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Responses Consistent (response + consistent)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

IgG Subclass Responses in Childhood Helicobacter pylori Duodenal Ulcer: Evidence of T-Helper Cell Type 2 Responses

HELICOBACTER, Issue 4 2004
David I. Campbell
ABSTRACT Background., Duodenal ulcer in adults chronically infected with Helicobacter pylori is associated with a polarized T-helper cell type 1 (Th1) mucosal immune response, with a predominantly immunoglobulin G2 (IgG2) systemic specific response. It has been suggested that children colonized by H. pylori also produce a mucosal Th1 response, but there are few studies that have measured IgG subclass responses in children with duodenal ulcer. Materials and methods., Seven children with endoscopically proven duodenal ulcer and H. pylori infection and 18 children with biopsy proven H. pylori infection but no duodenal ulcer had relative concentrations of IgG subclass responses (IgGsc) against H. pylori antigens measured by ELISA. Eighteen IgG seropositive adults acted as controls. The range of antigens recognised by IgG1 and IgG2 subclass responses were investigated by Western blots. Results., There were no differences in mean IgGsc responses between children with or without duodenal ulcer. Adults produced an IgG2 predominant response. Western blots showed no qualitative differences in antigens recognised by IgG1 or IgG2. Conclusion., Children with duodenal ulcer, in contrast to adults, produce an IgGsc response consistent with a mucosal Th2 response to H. pylori regardless of the presence of duodenal ulceration. This suggests that disease causation amongst children with H. pylori associated duodenal ulceration may not be dependant upon a mucosal Th1 biased response. [source]

Electrophysiological Signals of Familiarity and Recency in the Infant Brain

INFANCY, Issue 5 2010
Kelly A. Snyder
Electrophysiological work in nonhuman primates has established the existence of multiple types of signals in the temporal lobe that contribute to recognition memory, including information regarding a stimulus's relative novelty, familiarity, and recency of occurrence. We used high-density event-related potentials (ERPs) to examine whether young infants represent these distinct types of information about previously experienced items. Twenty-four different highly familiar and initially novel items were each repeated exactly once either immediately (Experiment 1), or following one intervening item (Experiment 2). A late slow wave (LSW) component of the ERP exhibited neural responses consistent with recency signals over right-central leads, but only when there were no intervening stimuli between repetitions. The LSW also exhibited responses consistent with familiarity signals over anterior-temporal leads, but only when there were intervening stimuli between repetitions. A mid-latency negative component (i.e., the Nc) also distinguished familiar from novel items, but did not exhibit a pattern of responding consistent with familiarity signals. These findings suggest that infants encode information about a variety of objects from their natural environments into long-term memory, and can discriminate between familiar and unfamiliar items, and between recently seen and new items, very quickly (within 1 sec). They also suggest that infants represent information about not only whether a stimulus is familiar or unfamiliar but also whether it has been seen recently. [source]

Classifying simulated air threats with fast and frugal heuristics

JOURNAL OF BEHAVIORAL DECISION MAKING, Issue 1 2007
David J. Bryant
Abstract In three experiments, subjects learned to classify simulated aircraft using four probabilistic cues then classified test sets designed to contrast predictions of several compensatory and non-compensatory heuristics. Results indicated that a proportion of subjects appeared to use a non-compensatory fast and frugal heuristic but that significant proportions used less frugal compensatory decision rules. The relative proportions of subjects exhibiting responses consistent with the fast and frugal heuristic versus other decision rules was largely unaffected by manipulations of time pressure and perceived cue uncertainty. An extreme time constraint, however, did result in significant differences in the proportions of subjects who preferred non-compensatory to compensatory decision rules. These results suggest that it is possible to model multi-attribute decision tasks like threat assessment with a fast and frugal heuristic although no single heuristic is a general model for the simulated threat assessment task. Copyright © 2006 Crown in the right of Canada. Published by John Wiley & Sons, Ltd. [source]

Diagnosis of climate models in terms of transient climate response and feedback response time

ATMOSPHERIC SCIENCE LETTERS, Issue 1 2008
David G. Andrews
Abstract Climate models have traditionally been characterised by their climate sensitivity (equilibrium response to a doubling of CO2) and their ocean heat uptake. Together these determine a third property: the transient climate response to a linear increase in radiative forcing. A fourth property, the feedback response time is introduced here and shown to provide a complementary diagnostic of climate model behaviour. In particular, it demonstrates that the discrepancy between recent climate observations and the general circulation models in the ,IPCC ensemble' primarily arises because the models are undersampling the range of transient climate responses consistent with recent attributable greenhouse warming. Copyright © 2007 Royal Meteorological Society [source]

Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects

CELLULAR MICROBIOLOGY, Issue 11 2005
Jeffrey K. Ichikawa
Summary The type III secretion system (TTSS) is a dedicated bacterial pathogen protein targeting system that directly affects host cell signalling and response pathways. Our goal was to identify host responses to the Pseudomonas aeruginosa effectors, introduced into target cells utilizing the TTSS. We carried out expression profiling of a human lung pneumocyte cell line A549 exposed to isogenic mutants of P. aeruginosa PAK lacking individual or a combination of TTSS components. We then devised a data analysis method to isolate the key responses to specific secreted bacterial effector proteins as well as components of the TTSS machinery. Individually, the effector proteins elicited host responses consistent with their known functions, many of which were cell cycle-related. However, our analysis has shown that the effector proteins elicit a distinct host transcriptional response when present in combination, suggesting a synergistic effect. Furthermore, the pattern of host transcriptional responses is consistent with the pore forming ability of the TTSS needle complex. This study shows that the individual components of the TTSS define an integrated system and that a systems biology approach is required to fully understand the complex interplay between pathogen and host. [source]