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Selected AbstractsAttachment and sensitivity in family context: the roles of parent and infant genderINFANT AND CHILD DEVELOPMENT, Issue 4 2006Sarah J. Schoppe-Sullivan Abstract This study examined the role of child gender in fathers' and mothers' sensitivity to and attachment relationships with their infants from a family systems perspective. Eighty-seven 1-year-olds participated in the Strange Situation with each parent. Parental sensitivity was examined during a competing demands task. Results indicated that fathers and mothers were equally sensitive to sons, but fathers were less sensitive than mothers to daughters, and mothers were more sensitive to daughters than to sons. Although mothers and fathers within the same families were similarly sensitive to daughters and sons, daughters' attachment security with fathers and mothers was similar whereas sons' was not. Further analyses revealed that fathers were more sensitive to sons with an insecure relationship with their mothers. Results of this investigation suggest that child gender is relevant for parent,infant, especially father,infant, attachment relationships. Copyright © 2006 John Wiley & Sons, Ltd. [source] Social dynamics and individual plasticity of infant care behavior in cooperatively breeding cotton-top tamarinsAMERICAN JOURNAL OF PRIMATOLOGY, Issue 4 2010Sofia Refetoff Zahed Abstract Individual variation in infant caretaking behavior is prevalent among marmoset and tamarin monkeys. Although most group members participate in infant care, the timing and amount provided differs greatly. In this study, we quantified general trends in infant carrying behavior by using a longitudinal database that included 11 years of instantaneous scan observations following 80 births of cotton-top tamarins. Using detailed focal observations on a subset of the same families (10 births) we identified influences that affected expression of infant care at the group and individual levels. Fathers were the primary carriers and paternal carry time gradually decreased with increasing infant age. Paternal carry time also decreased significantly with an increasing number of older sibling helpers. Most fathers began to carry on the first day postpartum. However, we report circumstances in which fathers delayed carrying until almost a month postpartum. Fathers retrieved infants the most, although adult brothers' rates of retrievals peaked and surpassed fathers' rates during week 4 postpartum. Fathers delayed rejection of infants until week 4, whereas mothers rejected infants immediately and throughout the eight weeks. Nonetheless, infants climbed onto their mothers more than onto any other family member. Mothers showed a high initial investment in carrying during the first two weeks, decreasing quickly thereafter. Maternal contributions to infant carrying remained low and relatively consistent regardless of group size. However, mothers dramatically increased their infant carrying behavior in families in which fathers were absent. Older siblings cared for infants more than did younger siblings, and brothers retrieved and carried infants more than did sisters. Individual expression of infant care changed to accommodate infant needs and changed according to varying social dynamics and circumstances across litters. Am. J. Primatol. 72:296,306, 2010. © 2009 Wiley-Liss, Inc. [source] Age-dependent quantitative trait loci affecting growth traits in Scottish Blackface sheepANIMAL GENETICS, Issue 2 2009G. Hadjipavlou Summary To dissect age-dependent quantitative trait loci (QTL) associated with growth and to examine changes in QTL effects over time, the Gompertz growth model was fitted to longitudinal live weight data on 788 Scottish Blackface lambs from nine half-sib families. QTL were mapped for model parameters and weekly live weights and growth rates using microsatellite markers on chromosomes 1, 2, 3, 5, 14, 18, 20 and 21. QTL significance (using , = 0.05 chromosome-wide significance thresholds, unless otherwise stated) varied with age, and those for growth rate occurred earlier than equivalent QTL for live weight. A chromosome 20 QTL for growth rate was significant from 4 to 9 weeks (maximum significance at 6 weeks) and for maximum growth rate. For live weight, this QTL was significant from 8 to 16 weeks (maximum significance at 12 weeks). A nominally significant chromosome 14 QTL was detected for growth rates from birth to week 2 in the same families and location as an 8-week weight QTL. In addition, at the same position on chromosome 14, a QTL was significant for growth rate for 17,28 weeks (maximum significance at 24 weeks). A chromosome 3 QTL was significant for weights at early ages (birth to week 4) and a growth rate QTL on chromosome 18 was significant from 8 to 12 weeks. Fitting growth curves allowed the combination of information from multiple measurements into a few biologically meaningful variables, and the detection of growth QTL that were not observed from analyses of raw weight data. These QTL describe distinct parts of an animal's growth curve trajectory, possibly enabling manipulation of this trajectory. [source] Invasive Africanized honey bee impact on native solitary bees: a pollen resource and trap nest analysisBIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 1 2009DAVID W. ROUBIK Little is known of the potential coevolution of flowers and bees in changing, biodiverse environments. Female solitary bees, megachilids and Centris, and their nest pollen provisions were monitored with trap nests over a 17-year period in a tropical Mexican biosphere reserve. Invasion by feral Apis (i.e. Africanized honey bees) occurred after the study began, and major droughts and hurricanes occurred throughout. Honey bee competition, and ostensibly pollination of native plants, caused changes in local pollination ecology. Shifts in floral hosts by native bees were common and driven by plant phylogenetics, whereby plants of the same families or higher taxa were substituted for those dominated by honey bees or lost as a result of natural processes. Two important plant families, Anacardiaceae and Euphorbiaceae, were lost to competing honey bees, but compensated for by greater use of Fabaceae, Rubiaceae, and Sapotaceae among native bees. Natural disasters made a large negative impact on native bee populations, but the sustained presence of Africanized honey bees did not. Over 171 plant species comprised the pollen diets of the honey bees, including those most important to Centris and megachilids (72 and 28 species, respectively). Honey bee pollination of Pouteria (Sapotaceae) plausibly augmented the native bees' primary pollen resource and prevented their decline. Invasive generalist pollinators may, however, cause specialized competitors to fail, especially in less biodiverse environments. No claim to original US government works. Journal compilation © 2009 The Linnean Society of London, Biological Journal of the Linnean Society, 2009, 98, 152,160. [source] Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain,CYTOSKELETON, Issue 5 2010E. Le Goff Abstract Recent evidences suggest that plastin/fimbrin is more than a simple actin cross-linking molecule. In this context and based on the fact that other members of the same family interact with transmembrane proteins, such as integrins, we have investigated a possible interaction between L-plastin and integrins. By combining coimmunoprecipitation of endogenous proteins and in vitro techniques based on solid phase and solution assays, we demonstrate that L-plastin is an additional binding partner for the ,-chain of integrin and confirmed that both proteins display some colocalization. We then show that L-plastin binds to the cytoplasmic domain of ,1 integrin and to ,1 and ,2 peptides. Using recombinant L-plastin domains, we demonstrate that the integrin-binding sites are not located in NH2 terminal part of L-plastin but rather in the two actin-binding domains. Using pull-down, cross-linking experiments, and enzyme-linked immunosorbent assay, we show that the L-plastin/integrin complex is regulated by ,-calpain cleavage and is not directly dissociated by calcium. Indeed, despite the ability of calpain to cleave both proteins, only the cleavage of , integrin hindered the formation of the L-plastin/integrin complex. We discuss these results in the light of the three-dimensional structure of the actin-binding domains of L-plastin. © 2010 Wiley-Liss, Inc. [source] Bves expression during avian embryogenesisDEVELOPMENTAL DYNAMICS, Issue 3 2004Megan E. Osler Abstract Bves (blood vessel/epicardial substance) is a transmembrane protein postulated to play a role in cell adhesion. While it is clear that Bves and gene products of the same family are expressed in adult striated muscle cells, the distribution of these proteins during development has not been critically examined. An understanding of the expression pattern of Bves is essential for a determination of protein function and its role in embryogenesis. In this study, we present an expression analysis of Bves during chick gastrulation and germ layer formation. Our data show that Bves is expressed in epithelia of all three germ layers early in development. Furthermore, Bves protein is observed in epithelial tissues during organogenesis, specifically the developing epidermis, the gut endoderm, and the epicardium of the heart. These data support the hypothesis that Bves may play a role in cell adhesion and movement of epithelia during early embryogenesis. Developmental Dynamics 229:658,667, 2004. © 2004 Wiley-Liss, Inc. [source] Alien spider introductions to Europe supported by global tradeDIVERSITY AND DISTRIBUTIONS, Issue 2 2008Manuel Kobelt ABSTRACT Global trade is permanently ongoing and increases its volume every year. In this study, the occurrence of 87 unintentionally introduced spider species alien to Europe is analysed. The analysis includes (1) the introduction potential of six different origin areas of the world according to trade volume, area size, and geographical distance; (2) the body size of native and alien species; and (3) occurrence in or at buildings (synanthropic) or in natural habitats. We found the eastern Palearctic as the most influencing origin area with 44 introduced spider species to Europe. The eastern Palearctic and the Indomalayan provided a significantly higher number of introductions than expected, whereas the Nearctic, Neotropical, and Afrotropical provided a significantly lower number of introduced species than expected. This can be explained with their lower trade volume, smaller area, larger geographical distance to Europe, and stronger climate differences to Europe. Comparing the body size of introduced and native European spider species of the same family, we found for Theridiidae significantly larger alien spiders and for all other tested families a trend to a larger body size of alien species compared to the native spiders. The family affiliation of alien spiders is the most important factor for synanthropic occurrence in Europe. On the base of a very conservative estimation of spider species introductions to Europe combined with possible effects of climate change, we predict for the near future a permanent increase in the number of alien spider species in Europe. [source] Familial partial epilepsy with variable foci: A new family with suggestion of linkage to chromosome 22q12EPILEPSIA, Issue 9 2010José Morales-Corraliza Summary Familial partial epilepsy with variable foci (FPEVF) is an autosomal dominant form of partial epilepsy characterized by the presence of epileptic seizures originating from different cerebral lobes in different members of the same family. Linkage to chromosomes 22q12 and 2q36 has been reported, although only six families have been published. We studied a new FPEVF family including nine affected individuals. The phenotype in this family was similar to that previously described and consisted of nocturnal and daytime seizures with semiology suggesting a frontal lobe origin. A video-EEG (electroencephalography) recording of the proband's seizures is presented and revealed hyperkinetic seizures of frontal lobe origin preceded by left frontal spikes. We excluded linkage to chromosome 2q36 and found a suggestion of linkage to chromosome 22q12 with a lod score of 2.64 (, = 0) for marker D22S689. [source] POSTMATING SEXUAL SELECTION: ALLOPATRIC EVOLUTION OF SPERM COMPETITION MECHANISMS AND GENITAL MORPHOLOGY IN CALOPTERYGID DAMSELFLIES (INSECTA: ODONATA)EVOLUTION, Issue 2 2004A. Cordero Rivera Abstract Postmating sexual selection theory predicts that in allopatry reproductive traits diverge rapidly and that the resulting differentiation in these traits may lead to restrictions to gene flow between populations and, eventually, reproductive isolation. In this paper we explore the potential for this premise in a group of damselflies of the family Calopterygidae, in which postmating sexual mechanisms are especially well understood. Particularly, we tested if in allopatric populations the sperm competition mechanisms and genitalic traits involved in these mechanisms have indeed diverged as sexual selection theory predicts. We did so in two different steps. First, we compared the sperm competition mechanisms of two allopatric populations of Calopteryx haemorrhoidalis (one Italian population studied here and one Spanish population previously studied). Our results indicate that in both populations males are able to displace spermathecal sperm, but the mechanism used for sperm removal between both populations is strikingly different. In the Spanish population males seem to empty the spermathecae by stimulating females, whereas in the Italian population males physically remove sperm from the spermathecae. Both populations also exhibit differences in genital morphometry that explain the use of different mechanisms: the male lateral processes are narrower than the spermathecal ducts in the Italian population, which is the reverse in the Spanish population. The estimated degree of phenotypic differentiation between these populations based on the genitalic traits involved in sperm removal was much greater than the differentiation based on a set of other seven morphological variables, suggesting that strong directional postmating sexual selection is indeed the main evolutionary force behind the reproductive differentiation between the studied populations. In a second step, we examined if a similar pattern in genital morphometry emerge in allopatric populations of this and other three species of the same family (Calopteryx splendens, C. virgo and Hetaerina cruentata). Our results suggest that there is geographic variation in the sperm competition mechanisms in all four studied species. Furthermore, genitalic morphology was significantly divergent between populations within species even when different populations were using the same copulatory mechanism. These results can be explained by probable local coadaptation processes that have given rise to an ability or inability to reach and displace spermathecal sperm in different populations. This set of results provides the first direct evidence of intraspecific evolution of genitalic traits shaped by postmating sexual selection. [source] Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37RvFEBS JOURNAL, Issue 1 2009Md. Suhail Alam The whiB -like genes (1-7) of Mycobacterium tuberculosis are involved in cell division, nutrient starvation, pathogenesis, antibiotic resistance and stress sensing. Although the biochemical properties of WhiB1, WhiB3 and WhiB4 are known, there is no information about the other proteins. Here, we elucidate in detail the biochemical and biophysical properties of WhiB2, WhiB5, WhiB6 and WhiB7 of M. tuberculosis and present a comprehensive comparative study on the molecular properties of all WhiB proteins. UV,Vis spectroscopy has suggested the presence of a redox-sensitive [2Fe,2S] cluster in each of the WhiB proteins, which remains stably bound to the proteins in the presence of 8 m urea. The [2Fe,2S] cluster of each protein was oxidation labile but the rate of cluster loss decreased under reducing environments. The [2Fe,2S] cluster of each WhiB protein responded differently to the oxidative effect of air and oxidized glutathione. In all cases, disassembly of the [2Fe,2S] cluster was coupled with the oxidation of cysteine-thiols and the formation of two intramolecular disulfide bonds. Both CD and fluorescence spectroscopy revealed that WhiB proteins are structurally divergent members of the same family. Similar to WhiB1, WhiB3 and WhiB4, apo WhiB5, WhiB6 and WhiB7 also reduced the disulfide of insulin, a model substrate. However, the reduction efficiency varied significantly. Surprisingly, WhiB2 did not reduce the insulin disulfide, even though its basic properties were similar to those of others. The structural and functional divergence among WhiB proteins indicated that each WhiB protein is a distinguished member of the same family and together they may represent a novel redox system for M. tuberculosis. [source] Purification and cDNA cloning of nitric oxide reductase cytochrome P450nor (CYP55A4) from Trichosporon cutaneumFEBS JOURNAL, Issue 11 2001Li Zhang Cytochrome P450nor is involved in fungal denitrification as nitric oxide (NO) reductase. Although the heme protein has been known to occur in restricted species of fungi that belong to ascomycotina, we have previously suggested that it would also occur in the yeast Trichosporon cutaneum, which is phylogenetically far from those P450nor-producing ascomycetous fungi. Here we isolated and characterized the heme protein from the basidiomycetous yeast T. cutaneum. P450nor of the yeast (TcP450nor) exhibited properties in terms of catalysis, absorption spectrum and molecular mass that are almost identical to those of its counterparts in ascomycetous fungi. We also isolated and sequenced its cDNA. The predicted primary structure of TcP450nor showed high sequence identities (around 65%) to those of other P450nors, indicating that they belong to the same family. TcP450nor protein cofractionated with cytochrome c oxidase by subcellular fractionation and its predicted primary structure contained an extension on its amino terminus that is characteristic of a mitochondrial-targeting signal, indicating that it is a mitochondrial protein like some of the isoforms of other fungi. On the other hand, TcP450nor was unique in that inducers such as nitrate, nitrite, or NO were not required for its production in the cells. The occurrence of P450nor across the subdivisions of eumycota suggests that P450nor and denitrification are distributed more universally among fungi than was previously thought. [source] The mechanism of emergenesisGENES, BRAIN AND BEHAVIOR, Issue 4 2006D. T. Lykken Since each individual produced by the sexual process contains a unique set of genes, very exceptional combinations of genes are unlikely to appear twice even within the same family. E. O. Wilson (1978) The intraclass correlations of monozygotic twins who were separated in infancy and reared apart (MZA twins) provide estimates of trait heritability, and the Minnesota Study of Twins Reared Apart [MISTRA: Bouchard et al. (1990), The sources of human psychological differences: the Minnesota study of twins reared apart, Science 250, 223,228] has demonstrated that MZA pairs are as similar in most respects as MZ pairs reared together. Some polygenic traits,e.g. stature, IQ, harm avoidance, negative emotionality, interest in sports,are polygenic-additive, so pairs of relatives resemble one another on the given trait in proportion to their genetic similarity. But the existence and the intensity of other important psychological traits seem to be emergent properties of gene configurations (or configurations of independent and partially genetic traits) that interact multiplicatively rather than additively. Monozygotic (MZ) twins may be strongly correlated on such emergenic traits, while the similarity of dizygotic (DZ) twins, sibs or parent,offspring pairs may be much less than half that of MZ pairs. Some emergenic traits, although strongly genetic, do not appear to run in families. MISTRA has provided at least two examples of traits for which MZA twins are strongly correlated, and DZA pairs correlate near zero, while DZ pairs reared together (DZTs) are about half as similar as MZTs. These findings suggest that even more traits may be emergenic than those already identified. Studies of adoptees reared together (who are perhaps more common than twins reared apart) may help to identify traits that are emergenic, but that also are influenced by a common rearing environment. [source] Homoclinic bifurcation and global indeterminacy of equilibrium in a two-sector endogenous growth modelINTERNATIONAL JOURNAL OF ECONOMIC THEORY, Issue 1 2009Paolo Mattana C62; E32; O41 This paper considers an endogenous growth model that belongs to the same family as the Lucas model. In the Lucas model an external effect appears in the physical-goods sector, whereas in our model, it appears in the educational sector. In our model, this external effect yields multiple balanced growth paths. Our model undergoes a homoclinic bifurcation and exhibits global indeterminacy of equilibrium. [source] Observer variance within families: confluence among maternal, paternal and child ratingsINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 1 2001Dr Anne I.H. Borge Abstract This paper examines patterns of agreement among different informants within the same family in order to determine the effects of maternal distress on the ratings of mothers and fathers. Mothers, fathers and children from a community cohort of 216 families with 13 to 15 years olds reported children's difficulties and strengths measured by the Rutter Revised Scale. The absolute scores on the children's ratings were higher than those of the fathers and mothers. The odds ratios for agreements between fathers and children ranged between 1.70 and 4.01 and for mother-child agreement between 0.83 and 3.40. There were no significant differences between the mothers and fathers in the extent of their agreement with their children. When mothers were emotionally distressed, there was a significantly higher level of emotional disturbance in the children according to the ratings of both mothers and fathers, but not according to children's ratings. There is value in obtaining paternal, as well as maternal and child, ratings of children's behaviour. Maternal distress affects the ratings of both parents, but not those of the children; the reasons for these effects require further study but they cannot be assumed to reflect rating bias. Copyright © 2001 Whurr Publishers Ltd. [source] Having a child with asthma,Quality of life for Jordanian parentsINTERNATIONAL JOURNAL OF NURSING PRACTICE, Issue 6 2009Nemeh Al-Akour DSN This study was conducted to assess the quality of life (QoL) of Jordanian parents of children with asthma and its associated factors. Three hundred and twenty-six parents of 200 children participated in the study. The Pediatric Asthma Caregivers' Quality of Life Questionnaire (PACQLQ) was used to measure how parents of children with asthma disease impaired their daily life during the previous week on two domains ,activity limitations' and ,emotional function'. In this study, parents of children with asthma scored their QoL during the past week moderately to the positive end of the scale but they scored more limitations in the domain of activities than in emotions. Parents in the same family scored activity domain fairly similar and there was a significant difference in their scoring of total emotional function. Parents with older children, living in the rural areas, mothers of children with mild asthma were associated with higher QoL. Children received needed daily asthma medication during the preceding week. Asthma medication might mean to the parents that the child was getting the best possible treatment. Further studies to identify the factors that influence QoL of parents of children with asthma in Jordan are needed. [source] Null model analysis of communities on gradientsJOURNAL OF BIOGEOGRAPHY, Issue 6 2004James G. Sanderson Abstract Aim, I employed a novel null model and metric to uncover unusual species co-occurrence patterns in a herpetofaunal assemblage of 49 species collected at discrete elevations along a gradient. Location, Mount Kupe, Cameroon. Methods, Using a construction algorithm that started from a matrix of 0s, a sample null space of 25,000 unique null matrices was generated by simultaneously conserving (1) the number of occurrences of each species, (2) site richness and (3) species range spans derived from the observed incidence matrix. I then compared the number of times each pair of confamilial species co-occurred in the null space with the same number derived from the observed incidence matrix. Two cases dealing with embedded absences in species ranges were tested: (1) embedded absences were maintained, and (2) embedded absences were assumed to be sampling omissions and were replaced by presences. Results, In the observed absence/presence assemblage there were 147 possible confamilial species pairs. Therefore, 5% or eight were expected by chance alone to have co-occurrence patterns that differed from chance expectations by chance alone. Of these confamilial species pairs, 38 were congeneric and so 5% or two were expected to differ from chance expectations. For case (1) 16, and for case (2) 17 confamilial species pairs' co-occurrence patterns differed significantly from chance expectations. For case (1) nine congeneric species pairs, and for case (2) 10 congeneric pairs differed significantly from chance expectations. For case (1) four, and for case (2) five congeneric species pairs formed checkerboards (patterns of mutual exclusion). Results from case (1) were a proper subset of case (2) indicating that sampling omissions did not alter greatly the results. Main conclusions, I have demonstrated that null models are valuable tools to analyse ecological communities provided that proper models are employed. The choice of the appropriate null space to analyse distributions is critical. The null model employed to analyse birds on islands of an archipelago can be adapted to analyse species along gradients provided an additional range constraint is added to the null model. Moreover, added precision to results can be obtained by analysing each species pair separately, particularly those in the same family or genus, as opposed to applying a community-wide metric to the faunal assemblage. My results support some of the speculations of previous authors who were unable to demonstrate their suspicions analytically. [source] Creole Materialities: Archaeological Explorations of Hybridized Realities on a North American PlantationJOURNAL OF HISTORICAL SOCIOLOGY, Issue 1 2010STEPHEN A. MROZOWSKI This paper explores the hybridized realities of European, Native American and Afro-Caribbean/Afro-American residents of Sylvester Manor, New York and Constant Plantation, Barbados during the seventeenth century. It draws on archaeological and landscape evidence from two plantations that were owned and operated by different members of the same family during the seventeenth century. One of plantations, known as Sylvester Manor, encompassed all 8,000 acres of Shelter Island, New York. It was established in 1652 primarily to help in the provisioning of two large sugar plantations on Barbados, Constant and Carmichael plantations. Sylvester Manor was operated by Nathaniel Sylvester; an Englishman who spent the first twenty years of life living in Amsterdam where his father was a merchant. Constant and Carmichael plantations were operated by his brother Constant Sylvester. Both the Barbados and New York plantations relied upon a labor force of enslaved Afro-Caribbean's. Archaeological evidence from Sylvester Manor has also revealed that Native American laborers played a prominent role in the daily activities of this northern plantation. Material and landscape evidence reveal the construction of hybridized identities that in the case of Barbados, are still part of the fabric of a postcolonial reality. Evidence from Sylvester Manor provides detailed insights into the construction of hybridized identities under the exigencies of a plantation economy whose global connections are dramatically visible in the archaeological record. [source] The More the Merrier?JOURNAL OF MARRIAGE AND FAMILY, Issue 1 2009Multiple Parent-Adult Child Relations Although parent-adult child ties are generally positive, most parents have multiple children whose relations may yield collective ambivalence combining higher and lower quality. Little research has investigated these multiple relations. NSFH respondents aged 50+ with adult children (N = 2,270) are used to assess patterns of quality and contact across multiple children in the same family. This illuminates mixed experiences, especially for lowest quality and contact across children, contributing to collective ambivalence in parent-adult child relations within families. Having more children increases prevalence of both positive and negative relations. Stepchildren exhibit more negative relations than nonstepchildren, even in the same family. Mothers have more positive but not more negative relations than fathers, but mothers have more negative relations with stepchildren. [source] Formation of complexes between uracil and calcium ions: an ESI/MS/MS study in combination with theoretical calculationsJOURNAL OF MASS SPECTROMETRY (INCORP BIOLOGICAL MASS SPECTROMETRY), Issue 5 2009Emilie-Laure Zins Abstract Cationized uracil clusters around calcium metal ions were generated in the gas phase by electrospray ionization (ESI). A previous study showed that with particular experimental conditions, hexamer, octamer, decamer, dodecamer and tetradecamer uracil clusters are present in high quantities. New experiments were carried out to understand the reasons for the particular stability of these complexes. MS/MS experiments suggested that these uracil clusters belong to the same family. Based on ab initio and DFT quantum chemistry calculations, structures in agreement with experimental results are proposed for these clusters. Copyright © 2009 John Wiley & Sons, Ltd. [source] Cannabinoid,vanilloid receptor interactions in pain signalingJOURNAL OF NEUROCHEMISTRY, Issue 2003V. Di Marzo Agents that activate cannabinoid CB1 receptors for marijuana's active principal, THC, or vanilloid VR1 receptors for red chilli peppers' pungent ingredient, capsaicin, modulate pain perception. Stimulation of presynaptic CB1 leads to inhibition of glutamate release in the spinal cord, whereas VR1 stimulation causes release of substance P and CGRP from DRG neurons. VR1 undergoes rapid desensitization by its agonists, which makes VR1-expressing neurons insensitive to subsequent stimulation and results in analgesia. Thus, both CB1 and VR1, which are coexpressed in several spinal and DRG neurons, are targets for analgesic drug development. CB1 and VR1 also share endogenous agonists, namely anandamide, NADA and some of their analogs, and may be regarded as metabotropic and ionotropic receptors for the same family of mediators, with opposing roles in pain perception. The development of ,hybrid' CB1/VR1 agonists as potent analgesics and the functional relationships between CB1 and VR1 in sensory neurons will be discussed. [source] Alveolar capillary dysplasia with antenatal anomalies mimicking trisomy 21JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 1 2001J. McGaughran Abstract: Alveolar capillary dysplasia (ACD) has been described in conjunction with a number of congenital abnormalities. The case reported here was noted in utero to have duodenal atresia and a partial atrioventricular canal defect and a provisional diagnosis of trisomy 21 was considered. A fetal blood sample showed a normal karyotype. The diagnosis of ACD was made at post-mortem following a neonatal death on the tenth day. This case further highlights the range of congenital abnormalities that may be present in cases of ACD that may mimic other conditions, including trisomy 21, on antenatal scan. However, the absence of congenital anomalies, even in the same family, would not exclude the diagnosis of ACD. [source] Amitriptyline has a dual effect on the conductive properties of the epithelial Na channelJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 10 2002Florentina Pena This study was undertaken with the aim of testing the action of amitriptyline on the epithelial Na channel (ENaC), which belongs to the same family (Deg/ENaC) as ASICs (acid-sensing ion channels) and many other putative members in the brain. We assumed that, having a common protein structure, characterization of the amitriptyline-ENaC interaction could help to elucidate the analgesic mechanism of this tricyclic antidepressant. Na-channel characteristics were derived from the analysis of blocker-induced lorentzian noise produced by amiloride. The effect of amitriptyline, present in the mucosal bathing solution, on the transepithelial short-circuit current (1sc) and conductance (Gt), and on the blocker-induced noise of apical Na channels, was studied on isolated ventral skin of the frog Rana ridibunda. Amitriptyline exerted a dual effect on the macroscopic short-circuit current and conductance of the epithelia, increasing these two parameters in the concentration range 0.1,50 ,M, while at higher concentrations (100,1000 ,M) it showed an inhibitory action. The decrease in the association rate (k01) of amiloride to the apical Na channels from 15.6 ± 4.2 ,M,1 S,1 in control Cl-Ringer to 7.4 ± 1.7 ,M,1 S,1 at 200 ,M amitriptyline in a concentration-dependent manner suggests a competitive binding of amitriptyline to the pyrazine ring binding site for amiloride. [source] The Role of Family Ties in the Labour Market.LABOUR, Issue 4 2001An Interpretation Based on Efficiency Wage Theory By casual empiricism, it seems that many firms take explicit account of the family ties connecting workers, often hiring individuals belonging to the same family or passing jobs on from parents to their children. This paper makes an attempt to explain this behaviour by introducing the assumption of altruism within the family and supposing that agents maximize a family utility function rather than an individual one. This hypothesis has been almost ignored in the analysis of the relationship between employers and employees. The implications of this assumption in the efficiency wage models are explored: by employing members of the same family, firms can use a (credible) harsher threat , involving a sanction for all the family's members in case of one member's shirking , that allows them to pay a lower efficiency wage. On the other hand, workers who accept this agreement exchange a reduction in wage with an increase in their probability of being employed: this can be optimal in a situation of high unemployment. Moreover, the link between parents and children allows the firm to follow a strategy that solves the problem of an individual's finite time horizon by its making use of the family's reputation. [source] Complete assignment of the 1H and 13C NMR spectra of garciniaphenone and keto-enol equilibrium statements for prenylated benzophenonesMAGNETIC RESONANCE IN CHEMISTRY, Issue 3 2008Priscilla B. M. C. Derogis Abstract This article reports the structural elucidation by IR, UV and MS spectroscopic data along with 1H and 13C NMR chemical shift assignments of two benzophenones isolated from the fruit pericarp of Garcinia brasiliensis Mart. (Clusiaceae): garciniaphenone, (1R,5S,7S)-3-benzoyl-4-hydroxy-6,6-dimethyl-5,7-di(3-methyl-2-butenyl)bicyclo[3.3.1]non-3-ene-2,9-dione, a novel triprenylated benzophenone; and 7- epi -clusianone, a tetraprenylated benzophenone that has already been extracted from another species of the same family. Furthermore, the keto-enol tautomeric equilibrium at solution-state was described for these compounds by 1D and 2D NMR spectral methods and one attempt to rationalize the different ratios between the noted tautomers was based on stereochemical features. Copyright © 2008 John Wiley & Sons, Ltd. [source] Development of eight microsatellite markers in the parsley frog (Pelodytes punctatus)MOLECULAR ECOLOGY RESOURCES, Issue 1 2009HELENE JOURDAN-PINEAU Abstract We characterized eight microsatellite loci to study spatial and temporal population structure of Pelodytes punctatus, a European anuran that has a peculiar breeding pattern among amphibians. The eight loci proved to be highly polymorphic with the number of alleles per locus ranging from two to 15 within two populations. Cross-amplification indicates that those markers may be also useful for closely related species from the same family. [source] Isolation and characterization of microsatellite markers in Koompassia malaccensis (Leguminosae), an important tropical timber speciesMOLECULAR ECOLOGY RESOURCES, Issue 4 2006C. T. LEE Abstract This paper reports the isolation and characterization of 24 polymorphic microsatellite markers in an important tropical timber species, Koompassia malaccensis (Leguminosae). The primers were designed from a genomic library enriched for dinucleotide (CT) repeats and screened on 24 samples from a natural population. The number of alleles detected per locus ranged from two to 13 while the observed heterozygosity ranged from 0.042 to 1.000. Significant departure from Hardy,Weinberg equilibrium (P < 0.05) was detected in two loci. These microsatellite markers were tested across 13 timber species of the same family. The amplification success appeared to be associated with taxonomy classification at the genus but not subfamily levels. [source] Silicified Upper Ordovician trilobites from Pai-Khoi, Arctic RussiaPALAEONTOLOGY, Issue 6 2009ROBERT M. OWENS Abstract:, A collection of silicified trilobites extracted from samples obtained by F. Nansen from the Upper Ordovician of Khabarovo, Pai Khoi, Russian Arctic is dominated by two new species of the proetide Lasarchopyge, a genus known hitherto only from the Argentine Precordillera. Comparison of Lasarchopyge with Scharyia reveals a range of common characters that support inclusion of both genera in the same family. The rest of the fauna comprises a metagnostid (Trinodus elspethi), an asaphid (Isotelus sp.), two remopleuridids (Remopleurides cf. caelatus and R. sp. nov. A), an aulacopleurid (Harpidella triloba), a lichid and an odontopleurid (Apianurus cf. barbatus), the last two being represented by very fragmentary material. T. elspethi, H. triloba, R. cf. caelatus and A. cf. barbatus are common to or closely resemble taxa from the Edinburg Formation, Virginia. Closely related taxa are present also in the Esbataottine Formation, NW Territories, Canada, and in the Albany Group, Girvan district, Scotland. All of these occurrences are of early Caradoc (Sandbian) age, and most lay at palaeolatitudes of 20°,30° south; all are interpreted as having been deposited on the outer shelf, which is consistent with their distribution. [source] Antigenic cross-reactivity between different alleles of the Plasmodium falciparum merozoite surface protein 2PARASITE IMMUNOLOGY, Issue 11-12 2003Ingrid Felger SUMMARY The polymorphic domain of the gene encoding Plasmodium falciparum merozoite surface protein 2 (MSP2) was PCR amplified from blood of malaria patients, genotyped, and 19 distinct fragments were cloned and expressed in E. coli. The reactivity of naturally occurring antibodies against this panel of recombinant MSP2 antigens was tested using 67 homologous or heterologous sera from a serum bank of travel clinic patients. Sera from semi-immune individuals strongly recognized almost all recombinant antigens. Sera from primary infected patients either did not react at all (9 sera), or reacted weakly against varying numbers of antigens (39 sera). The antigens that showed reactions were mostly of the allelic family corresponding to the infecting clone, but in very few cases also of the alternative allelic family. Single clone infections and repeated samples from the same individual were analysed in greater detail. Thus, we were able to quantify cross-reactivity induced by a single P. falciparum infection. Within the two allelic families of MSP2, cross-reactivity was observed between some but not all alleles of the same family, whereas antibodies cross-reactive between variants belonging to different allelic families were detected in only a few cases. [source] Common variable immunodeficiency: 20-yr experience at a single centrePEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 2 2009Ma Pilar Llobet Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. It can present at any age in patients with a history of recurrent bacterial infections, with or without a family history of other primary immunodeficiencies (PID), and shows a wide range of clinical manifestations and immunological data. Diagnosis is based on low IgG, IgM and/or IgA levels. Delayed diagnosis and therapy can lead to bronchiectasis and malabsorption. The aim of this study was to describe a paediatric population diagnosed of CVID and its evolution in the population. Memory B-cell (MB) classification carried out in these patients was correlated with clinical manifestations and outcome. Clinical and immunological data of 22 CVID children under 18 yr treated at our centre between 1985 and 2005 are presented. Immunological studies included those for diagnosis and MB quantification. Differences in form of presentation, familial incidence and MB classification were reviewed. A statistical descriptive analysis was made. Infections were the commonest manifestation, affecting mainly respiratory (19/22) and gastrointestinal (10/22) tracts. Bronchiectasis was present in seven cases, and detected prior to CVID diagnosis in five. Replacement therapy led to a significant reduction in the number of infections. Severe complications appeared mostly in patients without MB. Patients of the same family share the same MB group. Family members had also been diagnosed of CVID in seven cases. Early diagnosis and therapy are essential to improve outcome in these patients. MB studies are useful in children to orient prognosis and further genetic studies. [source] Familial cases of Henoch-Schönlein purpura in eight familiesPEDIATRICS INTERNATIONAL, Issue 6 2005Osamu Motoyama AbstractBackground:,Familial cases of Henoch-Schönlein purpura (HSP) have rarely been reported. Methods:,Familial cases of HSP were reviewed by medical records of 418 children with HSP. Results:,Two members developed HSP in eight families. HSP occurred in a mother and her daughter in one family and in siblings, including one pair of twin sisters, in seven other families. Four pairs of patients developed HSP at the same age. Three pairs presented HSP within 1 month of each other and the other pairs presented HSP between 9 months and 5 years. Seven patients had a history of allergic diseases. The clinical courses of 12 patients were reviewed. Upper respiratory tract infection preceded HSP in 10 patients, two of whom had elevated antistreptolysin-O titers. No pairs of patients in a family received the same drugs before the onset of HSP. Abdominal pain was noted in eight patients, arthralgia in six and nephritis in four. Severity of skin lesions, presence of abdominal pain and nephritis, and serum IgA levels at the acute stage varied among family members of HSP. Conclusions:,The incidence of HSP in family members of children with HSP seems to be high. Onset at the same age and onset of HSP within 1 month in siblings have not previously been reported. There were no characteristic or similar findings between two patients of the same family. No trigger or genetic factor causing HSP was identified. [source] | ||||||||||||||||||||||||||||||||||||||||