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SARS Outbreak (sars + outbreak)
Selected AbstractsSARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARSEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 7 2009G. Y. Oudit Abstract Background, Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1,7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease including arrhythmias, sudden cardiac death, and systolic and diastolic dysfunction. Materials and methods, We studied mice infected with the human strain of the SARS-CoV and encephalomyocarditis virus and examined ACE2 mRNA and protein expression. Autopsy heart samples from patients who succumbed to the SARS crisis in Toronto (Canada) were used to investigate the impact of SARS on myocardial structure, inflammation and ACE2 protein expression. Results, Pulmonary infection with the human SARS-CoV in mice led to an ACE2-dependent myocardial infection with a marked decrease in ACE2 expression confirming a critical role of ACE2 in mediating SARS-CoV infection in the heart. The SARS-CoV viral RNA was detected in 35% (7/20) of autopsied human heart samples obtained from patients who succumbed to the SARS crisis during the Toronto SARS outbreak. Macrophage-specific staining showed a marked increase in macrophage infiltration with evidence of myocardial damage in patients who had SARS-CoV in their hearts. The presence of SARS-CoV in the heart was also associated with marked reductions in ACE2 protein expression. Conclusions, Our data show that SARS-CoV can mediate myocardial inflammation and damage associated with down-regulation of myocardial ACE2 system, which may be responsible for the myocardial dysfunction and adverse cardiac outcomes in patients with SARS. [source] SARS in Canada and China: Two Approaches to Emergency Health PolicyGOVERNANCE, Issue 2 2007JAMES LAWSON China and Canada addressed the transnational 2003 SARS outbreak within a common, multilevel network of public-health expertise. The two countries deployed distinct public-health strategies, and faced distinct levels of resistance. This article addresses this comparison. During this epidemic "state of exception," both countries adopted emergency policy instruments and overall policy styles. However, Chinese emergency boundary policing corresponded better to everyday experience than did hospital-based screening in Canada, and China's policing targeted collectivities where Canada emphasized individual case tracking. While Canadian efforts were smaller in scale and faced infrastructural deficiencies, prior campaigns to address endemic health problems formed a basis for compliant popular subject positions. Power/resistance relations and their cultivation during endemic conditions must become the center of analyzing effective approaches to emergency planning. [source] Severe acute respiratory syndrome, tourism and the mediaINTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 1 2005Peter Mason Abstract There has been an assumption, based on trends from the last two decades of the twentieth century, that global tourism will continue to grow. A number of events in the early twenty first century, however, have called this into question. Some of these have been natural occurrences, others anthropogenic, such as the terrorist attacks in New York in 2001, which indirectly affected global tourism, and that in Bali in 2002, where tourists were the major target. The outbreak of the disease severe acute respiratory syndrome (SARS) in early 2003 had direct and significant impacts on global tourism. This article provides an overview of the SARS outbreak and its impact on global tourism, and focuses on the role of the media in relation to the disease outbreak. Eighteen months on from the height of the outbreak, SARS appeared to have been checked, but there have a number of subsequent cases and of particular concern, it has been predicted that the disease will return on a large scale, and therefore a future research agenda is also presented. Copyright © 2005 John Wiley & Sons, Ltd. [source] An evaluation of nursing practice models in the context of the severe acute respiratory syndrome epidemic in Hong Kong: a preliminary studyJOURNAL OF CLINICAL NURSING, Issue 6 2006Engle Angela Chan PhD Aim and objective., Like other health-care workers, Hong Kong nurses had their professional knowledge and skills seriously challenged during the SARS outbreak. Could current nursing practices support the care of SARS or SARS-like patients in the future? If not, alternative practices would be needed. Providing a preliminary understanding, this paper compares the conventional with different nursing delivery models in a simulated SARS ward and focuses on nurses' efficiency, infection control practices and views of the two models. Design and methods., This study was conducted in three phases. First, a baseline understanding of nursing practices was achieved through four workflow observations. In an eight-hour day, four research assistants observed nursing activities in the medical and fever wards. These data were used in the second phase to construct two sets of clinical vignettes, pertaining to SARS patient care in both conventional and alternative practice models. These scripts were discussed with nine nurses of various ranks from the hospital under study for their expert validation and input. In the third phase, nurse participants and patient actors enacted the vignettes in a simulated setting. Video-taped observations and four nurse participant interviews were employed. Observational data were analysed through descriptive statistics and independent t -tests. Textual data were coded and categorized for common meanings. Results., Conventional practice from the findings consisted of cubicle and named nurse nursing. While the former reflected modified team and functional nursing, it did not confine patient care within a cubicle as suggested by its name. The latter depicted a modified primary nursing approach in a team, with delegation of care. Preliminary findings concerning infection control and nurse satisfaction revealed that the alternative model had an advantage over the conventional. Relevance to clinical practice., This study findings lay the foundation for clinical trials, which would evaluate the significance of patient-care quality, cost-effectiveness and better human resource management by restructuring current nursing practices. [source] The psychology behind the masks: Psychological responses to the severe acute respiratory syndrome outbreak in different regionsASIAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 1 2004Cecilia Cheng Severe acute respiratory syndrome (SARS) was first reported in China, and spread to 29 regions, affecting over 8000 people worldwide. For the general public, the psychological impact of SARS may have been greater than the physical health danger of the disease. The present paper proposes the influence of psychological factors on people's cognitive, affective, and behavioral responses during the SARS outbreak. The various papers in this special issue of the Journal reveal how people have reacted during the SARS outbreak: People's general coping styles may be related to their health behavior during the outbreak. Cultural differences were evident in the perception of SARS, and individuals' perceptual styles may have influenced their ability to cope with the outbreak. The way in which individuals coped with SARS-related stressful events was different from their usual practices of managing daily stress. Individual differences in the adoption of preventive measures were related to the distinct susceptibility to several social-cognitive biases. [source] Facing highly infectious diseases: new trends and current conceptsCLINICAL MICROBIOLOGY AND INFECTION, Issue 8 2009P. Brouqui Abstract A highly infectious disease (HID) that is transmissible from person to person causes life-threatening illness and presents a serious hazard in the healthcare setting and in the community that requires specific control measures. Due to environmental factors, changes in lifestyle and many other unknown factors, the emergence of such HIDs is becoming more and more likely. As has already been demonstrated during the SARS outbreak, healthcare facilities are likely to be the origin of future HID outbreaks. Preparedness planning will be essential in helping facilities manage future outbreaks of emerging or resurgent infectious diseases. Guidelines have been developed by national and international institutions. To avoid contamination of healthcare workers, the care of HID patients should follow the same infection control rules that are applied to laboratory workers exposed to similar agents. Here, the current knowledge concerning the clinical care of patients with HIDs is reviewed, and specific aspects of the management of such diseases are introduced. [source] | ||||||||||