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Rising Concerns (rising + concern)
Selected AbstractsLow variation but strong population structure in mitochondrial control region of the plains topminnow, Fundulus sciadicusJOURNAL OF FISH BIOLOGY, Issue 5 2009C. Li The plains topminnow Fundulus sciadicus is a freshwater killifish endemic to the Great Plains of North America. Rising concerns for future viability of this species have prompted recent changes in its conservation status. In this study, the results of a range-wide population genetic survey based on the sequence of entire mitochondrial control region (CR) are presented. A total of 181 fish were collected from 11 sites in Nebraska and 10 sites in Missouri spanning the distribution range of the species. Seven polymorphic sites were found in the 966 base pairs of the CR, and only nine unique haplotypes were detected among all fish. Phylogenetic analysis and statistical parsimony networks identified two distinct clades. The first included fish in the Osage, Gasconade and Spring River drainages in Missouri, while the second included individuals from Nebraska and the Lamine River in Missouri, although the Lamine River is much closer to the other Missouri sites than to the Nebraska sites. Pair-wise FST and average population distances indicated that populations from most drainages are genetically distinct, as 93% of the total molecular variance was attributed to among-drainage effects. Four sites within the main distributions of this species and a highly disjunct site from the south-western portion of the range are suggested as potential targets for conservation. [source] Pharmacokinetics of oxytetracycline in the American horseshoe crab, Limulus polyphemusJOURNAL OF VETERINARY PHARMACOLOGY & THERAPEUTICS, Issue 5 2007M. W. NOLAN The American horseshoe crab, Limulus polyphemus, is regularly cultured and maintained in research laboratories and public aquaria. Rising concerns over the health of these captive animals makes the diagnosis and treatment of pathological conditions in L. polyphemus essential. This study investigated the kinetics of oxytetracyline following either intravascular or oral dosing. Oxytetracylcine is a broad-spectrum antibiotic used in the treatment of various bacterial diseases of aquatic animals. A noncompartmental model was developed to describe the pharmacokinetics of oxytetracycline (OTC) in the horseshoe crab. The following parameters were determined for a single intravascular bolus of 25 mg/kg OTC: AUC = 9524.60 ,g·h/mL, MRT = 443.65 h, Clb = 0.044 mL/min/kg, Vd(ss) = 1.164 L/kg, t1/2 = 128.3 h, Cmax = 55.90 ,g/mL, Cave = 27.39 ,g/mL. Following a single oral bolus of 25 mg/kg, these parameters were calculated: AUC = 5861.81 ,g·h/mL, MRT = 395.89 h, Clb = 0.071 mL/min/kg, Vd(ss) = 1.688 L/kg, t1/2 = 210.0 h, Cmax = 7.83 ,g/mL, Cave = 2.89 ,g/mL, F = 61.56%. [source] Sex Differences in Perceived Family Functioning and Family Resources in Hong Kong Families: Implications for Social Work PracticeASIAN SOCIAL WORK AND POLICY REVIEW, Issue 3 2009Joyce L.C. Ma Although enhancing family functioning has become a rising concern of social workers in Chinese contexts such as Hong Kong, little has been known on perceived family functioning and family resources. To fill in this knowledge gap, this article reports part of the results of a telephone survey conducted in Hong Kong, aiming to identify the sex differences in these two areas. The results of the study have shown that Chinese women perceived better affective involvement, one of the crucial indicators of family functioning, than Chinese men. However, among the different family resources, men rated better physical and mental well-being whereas women's social connection was stronger than men's. Further analysis have shown that the linkage of three family resources (namely stress coping efficacy, time spent with family and income) to perceived family functioning was statistically significant irrespective of genders. Implications of this study for social work practice are discussed at the end of the article. [source] Potential impacts on the incidence of fatal heroin-related overdose in Western Australia: a time-series analysisDRUG AND ALCOHOL REVIEW, Issue 4 2002KIM HARGREAVES Abstract In response to the rising concerns about the rate of heroin-related fatalities, overdose prevention campaigns, run by both users' organizations and government agencies, have been implemented in a number of states across Australia. In Western Australia (WA) in mid-1997, various overdose prevention initiatives were implemented. These included the implementation of a protocol limiting police presence at overdose events; the commencement of naloxone administration by ambulance staff; and the establishment of the Opiate Overdose Prevention Strategy (OOPS) which provided follow-up for individuals treated for overdose in emergency departments. This paper reports the results of a multiple linear regression analysis of 60 months of time-series data, both prior to and following the implementation of these interventions, to determine their impact on the number of fatal heroin overdoses in WA. The model employed in the analysis controlled for changes over time in proxy indicators of use and community concerns about heroin, as well as market indicators. The results suggest that, although the interventions implemented have managed to reduce the expected number of fatalities, they have become less successful in doing so as time passes. This has implications for both existing and potential interventions to reduce fatal heroin-related overdose. [source] Potentially Inappropriate Medication Utilization in the Emergency Department Visits by Older Adults: Analysis From a Nationally Representative SampleACADEMIC EMERGENCY MEDICINE, Issue 3 2010William J. Meurer MD Abstract Objectives:, The objectives were to determine the frequency of administration of potentially inappropriate medications (PIMs) to older emergency department (ED) patients and to examine recent trends in the rates of PIM usage. Methods:, The data examined during the study were obtained from the National Hospital Ambulatory Medical Care Survey (NHAMCS). This study utilized the nationally representative ED data from 2000,2006 NHAMCS surveys. Our sample included older adults (age 65 years and greater) who were treated in the ED and discharged home. Estimated frequencies of PIM-associated ED visits were calculated. A multivariable logistic regression model was created to assess demographic, clinical, and hospital factors associated with PIM administration and to assess temporal trends. Results:, Approximately 19.5 million patients, or 16.8% (95% confidence interval [CI] = 16.1% to 17.4%) of eligible ED visits, were associated with one or more PIMs. The five most common PIMs were promethazine, ketorolac, propoxyphene, meperidine, and diphenhydramine. The total number of medications prescribed or administered during the ED visit was most strongly associated with PIM use. Other covariates associated with PIM use included rural location outside of the Northeast, being seen by a staff physician only (and not by a resident or intern), presenting with an injury, and the combination of female sex and age 65,74 years. There was a small but significant decrease in the proportion of visits associated with a PIM over the study period. Conclusions:, Potentially inappropriate medication administration in the ED remains common. Given rising concerns about preventable complications of medical care, this area may be of high priority for intervention. Substantial regional and hospital type (teaching versus nonteaching) variability appears to exist. ACADEMIC EMERGENCY MEDICINE 2010; 17:231,237 © 2010 by the Society for Academic Emergency Medicine [source] Unlicensed Residential Programs: The Next Challenge in Protecting YouthAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 3 2006Robert M. Friedman Over the past decade in the United States, the number of private residential facilities for youth has grown exponentially, and many are neither licensed as mental health programs by states, nor accredited by respected national accrediting organizations. The Alliance for the Safe, Therapeutic and Appropriate use of Residential Treatment (A START) is a multi,disciplinary group of mental health professionals and advocates that formed in response to rising concerns about reports from youth, families and journalists describing mistreatment in a number of the unregulated programs. This article summarizes the information gathered by A START regarding unregulated facilities. It provides an overview of common program features, marketing strategies and transportation options. It describes the range of mistreatment and abuse experienced by youth and families, including harsh discipline, inappropriate seclusion and restraint, substandard psychotherapeutic interventions, medical and nutritional neglect, rights violations and death. It reviews the licensing, regulatory and accrediting mechanisms associated with the protection of youth in residential programs, or the lack thereof. Finally, it outlines policy implications and provides recommendations for the protection of youth and families who pursue residential treatment. [source] | ||||||||||