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Selected AbstractsSemi-Automatic Time-Series Transfer Functions via Temporal Clustering and SequencingCOMPUTER GRAPHICS FORUM, Issue 3 2009Jonathan Woodring Abstract When creating transfer functions for time-varying data, it is not clear what range of values to use for classification, as data value ranges and distributions change over time. In order to generate time-varying transfer functions, we search the data for classes that have similar behavior over time, assuming that data points that behave similarly belong to the same feature. We utilize a method we call temporal clustering and sequencing to find dynamic features in value space and create a corresponding transfer function. First, clustering finds groups of data points that have the same value space activity over time. Then, sequencing derives a progression of clusters over time, creating chains that follow value distribution changes. Finally, the cluster sequences are used to create transfer functions, as sequences describe the value range distributions over time in a data set. [source] Cuticular hydrocarbons in workers of the slave-making ant Polyergus samurai and its slave, Formica japonica (Hymenoptera: Formicidae)ENTOMOLOGICAL SCIENCE, Issue 3 2003Zhibin LIU Abstract Comparisons of cuticular hydrocarbons between workers of the dulotic ant Polyergus samurai and its slave, Formica japonica, were carried out. Gas chromatography,mass spectrometry showed that the slave-maker and its slave shared the major cuticular hydrocarbon compounds, but possessed several minor products unique to each species. No difference in hydrocarbon composition was detected between enslaved and free-living F. japonica workers, suggesting that association with P. samurai has no qualitative effect on hydrocarbon composition in these ants. Principal component analyses of the cuticular hydrocarbon profiles (CHP) revealed that (i) CHP was species specific in a given mixed colony; and (ii) among mixed colonies, P. samurai workers had species-colony specific CHP, while the same feature was not always found in enslaved and free-living F. japonica workers. Therefore, a ,uniform colony odor' in terms of CHP is not achieved in naturally mixed colonies of P. samurai nor those of its slaves, F. japonica. [source] Of coiled oysters and big brains: how to rescue the terminology of heterochrony, now gone astrayEVOLUTION AND DEVELOPMENT, Issue 5 2000Stephen Jay Gould SUMMARY During the past decade, the terminology of heterochrony, heretofore consistent and workable, has become internally illogical and incoherent as the unfortunate result of an extension of terms, properly devised to describe shifts in developmental timing of shapes and features, to the rates and timings that cause these shifts. All the resulting, and extensive, confusion in the literature arises as a pure consequence of this error in logic and nomenclature, and not at all from disagreement about the important empirical questions described by this central concept and phenomenon in the integration of evolution and development. In particular, the claim that the same feature in human evolution (the paedomorphic shape of the human cranium) expresses either neoteny or the apparently opposite phenomenon of hypermorphosis only records the terminological error, and not any factual disagreement,for this neotenic feature has probably arisen by a prolongation of juvenile growth patterns inappropriately designated as "hypermorphosis of rate." I show that a prominent and unchallenged case of neoteny in fossil oysters arises by exactly the same evolutionary mode. When we restore the terminology of heterochrony by the "paedomorphic" intellectual event of dropping these inadaptive terminal accretions (the illogical extension of shape categories to describe rates), then the concept of heterochrony will again make proper distinctions by designating a clearly meaningful category of evolutionary changes originating by shifts in timing for features already present in ancestors. "It's not all heterochrony",and this particular statement of "less is more" represents heterochrony's strength as an interesting subset with definite meaning, rather than an illogical hodge-podge apparently applicable to all phenomena, and therefore explaining nothing. [source] Memory, Identity, and NAGPRA in the Northeastern United StatesAMERICAN ANTHROPOLOGIST, Issue 2 2010April M. Beisaw ABSTRACT, Determinations of cultural affiliation in compliance with the Native American Graves Protection and Repatriation Act (NAGPRA) often rely on culture history and the direct-historical approach. Both methods ignore important developments in our understanding of identity. A recent NAGPRA claim illustrates an alternative. Using culture history and the direct-historical approach, it was difficult to ascribe the Engelbert Site of New York State to a federally recognized tribe because it contained material from multiple culture-historic taxa, often in the same feature. Taphonomic analyses of selected mixed deposits revealed a previously undocumented mortuary ritual that has since been found at other sites. Using memory as a framework for interpretation, this ritual appears reflective of a kinship-based shared identity between culture-historic taxa. The multivocality of this ritual provided an additional means for evaluating cultural affiliation by ascribing a consciousness of history to the subjects of this repatriation claim. [source] Hertz, Wittgenstein and Philosophical Method1PHILOSOPHICAL INVESTIGATIONS, Issue 1 2008John Preston There have recently appeared claims that the influence Heinrich Hertz exerted over Wittgenstein's later work was far more abiding than previously recognised. I critically evaluate such claims by Gordon Baker and Allan Janik. I first show that Hertz was indeed concerned with the same feature, clarity, which often exercised Wittgenstein. But I then argue that Wittgenstein should not be seen as having adopted the conception of philosophical method, which Hertz deployed in The Principles of Mechanics. I show that Hertz ,clarifies' the concept of force only in the sense that he alters that concept, and that he is not using the sort of ,contrastive' methods characteristic of Wittgenstein's later works. [source] The esthetic outcome of autotransplanted premolars replacing maxillary incisorsDENTAL TRAUMATOLOGY, Issue 5 2002Ewa Monika Czochrowska Abstract ,,,Autotransplantation of developing premolars to replace maxillary incisors has been documented to provide physiologically sound results, but comprehensive studies of the esthetic outcome have not been made previously. In order to assess the applicability of this approach and to identify factors important for planning of treatment, 22 autotransplanted premolars reshaped to incisor morphology were compared to their natural, contralateral maxillary incisors by scoring of features considered important for esthetics (color, soft tissue appearance, tooth morphology, and position). The sum of scores for each feature was used to place the reshaped transplant in one of three categories , Match, Deviate, Mismatch. The 22 patients were asked to fill in a questionnaire which addressed the same features that were examined professionally, and the responses were categorized as either Satisfied, Acceptable, or Dissatisfied. Eleven of the 22 patients had received orthodontic treatment with fixed appliances following the transplantation. Most of the transplanted premolars matched the contralateral incisor, and the majority of patients were satisfied with the appearance of the transplant. Fourteen percentage of the transplants were categorized as Mismatch and 18% of patients reported dissatisfaction. The distribution in categories assessed professionally and by the patients was not significantly different. The color and gingival width of the transplanted tooth were scored as different from the natural incisor in about half of the bilateral comparisons. For those teeth categorized professionally as Mismatch and by patients as Dissatisfied, a potential for esthetic improvement could be identified, as allocation to these categories was primarily due to suboptimal positioning and restorative build-up of the transplant. Inter-disciplinary planning is important for successful esthetic results. [source] Independent component analysis of erroneous and correct responses suggests online response controlHUMAN BRAIN MAPPING, Issue 9 2010Sven Hoffmann Abstract After errors in reaction tasks, a sharp negative wave emerges in the event-related potential (ERP), the error (related) negativity (Ne or ERN). However, also after correct trials, an Ne-like wave is seen, called CRN or Nc, which is much smaller than the Ne. This study tested the hypothesis whether Ne and Nc reflect the same functional process, and whether this process is linked to online response control. For this purpose, independent component analysis (ICA) was utilized with the EEG data of two types of reaction tasks: a flanker task and a mental rotation task. To control for speed-accuracy effects, speed and accuracy instructions were balanced in a between subjects design. For both tasks ICA and dipole analysis revealed one component (Ne-IC) explaining most of the variance for the difference between correct and erroneous trials. The Ne-IC showed virtually the same features as the raw postresponse ERP, being larger for erroneous compared to correct trials and for the flanker than for the rotation task. In addition, it peaked earlier for corrected than for uncorrected errors. The results favor the hypothesis that Ne and Nc reflect the same process, which is modulated by response correctness and type of task. On the basis of the literature and the present results, we assume that this process induces online response control, which is much stronger in error than correct trials and with direct rather than indirect stimulus response mapping. Hum Brain Mapp, 2010. © 2010 Wiley-Liss, Inc. [source] A comparison between clearing and radiographic techniques in the study of the root-canal anatomy of maxillary first and second molarsINTERNATIONAL ENDODONTIC JOURNAL, Issue 5 2004O. E. Omer Abstract Aim, To compare a clearing technique with conventional radiography in studying certain features of the root-canal system of maxillary right first and second molars. A secondary aim was to assess interexaminer agreement for these features using radiographs. Methodology, Eighty-three recently extracted permanent maxillary right first molars and 40 recently extracted maxillary right second molars from an Irish population were included. Standard periapical radiographs were taken from a buccolingual and mesiodistal direction. The specimens were then decoronated, demineralized in 10% hydrochloric acid for 8 days and then cleared using methyl salicylate. The cleared teeth were examined using a dissecting microscope (×20), and data relating to number of roots, canal type following Vertucci's classification, presence of lateral canals, presence of transverse anastomoses and position/number of apical foramina were collected. The radiographs were examined by two independent trained endodontists using an X-ray viewer and a magnifying lens (×2) in a dark room for the same features studied using the clearing technique. Results, The Kappa values for the agreement between the radiographic examiners A and B and the clearing technique and between the two examiners for the number of roots were 0.60, 0.64 and 0.53; for the root-canal type, 0.37, 0.41 and 0.42; for the number of roots with lateral canals, 0.21, 0.18 and 0.14; and for the transverse anastomoses, 0.29 for radiographic Examiner A. Radiographic Examiner B did not feel capable of accurately recognizing transverse anastomoses from the radiographs. For the position/number of apical foramina, the Kappa values were 0.33 and 0.24, respectively. In general, the Kappa values were low to modest for all comparisons. Conclusions, It is concluded that the agreement between the two radiographic examiners and the agreement between either radiographic examiner and the clearing technique were poor to moderate, indicating the limited value of radiographs alone when studying certain aspects of the root-canal system. [source] P-wave and S-wave decomposition in boundary integral equation for plane elastodynamic problemsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, Issue 12 2003Emmanuel Perrey-Debain Abstract The method of plane wave basis functions, a subset of the method of Partition of Unity, has previously been applied successfully to finite element and boundary element models for the Helmholtz equation. In this paper we describe the extension of the method to problems of scattering of elastic waves. This problem is more complicated for two reasons. First, the governing equation is now a vector equation and second multiple wave speeds are present, for any given frequency. The formulation has therefore a number of novel features. A full development of the necessary theory is given. Results are presented for some classical problems in the scattering of elastic waves. They demonstrate the same features as those previously obtained for the Helmholtz equation, namely that for a given level of error far fewer degrees of freedom are required in the system matrix. The use of the plane wave basis promises to yield a considerable increase in efficiency over conventional boundary element formulations in elastodynamics. Copyright © 2003 John Wiley & Sons, Ltd. [source] Non-uniform plastic deformation of micron scale objectsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 7 2003Christian F. Niordson Abstract Significant increases in apparent flow strength are observed when non-uniform plastic deformation of metals occurs at the scale ranging from roughly one to ten microns. Several basic plane strain problems are analysed numerically in this paper based on a new formulation of strain gradient plasticity. The problems are the tangential and normal loading of a finite rectangular block of material bonded to rigid platens and having traction-free ends, and the normal loading of a half-space by a flat, rigid punch. The solutions illustrate fundamental features of plasticity at the micron scale that are not captured by conventional plasticity theory. These include the role of material length parameters in establishing the size dependence of strength and the elevation of resistance to plastic flow resulting from constraint on plastic flow at boundaries. Details of the finite element method employed in the numerical analysis of the higher order gradient theory will be discussed and related to prior formulations having some of the same features. Copyright © 2003 John Wiley & Sons, Ltd. [source] Supercooled Barium Boric Oxide Melts: X-Ray Diffraction Measurements and Glass FormationJOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 3 2007Seiichi Matsumura It is well-known that oxide melts easily form a glass state from a supercooled state; however, it is difficult for some oxides to transform to the glass state from the corresponding supercooled state. ,-BaB2O4 (,-BBO) crystals are important materials for laser applications. The ,-BBO crystal easily grows from the supercooled melt, and it is therefore difficult to form the BBO glass state. We attempted to make BBO glass by a containerless technique using the conical nozzle gas-jet levitation (CNL) method. We were successful in making BBO glass with a diameter of 2 mm from a highly supercooled melt without rapid quenching. In order to clarify the phase selection mechanism of the BBO melt, we performed high-energy X-ray (113.6 keV) diffraction experiments on the glassy and supercooled liquid BBO using the CNL technique at the BL04B2 beamline of SPring-8. From these experiments, the structure factor S(Q) of BBO glasses and supercooled melts were found to have almost the same features. From these S(Q), we obtained the radial distribution function T(r)=4,rg(r). The analysis also showed that BBO glass and the BBO-supercooled melt have the same short-range distances. For phase selection between crystalline and glassy phases, we discuss a structure model of the BBO melt, including medium range structure based on the short-range structure obtained in this experiment. [source] Evaluation of Endothelial Cell Adhesion onto Different Protein/Gold Electrodes by EISMACROMOLECULAR BIOSCIENCE, Issue 5 2007Amira Bouafsoun Abstract To study cell attachment to biomaterials, several proteins such as fibronectin, collagen IV, heparin, immunoglobulin G, and albumin have been deposited onto polystyrene adsorbed on a self-assembled monolayer (silane or thiol) on glass or gold, respectively. The different steps of this multilayer assembly have been characterized by electrochemical impedance spectroscopy (EIS). These data are compared to those of adhesion rate, viability percentage, and cytoskeleton labeling for a better understanding of the cell adhesion process to each protein. All the proteins are endothelial cell adhering biomolecules but not with the same features. A linear relationship has been established between adhesion rate and resistance of the endothelial cell/protein interface for all negatively charged proteins. [source] Microarray expression profiling: capturing a genome-wide portrait of the transcriptomeMOLECULAR MICROBIOLOGY, Issue 4 2003Tyrrell Conway Summary The bacterial transcriptome is a dynamic entity that reflects the organism's immediate, ongoing and genome-wide response to its environment. Microarray expression profiling provides a comprehensive portrait of the transcriptional world enabling us to view the organism as a ,system' that is more than the sum of its parts. The vigilance of microorganisms to environmental change, the alacrity of the transcriptional response, the short half-life of bacterial mRNA and the genome-scale nature of the investigation collectively explain the power of this method. These same features pose the most significant experimental design and execution issues which, unless surmounted, predictably generate a distorted image of the transcriptome. Conversely, the expression profile of a properly conceived and conducted microarray experiment can be used for hypothesis testing: disclosure of the metabolic and biosynthetic pathways that underlie adaptation of the organism to chang-ing conditions of growth; the identification of co-ordinately regulated genes; the regulatory circuits and signal transduction systems that mediate the adaptive response; and temporal features of developmental programmes. The study of bacterial pathogenesis by microarray expression profiling poses special challenges and opportunities. Although the technical hurdles are many, obtaining expression profiles of an organism growing in tissue will probably reveal strategies for growth and survival in the host's microenvironment. Identifying these colonization strategies and their cognate expression patterns involves a ,deconstruction' process that combines bioinformatics analysis and in vitro DNA array experimentation. [source] Evidence of alarm pheromones in the venom of Polistes dominulus workers (Hymenoptera: Vespidae)PHYSIOLOGICAL ENTOMOLOGY, Issue 3 2006CLAUDIA BRUSCHINI Abstract The active and coordinating capacity of defending the nest is a key feature of social insects. The present study investigates the presence of alarm pheromones in the venom of workers of the social wasp, Polistes dominulus. Laboratory experiments were performed with caged colonies of P. dominulus using a wind tunnel apparatus to test the behavioural response of workers to venom released by other workers and to venom extracts. Contrary to that previously reported for European paper wasps, the present results show that the venom is the source of alarm pheromones. Field experiments combining a visual (black target) and a chemical stimulus (venom extract) were performed to test the effect of the venom on the reaction of colonies. Wasps leave the nest, land on the visual target and attack the target significantly more once exposed to venom extract plus target than to solvent plus target. This work shows that the venom of P. dominulus workers elicits an alarm response, reduces the threshold for attack and acts as an attractant on targets. These results using P. dominulus indicate that, in both American and European species, colony defence is based on the same features, suggesting that chemical alarm is a widespread trait in the genus Polistes. [source] The difficulty with experience: Does practice increase susceptibility to premature closure?THE JOURNAL OF CONTINUING EDUCATION IN THE HEALTH PROFESSIONS, Issue 3 2006Kevin W. Eva PhD Abstract Introduction: A recent review of the physician performance literature concluded that the risk of prematurely closing one's diagnostic search increases with years of experience. To minimize confounding variables and gain insight into cognitive issues relevant to continuing education, the current study was performed to test this conclusion. Methods: Physician participants were shown a series of case histories and asked to judge the probability of a pair of diagnoses. The order in which features were presented was manipulated across participants and the probabilities compared to determine the impact of information order. Two groups of participants were recruited, 1 older than and 1 younger than 60 years. Results: The probability assigned to a diagnosis tended to be greater when features consistent with that diagnosis preceded those consistent with an alternative than when the same features followed those consistent with the alternative. Older participants revealed a greater primacy effect than less experienced participants across 4 experimental conditions. Discussion: Physicians with greater experience appear to weigh their first impressions more heavily than those with less experience. Educators should design instructional activities that account for experience-specific cognitive tendencies. [source] 100 Years On: Who are the Inheritors of the ,New Liberal' Mantle?THE POLITICAL QUARTERLY, Issue 1 2007ALISON HOLMES The ,great divorce' of progressive politics at the end of the nineteenth century permanently altered British politics. While the philosophies of the Labour movement and the Liberal Party had many common elements, ideologically they diverged on issues of the role of liberty and the state in relation to the individual and the community to the point that they became irreconcilable. New Liberalism was one result of that debate. Contemporary political debate reflects many of the same features as the turmoil present a century ago, and the Labour Party and the Liberal Democrats are again contesting much of the same ground. This article seeks to draw out the salient aspects of this debate to conclude which, if either, party is the inheritor of the New Liberal tradition. [source] Long-term effects of stapled haemorrhoidectomy on internal anal function and sensitivity,BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 11 2001Dr D. F. Altomare Background: Stapled haemorrhoidectomy is gaining wide acceptance but there is still some concern about the risk of injury to the internal anal sphincter (IAS). IAS function and morphology, and anal canal sensitivity were studied prospectively in patients undergoing this operation. Methods: Twenty patients (11 women; mean age 43 years) with stage III haemorrhoids entered the study. All underwent preoperative anorectal manometry, rectoanal inhibitory reflex (RAIR) testing and three-dimensional transanal ultrasonography. A test of anal sensation was administered to evaluate ability to discriminate between air and warm water. All the investigations were repeated 6 months after the operation. Results: The mean(s.d.) maximal resting pressure was 87(30) mmHg before surgery and 81(20) mmHg afterwards (P not significant). The maximal squeeze pressure did not change after operation (178(43) versus 174(60) mmHg). The RAIR showed the same features in 19 of 20 patients before and 18 of 20 after operation. Three-dimensional ultrasonography demonstrated no changes in the width of the IAS (mean(s.d.) 2·1(4) mm before and 2·1(3) mm after surgery). The ability of the anal mucosa to discriminate air from warm water improved in five patients. Continence scores did not differ significantly after 6 months. Conclusion: Stapled haemorrhoidectomy does not affect the function and morphology of the IAS in the long term. The sensitivity of the anal canal can improve in patients with preoperative sensory impairment. © 2001 British Journal of Surgery Society Ltd [source] Hereditary diffuse gastric cancer: A manifestation of lost cell polarityCANCER SCIENCE, Issue 7 2009Bostjan Humar Hereditary diffuse gastric cancer is a cancer syndrome caused by germline mutations in the gene for the cell adhesion protein E-cadherin (CDH1). E-cadherin plays a central role in the maintenance of cell polarity and its loss during tumorigenesis is associated with poorly differentiated cancers and a poor prognosis. Hereditary diffuse gastric cancer is dominated by diffuse-type gastric adenocarcinoma, often with signet ring cell morphology. Large numbers of stage T1a signet ring cell carcinomas exist in the stomachs of CDH1 mutation carriers from a young age, and these foci sometimes show enrichment to the transition zone between the body and antrum. Generally these signet ring cell carcinomas are hypoproliferative, lack Wnt pathway activation, and are relatively indolent. However, a small proportion of the T1a foci contain cells that are poorly differentiated, display mesenchymal features, and express activated c-Src and its downstream targets. These same features are observed in more advanced stages of hereditary diffuse gastric cancer progression, suggesting that an epithelial,mesenchymal transition is required for tumor invasion beyond the muscularis mucosae. Hereditary diffuse gastric cancer initiation requires somatic down-regulation of the second CDH1 allele, which in most cases is caused by DNA promoter hypermethylation. Subsequent to CDH1 down-regulation, lost polarity in gastric stem or progenitor cells would be predicted to interfere with mitotic spindle orientation and the segregation of cell fate determinants. We predict that this disruption of cell division results in daughter cells being deposited in the lamina propria where their population expands and partially differentiates, resulting in the formation of foci of signet ring cells. (Cancer Sci 2009; 100: 1151,1157) [source] CD1a expression defines an interleukin-12 producing population of human dendritic cellsCLINICAL & EXPERIMENTAL IMMUNOLOGY, Issue 3 2009M. Cernadas Summary Human and murine dendritic cell (DC) subsets are often defined by phenotypic features that predict their functional characteristics. In humans and mice, DC have been shown to have the ability to polarize naive CD4 T cells to a T helper type 1 (Th1) or Th2 phenotype. However, human myeloid DC generated from monocytes (monocyte-derived DC) have often been regarded as a homogeneous population, both phenotypically and functionally. Monocytes give rise to subpopulations of DC in vitro that can be separated on the basis of their expression of CD1a, a well-described DC subset marker. Importantly, we show that the CD1a+ DC subset produces significant quantities of interleukin-12p70 (IL-12p70) upon stimulation and, similar to the murine CD8,+ DC subset, can polarize naive CD4+ T cells to a Th1 phenotype. In contrast, CD1a, DC, similar to murine CD8,, DC, do not produce significant amounts of IL-12p70 upon stimulation or polarize T cells to a Th1 phenotype. Like monocyte-derived DC, CD1a+ and CD1a, DC subsets obtained from CD34+ haematopoietic progenitors under distinct culture conditions were found to have these same features, suggesting that CD1a expression is a marker for myeloid DC that are a major source of IL-12 and Th1 CD4+ T cell polarization in man. [source] | ||||||||||||||||||||||