glycaemic variation during the study time when compared with the control period. Conclusions In an uncontrolled, social context, moderately heavy alcohol consumption by adolescents with Type 1 diabetes appears to be associated with increased glycaemic variation, but not with low glucose levels. [source]

Funding and Publishing Trends of Original Research by Emergency Medicine Investigators over the Past Decade

ACADEMIC EMERGENCY MEDICINE, Issue 1 2006
Robert H. Birkhahn MD
Abstract Objectives: To update the profile of author-reported funding of reports of original research published since 1994 in the four U.S. peer-reviewed general emergency medicine (EM) journals. Methods: For the primary analysis, articles published in Academic Emergency Medicine, American Journal of Emergency Medicine, Annals of Emergency Medicine, and Journal of Emergency Medicine between 1994 and 2003 were reviewed by two emergency physicians trained in abstracting from the literature. Original research was identified; case reports, case series, abstracts, and meta-analysis were excluded. Articles were classified by author report of extramural funding as government (public), private nonprofit (foundation), for profit (industry), or multiple. Data are reported as percent per year per journal. A secondary analysis of MEDLINE was performed to identify publishing trends by EM investigators outside of these four journals over the same period. Results: The primary analysis identified 5,728 articles; 3,278 (57%) were considered original research, with 32% of these reporting extramural funding. In 1994, there were 292 articles with 28% funded (28% public, 43% foundation, 17% industry, and 12% multiple). By 2003, there were 358 articles with 36% funded (42% public, 30% foundation, 18% industry, and 10% multiple). There was a trend toward increased extramural funding in all four journals (p = 0.007), with an estimated growth of 3.6% (95% confidence interval = 1.0% to 6.3%) per year over the past decade. The primary review identified 48% of all articles published by EM investigators. Conclusions: Author-reported extramural funding rates for original research have increased in the EM literature over the past decade. Foundations have funded the largest number of studies, with public (government) sources increasing in 2003. [source]

Resection surgery with neoadjuvant chemoradiotherapy improves outcomes of patients with T4 esophageal carcinoma

DISEASES OF THE ESOPHAGUS, Issue 2 2003
T. Noguchi
SUMMARY The prognosis of patients with T4 esophageal carcinoma is poor, and thus an effective treatment needs to be established. The present study assessed the effect of chemoradiotherapy (CRT), postoperative morbidity and mortality, and survival time in 41 patients with T4 esophageal carcinoma. Of these, 24 received CRT followed by surgery (group A) and the remaining 17 were treated with CRT alone (group B). Postoperative complications in group A were compared with 251 patients (group C) who underwent surgery without CRT during the same period. Postoperative complications were more frequent in group A than group C (29.2%vs 8.4%, P < 0.05). The overall median survival of group A was statistically longer than that of group B (13.8 months and 3.3 months respectively, P < 0.001). Complete histologic response (grade 3) was documented in 4 group A patients (16.7%). The overall median survival of grade 3 patients was statistically longer than the rest of group A (38.9 months vs 8.8 months, P < 0.05). The data confirm that chemoradiotherapy creates tumor regression in some patients and allows resection surgery in T4 esophageal carcinoma. Moreover, surgery with CRT confers a survival advantage in T4 esophageal carcinoma. [source]

Evaluation of the influence of vertical irregularities on the seismic performance of a nine-storey steel frame

EARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 12 2006
Fragiadakis Michalis
Abstract A methodology based on incremental dynamic analysis (IDA) is presented for the evaluation of structures with vertical irregularities. Four types of storey-irregularities are considered: stiffness, strength, combined stiffness and strength, and mass irregularities. Using the well-known nine-storey LA9 steel frame as a base, the objective is to quantify the effect of irregularities, both for individual and for combinations of stories, on its response. In this context a rational methodology for comparing the seismic performance of different structural configurations is proposed by means of IDA. This entails performing non-linear time history analyses for a suite of ground motion records scaled to several intensity levels and suitably interpolating the results to calculate capacities for a number of limit-states, from elasticity to final global instability. By expressing all limit-state capacities with a common intensity measure, the reference and each modified structure can be naturally compared without needing to have the same period or yield base shear. Using the bootstrap method to construct appropriate confidence intervals, it becomes possible to isolate the effect of irregularities from the record-to-record variability. Thus, the proposed methodology enables a full-range performance evaluation using a highly accurate analysis method that pinpoints the effect of any source of irregularity for each limit-state. Copyright © 2006 John Wiley & Sons, Ltd. [source]

How much alcohol do you buy?

ADDICTION, Issue 4 2010
A comparison of self-reported alcohol purchases with actual sales
ABSTRACT Background Unrecorded alcohol has increased in the Nordic countries during recent years, above all in terms of cross-border trade. This implies that trends and levels of per capita consumption would look different without estimates of this source of alcohol, estimates that in Sweden and other countries are made through surveys. Aim The overall aim is to analyse the validity of Swedish survey estimates of alcohol bought in the cross-border trade and possibly to develop weights that can be applied to such estimates. Data and method The analysis consists of comparing self-reported purchases of spirits, wine, cider/alcopops and beer at retail monopoly (Systembolaget) during 2008 (n = 18 000) with actual sales during the same period overall and monthly. Findings Of the recorded amount of purchases at Systembolaget, 87% was reported in the survey, compared with the 40,60% usually found for self-reported consumption. Significant differences across beverages were revealed, showing a lower coverage rate for beer and spirits and a higher coverage rate for wine and cider. Changes in purchases of all beverages were captured fairly well, at least changes taking place from one month to another. Conclusions Self-reported alcohol purchases achieve a higher coverage rate than found typically in studies based on self-reported use of alcohol. If adjustments are to be made to correct for underreporting in self-reported data on alcohol purchases, different weights should be applied to different beverages. Furthermore, at least major changes in how much alcohol is purchased in the population can be monitored using well-designed population surveys. [source]

Failure to reduce drinking and driving in France: a 6-year prospective study in the GAZEL cohort

ADDICTION, Issue 1 2010
Aymery Constant
ABSTRACT Aim An unprecedented decline in alcohol consumption and road mortality has been observed recently in France, but it is still unclear whether or not these changes affected driving while alcohol-intoxicated (DWI). The objective of the study was to estimate prospectively trends of excessive speed on the roads, alcohol consumption and DWI between 2001 and 2007 in a large cohort of experienced drivers. Methods Participants were current employees or recent retirees of the French national electricity and gas company, who volunteered to participate in a research cohort established in 1989 under strict conditions of anonymity. An annual cohort questionnaire is sent to participants that includes two questions about overall alcohol consumption. In 2001 and 2007, 10 684 participants reported their driving behaviours using the same self-administered questionnaire. Results Between 2001 and 2007, the proportion of participants (n = 10 684) who reported having driven at speeds at least 20 km/hour above the limit decreased from 23.7% to 4.1% in built-up areas (P < 0.001), from 34.3% to 9.3% on rural roads (P < 0.001) and from 24.3% to 2.7% on highways (P < 0.001). Regular and non-regular excessive alcohol consumption decreased from 22.7% to 19.7% and from 18.0% to 14.9%, respectively, whereas DWI increased from 22.9% to 25.3% over the same period (P < 0.001). Conclusions A recent crackdown on road violations by the French government has failed to deter DWI. Given that DWI seems to be a sporadic and rarely punished behaviour, its prevention requires more coercive measures, such as using a breath alcohol ignition interlock device. [source]

Capital quality improvement and the sources of economic growth in the euro area

ECONOMIC POLICY, Issue 42 2005
Plutarchos Sakellaris
SUMMARY Capital quality improvement and Euroland growth Sources of growth Europe's growth slowed in the 1990s, reinforcing the overall impression of a need to catch up with the US regarding standards of living. In reaction, EU leaders adopted the famous Lisbon Agenda in 2000. The Agenda is now under review, the aim being to determine why progress on its pro-growth goals has been unsatisfactory and what can be done about it. The first crucial step in this process is to understand the true sources of the European growth slowdown. Sources-of-growth calculations have always been imprecise, but evidence from the US suggests that ,quality upgrading', especially in capital goods , has substantially worsened the precision problem since the 1990s. Unfortunately, quality adjusted sources-of-growth calculations, however, have not performed satisfactorily for Europe, so Europe's leaders are working with potentially misleading accounts of Europe's growth slowdown. Redressing this omission is the goal of this paper. Failure to account properly for capital quality improvements leads to two mistakes. First, overall GDP is underestimated. Our calculations, for example, show that euro area GDP growth was underestimated on average by 0.7 percentage points annually in the late 1990s. However, similar quality-adjustment figures raise US growth figures in the same period by even more, so quality-adjusting suggests that the US,EU growth gap was even more pronounced than previously believed. Secondly, the sources-of-growth calculations used to prioritize Europe's pro-growth policies are skewed. Our calculations show that the contribution of the slowdown in disembodied technical progress to the overall slowdown is more pronounced after quality adjustment. Our findings point to the need for adoption of microeconomic measures aimed at enhancing overall efficiency and boosting innovation activity. Such measures would aim at a better business environment, e.g. by easing regulatory and administrative burden and liberalizing energy and telecommunications markets. , Plutarchos Sakellaris and Focco Vijselaar [source]

Discrepancies Between Score Trends from NAEP and State Tests: A Scale-Invariant Perspective

EDUCATIONAL MEASUREMENT: ISSUES AND PRACTICE, Issue 4 2007
Andrew D. Ho
State test score trends are widely interpreted as indicators of educational improvement. To validate these interpretations, state test score trends are often compared to trends on other tests such as the National Assessment of Educational Progress (NAEP). These comparisons raise serious technical and substantive concerns. Technically, the most commonly used trend statistics,for example, the change in the percent of proficient students,are misleading in the context of cross-test comparisons. Substantively, it may not be reasonable to expect that NAEP and state test score trends should be similar. This paper motivates then applies a "scale-invariant" framework for cross-test trend comparisons to compare "high-stakes" state test score trends from 2003 to 2005 to NAEP trends over the same period. Results show that state trends are significantly more positive than NAEP trends. The paper concludes with cautions against the positioning of trend discrepancies in a framework where only one trend is considered "true." [source]

Customer Satisfaction in a Large Urban Fire Department Emergency Medical Services System

ACADEMIC EMERGENCY MEDICINE, Issue 1 2004
David E. Persse MD
Objectives: The purpose of this study was to determine if emergency medical services (EMS) customer satisfaction could be assessed using telephone-survey methods. The process by which customer satisfaction with the EMS service in a large, fire department,based EMS system is reported, and five month results are presented. Methods: Ten percent of all patients transported during the period of October 15, 2001, through March 15, 2002, were selected for study. In addition, during the same period, all EMS incidents in which a patient was not transported were identified for contact. Customer-service representatives contacted patients via telephone and surveyed them from prepared scripts. Results: A total of 88,528 EMS incidents occurred during the study period. Of these, 53,649 resulted in patient transports and 34,879 did not. Ten percent of patients transported (5,098) were selected for study participation, of which 2,498 were successfully contacted; of these, 2,368 (94.8%) reported overall satisfaction with the service provided. Of the 34,879 incidents without transport, only 5,859 involved patients who were seen but not transported. All of these patients were selected for study. Of these, 2,975 were successfully contacted, with 2,865 (96.3%) reporting overall satisfaction. The most common reason given for nonsatisfaction in both groups was the perception of a long response time. Conclusions: It is possible to conduct a survey of EMS customer satisfaction using telephone-survey methods. Although difficulties exist in contacting patients, useful information is made available with this method. Such surveys should be an integral part of any EMS system's quality-improvement efforts. In this survey, the overwhelming majority of patients, both transported and not transported, were satisfied with their encounter with EMS. [source]

Opportunism of Conidiobolus obscurus stems from depression of infection in situ to progeny colonies of host alatae as disseminators of the aphid-pathogenic fungus

ENVIRONMENTAL MICROBIOLOGY, Issue 4 2007
Guo-Zhong Zhang
Summary Conidiobolus (Entomophthorales: Ancylistaceae) includes common aphid pathogens but causes sporadic mycosis worldwide. This epizootiological opportunism was explored herein by examining the potential of mycosis transmission in the progeny colonies of 513 Myzus persicae alates as disseminators of C. obscurus often infecting aphids. The alates exposed to spore showers were flown for 2.05 (0.01,8.95) km on flight mills and then reared individually on cabbage at 20,23°C for 14 day colonization. All truly infected alates were mycosed within 6 days and averagely left 3.9 (0,15) nymphs while those uninfected produced 11.6 (0,35) nymphs during the same period. Secondary and tertiary infections occurred only in 16.2% and 4.8% of the progeny colonies of the mycosed alates respectively, due to c. 60% of the cadavers forming resting spores. Most of the contagious infections appeared on days 4,8 after colonization and no more occurred from day 11 onwards. Trends of colony sizes (last-day averaging 51.5 aphids) and mycosis transmission (sixth-day maximum 6.3%) fit well to logistic (r 2 = 0.99) and Gompertz growth models (r 2 = 0.91) respectively. The results confirm that the opportunism of C. obscurus stems from depression of contagious infection after dissemination by host alates and suggest that it be overwhelmed by the prevalence of other non-resting fungal species. [source]

Methadone maintenance treatment: the balance between life-saving treatment and fatal poisonings

ADDICTION, Issue 3 2007
A. Fugelstad
ABSTRACT Aim To determine the total mortality related to the Stockholm methadone programme during the period 1988,2000, both the mortality related to the treatment and fatal methadone intoxications in the Stockholm area during the same period. Methods The study comprised all individuals (n = 848) who had been in contact with the methadone programme in Stockholm during the study period, including those patients who had been discharged from treatment and those opiate users who had applied for but not received methadone treatment. All deaths that had been the subject of medico-legal examination at the Department of Forensic Medicine in Stockholm where methadone was found in blood or urine were also analysed during the same period. Results The mortality was lower among those opiate users who remained in maintenance treatment and 91% of the deceased individuals had died due to natural causes, in most cases related to HIV or hepatitis C, acquired before admission to the programme. Those who had been discharged from methadone treatment had a 20 times higher risk of dying from unnatural causes compared to the patients who remained in treatment. The majority died due to heroin injections (,overdoses'). Eighty-nine cases of fatal methadone intoxication were found, but in only two of these cases was there evidence of leakage from maintenance treatment. Conclusion The ,high threshold programme' is safe as long as the patients remain in treatment and there are very few deaths due to leakage from the programme. However, there is a high mortality among those discharged from the programme and only a minority of the heroin users in Stockholm had applied for treatment. [source]

Epidemiology of tomato yellow leaf curl begomovirus in the Fayium area, Egypt

EPPO BULLETIN, Issue 2 2000
A. E. Aboul-Ata
Tomato yellow leaf curl begomovirus (TYLCV) severely invaded tomato plantations in Egypt (Lower and Middle Egypt) in 1989. This study aimed to discover the relationship between TYLCV and other epidemic-associated factors in the Fayium area. The rate of TYLCV infection was inspected visually for three successive years (1994/1996) in the Fayium area. During the same period, whiteflies were collected for virus detection using bait-plant and DNA hybridization techniques. DAS-ELISA was used to detect mixed virus infections in tomato plants. TYLCV infection was prevalent (60,68%) and severe (2.1,3.0) in the Fayium fields. Cucumber mosaic cucumovirus (CMV) was found in some fields (5,28%) with moderate severity (1.0,20). Potato Y potyvirus (PVY) and potato leaf roll polerovirus (PLRV) were found in few fields (5,19% and 5% respectively) at very low severity. There was a negative correlation between TYLCV occurrence and distance from the source of infection, and a positive correlation (98%) between TYLCV intensity and percentage of viruliferous whiteflies in 1994 and 1995. There was no positive correlation between TYLCV and the total population of whiteflies caught during the same period. Five percent of viruliferous whiteflies, as proved by cDNA hybridization, led to 46% TYLCV infection. The same percentage of whiteflies, as shown by bioassay, led to 68% TYLCV infection. Monitoring of viruliferous whiteflies could be used for early prediction of TYLCV infection. [source]

Effects of a MAPK p38 inhibitor on lung function and airway inflammation in equine recurrent airway obstruction

EQUINE VETERINARY JOURNAL, Issue 6 2008
J.-P. LAVOIE
Summary Reasons for performing study: It has been suggested that many of the beneficial effects of corticosteroids are mediated through mitogen-activated protein kinase (MAPK) p38 inhibition. Objective: To investigate the efficacy of the MAPK p38 inhibitor compound MRL-EQ1 to either prevent (Phase 1) or treat (Phase 2) recurrent airway obstruction (RAO) in horses. Methods: MRL-EQ1 was administered i.v. at a dosage of 0.75-1.5 mg/kg bwt q. 12 h. In Phase 1, susceptible horses in clinical remission were divided into 2 groups (n = 5/group), based on historical values of respiratory mechanics. All horses were entered in the study in pairs (one control, one treated horse) and exposed to the same environmental challenge (stabling, mouldy hay and dusty conditions). The treatment group received MRL-EQ1 for 14 days while the control horses were untreated during the same period. In Phase 2, affected horses were ranked by severity of respiratory dysfunction and split randomly into either dexamethasone or MRL-EQ1 treatment groups (n = 5/group). Bronchoalveolar lavage fluid, respiratory mechanic measurements, MRL-EQ1 plasma concentration and tumour necrosis factor (TNF) whole blood activity were evaluated sequentially. Results: In Phase 1, MRL-EQ1 did not prevent the occurrence of clinical signs and pulmonary inflammation. However, treatment was associated with a reduction in severity and a delay in the onset of signs and a reduction in pulmonary neutrophilia. In Phase 2, plasma concentrations achieved resulted in ex vivo suppression of lipopolysaccharide-induced TNF production in equine blood. MRL-EQ1 did not improve airway inflammation or lung function and was associated in a dose dependent manner with behavioural (depression, excitability) and blood changes (neutrophilia, increased serum muscle enzyme concentrations). Conclusions: Inhibition of p38 in the horse was partially effective in reducing clinical signs and airway inflammation when administered prior to, but not during clinical exacerbation in RAO. Potential relevance: Inhibitors of p38 MAPK with a better toxicity profile may be effective in the prevention or treatment of RAO. [source]

Brain natriuretic peptide in the prediction of recurrence of angina pectoris

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 2 2004
H. Takase
Abstract Background, Circulating levels of brain natriuretic peptide (BNP) provide prognostic information for patients with heart failure, but little is known about its prognostic usefulness in patients with stable angina pectoris. We investigated whether BNP could be used as a marker for the prediction of anginal recurrence after successful treatment. Design, Brain natriuretic peptide levels of 77 patients with stable angina pectoris were measured at enrolment and after confirmation of successful treatment (i.e. no anginal attack for at least 6 months: chronic phase) with percutaneous transluminal coronary angioplasty and/or conventional medication. Then, we prospectively followed them up for 25·9 ± 1·4 months, with the endpoint being a recurrence of anginal attacks. Results, An anginal attack recurred in seven patients. In patients without recurrence, BNP levels in the chronic phase (21 ± 12 [median ± median absolute deviation] pg mL,1) were lower than those measured at enrolment (46 ± 25 pg mL,1, P < 0·0001), whereas the levels in patients with recurrence increased during the same period (from 36 ± 16 to 72 ± 42 pg mL,1, P < 0·05). A univariate analysis revealed that the BNP level measured in the chronic phase was the significant predictor of future anginal recurrence. Analysis of the receiver operating characteristic curve indicated that the cutoff level of BNP in the chronic phase was 68 pg mL,1. The Kaplan-Meier method revealed that the incidence of anginal recurrence was higher in patients with higher (71·4%) than lower levels of BNP (2·9%; P < 0·0001). Conclusions, Measurement of BNP levels after successful therapy is clinically useful for the prediction of recurrence of anginal attacks in patients with angina pectoris. [source]

Establishing climate,growth relationships for yelloweye rockfish (Sebastes ruberrimus) in the northeast Pacific using a dendrochronological approach

FISHERIES OCEANOGRAPHY, Issue 5 2008
BRYAN A. BLACK
Abstract We applied dendrochronology (tree-ring) methods to develop multidecadal growth chronologies from the increment widths of yelloweye rockfish (Sebastes ruberrimus) otoliths. Chronologies were developed for the central California coast, a site just north of Vancouver Island, British Columbia, and at Bowie Seamount west of the Queen Charlotte Islands, British Columbia. At each site, synchronous growth patterns were matched among otoliths via the process of cross-dating, ensuring that the correct calendar year was assigned to all increments. Each time series of growth-increment measurements was divided by the values predicted by a best-fit negative exponential function, thereby removing age-related trends. These detrended time series were averaged into a master chronology for each site, and chronologies were correlated with monthly averages of sea surface temperatures, upwelling, the Northern Oscillation Index, and the Pacific Decadal Oscillation. The two northern growth chronologies positively correlated with indices of warm ocean conditions, especially from the prior summer through the spring of the current year. During the same period, the California chronology positively correlated with indices of cool ocean conditions, indicating an opposing productivity regime for yelloweye rockfish between the California Current and the Gulf of Alaska. Overall, this study demonstrates how tree-ring techniques can be applied to quickly develop annually resolved chronologies and establish climate,growth relationships across various temporal and spatial scales. [source]

Application of a habitat-based model to estimate effective longline fishing effort and relative abundance of Pacific bigeye tuna (Thunnus obesus)

FISHERIES OCEANOGRAPHY, Issue 3 2002
Keith A. Bigelow
A new habitat-based model is developed to improve estimates of relative abundance of Pacific bigeye tuna (Thunnus obesus). The model provides estimates of `effective' longline effort and therefore better estimates of catch-per-unit-of-effort (CPUE) by incorporating information on the variation in longline fishing depth and depth of bigeye tuna preferred habitat. The essential elements in the model are: (1) estimation of the depth distribution of the longline gear, using information on gear configuration and ocean currents; (2) estimation of the depth distribution of bigeye tuna, based on habitat preference and oceanographic data; (3) estimation of effective longline effort, using fine-scale Japanese longline fishery data; and (4) aggregation of catch and effective effort over appropriate spatial zones to produce revised time series of CPUE. Model results indicate that effective effort has increased in both the western and central Pacific Ocean (WCPO) and eastern Pacific Ocean (EPO). In the WCPO, effective effort increased by 43% from the late 1960s to the late 1980s due primarily to the increased effectiveness of effort (deeper longline sets) rather than to increased nominal effort. Over the same period, effective effort increased 250% in the EPO due primarily to increased nominal effort. Nominal and standardized CPUE indices in the EPO show similar trends , a decline during the 1960s, a period of stability in the 1970s, high values during 1985,1986 and a decline thereafter. In the WCPO, nominal CPUE is stable over the time-series; however, standardized CPUE has declined by ,50%. If estimates of standardized CPUE accurately reflect relative abundance, then we have documented substantial reductions of bigeye tuna abundance for some regions in the Pacific Ocean. A decline in standardized CPUE in the subtropical gyres concurrent with stability in equatorial areas may represent a contraction in the range of the population resulting from a decline in population abundance. The sensitivity of the results to the habitat (temperature and oxygen) assumptions was tested using Monte Carlo simulations. [source]

Abundance and production of bacteria, and relationship to phytoplankton production, in a large tropical lake (Lake Tanganyika)

FRESHWATER BIOLOGY, Issue 6 2009
STEPHANE STENUITE
Summary 1. Abundance and bacterial production (BP) of heterotrophic bacteria (HBact) were measured in the north and south basins of Lake Tanganyika, East Africa, during seasonal sampling series between 2002 and 2007. The major objective of the study was to assess whether BP can supplement phytoplankton particulate primary production (particulate PP) in the pelagic waters, and whether BP and particulate PP are related in this large lake. HBact were enumerated in the 0,100 m surface layer by epifluorescence microscopy and flow cytometry; BP was quantified using 3H-thymidine incorporation, usually in three mixolimnion layers (0,40, 40,60 and 60,100 m). 2. Flow cytometry allowed three subpopulations to be distinguished: low nucleic acid content bacteria (LNA), high nucleic acid content bacteria (HNA) and Synechococcus -like picocyanobacteria (PCya). The proportion of HNA was on average 67% of total bacterial abundance, and tended to increase with depth. HBact abundance was between 1.2 × 105 and 4.8 × 106 cells mL,1, and was maximal in the 0,40 m layer (i.e. roughly, the euphotic layer). Using a single conversion factor of 15 fg C cell,1, estimated from biovolume measurements, average HBact biomass (integrated over a 100-m water column depth) was 1.89 ± 1.05 g C m,2. 3. Significant differences in BP appeared between seasons, especially in the south basin. The range of BP integrated over the 0,100 m layer was 93,735 mg C m,2 day,1, and overlapped with the range of particulate PP (150,1687 mg C m,2 day,1) measured in the same period of time at the same sites. 4. Depth-integrated BP was significantly correlated to particulate PP and chlorophyll- a, and BP in the euphotic layer was on average 25% of PP. 5. These results suggest that HBact contribute substantially to the particulate organic carbon available to consumers in Lake Tanganyika, and that BP may be sustained by phytoplankton-derived organic carbon in the pelagic waters. [source]

Dextropropoxyphene withdrawal from a French university hospital: impact on analgesic drug consumption

FUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 2 2009
Sabine Gaubert
Abstract Dextropropoxyphene is a weak opioid analgesic, widely used as a step 2 analgesic (according to WHO classification) in combination with peripheral analgesics, mainly paracetamol. Recent data have underlined its poor analgesic efficacy (in comparison with paracetamol), risks of serious adverse drug reactions (i.e. hepatic reactions, hallucinations, abuse, withdrawal symptoms, hypoglycaemia), possible lethality after overdose, its risk of accumulation in patients with renal failure or in elderly people and some pharmacokinetic insufficiencies (i.e. different half-lives for dextropropoxyphene and paracetamol). Taking into account these data, the drug committee of the Toulouse University Hospital (France) decided to withdraw dextropropoxyphene from the hospital formulary since 1 June 2005. The aim of our study was to investigate the consequences of this withdrawal by comparing use of analgesic drugs in Toulouse University Hospital before (2004) and after (2006) dextropropoxyphene withdrawal (using defined daily dose for 1000 hospitalization-days as the unit measure). Before withdrawal, dextropropoxyphene (in combination with paracetamol) was the second most used analgesic drug after paracetamol alone. After dextropropoxyphene withdrawal, total consumption of analgesic drugs decreased by 4.6% (2006 vs. 2004). There was a 28% decrease in consumption of step 2 analgesics [with an increase in oral tramadol and a slight decrease in codeine (in combination with paracetamol)]. During the same period, step 1 analgesic consumption increased by 11% (mainly paracetamol) and that of step 3 analgesics slightly decreased (,8%). These results show that dextropropoxyphene withdrawal was not associated with a marked switch in prescriptions towards other analgesic drugs. This paper underlines the interest of a hospital-based drug committee to promote rational drug use. Finally, the present data allow us to discuss putative misuse of dextropropoxyphene. [source]

The Substance of Sexual Difference: Change and Persistence in Representations of the Body in Eighteenth,Century England

GENDER & HISTORY, Issue 2 2002
Karen HarveyArticle first published online: 16 DEC 200
The claims of Thomas Laqueur for a shift from a one,sex to a two,sex model of sexual difference are incorporated into many recent histories of gender in England between 1650 and 1850. Yet the Laqueurian narrative is not supported by discussions of the substance of sexual difference in eighteenth,century erotic books. This article argues that different models of sexual difference were not mutually exclusive and did not change in linear fashion, but that the themes of sameness and difference were strategically deployed in the same period. Thus, there was an enduring synchronic diversity which undermines claims for linear transformation. [source]