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Rome II (rome + ii)
Terms modified by Rome II Selected AbstractsHealth-related quality of life and symptom classification in patients with irritable bowel syndromeJOURNAL OF NURSING AND HEALTHCARE OF CHRONIC ILLNE SS: AN INTERNATIONAL INTERDISCIPLINARY JOURNAL, Issue 1 2010Graeme D Smith smith gd, steinke dt, penny ki, kinnear m & penman id (2010) Journal of Nursing and Healthcare of Chronic Illness2, 4,12 Health- related quality of life and symptom classification in patients with irritable bowel syndrome Background., Previous research has established that health-related quality of life can be adversely affected by irritable bowel syndrome IBS. Irritable bowel syndrome has been classified to subgroups by predominant bowel symptom: constipation, diarrhoea or alternating between the two. Little is presently known about the specific impact of irritable bowel syndrome on health-related quality of life within disease sub-groups across time. Aims., To examine the health-related quality of life in a cohort of individuals with irritable bowel syndrome to explore the association between quality of life and disease subtype classification. Setting., The general population of the UK. Design., Longitudinal cohort survey was conducted. Methods., Individuals with symptoms of irritable bowel syndrome were recruited via a UK-wide newspaper advertisement. The health-related quality of life was measured using a battery of validated questionnaires. Results., Data on 494 participants with a Rome II confirmed diagnosis of irritable bowel syndrome were examined. Measurement of generic health-related quality of life revealed lower median scores (poorer quality of life) in anxiety/depression and pain/discomfort domains of health. Conclusion., Health-related quality of life is impaired in community based individuals with IBS. Patients appear to fluctuate between sub-groups when irritable bowel syndrome is classified across time. This study suggests that the impact of irritable bowel syndrome may be greatly underestimated. Relevance for clinical practice., The use of sub-group classification and understanding of predictive factors may allow for a more flexible and efficient approach to healthcare assessment and patient care for people with irritable bowel syndrome. [source] Stability of the irritable bowel syndrome and subgroups as measured by three diagnostic criteria , a 10-year follow-up studyALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 5 2010L. B. Olafsdottir Aliment Pharmacol Ther 2010; 32: 670,680 Summary Background, The irritable bowel syndrome (IBS) is a common disorder, but information on its natural history is limited. Aim, To study the performance of four IBS criteria in detecting incidence and stability of categories over a 10-year period. Method, This study was a population-based postal study. Questionnaire was mailed to the same age- and gender-stratified random sample of the Icelandic population aged 18,75 years in 1996 and again in 2006. IBS was estimated by the Manning criteria, Rome II, Rome III, subgroups and self-report. Results, Prevalence of IBS varied according to criteria: Manning showed the highest (32%) and Rome II the lowest (5%). Younger subjects and females were more likely to have IBS. Prevalence was stable over 10 years for all criteria except Rome III. There was a turnover in all IBS subgroups and a strong correlation among IBS, functional dyspepsia and heartburn. Conclusions, The prevalence of the IBS remained stable over a 10-year period with a turnover in symptoms. The study suggests that IBS is a cluster of symptoms that float in time between different IBS categories, functional dyspepsia and heartburn. The irritable bowel syndrome in Iceland is very common and indicates a chronic condition, which poses a heavy burden on the health care system. [source] Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndromeALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 4 2008J.-M. SABATE Summary Background, Relationships between pain threshold during rectal distension and both symptoms intensity and alteration in quality of life (QoL) in irritable bowel syndrome (IBS) patients have been poorly evaluated. Aim, To evaluate relationships between rectal sensitivity, IBS symptom intensity and QoL in a multicentre prospective study. Methods, Rectal threshold for moderate pain was measured during rectal distension in IBS patients (Rome II), while IBS symptoms intensity was assessed by a validated questionnaire and QoL by the Functional Digestive Disorder Quality of Life questionnaire. Results, Sixty-eight patients (44.2 ± 12.7 years, 48 women) were included. The mean rectal distending volume for moderate pain was 127 ± 35 mL while 45 patients (66%) had rectal hypersensitivity (pain threshold <140 mL). Rectal threshold was not significantly related either to overall IBS intensity score (r = ,0.66, P = 0.62) or to its different components, or to FDDQL score (r = 0.30, P = 0.14). Among FDDQL domains, only anxiety (r = 0.30, P = 0.01) and coping (r = 0.31, P = 0.009) were significantly related with pain threshold. Conclusions, In this study, two-thirds of IBS patients exhibited rectal hypersensitivity. No significant correlation was found between rectal threshold and either symptom intensity or alteration in QoL. [source] Biliary events and an increased risk of new onset irritable bowel syndrome: a population-based cohort studyALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 3 2008M. A. MCNALLY Aliment Pharmacol Ther,28, 334,343 Summary Background, Prospective data are lacking to determine if irritable bowel syndrome (IBS) is a risk factor for cholecystectomy, or if biliary disease and cholecystectomy predisposes to the development of IBS. Aim, To test the hypothesis that IBS and biliary tract disease are associated. Methods, Validated symptom surveys sent to cohorts of Olmsted County, MN, (1988,1994) with follow-up in 2003. Medical histories were reviewed to determine any ,biliary events' (defined by gallstones or cholecystectomy). Analyses examined were: (i) time to a biliary event post-initial survey and separately and (ii) risk of IBS (Rome II) in those with vs. without a prior biliary event. Results, A total of 1908 eligible subjects were mailed a follow-up survey. For analysis (i) of the 726 without IBS at initial survey, 44 (6.1%) had biliary events during follow up, in contrast to 5 of 93 (5.4%) with IBS at initial survey (HR 0.8, 95% CI 0.3,2.1). For analysis (ii) of the 59 subjects with a biliary event at initial survey, 10 (17%) reported new IBS on the follow-up survey, while in 682 without a biliary event up to 1.5 years prior to the second survey, 58 (8.5%) reported IBS on follow-up (OR = 2.2, 95% CI 1.1,4.6, P = 0.03). Conclusion, There is an increased risk of new IBS in community subjects who have been diagnosed as having a biliary event. [source] The ties that bind: perceived social support, stress, and IBS in severely affected patientsNEUROGASTROENTEROLOGY & MOTILITY, Issue 8 2010J. M. Lackner Abstract Background, This study assessed the association between social support and the severity of irritable bowel syndrome (IBS) symptoms in a sample of severely affected IBS patients recruited to an NIH-funded clinical trial. In addition, we examined if the effects of social support on IBS pain are mediated through the effects on stress. Methods, Subjects were 105 Rome II diagnosed IBS patients (F = 85%) who completed seven questionnaires which were collected as part of a pretreatment baseline assessment. Key Results, Partial correlations were conducted to clarify the relationships between social support and clinically relevant variables with baseline levels of psychopathology, holding constant number of comorbid medical diseases, age, gender, marital status, ethnicity, and education. Analyses indicated that social support was inversely related to IBS symptom severity. Social support was positively related with less severe pain. A similar pattern of data was found for perceived stress but not quality of life impairment. Regression analyses examined if the effects of social support on pain are mediated by stress. The effects of social support on bodily pain were mediated by stress such that the greater the social support the less stress and the less pain. This effect did not hold for symptom severity, quality of life, or psychological distress. Conclusions & Inferences, This study links the perceived adequacy of social support to the global severity of symptoms of IBS and its cardinal symptom (pain). It also suggests that the mechanism by which social support alleviates pain is through a reduction in stress levels. [source] Novel pharmacology: asimadoline, a ,-opioid agonist, and visceral sensationNEUROGASTROENTEROLOGY & MOTILITY, Issue 9 2008M. Camilleri Abstract, Asimadoline is a potent ,-opioid receptor agonist with a diaryl acetamide structure. It has high affinity for the , receptor, with IC50 of 5.6 nmol L,1 (guinea pig) and 1.2 nmol L,1 (human recombinant), and high selectively with , : , : , binding ratios of 1 : 501 : 498 in human recombinant receptors. It acts as a complete agonist in in vitro assay. Asimadoline reduced sensation in response to colonic distension at subnoxious pressures in healthy volunteers and in irritable bowel syndrome (IBS) patients without alteration of colonic compliance. Asimadoline reduced satiation and enhanced the postprandial gastric volume (in female volunteers). However, there were no significant effects on gastrointestinal transit, colonic compliance, fasting or postprandial colonic tone. In a clinical trial in 40 patients with functional dyspepsia (Rome II), asimadoline did not significantly alter satiation or symptoms over 8 weeks. However, asimadoline, 0.5 mg, significantly decreased satiation in patients with higher postprandial fullness scores, and daily postprandial fullness severity (over 8 weeks); the asimadoline 1.0 mg group was borderline significant. In a clinical trial in patients with IBS, average pain 2 h post- on-demand treatment with asimadoline was not significantly reduced. Post hoc analyses suggest that asimadoline was effective in mixed IBS. In a 12-week study in 596 patients, chronic treatment with 0.5 mg and 1.0 mg asimadoline was associated with adequate relief of pain and discomfort, improvement in pain score and number of pain-free days in patients with IBS-D. The 1.0 mg dose was also efficacious in IBS-alternating. There were also weeks with significant reduction in bowel frequency and urgency. Asimadoline has been well tolerated in human trials to date. [source] The effect of new diagnostic criteria for irritable bowel syndrome on community prevalence estimatesNEUROGASTROENTEROLOGY & MOTILITY, Issue 6 2003Y. A. Saito Abstract, The ,Rome' criteria for irritable bowel syndrome (IBS) have evolved over 15 years with four published versions. The impact of these changes on community prevalence rates is not known. Study aims were to estimate the prevalence of IBS using the four Rome criteria and agreement between Rome II and previous criteria. Questionnaires were mailed to a random sample of Olmsted County, Minnesota residents in 1992. Age- and gender-adjusted prevalence estimates were calculated for Rome II (1999), Rome I (1992), Rome (1990), and Rome (1989) criteria. Per cent agreement and kappa values were calculated to assess agreement. Of 892 eligible subjects, 643 (72%) responded. The age- and gender-adjusted prevalence of IBS was 5.1% [95% confidence interval (CI): 3.1, 7.0], 6.8% (95% CI: 4.7, 8.9), 5.1% (95% CI: 3.2, 7.1) and 27.6% (95% CI: 23.6, 31.5), respectively. In comparison with Rome II criteria, per cent agreement and , values were 97.2% and 0.78 (95% CI: 0.69, 0.88), 96.4% and 0.68 (95% CI: 0.55, 0.80), and 79.0% and 0.29 (95% CI: 0.19, 0.40), respectively. Thus, although differences were seen with the older criteria, compared with the Rome I criteria, good agreement was seen and community prevalence estimates were similar with the Rome II criteria. [source] | ||||||||||